In the environment of science and technology globalization, researching the related theory of international scientific and technological cooperation, and using the theory to guide the policy making of China"s international science and technology cooperation helps Guangdong carry out international scientific and technological cooperation effectively and enhances the technological strength and competitiveness. This paper straightens out theories of domestic and international scientific and technological cooperation, and researches the practice and policy features of the world of international science and technology cooperation, and summarizes the characteristics and trends of China’s international scientific and technological cooperation, and combines with the development trend of Guangdong International Science and Technology Cooperation, indicating the useful inspiration for Guangdong.