The nineteen Party proposed regional coordinated development strategy, and rising it a new height of the overall development of the party and the state. Guangdong is a typical area for regional development incongruity. Problems such as poor innovation ability, weak industrial foundation and insufficient endogenous development power, is very serious. From view of innovation elements, this paper analysis the foundation and short board of innovation of Guangdong southeast northwest,comparisonning and drawing lessons from the North area in Jiangsu.Based on this, this paper researchs Innovation development strategy of Guangdong southeast northwest in New period.