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1.
《科学中国人》2017,(24)
目的研究熊去氧胆酸治疗原发性胆汁肝硬化的临床效果并之后做具体探讨。方法选取某院2012年5月到2013年5月收治的88例原发性胆汁性肝硬化患者,把它们随机分为传统组和氧胆酸组,每组各44名患者。传统组的患者采用的是传统治疗方法,氧胆酸组的患者采用的是熊去氧胆酸进行治疗。再对两组的患者进行比较。结果:氧胆酸组的黄疸、腹胀和乏力的情况都要由于传统组,氧胆酸组的ALT、AST、GGT和TBIL的指标要优于传统组。传统组患者的总体有效率为75%,氧胆酸组的总体有效率为90.91%。氧胆酸组的临床效果要普遍优于对照组(p0.05).其两组的差异具有统计学意义。结论:熊去氧胆酸对于治疗原发性胆汁性肝硬化有着很好的疗效,并能够在最快的速度下进行肝功能的修复,非常值得在临床上进行推广。 相似文献
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胆盐制备工艺的研究/探讨 总被引：1，自引：0，他引：1
《青海科技》2014,(4):86-87
<正>本文叙述了利用高纯度胆酸尾渣制备胆盐的工艺流程。探索了通过技术处理制备胆盐,胆盐的出现实现了工业尾渣的再次资源化,大大的降低了环境污染,生产尾渣得到了最大限度的利用。胆盐(bile salts)是由肝细胞分泌的胆汁中的初级胆汁酸(包括胆酸、鹅脱氧胆酸及其与甘氨酸或牛磺酸的结合产物)与次级胆汁酸(主要包括脱氧胆酸、石胆酸及在肝中分别与甘氨酸或牛磺酸结台生成的结合产物)均以钠盐或钾盐的形式存在,形成相应的胆汁酸盐,简称胆盐。它是胆汁中参与脂肪消化和吸收的主要成分。胆盐随肝胆汁排至小肠后,约有95%在回肠末端被吸收入血,经门静 相似文献
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牛黄,是在牛胆囊、胆管、肝胆管中由胆汁沉积而成的结石。其中在胆囊中生成的牛黄又称胆黄或蛋黄,色泽呈金黄色,形状呈椭圆形、三角形或沙料形等,系牛黄中精品。其它部位形成的牛黄称管黄,色泽呈黄色或褐色。牛黄的成份和胆汁的成份基本一致,主要为胆酸盐、胆红素、胆固醇、卵磷酯、皂化酯酸等。牛黄 相似文献
4.
目的:研究并分析妇宁阴道膨胀栓的处方工艺,增加了冰片、猪去氧胆酸的鉴别项。方法:采用高薄层色谱鉴别法冰片、猪去氧胆酸。结果:本为所述检测方法能很好的控制妇宁阴道膨胀栓中冰片和猪胆粉的质量,可以较好控制该品种的质量。 相似文献
5.
熊去氧胆酸与鹅去氧胆酸的对比研究 总被引：4，自引：0，他引：4
郑兴 《内蒙古科技与经济》2008,(2):28-29,32
文章对熊去氧胆酸和鹅去氧胆酸两种药物进行了系统的比较研究,从结构关系、临床应用、测定方法、制备工艺、研究进展等方面作了综合分析. 相似文献
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目的：探讨奥曲肽在胆汁瘘治疗中的作用及其机理。方法 对我科在１９９７年５月至１９９９年１２月期间收治的７例胆汁瘘患者在抗炎，维持水、电解质及酸碱平衡，加强支持治疗的基础上，给予奥曲肽治疗，奥曲肽的具体用法为：首日予奥曲肽３００ｕｇ＋生理盐水２０ｍｌ，ｉ．ｖ；以厉１００ｕｇ，皮下注射，Ｑ８ｈ，根据病情连用７～１４天，结果。７例患者均获治愈，瘘道闭合时间８～１４天。结论 奥曲肽是治疗胆汁瘘的有效药物， 相似文献
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本实验运用离子选择性微电极技术直接测定了鼠胆道梗阻前后肝、肾细胞内的胆汁酸活度。结果表明，胆道梗阻２周，肝、肾细胞内胆汁酸活度明显升高，其中肝细胞内达５．４６ｍｍｏｌ／Ｌ，肾细胞内达０．３７ｍｍｏｌ／Ｌ，已达到或接近体外膜损害浓度，提示胆汁酸可能是梗阻性黄疸引起肝、肾细胞超微结构损害的因素之一。 相似文献
12.
In this study, we propose a microfluidic cell culture device mimicking the microscopic structure in liver tissue called hepatic cords. The cell culture area of the device was designed to align hepatocytes in two lines in a similar way to hepatic cords. Thanks to the structural design together with a cell seeding procedure, rat primary hepatocytes were successfully aligned in two lines and cultured under perfusion condition. It is shown that aligned hepatocytes gradually self-organize and form bile canaliculi along the hepatic cord-like structure. The present technique to culture hepatocytes with functional bile canaliculi could be used as an alternative to animal testing in the field of drug discovery and toxicological studies, and also be beneficial to tissue engineering applications. 相似文献
13.
Vitamin C in Disease Prevention and Cure: An Overview 总被引：1，自引：0，他引：1
Shailja Chambial Shailendra Dwivedi Kamla Kant Shukla Placheril J. John Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2013,28(4):314-328
The recognition of vitamin C is associated with a history of an unrelenting search for the cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radical damage. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight off infections. However the significance and beneficial effect of vitamin C in respect to human disease such as cancer, atherosclerosis, diabetes, neurodegenerative disease and metal toxicity however remains equivocal. Thus further continuous uninterrupted efforts may open new vistas to understand its significance in disease management. 相似文献
14.
Prasheeda Chandran Pradeep Garg Chandra S. Pundir 《Indian journal of clinical biochemistry : IJCB》2005,20(2):81-85
Total cholesterol, total bilirubin, calcium, oxalate, inorganic phosphate, magnesium, iron, copper, sodium and potassium were
analyzed quantitatively in gallstones, bile of gall bladder and sera of 200 patients of cholelithiasis (52 cholesterol, 76
mixed and 72 pigment stone patients) and their contents were correlated between calculi and bile and sera and bile in these
three type of stone patients. A significant positive correlation was observed between total cholesterol, total bilirubin of
calculi and bile, copper of bile and sera of cholesterol stone patients, copper of calculi and bile, total bilirubin, oxalate,
magnesium, potassium of sera and bile of pigment stone patients and oxalate and iron of stone and bile, total bilirubin, oxalate,
sodium of sera and bile of mixed stone patients. A significant negative correlation was found between magnesium of serum and
bile of cholesterol stone patients, oxalate of calculi and bile of pigment stone patients and magnesium of serum and bile
of mixed stone patients. 相似文献
15.
R. S. Kanwar D. C. Merwaha R. R. Gupta P. S. Shukla S. S. Minhas S. Negi 《Indian journal of clinical biochemistry : IJCB》1996,11(2):173-175
Cholesterol and phospholipids were estimated in serum and bile from hepatic duct and gallbladder of twenty five patients of gallstone with functioning gallbladder (Group-I) and an equal number of patients having diseases other than of hepatobiliary system acting as control (Group-II). Group-I patients showed high serum cholesterol and low serum phospholipid levels as compared to those of Group-II. Cholesterol levels in hepatic duct and gallbladder bile were higher in Group-I than in Group-II whereas the phospholipid levels in the bile of Group-I were lower than in Group-II. The phospholipid: cholesterol ratios in hepatic duct and gallbladder bile of Group-I were 2.76 and 3.03 respectively as compared to 5.62 and 5.92 in Group-II. 相似文献
16.
P. Chandran N. K. Kuchhal P. Garg C. S. Pundir 《Indian journal of clinical biochemistry : IJCB》2007,22(2):145-150
Chemical composition of gall stones is essential for aetiopathogensis of gallstone disease. We have reported quantitative
chemical analysis of total cholesterol bilirubin, calcium, iron and inorganic phosphate in 120 gallstones from haryana. To
extend this chemical analysis of gall stones by studying more cases and by analyzing more chemical constituents. A quantitative
chemical analysis of total cholesterol, total bilirubin, fatty acids, triglycerides, phospholipids, bile acids, soluble proteins,
sodium potassium, magnesium, copper, oxalate and chlorides of biliary calculi (52 cholesterol, 76 mixed and 72 pigment) retrieved
from surgical operation of 200 patients from Haryana state was carried out. Total cholesterol as the major component and total
bilirubin, phospholipids, triglycerides, bile acids, fatty acids (esterified), soluble protein, calcium, magnesium, iron,
copper, sodium, potassium, inorganic phosphate, oxalate and chloride as minor components were found in all types of calculi.
The cholesterol stones had higher content of total cholesterol, phospholipids, fatty acids (esterified), inorganic phosphate
and copper compared to mixed and pigment stones. The mixed stones had higher content of iron and triglycerides than to cholesterol
and pigment stones. The pigment stones were richer in total bilirubin, bile acids, calcium, oxalate, magnesium, sodium, potassium,
chloride and soluble protein compared to cholesterol and mixed stones. Although total cholesterol was a major component of
cholesterol, mixed and pigment gall stone in Haryana, the content of most of the other lipids, cations and anions was different
in different gall stones indicating their different mechanism of formation. 相似文献
17.
Rats administered antibiotics showed increased hepatic cholesterogenesis as was evident from the increased activity of HMG-CoA
reductase and increased incorporation of labelled acetate into liver cholesterol. But hepatic degradation of cholesterol to
bile acids was decreased. There was increased release of lipoproteins into the circulation but their clearance from the circulation
was lower as was evident from the decreased activity of lipoprotein lipase of the extrahepatic tissues. Activity of plasma
LCAT was also decreased. 相似文献
18.
BackgroundHelicobacter pylori is considered as the main risk factor in the development of gastric cancer. In the present study, we performed a detailed characterization of the probiotic properties and the anti-H. pylori activity of a previously isolated lactobacillus strain — Lactobacillus fermentum UCO-979C — obtained from human gut.ResultsThe strain tolerated pH 3.0; grew in the presence of 2% bile salts; produced lactic acid and hydrogen peroxide; aggregated in saline solution; showed high hydrophobicity; showed high adherence to glass; Caco-2 and gastric adenocarcinoma human cells (AGS) cells; showed an efficient colonization in Mongolian Gerbils; and potently inhibited the growth and urease activity of H. pylori strains. L. fermentum UCO-979C significantly inhibited H. pylori-induced IL-8 production in AGS cells and reduced the viability of H. pylori. With regard to innocuousness, the strain UCO-979C was susceptible to several antibiotics and did not produce histamine or beta-haemolysis in blood agar containing red blood cells from various origins.ConclusionThe results demonstrated that L. fermentum UCO-979C is a very good candidate as a probiotic for the protection of humans against H. pylori infections. 相似文献
19.
Gaurav Chikara Pramod Kumar Sharma Pradeep Dwivedi Jaykaran Charan Sneha Ambwani Surjit Singh 《Indian journal of clinical biochemistry : IJCB》2018,33(2):121-131
Prevalence of diabetes mellitus, a chronic metabolic disease characterized by hyperglycemia, is growing worldwide. The majority of the cases belong to type 2 diabetes mellitus (T2DM). Globally, India ranks second in terms of diabetes prevalence among adults. Currently available classes of therapeutic agents are used alone or in combinations but seldom achieve treatment targets. Diverse pathophysiology and the need of therapeutic agents with more favourable pharmacokinetic-pharmacodynamics profile make newer drug discoveries in the field of T2DM essential. A large number of molecules, some with novel mechanisms, are in pipeline. The essence of this review is to track and discuss these potential agents, based on their developmental stages, especially those in phase 3 or phase 2. Unique molecules are being developed for existing drug classes like insulins, DPP-4 inhibitors, GLP-1 analogues; and under newer classes like dual/pan PPAR agonists, dual SGLT1/SGLT2 inhibitors, glimins, anti-inflammatory agents, glucokinase activators, G-protein coupled receptor agonists, hybrid peptide agonists, apical sodium-dependent bile acid transporter (ASBT) inhibitors, glucagon receptor antagonists etc. The heterogeneous clinical presentation and therapeutic outcomes in phenotypically similar patients is a clue to think beyond the standard treatment strategy. 相似文献
20.
Gururao Hariprasad Divya Kota Sundararajan Baskar Singh Alagiri Srinivasan Souparno Adhikary 《Indian journal of clinical biochemistry : IJCB》2014,29(4):430-441
Clonorchis sinensis or the Chinese liver fluke is one of the most prevalent parasites affecting a major population in the oriental countries. The parasite lacks lipid generating mechanisms but is exposed to fatty acid rich bile in the liver. A secretory phospholipase A2, an enzyme that breaks down complex lipids, is important for the growth of the parasite. The enzyme is also implicated in the pathogenesis leading up to the hepatic fibrosis and its complications including cancer. The five isoforms of this particular enzyme from the parasite therefore qualify as potential drug targets. In this study, a detailed structural and ligand binding analysis of the isoforms has been done by modeling. The overall three dimensional structures of the isoforms are well conserved with three helices and a β-wing stabilized by four disulfide bonds. There are characteristic differences at the calcium binding loop, hydrophobic channel and the C-terminal domain that can potentially be exploited for drug binding. But the most significant feature pertains to the catalytic site where the isoforms exhibit three variations of either a histidine-aspartate-tyrosine or histidine-glutamate-tyrosine or histidine-aspartate-phenylalanine. Molecular docking studies show that isoform specific residues and their conformations in the substrate binding hydrophobic channel make unique interactions with certain inhibitor molecules resulting in a perfect tight fit. The proposed ligand molecules have a predicted affinity in micro-molar to nano-molar range. Interestingly, few of the ligand binding interaction patterns is in accordance to the phylogenetic studies to thereby establish the usefulness of evolutionary mechanisms in aiding ligand design. The molecular diversity of the parasitic PLA2 described in this study provides a platform for personalized medicine in the therapeutics of clonorchiasis.