Nodes exit from technology innovation network will affect stability of the network, even lead to network collapse． The study on influencing factors of nodes exit from network will help nodes’ relationship management． This paper analyzes influencing factors of nodes exit as an example of the patent cooperation network ,using social network analysis and statistical analysis． Studies show that the larger the size of node and the density of the network and the node betweeness centrality, node is more difficult to exit the network; the larger the diversity of network size and the distance of network size , node is more likely to exit the network ．