共查询到20条相似文献,搜索用时 234 毫秒
1.
Pushpa Durgawale Sangita Patil P. S. Shukla Ajit Sontakke Satish Kakade Sunil Yadav 《Indian journal of clinical biochemistry : IJCB》2009,24(1):30-35
Fasting samples of 914 subjects from healthy population were analyzed for total cholesterol, triglyceride and three major
fractions of lipoproteins i.e. high-density lipoprotein cholesterol, low lipoprotein cholesterol and very low-density lipoprotein
cholesterol. The values obtained were (in mg/dl) 165.7±30.2,88.36±31.2, 44.86±10.68, 101.66±29.8 and 18.11±7.35 respectively.
When these subjects were grouped according to the age and sex, no appropriate differences were observed between most of the
groups. Triglycerides were found to be low and HDL cholesterol was high in female when compared with male of similar age.
Beyond age 40 years cholesterol level and low density lipoprotein cholesterol was found to be gradually increased in case
of women. Minor difference was observed with dietary pattern. Present study suggests that clinical evaluation of patient should
be made on the basis of these reference values for Western Maharashtra population. 相似文献
2.
Fasting blood sample of 50 normal subjects (control) and 100 patients of breast cancer were investigated for serum total cholesterol,
high density lipoprotein cholesterol, low density lipoprotein cholesterol, very low density lipoprotein, high density lipoprotein
cholesterol:low density lipoprotein cholesterol ratio and total cholesterol:high density lipoprotein cholesterol ratio during
breast cancer of women. Five cancer stages, types, age groups, parity and menopausal status were undertaken for the study.
It was observed that there was a significant rise in serum total cholesterol and low density lipoprotein cholesterol whereas
high density lipoprotein cholesterol and very low density lipoprotein cholesterol were not significant. The ratio of high
density lipoprotein cholesterol:low density lipoprotein cholesterol and total cholesterol:high density lipoprotein cholesterol
values increased significantly in breast cancer patients. 相似文献
3.
12hrs fasting samples of 1485 apparently healthy, Assamese population in the age group of 20–80 yrs., mostly from the urban
area of Assam were tested for serum lipid profile that includes total cholesterol, triacylglycerol, high density lipoprotein
cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) over
a period of three years. The values (median and range in mg/dl) obtained were 170 (93–263); 110 (40–256); 40 (23–73); 103
(40–173) and 22 (8–51) respectively. After grouping these subjects according to the age and sex no significant difference
were observed between most of the groups. Median and upper range of total cholesterol, HDL-C and LDL-C were found to be higher
in women than in men in all the age groups. But triacylglycerol and VLDL-C concentrations were observed to be higher in the
men than women except in age group of 61–70 yrs. It can be suggested that lipid values obtained in this study can be used
as the reference value, based on which clinical correlation can be made. 相似文献
4.
Vaneet Kaur Minni Verma Amandeep Kaur Shalini Gupta Kamaljit Singh 《Indian journal of clinical biochemistry : IJCB》2012,27(3):290-295
Overnight fasting samples of 1,031 apparently healthy people of Punjab visiting the hospital over a period of 3 years were tested for serum lipid profile. The mean ± SD of serum total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol and very low density lipoprotein cholesterol in mg/dl were 182.2 ± 33.9, 122.4 ± 33.4, 44.1 ± 6.8, 113.9 ± 32.0, 24.6 ± 7.1 respectively. When these subjects were grouped according to age and sex, no appreciable difference was observed between most of the groups. Serum triglycerides were found to be low and HDL-C was high in females when compared with males of similar age and vice versa. With advancing age, total cholesterol and low density lipoprotein cholesterol levels were found to be higher in women. The present study suggests that the obtained lipid values should be taken into consideration during clinical evaluation. 相似文献
5.
Ananthakrishnan Ramani Sudhakar S. Nayak A. R. Aroor G. N. Kundaje 《Indian journal of clinical biochemistry : IJCB》1991,6(1):59-64
Both cigarette smoking and propranolol administration significantly alter plasma lipid profile. We examined the relationship
of cigarette smoking and propranolol administration with fasting serum total cholesterol, triglyceride, lipoprotein cholesterol
subfractions (high density, low density, and very low density), Apo-A, Apo-B and ratios obtained from these variables in 42
hypertensive patients. Significantly lower values of HDL cholesterol, Apo-A and HDL-C/total cholesterol and Apo-A/Apo-B ratios
were observed in smokers taking propranolol than non-smokers not taking propranolol. Smokers who were not on propranolol also
had significantly lower values as compared to non-smokers. These findings suggest that smoking may be the more significant
factor responsible for alteration in lipid profile. 相似文献
6.
Fasting samples of 1396 apparently healthy, middle class Bengali population of Kolkata, West Bengal were tested for total
cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol and very low density
lipoprotein cholesterol, over a period of three years. The values obtained were (in mg/dl) 190±33, 132±42, 53±10, 116±30 and
21±7 respectively. When these subjects were grouped according to the age and sex, no appreciable difference were observed
between most of the groups. Triglyceride was found to be low and HDL cholesterol was high in women below 30 years when compared
with men of similar age. Beyond 60 years, cholesterol level as well as low density lipoprotein cholesterol was found to be
gradually increased in case of women. Besides these changes, other minor differences were not statistically significant. It
is suggested that the lipid values of the present study should be taken as a base parameters and the clinical evaluation be
made on the basis of these finding. 相似文献
7.
Effects of three drugs, Gemfibrozil, Diltiazem and lsosorbide dinitrate (ISDN) on various lipid parameters were studied in patients with ischemic heart disease (IHD) with positive treadmill stress response. Gemfibrozil and diltiazem significantly lowered the levels of serum total lipids (TL), triglycerides (TG), phospholipids (PL), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C), and incroased the levels of serum high density lipoprotein cholesterol (HDL-C) significantly. However, patients administered with ISDN showed a significant increase in all the lipid parameters except HDL-C, which showed a significant decrease. 相似文献
8.
A. Ray S. L. Dayalu Naik A. K. Bahadur S. T. Pasha R. S. Rautela B. K. Sharma 《Indian journal of clinical biochemistry : IJCB》2001,16(1):101-105
Serum levels of various lipid parameters, i.e., triglycerides, total cholesterol, alpha lipoprotein or high density lipoprotein
(HDL)-cholesterol and beta lipoprotein or low density lipoprotein (LDL)-cholesterol were measured in a total of 138 histologically
proven cases of breast cancer along with 146 control women. The mean levels of serum triglycerides, total cholesterol and
LDL-cholesterol were found to be significantly higher in breast cancer cases as compared to controls. However, lower mean
levels of serum HDL-cholesterol and sex-hormone binding glubulin (SHBG) were observed in breast cancer patients than the control
subjects. The results indicate a probable relation between serum lipids and the activity of sex-hormones. Moreover, the study
reflects an overall disturbance of lipid metabolism in the pathological process of breast cancer. 相似文献
9.
K. K. Reddy T. Ramachandraiah K. Soorya Kumari P. Reddanna K. Thyagaraju 《Indian journal of clinical biochemistry : IJCB》1992,7(2):125-133
The association of serum antioxidatns and lipids was studied in 350 urban individuals with an age range of 40–76 years, in comparison with a control rural sample of equal size. Glutathione Peroxidase (GPx) activity was found to be significantly higher in urban population when compared to rural population. Urban population were characterised by elevated levels of serum cholesterol (SC), low density lipoprotein cholesterol (LDLC) and triglycerides (TG) in comparison with rural population. In urban females both tocopherol (T) and GPx were negatively related with age. The serum lipid levels were found to be increased with age in urban population when compared to rural population. Further the correlation coefficients revealed that LDLC positively (.285:P<.05), and TG inversely (?.512:P<.05) related to ascorbic acid (AA), and an inverse association of SC (?.625:P<.05), high density lipoprotein cholesterol (HDLC) (?.369:P<.05) and LDLC (?.532:P<.05) with T in urban population. In rural population GPx shown a good positive correlation with lipid levels. The results of this study revealed that accumulation of lipids with unaltered antioxidants may be the consequence of urbanization. 相似文献
10.
A. Dasgupta J. K. Agarwal S. S. Dubey 《Indian journal of clinical biochemistry : IJCB》1992,7(1):33-36
The aim of the present study was to evaluate the serum levels of lecithin cholesterol acyl transferase and lipoprotein cholesterol in hyperthyroid patients. The serum levels of total cholesterol and triacylglycerols were also determined in order to assess the lipid status of these patients. It was observed that serum content of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density liproprotein cholesterol (HDL-C) were significantly lower (P<0.001) in these patients whereas serum triacylglycerols (Tg.) and very low density lipoprotein cholesterol (VLDL-C) (P>0.05) did not show any significant change as compared to control values. However, the serum level of lecithin cholesterol acyl transferase (LCAT) was significantly higher (P<0.001) in these patients. It is concluded that an increased LCAT activity plays a significant role in regulating lipoprotein cholesterol levels in hyperthyroid patients. 相似文献
11.
The incidence of cardiovascular and cerebrovascular disease is steadily increasing in South East Asian countries including
Indian sub continent. Many lipids, apolipoproteins and Lp (a) except HDL-C and apo A-I, A-II are implicated as risk factors
for coronary artery disease and cerebrovascular disease. There is great need to have national guidelines for each country
like the ATP III guidelines recommended for U.S. population. For recommending appropriate medical decision limits, it is mandatory
that each country establishes reference intervals pertaining to their population due to dietary, genetic and environmental
diversity. In the present study, reference intervals for serum lipids, apolipoproteins and Lp (a) were established in a total
of 1923 healthy Indian reference individuals comprising 1161 healthy men and 762 healthy women from Andhra Pradesh. For each
analyte viz., serum total cholesterol, HDL-C, LDL-C, triglycerides, Lp (a), Apo A-I, Apo A-II, B, C-II, C-III and E, mean,
two SD, median, confidence limits of mean, different percentile values are presented. The study also includes decade wise
changes in each analyte and comparison of lipids, lipoproteins and Lp (a) among few populations covering U.S., India, Japan,
Sweden, Finland and China. Reference Intervals for all lipid and lipoprotein parameters will immensely help in assessing associated
risk for cardiovascular and cerebrovascular diseases in India. Additionally, the results will be beneficial in formulating
our own guidelines pertaining to Indian population. 相似文献
12.
V. S. Choudhary M. D. Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》1989,4(1):31-35
20 male dogs weighing 20–25 kg were assigned an exercise schedule for 2 months. Blood samples were collected before exercise and again at the end of the exercise schedule, thus each dog served as its own control. Physical exercise caused a significant reduction in total lipids, total cholesterol and low density lipoprotein (LDL) cholesterol, whereas unesterified cholesterol (UC), high density lipoprotein (HDL) and very low density lipoprotein (VLDL) cholesterol remained unaffected. However, the ratio of HDL cholesterol to LDL cholesterol raised significantly from 0.36±0.01 to 0.58±0.01. Aerobic exercise also resulted in an increase in creatinine phosphokinase (CPK) level. The results show that aerobic exercise programme can significantly affect serum cholesterol and lipoprotein concentration. 相似文献
13.
S. Mukhopadhyaya D. Sharma R. Shankar 《Indian journal of clinical biochemistry : IJCB》1995,10(2):93-97
The serum lipid classes in 75 pregnant women (25 in each trimester) and 25 matched controls were investigated. The lipid classes
studied were very low density lipoproteins (VLDLc), low density lipoproteins (LDLc), high density lipoproteins (HDLc), total
triacylglycerols (Tg), phospholipids (PL) and total cholesterol (Tc). It was found that there is increase in HDLc during first
trimester followed by decrease during second and third trimesters. All other lipid classed including Tc and PL showed a progressive
increase. Analysis of data showed that Tc/HDLc ratio has an increasing trend with parity. LDLc/HDLc also showed similar correlation.
The results of our study indicates that there is likely to be increased risk for CHD in multiparous women as predicted from
serum lipid parameters. 相似文献
14.
Ajai Kumar M. C. Pant H. N. Pandey J. L. Aggarwal R. S. Sharma L. D. Joshi S. Singh 《Indian journal of clinical biochemistry : IJCB》1993,8(1):47-50
Effect of feeding ripe and unripe papaya fruit pulps were investigated on blood lipid profile of normal male adult albino rabbits by giving them pulps separately at the dose of 15 and 30g per day along with standard diet over a period of six weeks. As compared to controls both fruit pulps resulted in highly significant (p<0.001) and consistent lowering of serum cholesterol, low density lipoprotein cholesterol and triglycerides and elevation in phospholipids and high density lipoprotein cholesterol levels at 1,3 and 6 weeks of fruit pulp feeding indicating a dose dependent effect. Observations clearly support medicinal value ofC. Papaya in the management of atherosclerosis, fatty liver, ischaemic changes and consequential myocardial infarction. 相似文献
15.
Maninder Kaur Kiranjeet Kaur Gurdeep Kaur Bedi Gurpreet Singh Sidhu Roopan Sikand 《Indian journal of clinical biochemistry : IJCB》2000,15(2):63-67
Forty patients suffering from mild to moderate degree of hypertension were put on felodipine. Their lipid profile was analysed
before the start of their therapy and consecutively at two and four months after starting felodipine. There was a statistically
significant fall in the levels of serum cholesterol, serum triglycerides and serum total lipids; though no appreciable variation
was observed in HDL and LDL cholesterol levels. At baseline there were a few patients who had higher than the normal range
of the serum lipid profile. Analysis of these patients showed a highly significant fall in the levels of serum cholesterol,
serum triglycerides, serum LDL-cholesterol and serum total lipids i.e. felodipine modified the lipid profiles of hypertensive
patients in a positive way. 相似文献
16.
This study was undertaken to evaluate the effects of n-3 fatty acid supplementation on blood glucose, lipid profile and cytokines
in humans. Twenty adult healthy subjects were supplemented with 1g/day fish oil concentrate capsules for 2 weeks. Fasting
blood samples were taken at baseline and again after 2 week intervention. Fish oil supplementation significantly lowered fasting
serum concentrations of total cholesterol, triacylglycerol, very low density lipoprotein and low density lipoprotein (P <
0.01). Also high density lipoprotein increased significantly compared with baseline value (P < 0.01). Fish oil did not significantly
altere the fasting blood glucose concentration but significantly reduced the serum cytokines (P < 0.001). This study demonstrated
that eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) supplementation altered serum lipids, lipoprotein and cytokine
concentrations in normal human subjects even at the small dose of 660 mg of EPA plus DHA per day. It appears that EPA plus
DHA can be a safe and perhaps beneficial supplement to inflammatory diseases. 相似文献
17.
Devendra K. Rai Prashant Kumar Rai Aradhna Gupta Geeta Watal Bechan Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(2):198-201
Wistar rats of 6–8 weeks in age weighing between 120–150 g were exposed to the fixed doses of each of the carbamate pesticides
such as cartap (50% LD50) and carbofuran (50% LD50) as well as a combination of these two with 25% LD50 of each for one week. The effect of treatments was studied in terms of serum lipid parameters such as high-density lipoprotein,
total cholesterol, triglyceride, low-density lipoprotein and very low-density lipoprotein. Treatment with individual doses
of carbofuran (50% LD50) and cartap (50 % LD50) caused significant alterations in the levels of serum lipid parameters. The pesticides treatment resulted in marked decrease
in the level of serum high-density lipoprotein where as that of other lipids got significantly elevated. Further, the rats
exhibited relatively higher impact of pesticides when treated with the compounds in combination (25 % LD50 of each). The results indicated that these compounds when used together may exert enhanced effect on the levels of serum
lipids in rat. 相似文献
18.
The level of serum cholesterol (Ch), serum-high density lipoprotein cholesterol (HDLc), serum-low density lipoprotein cholesterol
(LDLc), serum very low density lipoprotein cholesterol (VLDLc), Triglyceride (Tg), Apolipoprotein A-1, B and ratio of Apolipoprotein
A1/B were observed in 151 survivors of myocardial infarction in different age groups. A significant increase was found in
the level of triglyceride, LDLc, apolipoprotein-B and a significant decrease in apolipoprotein-A1 and the ratio of apolipoprotein
A1/B. No significant alteration was found in serum cholesterol, HDLc except in the age group of 31–40 years and 41–50 years
and VLDLc. Thus, serum Apo A-1 and Apo-B may be considerably better markers for coronary artery disease than traditional lipid
parameters. 相似文献
19.
Shrilekha Sairam Suhasini Domalapalli Sundaram Muthu Jayanthi Swaminathan Vivek A. Ramesh Lalitha Sekhar Palak Pandeya Udhaya Balasubramaniam 《Indian journal of clinical biochemistry : IJCB》2014,29(3):290-297
Clinical reference intervals among Indian population are poorly defined. Therefore, there is an urgent need to establish local clinical laboratory reference intervals for healthy Indian population. The present study aimed to identify the 95 % reference interval for hematological and biochemical parameters in apparently healthy Indian population. We undertook a multicentric cross-sectional study conducted at Apollo Hospitals Educational and Research Foundation across India. Of which 10,665 reference individuals identified as healthy by physicians. The 95 % of the reference distribution was estimated using 2.5th and 97.5th percentile reference limits. The 95 % reference intervals for hemoglobin (Males: 12.3–17 g/dL; Females: 9.9–14.3 g/dL), platelet count (Males: 1.3–3.8; Females: 1.3–4.2 Lakhs/µL), erythrocyte sedimentation rate (Males: 2–22; Females: 4–55 mm/h), serum uric acid in males: 3.5–8.2 mg/dL, gamma glutamyl transferase (Males: 13–61 U/L), fasting blood glucose (Males: 78–110 mg/dL), total cholesterol (Males: 115–254 mg/dL), low density lipoprotein (Males: 60–176 mg/dL) and triglycerides (Males: 55–267 mg/dL, Females: 52–207 mg/dL) were different from currently used reference values. Additionally need for gender based partitioning were observed for triglycerides and gamma glutamyl transferase. The observed findings are of clinical significance and it needs to be validated with additional community based studies. 相似文献
20.
P. K. Rai D. Jaiswal S. Mehta D. K. Rai B. Sharma Geeta Watal 《Indian journal of clinical biochemistry : IJCB》2010,25(2):175-181
This study deals with the effects of freeze dried rhizome powder of Curcuma longa (C. longa) dissolved in milk on normal as
well as diabetic models. Diabetes of type II and type I was within 3 days of a single administration of doses of 45 and 65
mg kg−1 of streptozotocin respectively. Various parameters such as blood glucose levels, triglycerides, total cholesterol, high density
lipoprotein, very low density lipoprotein, low density lipoprotein, serum glutamic oxaloacetic transaminase, serum glutamic
pyruvate transaminase, alkaline phosphatase, creatinine, hemoglobin, urine protein and urine sugar in addition to body weight
were taken in to consideration and were analyzed after administration of variable doses of rhizome powder. The dose of 200
mg kg−1 was identified as the most effective dose as it increased HDL, Hb and bw (P<0.05) with significant decrease in the levels
of blood glucose, lipid profile and hepatoprotective enzymes (P<0.001). 相似文献