According to the survey data of 308 science and technology commissioners involved in precision poverty alleviation activities in Chongqing, a structural equation model was established to explore the influence of the competence of science and technology commissioners on the help effect in the process of precision poverty alleviation and the relationship between them. The research results show that the competency model of science and technology commissioners includes 19 indicators of four dimensions: ideology, work skills, ability to guide and help, and entrepreneurial assistance. The ideology of science and technology commissioners has a strong positive impact on their ability to help poor villagers. Job skills have a positive impact on their ability to guide and help poor villagers. Excellent ability to help can produce accurate poverty alleviation positive effects. Therefore, according to the competency model, a long-term operation mechanism for improving the competency of science and technology commissioners should be established and improve its entrepreneurial management system in the process of precise poverty alleviation.