The biopharmaceutical industry is a component of hi-tech industry, and patent applications is particularly important for R D of new drugs. To identify its frontier technology and core technology, this paper constructed input-output network analysis method of bio-pharmaceuticals technology network, and established recognition model for frontier technology and core technology. Then we forecasted the trend of the number of patents by constructing dynamic input-output model. The results show that the technology group of IPC C12N (Microbes or enzymes; The combination; Breeding, preservation or maintain microorganisms; Mutation or genetic engineering; medium) is the core and frontier technology of the Bio-pharmaceuticals technology, and the trend of the patent number of IPC C12N will maintain steady for the next five years.