S: Based on the characteristics of scientific and technological innovation, the evaluation index system of regional scientific and technological innovation ability is constructed from three dimensions: science and technology development ability, scientific and technological achievements transformation ability and science and technology support ability, and the entropy method is used to analyze. The results show that the overall scientific and technological innovation ability of Guangdong Province is significantly improved from 2003 to 2015, but the three dimensions are different. The ability of science and technology development and the transformation of scientific and technological achievements are increasing, and the ability of science and technology support is slightly increased but fluctuating. In view of the problems existing in the scientific and technological innovation capability of Guangdong Province, suggestions are put forward from strengthening the investment in science and technology, strengthening the basic research, introducing talent and promoting the cultivation of technology market.S