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1.
Ze-wei Tao Long-gui Li Zhao-hua Geng Tao Dang Shan-jun Zhu 《Journal of Zhejiang University. Science. B》2010,11(4):238-248
Therapeutically delivered mesenchymal stem cells (MSCs) improve ventricular remodeling. However,the mechanism underlying MSC cardiac remodeling has not been clearly determined. Congestive heart failure (CHF) was induced in rats by cauterization of the left ventricular free wall. MSCs were cultured from autologous bone marrow and injected into the border zone and the remote myocardium 5 d after injury. Ten weeks later,when compared with sham operation,CHF significantly increased nucleus mitotic index,capilla... 相似文献
2.
Li-jiang Tang Jian-jun Jiang Xiao-feng Chen Jian-an Wang Xian-fang Lin Yu-xi Du Cong-feng Fang Zhao-xia Pu 《Journal of Zhejiang University. Science. B》2010,11(8):592-598
Objective:Uric acid(UA) is considered to be a powerful predictor of cardiovascular risk and hyperuricemia might be involved in the metabolic syndrome(MS).This study aims to investigate the relation between UA levels and aortic root dilatation.Methods:A total of 348 hypertensive patients [age(67.5±9.8) years] with or without MS were included in the study.The aortic root diameters at the aortic annulus,the sinuses of Valsalva,the sinotubular junction,and the proximal part of the ascending aorta were measured using a two-dimensional(2D) echocardiography.Serum UA levels were also measured for all patients.Results:A high UA level is independently associated with aortic root diameters at the sinuses of Valsalva(P=0.001) and the proximal ascending aorta(P0.0001) in the hypertensive patients without MS.In contrast,aortic root diameters were not significantly related to UA levels in the hypertensive patients with MS.Furthermore,increased UA levels were associated with an increased risk for aortic root dilatation in the patients without MS(sex-adjusted hazard ratio 1.75,95% confidence intervals(CI) 1.27-2.41),but not in those with MS.Conclusions:This study demonstrated an independent relationship between the aortic root dimensions and increased levels of serum UA in the hypertensive patients without MS.Further understanding of the mechanisms underlying these associations may allow a clearer interpretation of the potential value of specific urate-lowering treatment on cardiovascular disease. 相似文献
3.
Congestive heart failure (CHF) has emerged as a major worldwide epidemic and its main causes seem to be the aging of the population and the survival of patients with post-myocardial infarction. Cardiomyocyte dropout (necrosis and apoptosis) plays a critical role in the progress of CHF; thus treatment of CHF by exogenous cell implantation will be a promising medical approach. In the acute phase of cardiac damage cardiac stem cells (CSCs) within the heart divide symmetrically and/or asym-metrically in response to the change of heart homeostasis, and at the same time homing of bone marrow stem cells (BMCs) to injured area is thought to occur, which not only reconstitutes CSC population to normal levels but also repairs the heart by dif-ferentiation into cardiac tissue. So far, basic studies by using potential sources such as BMCs and CSCs to treat animal CHF have shown improved ventricular remodelling and heart function. Recently, however, a few of randomized, double-blind, pla-cebo-controlled clinical trials demonstrated mixed results in heart failure with BMC therapy during acute myocardial infarction. 相似文献
4.
Cell therapy in congestive heart failure 总被引：5，自引：0，他引：5
Congestive heart failure （CHF） has emerged as a major worldwide epidemic and its main causes seem to be the aging of the population and the survival of patients with post-myocardial infarction. Cardiomyocyte dropout （necrosis and apoptosis） plays a critical role in the progress of CHF; thus treatment of CHF by exogenous cell implantation will be a promising medical approach. In the acute phase of cardiac damage cardiac stem cells （CSCs） within the heart divide symmetrically and/or asymmetrically in response to the change of heart homeostasis, and at the same time homing of bone marrow stem cells （BMCs） to injured area is thought to occur, which not only reconstitutes CSC population to normal levels but also repairs the heart by differentiation into cardiac tissue. So far, basic studies by using potential sources such as BMCs and CSCs to treat animat CHF have shown improved ventricular remodelling and heart function. Recently, however, a few of randomized, double-blind, placebo-controlled clinical trials demonstrated mixed results in heart failure with BMC therapy during acute myocardial infarction. 相似文献
5.
Chen ZW Chen LY Dai HL Chen JH Fang LZ 《Journal of Zhejiang University. Science. B》2008,9(8):616-622
Objective:To investigate the relationship between alanine aminotransferase (ALT)levels and metabolic syndrome (MS)in nonalcoholic fatty liver disease(NAFLD).Methods:A total of 26527 subjects who received medical health checkup in our hospital from January 2005 to July 2007 were enrolled in the study.The diagnosis of fatty liver was based on ultrasound imaging.MS Was defined according to the criteria of the Adult Treatment Panel Ⅲ.ALT,triglyceride(TG),high density lipoprotein cholesterol(HDL-c),fasting plasma glucose(FPG),height,weight,waist circumference(WC),systolic blood pressure (SBP)and diastolic blood pressure(DBP)were measured in each subject to analyze the relationship between MS and ALT activity.Results:(1)The prevalence of NAFLD in men(30.94%)was significantly higher than that in women(15.65%);(2)The incidence of MS in NAFLD(33.83%)was significantly greater than that in non-NAFLD(10.62%);(3)Of the 6470 subjects with NAFLD,in the age-adjusted partial correlation analysis,there were statistically significant correlations between the ALT levels and most metabolic risk factors in each sex(P＜0.01),except that ALT levels had no correlation with HDL-c in women.Moreover,in the multiple stepwise regression analysis,SBP lost its significance,and WC,body mass index(BMI),age,DBP,TG and FPG were independently associated with ALT levels in both sexes (P＜0.05).HDL-c remained significant and was independently related to ALT leveis in men;(4)ALT levels were significantly higher in subjects with MS compared to those without MS(P＜0.001).Mean ALT levels increased with the number of MS cornponents in each sex (P.＜0.05 for trend).Conelusion:We found a strong relationship between ALT leveIs and MS in NAFLD and revealed that the cluster of MS components might be the predictor for ALT elevations. 相似文献
6.
Relationship between hyperuricemia and metabolic syndrome 总被引：6，自引：0，他引：6
Chen LY Zhu WH Chen ZW Dai HL Ren JJ Chen JH Chen LQ Fang LZ 《Journal of Zhejiang University. Science. B》2007,8(8):593-598
Objective: To investigate the relationship between metabolic syndrome and hyperuricemia. Methods: A total of 2 374 subjects who received health examination in our hospital from Jan. 2004 to Dec. 2006 were enrolled in our study. Hyperuricemia is defined as ≥7 mg/dl (in men) or ≥6.0 mg/dl (in women). Metabolic syndrome was defined using AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute) criteria. Results: (1) The overall prevalence of hyperuricemia was 13.10%. The condition was more common in men than in women (19.07% vs 3.42%). (2) Among men, uric acid concentration is statistically significantly positively correlated with waist circumference, blood pressure, and triglyceride. Uric acid is negatively correlated with serum high-density lipoprotein-cholesterol (HDL-C). Uric acid concentration is most strongly correlated with serum triglyceride (r=0.379) and waist circumference (r=0.297). Among women, statistically significant positive correlations were noted for the serum uric acid concentrations with waist circumference, triglyceride and fasting plasma glucose. Serum triglyceride (r=0.329) and waist circumference (r=0.234) are most strongly correlated with uric acid concentrations. (3) Men with hyperuricemia had a 1.634-fold increased risk of metabolic syndrome as compared with those without hyperuricemia odds ratio (OR)=1.634, P=0.000. Women with hyperuricemia had a 1.626-fold increased risk of metabolic syndrome (OR=1.626, P=0.000) as compared with those without hyperuricemia. Conclusion: Hyperuricemia is prevalent among Chinese population. Additionally, serum uric acid is positively associated with metabolic syndrome. 相似文献
7.
方雪 《安徽教育学院学报》2008,26(3)
以木质纤维素为原料生产燃料乙醇的生物转化包括预处理、酶水解和发酵过程,同步糖化发酵法是相对有效的发酵方法,本文对这些过程中的技术进展进行评述.并总结丙酮丁醇梭菌的生理生化特性和代谢工程菌的构建,指出使用丙酮丁醇梭菌进行木质纤维素的同步糖化发酵生产乙醇前景广阔. 相似文献
8.
提出了临界热流密度的一个分形模型,根据加热表面活化点的分形分布得到了临界热流密度的表达式,从该模型中发现大空间临界热流密度(CHF)是壁面过热度、接触角和流体物理特性的函数。接触角对临界热流密度有重要的影响。沸腾表面模型预测的结果与实验数据进行了比较,两者是极好的吻合。 相似文献
9.
陈彩凤 《山西财经大学学报(高等教育版)》2009,(4):48-50,54
大学英语四、六级考试一直都在改革中发展,但近年来频发的泄题及考试中高科技作弊现象,引起人们对大学英语四六级考试的种种质疑。一个曾认可度很高的考试,其传统的考试形式却面临着越来越多的问题。2008年12月的四级考试拉开了大学英语四、六级机考改革的序幕,文章通过回顾其改革进程,分析此次改革的优势与问题所在,提出了当前的大学英语教学应充分利用网络教学、提高学生实际综合应用能力、摆脱应试教育的观点。 相似文献
10.
非酒精性脂肪性肝病（NAFLD）和非酒精性脂肪性肝炎（NASH）是常见的肝组织发生病理学改变的临床代谢综合征.目前,研究者普遍认为氧化应激反应的失衡是导致和加剧肝细胞脂肪化的重要原因.因此,抗氧化药物的使用是临床上治疗NAFLD和NASH的方法之一.维生素E作为一种在医学领域广泛应用的抗氧化剂,能有效清除自由基,阻断由氧化应激引起的细胞衰老,同时预防血液中脂肪氧化及沉积.因此,维生素E能否用于NAFLD和NASH的治疗受到越来越到学者的关注.本文整理近几年的临床试验结果,从单独补充维生素E和维生素E结合其它药物两方面对维生素E在NAFLD和NASH中的疗效进行概括,为探索维生素E应用于NAFLD和NASH临床治疗提供线索. 相似文献
11.
Fabrice Tranchida Léopold Tchiakpe Zo Rakotoniaina Valérie Deyris Olivier Ravion Abel Hiol 《Journal of Zhejiang University. Science. B》2012,13(4):307-317
As the consumption of fructose and saturated fatty acids (FAs) has greatly increased in western diets and is linked with an increased risk of metabolic syndrome, the aim of this study was to investigate the effects of a moderate (10 weeks) and a prolonged (30 weeks) high fructose and saturated fatty acid (HFS) diet on plasma FA composition in rats. The effects of a few weeks of HFS diet had already been described, but in this paper we tried to establish whether these effects persist or if they are modified after 10 or 30 weeks. We hypothesized that the plasma FA profile would be altered between 10 and 30 weeks of the HFS diet. Rats fed with either the HFS or a standard diet were tested after 10 weeks and again after 30 weeks. After 10 weeks of feeding, HFS-fed rats developed the metabolic syndrome, as manifested by an increase in fasting insulinemia, total cholesterol and triglyceride levels, as well as by impaired glucose tolerance. Furthermore, the plasma FA profile of the HFS group showed higher proportions of monounsaturated FAs like palmitoleic acid [16:1(n-7)] and oleic acid [18:1(n-9)], whereas the proportions of some polyunsaturated n-6 FAs, such as linoleic acid [18:2(n-6)] and arachidonic acid [20:4(n-6)], were lower than those in the control group. After 30 weeks of the HFS diet, we observed changes mainly in the levels of 16:1(n-7) (decreased) and 20:4(n-6) (increased). Together, our results suggest that an HFS diet could lead to an adaptive response of the plasma FA profile over time, in association with the development of the metabolic syndrome. 相似文献
12.
《欧洲教育》2013,45(3):18-40
While it was preparing its report, the Joint Working Group for Vocational-Technical Education and Training set up a subordinate working group on technical progress, whose task it was to make a projection of the effects of technical progress on skill requirements and, on the basis of this, to determine the need for new courses of study and new curricula as well as for further education. Due to a lack of the necessary preliminary studies and documentation (occupational categories are inexactly defined, old job classifications are outmoded, and the statistical material is insufficient or too general), the group felt itself unable to forecast the effect of technical progress on employment and education accurately and reliably enough, and consequently interpreted its task as instead: "to determine how technical progress affects jobs so as to obtain some notion of the direction that the development of technology should take, and then, beginning with unsystematic observations, to work out ordered and systematized ideas concerning the relation that might exist between technical progress and changes in the job structure." (20) 相似文献
13.
目的 探讨血清IL-6和NT-proBNP在慢性心力衰竭患者中的临床诊断价值.方法 选择80例慢性心力衰竭患者为CHF组,60例健康人群作为对照组.采用双抗体夹心免疫法检测两组人群的血清IL-6和NT-proBNP浓度,并对检测结果进行统计学分析.结果 CHF组患者的血清IL-6和NT-proBNP浓度均明显高于对照组,且随心衰严重程度的加重而增高,两组间差异有统计学意义（P＜0.01）.冠心病组IL-6浓度明显高于其他原发病因组,组间差异有统计学意义（P＜0.01）,CHF患者不同原发病因组NT-proBNP浓度差异无统计学意义（P＞0.05）.结论 IL-6和NT-proBNP参数均与CHF的发生及严重程度密切相关,联合检测可用于对CHF的早期诊断. 相似文献
14.
王迅 《天津大学学报(英文版)》2004,10(1)
Thecriticalheatflux (CHF)intheforcedconvec tiveboilingwithawalljethasbeenstudied.KattoandIshii[1 ] measuredtheCHFofsaturatedwater,R1 1 3 ,andtrichloroethane (ρl/ ρg =2 0 3— 1 60 3)atatmosphericpressureforadownwardfacingplanewalljet,varyingthevelocityufrom 1 .5to 1 5m/sandtheheaterlengthLfrom 1 0to 2 0mm ,andproposedEq.(1 )topredicttheirCHFdata. qcoρghfgu=0 .0 1 6 4(ρl/ ρg) 0 .867(σρlu2 L) 1 / 3 (1 ) KattoandHaramura[2 ] ,further,haveextendedtheirvelocityrangefromu =1 .8t… 相似文献
15.
目的:探讨促红细胞生成素(EPO)在重度慢性心力衰竭(chronic heart faiture,CHF)伴贫血的患者中应用的有效性。方法:选择自2004.8～2005.8月间住院的重度CHF(心功能Ⅲ～Ⅳ级)伴贫血的患者,采用前瞻性队列研究,随机分为治疗组和对照组,两组患者均给予常规抗心衰治疗,治疗组加用重组促红细胞生成素(rhEPO)注射及铁剂口服治疗,随访1年,比较两组在客观指标上的差别。结果:两组患者在心脏射血分数(LVEF)、6min步行距离及死亡率上均有明显差异。结论:在常规控制心衰治疗的基础上,给予EPO抗贫血干预,可延缓重度CHF伴贫血患者的病情进展,降低死亡率。 相似文献
16.
This article represents a follow-up snapshot of a group of state secondary schools in the North of England. It examines the progress of the schools in the second year of the statutory inclusion of citizenship in the revised National Curriculum. The writers use the same modus operandi as in the previous article (Calvert and Clemitshaw, 2003) to present a picture of both the management and curriculum aspects of the changes. The article draws on data from interviews with the citizenship co-ordinators (CCs) of each school, and there is an overview in the form of a grid. Readers are encouraged to look back at the previous article to track the changes that have taken place since September 2002.
The study reveals that there are some common patterns and difficulties emerging, particularly with regard to assessment and reporting and some of the problems that have always beset PSHE and pastoral care. These same issues are predictably affecting the progress of the initiative. Principally, the status of the subject, resourcing and levels of understanding, training and commitment of staff are ongoing problems. A leitmotiv running through the interviews is the constant pressure of other initiatives and their effects on change at a time of internal turbulence for a number of the schools. Some progress is being made and it would have been unrealistic to expect all schools to adopt the subject without difficulty but, in spite of the CCs' best efforts, there are still issues that might give cause for concern and that are graphically highlighted by individual cases. 相似文献
The study reveals that there are some common patterns and difficulties emerging, particularly with regard to assessment and reporting and some of the problems that have always beset PSHE and pastoral care. These same issues are predictably affecting the progress of the initiative. Principally, the status of the subject, resourcing and levels of understanding, training and commitment of staff are ongoing problems. A leitmotiv running through the interviews is the constant pressure of other initiatives and their effects on change at a time of internal turbulence for a number of the schools. Some progress is being made and it would have been unrealistic to expect all schools to adopt the subject without difficulty but, in spite of the CCs' best efforts, there are still issues that might give cause for concern and that are graphically highlighted by individual cases. 相似文献
17.
《Pastoral Care in Education》2013,31(3):31-36
This article represents a follow-up snapshot of a group of state secondary schools in the North of England. It examines the progress of the schools in the second year of the statutory inclusion of citizenship in the revised National Curriculum. The writers use the same modus operandi as in the previous article (Calvert and Clemitshaw, 2003) to present a picture of both the management and curriculum aspects of the changes. The article draws on data from interviews with the citizenship co-ordinators (CCs) of each school, and there is an overview in the form of a grid. Readers are encouraged to look back at the previous article to track the changes that have taken place since September 2002. The study reveals that there are some common patterns and difficulties emerging, particularly with regard to assessment and reporting and some of the problems that have always beset PSHE and pastoral care. These same issues are predictably affecting the progress of the initiative. Principally, the status of the subject, resourcing and levels of understanding, training and commitment of staff are ongoing problems. A leitmotiv running through the interviews is the constant pressure of other initiatives and their effects on change at a time of internal turbulence for a number of the schools. Some progress is being made and it would have been unrealistic to expect all schools to adopt the subject without difficulty but, in spite of the CCs' best efforts, there are still issues that might give cause for concern and that are graphically highlighted by individual cases. 相似文献
18.
This article responds to the need to synthesize theory and research in educational psychology by introducing the Thriving with Social Purpose (TSP) conceptual framework. TSP results when the four components of human motivation—goals, capability beliefs, context beliefs, and emotions—are amplified in dynamic, mutually reinforcing patterns. The centerpiece of the TSP motivational pattern is an active approach goal orientation informed by a fundamental concern for others (social purpose). This orientation is supported and strengthened by a firm belief in one's ability to make progress toward meaningful goals (personal optimism), a persistent tendency to imagine alternative pathways when progress is challenged (mindful tenacity), and intentional efforts to align emotions and circumstances in ways that will best facilitate goal progress (emotional wisdom). The TSP framework also emphasizes positive (discrepancy increasing) feedback cycles that accelerate learning and competence development, facilitate meaningful change, and promote personal and social well-being. 相似文献
19.
焦更生 《渭南师范学院学报》2012,(2):57-60
为了提高C/C复合材料的高温抗氧化性能,设计了网状的SiC填充高性能的MoSi2和微量的TiSi2涂层,对制备涂层的化学形成机理进行了热力学分析.结果表明,在选择的实验条件下,制备设计的涂层是完全可行的,实验制备的涂层在1773K有氧环境下具有良好的抗氧化性能. 相似文献
20.
进入新世纪,区域经济已成为世界经济的主要特征.区县作为城市的有机组成部分,其创新能力的提升是区域经济持续发展的前提.天津市各区县创新能力的发展,对于各区县的经济起着巨大的推动作用,二者相互促进,共同发展.明确二者关系,有助于更好促进区县经济与创新能力的提升. 相似文献