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本文综述了辅酶Q10的主要合成方法，分析比较了其优、缺点，并对其以后合成研究提出了建议。文章简介了辅酶Q10的化学结构与性质。 相似文献
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《科学中国人》2017,(15)
目的:研究辅酶Q10对缺血性脑卒中大鼠血浆CRP、NF-κΒ、TNF-α水平的影响,为临床应用该药物预防和治疗缺血性脑血管病提供实验依据。方法:采用线栓法栓塞大鼠大脑中动脉建立局灶性缺血性脑卒中模型。用longa五级四分法对大鼠进行神经功能评分。用ELISA法检测血清中CRP、NF-κB、TNF-α水平在不同组间的变化。用SPSS13.0软件,方差分析法对各组间结果进行统计学分析。结果:各组神经学评分差异具有显著性。各组血浆CRP、NF-κΒ、TNF-α水平也具有显著性差异。干预组CRP、NF-κΒ、TNF-α水平随剂量的升高而降低。结论:大鼠血浆CRP、NF-κΒ、TNF-α的含量,其降低水平与辅酶Q10含量有关。说明辅酶Q10对缺血性脑卒中具有保护作用。 相似文献
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含有辅酶Q10的护肤品广告铺天盖地,已经成为化妆品界的主流。Q10广泛存在于人体细胞中,是细胞维持功能不可或缺的,但它们延缓皮肤衰老的效果却远不如宣传的那样好。 相似文献
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辅酶Q10是一种脂溶性的醌类化合物。因为其具有明显的抗脂质过氧化作用,近年来成为医学研究的热点之一。临床研究表明:它能清除氧自由基、有保护心肌的功能,可作为心脑血管病人的治疗药物;它具有抗肿瘤、免疫调节、抗皮肤皱纹和延缓皮肤衰老的功能,也可作为辅助药物。因此,在医药、食品添加剂、化妆品等各个领域已经被广泛应用。本文综述了辅酶Q10的研究以及作用机理。 相似文献
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玉溪健坤生物药业有限公司位于玉溪高新技术产业开发区创新路23号，占地面积3．5hm^2，注册资本1600万元人民币。公司是以生物科技产业具有自主知识产权的辅酶Q10、研发、生产、销售为一体的专业生产厂家。经过多年研发，具有完整、先进、配套的研发及工业生产设施以及提取高纯度茄尼醇，炯碱等多项中间体的先进生产线。 相似文献
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Q2黄土是中更新世沉积具有弱湿陷性和结构性的粘性土.文中以真三轴仪为基础,模拟了在三维应力条件下Q2黄土的受力状况,进行了不同固结围压、含水率和中主应力比下Q2黄土的真三轴试验,研究了不同含水率黄土的应力应变特性.得到了如下结论:通过4种含水率、4种中主应力比、4种不同固结围压下的Q2黄土真三轴试验结果,分析了复杂应力条件下不同含水率、中主应力比率和固结围压条件下Q2黄土的非线性应力应变特性.表明低含水率及固结围压条件下,随着中主应力比率的增大,应力应变曲线由强软化型逐渐转化为弱软化型或弱硬化型;同一固结围压及中主应力比率条件下,随着含水率的增大,应力应变曲线由弱硬化型或弱软化型转化为硬化型;同一含水率及中主应力比率条件下,随着固结应力增大,应力应变曲线由软化型转化为强硬化型. 相似文献
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Dina M. Abo-Elmatty Ehsan A. Badawy Jihan S. Hussein Somaya Abo Elela Hoda A. Megahed 《Indian journal of clinical biochemistry : IJCB》2012,27(4):379-384
The objective of this study to evaluate heme oxygenase (COHb), leptin and coenzyme Q10 (CoQ10) in pre-eclamptic women. Also Zinc, copper, Iron, total iron binding capacity, Ferritin and uric acid were assessed. 120 female subjects were included in this study. They were divided into, 60 female with normal pregnancy attending the outpatient clinic, 60 pre-eclamptic patients were recruited from obstetrics and gynaecology department El-kasr El-Aini hospital. The results showed that in pre-eclampatic group, leptin level was significantly increased while COHb and CoQ10 was significantly decreased. It is concluded that hemeoxygenase, leptin and coenzyme CoQ10 can be considered as new markers for prediction of pre-eclampsia. 相似文献
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A. S. Thakur G. P. Littaru S. Moesgaard C. Dan sindberg Y. Khan C. M. Singh 《Indian journal of clinical biochemistry : IJCB》2013,28(2):185-188
The study has been undertaken as number of sickle cell patients in Chhattisgarh tribal population is 23.7 %. The Co enzyme Q10 is a strong antioxidant and energy producing compound. The patients were divided into three groups group A homozygous (SS), group B heterozygous (AS) and group C controls for TBARS study. The age group is 10–55 years and 200 mg of CoQ10 was given to A and B groups. The hematological parameters, C reactive protein as well as RBC TBARS level were performed by usual and standard techniques. The results were obtained as 25.37 % increased RBC level in group A and 23.24 % in group B. The increased hemoglobin level was observed as 16.73 % in group A and 10.7 % in group B. In case of WBC it was observed increased 24.38 % in group A and 12.0 % in group B. C-reactive protein was observed 7.8 times decreased in group A and 1.54 times in group B. The RBC TBARS level was also found decreased 48 % in group A and 51 % in group B as compared to group C. During the supplementation of coenzyme Q10 the pain caused by vaso-occlusive events has reduced. This significant increase in hematological parameters as well as decreased C-reactive protein and TBARS level suggest that the Q10 should be included in the diet of sickle cell patients. 相似文献
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【目的 /意义】通过构建社区问答平台可用性评价指标体系并选取实证对象进行评价,为社区问答平台可
用性优化提供数据支持和参考。【方法/过程】通过文献梳理与用户调研,运用因子分析法确立社区问答平台评价指
标体系,综合应用MUSA、TOPSIS对社区问答平台可用性评价研究。【结果/结论】实际获得3个社区问答平台的可
用性用户测度结果,定位与分析了平台评价指标的最优方案、最劣方案,平台最优距离以及最劣距离,依据结果给
出了可用性优化策略。【创新/局限】本研究结合了MUSA和TOPSIS的优势,综合运用两种方法深化了对社区问答
平台可用性测度的研究,通过横向与纵向对比,使对社区问答平台可用性的测度更加细致与精准,但是在实证对象
的数量和调研样本数量方面还存在一定局限。 相似文献
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林祁 《中国科学院研究生院学报》2000,38(2):167-181
根据对18个国家和地区120个标本馆收藏的万余份八角属植物标本的研究,提出3个新组合,对13个种、6个亚种、3个变种和2个变型作了归并,确认全世界现有八角属植物34种3亚种和1变种。 相似文献
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社交问答是融合社会化特征并提供高质量知识服务的社区。在比较图书馆问答服务与典型社交问答网站的基础上,分析高校图书馆构建学科知识问答社区的优势,并就知识问答社区的定位、构建策略进行探讨。 相似文献
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栎属青冈亚属（壳斗科）的叶表皮研究 总被引：1，自引：0，他引：1
利用光镜和扫描电镜观察了栎属青冈亚属Quercus subgen. Cyclobalanopsis 48种植物的叶表皮，尤以对叶下表皮的毛被特征观察较为仔细。共观察到8种不同类型的叶表皮毛：单列毛、单毛、乳突、星状毛、溶和星状毛、具柄束毛、多出毛和水母状毛。其中乳突在青冈亚属中较常见，而在壳斗科其他属中仅在石栎属 Lithocarpus 少数种类中有报道；水母状毛首次在壳斗科中发现。毛被可能遵循以下的演化规律：乳突→单毛→星状毛；星状毛依照从简单→复杂的演化途径，分化出各种形态各异和结构复杂的毛系。初步讨论了毛被以及叶表皮其他特征(如毛基细胞和表皮细胞的形态、气孔的类型和密度等)的分类和系统学意义。 相似文献
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The plasma fractionation is a technology to separate therapeutic plasma proteins. The fractionation is carried out either
by solvent precipitation (ethanol) or recently by chromatography. During the process of chromatography lipids were found in
waste fraction. A new lipid rich lyophilised quality control (Q.C.) sera was prepared inexpensively using this waste plasma
fraction. This is probably the first attempt to prepare the Q.C. sera by large scale chromatographic method in India. 相似文献
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云南姜科新植物 总被引：1，自引：0，他引：1
童绍全 《中国科学院研究生院学报》1989,27(4):277-292
Twelve new species of Zingiberaceae are described from Yunnan
Province, China. They are Amomum fragle S. Q. Tong, A. quadrato-laminare S.
Q. Tong, A. verrucosum S. Q. Tong, A. glabrum S. Q. Tong, A. capsiciforme S.
Q. Tong, A. coriandriodorum S. Q. Tong, Alpinia rubromaculata S. Q. Tong, A.
emaculata S. Q. Tong, Zingiber nigrimaculatum S. Q. Tong, Hedychium glabrum
S. Q. Tong, Costus viridis S. Q. Tong and Costus oblongus S. Q.Tong. A key to
species of the genus Costus is given at the end of text. 相似文献
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In this paper, 10 species and varieties of the genus Panax from China were
studied by means of numerical taxonomic methods. At first, the geometric approaches
and statistical treatments were used and some new characters induced by the funda-
mental characters were defined for the numerical representation of the morphological
characters of plants. Consequently, forty-seven morphological, three chemical, one geo-
graphical and one cytological characters were adopted. The principal component ana-
lysis and the similarity coefficients were computed on the standardized data. Based
upon the correlation matrix and the distance matrix respectively, the Q and R cluster
analyses were carried out, and UPGMA was used in both Q and R cluster analyses.
According to the R cluster analysis, all characters are mainly divided into 5 sets:
A, B, C, D and E (Fig. 2). The tree-like diagram illustrates that chemical constitu-
ents of triterpenoids and the chromosome numbers are related to some morphological
characters, such as the roots, the rhizomes, the seeds and the leaves. It is of interest to
note that the thicker the fleshy roots, the larger the seeds and the wider the teeth of
leaflet, the higher the content of the tetracyclic triterpenoids of dammarane type it
contains. On the other hand, the Q cluster analysis showed that Panax as a whole
may be divided into two groups (Fig. 3). The first group includes P. ginseng, P.
quinquefolius, P. notoginseng and P. zingiberensis and the second group includes P.
stipuleanatus, P. pseudo-ginseng, P. japonicus var. japonicus, P. japonicus var. angus-
tifolius, P. japonicus var. major and P. japonicus var. bipinnatifidus. The results of
the computation of principal component analysis indicate that the first principal
component consistes of the characters occurring in the sets A and B. It shows that
the variation in Panax has two opposite directions. One of them, corresponding to the
set A, is represented by the first group, and the other, corresponding to the set B, is
by the second group. Finally, some questions about the use of the genus in medicine were discussed. 相似文献
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Shedid SM Saada HN Eltahawy NA Hammad AS 《Indian journal of clinical biochemistry : IJCB》2018,33(3):314-321
Radiation induced brain damage is associated with impairment of mitochondrial functions, variations in the level of neurotransmitters, and oxidative stress. Mitochondrial function is closely linked to the level of neurotransmitters since the precursors are supplied by the Kreb’s cycle intermediates. The objective of this study was to evaluate the influence of pantothenic acid, an essential component in the synthesis of Coenzyme A (CoA), on the activity of the Krebs cycle enzymes, isocitrate dehydrogenase (IDH), α-ketoglutarate dehydrogenase (α-KGDH), and succinate dehydrogenase (SDH); the level of aspartic, glutamic and GABA; the activity of transaminases, and oxidative stress, in the cerebrum of γ-irradiated rats. Pantothenic acid (26 mg/Kg) was orally administered to the rats, 2 h after irradiation and during the following 5 days. Animals were sacrificed the 7th day post-irradiation. The exposure of male albino rats to γ-rays (5 Gy) has triggered oxidative stress notified by a significant elevation in the level of malondialdehyde (MDA), an end product of lipid peroxidation, associated to a significant decrease in the content of phospholipids, and the antioxidant compound glutathione (GSH). The activity of IDH, α-KGDH, and SDH, has significantly decreased, while the level of aspartic, glutamic and GABA has significantly increased. In parallel to these changes, the activity of alanine and aspartate transaminase has significantly increased, compared to their values in the control rats. Pantothenic acid treatment, has significantly attenuated oxidative stress; enhanced the activity of IDH, α-KGDH, and SDH; minimized the increase in the level of amino acids and the activity of transaminases, compared to their values in the cerebrum of irradiated rats. In conclusion, pantothenic acid could improve the level of neurotransmitters amino acids, which depends on the enzymatic activities of Krebs cycle and linked to oxidative stress. 相似文献