Based on the perspective of knowledge integration, this paper takes 258 entrepreneurial team members as investigation object, investigates the influence of knowledge heterogeneity and knowledge integration capacity on team creativity by multiple regression analysis method, and then makes relevant tests to make sure whether environment uncertainty adjusts the impact that knowledge integration capacity on team creativity. Through the regression analysis, this paper has the following conclusions: entrepreneurial team knowledge heterogeneity can positively impact knowledge integration capacity, team creativity; knowledge integration ability positively affect team creativity; meanwhile, knowledge integration capacity plays a partial mediating effect on the influence of knowledge heterogeneity on team creativity; environment uncertainty has positive moderating effect in the relationship between knowledge integration capacity and team creativity. The research conclusions provide theoretical inspiration and practical guidance for the formation of entrepreneurial team and the stimulation of creativity.