University-enterprise cooperation is a kind of R D cooperation mode established by universities and enterprises. University-enterprise cooperation is a win-win resource information-sharing model; it has become an important way to achieve industrial innovation in developed countries. But the potential cooperation between universities and enterprises in China have not yet been developed, the university-enterprise cooperation remains difficult. After the survey to a university and some enterprises in an innovation park, based on theories of two-sided market, we found that the most important cause is the difficulty of finding a suitable partner. This paper analyzes the reasons why we can’t find a partner from the view of enterprises, universities and the society. From the perspective of regional innovation theory, we suggest that enterprises play a leading role in the cooperation relationship, with the help of other institutions.