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1.
Hyponatremia is a common disorder in elderly and can result in changes in cognition, seizures, coma or even respiratory arrest if not recognised and treated. Syndrome of inappropriate anti diuretic hormone secretion (SIADH) is the most common cause of hyponatremia in elderly hospitalised patients and in most cases the etiology cannot be determined on routine investigations. We present a 76 year old male with symptomatic hyponatremia who had chronic urinary retention due to a urethral stricture. His sodium levels improved with catheterisation and worsened again after the catheter was removed. This supports the hypothesis that urinary retention and bladder distension can stimulate ADH release from the posterior pituitary, producing a picture similar to SIADH. 相似文献
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Om Shankar Chaurasiya Lalit Kumar Rohit Shamsher Sethi 《Indian journal of clinical biochemistry : IJCB》2013,28(2):206-209
Hyperlipidemia is increasing prevalent risk factor in children, concomitant with worldwide epidemic of obesity. Lipid disorder can occur either as primary event or secondary to an underlying disease. The primary dyslipidemia are associated with overproductions/or impaired removal of lipoprotein. The latter defect can be induced by an abnormality in either the lipoprotein itself or in the lipoprotein receptor. A 2 month old male baby was found to have highly viscous and milky serum. S. Cholesterol was 2,200 mg/dl and triglycerides 13,292 mg%. There was no dysmorphic feature. Child was anemic and had hepatosplenomegaly and xanthomas. There was positive history of hyperlipidemia in first maternal cousin. Parents of index case had normal lipid profile. The child was put on lipid lowering agents, Iron drops, medium chain fatty acid. 相似文献
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为探讨经尿道气化术治疗浅表性膀胱肿瘤的临床效果，对1998年10月－2000年11月间26例浅表性膀胱肿瘤患者采用经尿道气化术进行治疗。26例均顺利完成手术操作，手术平均时间40min，术中均未输血，未发生膀胱穿孔及大出血。术后随访2－18个月,3例复发。结果表明，经尿道膀胱肿瘤气化术（TVBT）具有快速、出血少、手术并发症少等优点，疗效满意。 相似文献
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目的：分析高龄（〉75岁）股骨粗隆间骨折患者采用人工股骨头置换术的疗效。方法：对2004.1-2013.10我院103例高龄股骨粗隆间骨折患者采用人工股骨头假体置换治疗。其中女性67例,男性36例,最大年龄102岁,最小年龄75岁,平均83岁。结果：术中、术后死亡2例,余患者均得到随访,随访时间1-9年（平均3.5年）,参照Harris法评分[1]优65例,良26例,可6例,差4例。疗效优良率达88.34%。所有随访患者无发生脱位,经复查X片,假体、髋臼完好无松动93例,髋臼磨损5例,假体周围骨折2例,假体松动1例。结论：证实人工股骨头置换术治疗高龄股骨粗隆间骨折具有减少患者卧床时间,早日下地负重功能锻炼,减少术后并发症等优点。 相似文献
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M. Maneesh H. Jayalakshmi T A Singh Amit Chakrabarti 《Indian journal of clinical biochemistry : IJCB》2006,21(1):165-168
In view of association of diabetes mellitus and male infertility, present study was designed to investigate the functional
status of hypothalamic pituitary gonadal (HPG) axis in diabetic men. Thirty-five diabetic men (BMI 22.24±0.21) in the age
group 20–40 (30.6±4.7) years were selected. Twenty-five healthy men (BMI 23.85±0.25), in the same age group (29.5±4.8) served
as control. Blood samples were collected for hormonal and biochemical estimations. Diabetic men had significantly low serum
testosterone with low LH and FSH, hypercholesterolemia, hypertriglyceridemia, hypoalbuminemia and increased oxidative stress.
Low serum testosterone in diabetic men was accompanied by low LH and FSH; the inability of the pituitary gland to respond
appropriately to a decline in testosterone implying central effect of high serum glucose on the interaction between the nervous
and endocrine system. Nutritional deficiency, increased oxidative stress and increased aromatase activity due to excessive
body fat might have also contributed to low serum testosterone. 相似文献
6.
观察功劳木溶液联合麻油、白糖外敷治疗Ⅱ～Ⅲ期褥疮的临床疗效。132例Ⅱ～Ⅲ期褥疮患者随机分为治疗组（67例）与对照组（65例）;2组均采用相同的综合护理治疗,在此基础上,治疗组以无菌的功劳木溶液联合麻油、白糖浸透的纱布外敷创面,对照组以无菌的凡士林纱布外敷创面,均每日换药一次,观察4周后评价疗效。治疗组治愈40例,显效15例,有效8例,无效4例,总有效率94.03%;对照组治愈20例,显效6例,有效18例,无效21例,总有效率67.69%。2组疗效比较,治疗组明显优于对照组,差异有极显著性意义（经Ridit检验,u=4.27,P〈0.01）。功劳木溶液联合麻油、白糖外敷治疗褥疮具有较好的临床疗效,值得推广应用。 相似文献
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重症肺炎患者免疫功能的初步研究 总被引：1，自引：0，他引：1
目的 对重症肺炎患者的免疫功能变化进行研究。方法 用荧光单抗CD3^ ,CD4^ ,CD25^ ,CD95^ ,CD3^ /CD25^ ,CD8^ /CD28^ ,CD8^ /CD28^-,CD19^ 对淋巴细胞标记和计数。结果 重症肺炎患者体内CD3^ ,CD95^ ,CD3^ /CD25^ ,CD8^ /CD28^ 减少，CD4^ ,CD25^ ,CD19^ 无明显变化，而CD8^ /CD28^-增加。结论 重症肺炎患者B淋巴细胞变化不大，T淋巴细胞因大量凋亡而总数减少，亚群的变化又造成免疫功能紊乱，在临床治疗过程中需改善患者免疫功能。 相似文献
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因为对科学世界的更多关注,科学家总是处于一种孤独状态之中.这种孤独使科学家倾注于科研的努力表现为一种大众眼中的反常。当这种努力达至一种极致而有所成就时,又形成一种令科学家自身所惊异的反常。但科学家所表现出的这些反常,却恰恰是科学家正常的一种表现。 相似文献
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目的:探讨主动脉夹层患者的临床特点及其与Stanford分型、临床症状的关系,减少误诊率。方法:回顾性分析广西中医药大学附属瑞康医院2005年1月至2015年9月间收治确诊为主动脉夹层的住院治疗患者31例的临床资料、生化指标及转归。按Stanford分型及性别分组,对每组患者进行统计分析。结果:31例患者中男性患者28例,女性3例,既往有高血压病史15例,缺血性心肌病7例,马方综合征1例。5例死亡(2例死于并发症,3例自然破裂),死亡率16.12%。3例行人工血管置换,2例行带膜支架植入成功,男性发病年龄小于女性,二者差异有统计学意义(P=0.043)。女性患病人数明显少于男性。男女组患Stanford A、B型年龄差异无统计学意义;A型住院天数短于B型,但差异无统计学意义(P=0.053);A型转归差于B型;合并高血压患者入院收缩压高于无高血压患者,舒张压二组无差别。结论:在入院治疗患者中,男性患病人数较多。Stanford A型住院天数较短,预后较B型差。 相似文献
12.
由于化疗、放疗、免疫抑制剂治疗、介入治疗的广泛开展及抗生素的广泛应用,恶性肿瘤继发肺部真菌感染呈上升趋势。肺部真菌感染的确诊有赖于真菌的培养和分离,而常用的咳痰标本又极易受到污染,很难确定其病原性。我们经纤维支气管镜(纤支镜)防污染毛刷(protectedspecimenbrush,PSB)对135例可疑肺部真菌感染患者采样进行真菌培养和涂片检查,其中56例恶性肿瘤继发的肺部感染患者中26例诊断为肺部真菌感染。现报告如下。1,资料与方法1.1,临床资料56例均为我院住院和门诊可疑肿瘤继发的肺部真菌感染患者,男31例,女25例,年龄47￣68岁,平均年龄6… 相似文献
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慢性支气管炎急性发作期患者T淋巴细胞亚群的研究 总被引：5，自引：1，他引：5
对慢性支气管炎急性发作期和缓解期患者体内T淋巴细胞亚群进行研究，用荧光单抗CD4^ 、C8^ /CD28^-,CD8^ /CD28^ 对T淋巴细胞亚群进行标记和计数。检测结果显示慢性支气管炎急性发作期患者体内CD4^ 无明显变化；CD8^ /CD28^-增加;CD8^ /CD28^ 减少。我们认为慢性支气管炎急性期患者T淋巴细胞亚群变化造成免疫功能紊乱。因此在治疗疾病过程中，除对症处理外，另须配合使用提高免疫功能药物，改善免疫功能。 相似文献
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Saraswathi Susarla Mohammed Kunhi Kishore Kumar Praveen Shetty 《Indian journal of clinical biochemistry : IJCB》2002,17(2):101-103
Excess glucocorticoids exert feedback suppression on hypothalamus and pituitary, Thereby the release of CRH and ACTH are suppressed
which results in bilateral adrenal cortical atrophy, at the same time patients is having features of latrogenic Cushing syndrome.
The interesting part of this case is excess glucocorticoids have exerted cross feedback suppression on hypothalamus and pituitary
resulting in suppression of release of GHRH, GH and LHRH, LH and FSH also from hypothalamus and pituitary thereby resulting
in growth retardation as well as hypogonadotrophic hypogonadism. Combination of feedback and cross feedback effect of excess
glucocorticoids are seen in one patient which is an interesting part of the case. 相似文献
15.
为了研究内痔的中西医结合治疗机理，采用中西医结合治疗72例II期内痔患者，其中36例采用肛门内托约肌切断术，结合消痔灵注射治疗，另36例II期内痔为对照组，仅采用消痔灵注射治疗，结果为：（1）72例内痔在治疗后3－7天，病人的排便不畅和不适应感消失，便血停止；（2）1年后复查，36例结合治疗组无一例复发，痔核明显缩小，甚至消失，病变处粘膜基本恢复正常，36例对照组中有2例复发；（3）在肛门直肠指诊时，36例结合治疗组无肛内紧缩感，对II期内痔治疗，用中西医结合治疗的疗效明显优于单纯的消痔灵注射治疗。 相似文献
16.
用脑电地形图（ＢＥＡＭ）技术观察了３０例急性脑血管意外患者．并同时进行了脑电图（ＥＥＧ）检查，其中２３例作了ＣＴ扫描．结果表明，ＢＥＡＭ对急性脑血管意外的阳性率、定侧率与ＥＥＧ比较均有显著差异（Ｐ＜０．０５）；与ＣＴ比较总阳性率无明显差异（Ｐ＞０．０５）；但三无内检查阳性率有显著差异（Ｐ＜０．０５）． 相似文献
17.
目的:观察祛银方联合雷公藤多甙片治疗寻常型银屑病临床疗效及安全性。方法:74例寻常型银屑病血热证患者随机分为祛银方联合雷公藤多甙片治疗组和雷公藤多甙片对照组。治疗4周后,评价治疗前后患者临床疗效、生活质量指数(DLQI)评分、中医临床症候症状等方面的改变,同时观察不良反应。结果:治疗后治疗组、对照组临床总有效率分别为87%、73%;两组生活质量指数(DLQI)均低于治疗前(P0.01),治疗后两组的DLQI评分有显著性差异(P0.01);治疗组中医症候均有显著性差异(P0.01);对照组除瘙痒症候治疗有显著性差异外(P0.01),余均无显著性差异(P0.05)。结论:祛银方联合雷公藤多甙片治疗寻常型银屑病具有良好的临床效果,尤其在改善中医症状如瘙痒、口渴等方面效果显著,能有效减轻雷公藤的毒副作用,起到减毒增效的作用。 相似文献
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Yun Feng Yaonan Wang Jun-Wei Wang Han-Xiong Li 《Journal of The Franklin Institute》2021,358(2):1656-1672
Detection and estimation of abnormalities for distributed parameter system (DPS) have wide applications in industry, e.g., battery thermal fault diagnosis, quality monitoring of hot-rolled strip laminar cooling process. In this paper, the abnormal spatio-temporal (S-T) source detection and estimation problem for a linear unstable DPS is first studied. The proposed methodology consists of two steps: first, an abnormality detection filter (ADF) which generates a residual signal for abnormality detection in the time domain is constructed using pointwise measurement; Then, an adaptive Luenberger-type PDE observer including an adaptive estimation algorithm is designed and triggered only when an alarm raises from the ADF. Theoretic analysis based on the spatial domain decomposition approach is presented to show the convergence of the estimation errors. Finally, an illustrative example is presented to show the performance of the proposed method. 相似文献
20.
Jain A Mal J Mehndiratta V Chander R Patra SK 《Indian journal of clinical biochemistry : IJCB》2011,26(1):78-81
Vitiligo is an idiopathic, acquired, circumscribed, hypomelanotic skin disorder, characterized by milky white patches of different
sizes and shapes. It is due to the destruction of melanocytes resulting in the absence of pigment production of the skin and
mucosal surfaces. Oxidative stress has been implicated in pathophysiology of vitiligo. To study the activity of blood Superoxide
dismutase (SOD) and Glutathione peroxidase (GPx) in vitiligo patients. A case–control study was conducted in which 100 patients
were enrolled after written consent. 50 cases were of active vitiligo and 50 served as control (25 healthy control and 25
with stable vitiligo). SOD—In our study, among the active vitiligo cases 90% had high level of SOD and 10% had normal level
of SOD. Among the stable vitiligo controls, 92% had normal level of SOD and 8% had low levels of SOD.The difference between
active vitiligo cases and stable vitiligo control as well as with healthy control was statistically significant (P value < 0.05). GPx—Among the active vitiligo cases 74% had normal GPx levels, 22% had low and only 4% had high levels of
GPx. Among the stable vitiligo controls, 64% had normal GPx levels, 16% had low, and 20% had high levels of GPx. The difference
between active vitiligo cases and stable vitiligo control as well as with healthy control was statistically not significant
(P value > 0.05). Our study shows that oxidative stress is involved in the pathophysiology of vitiligo, as indicated by the
high levels of serum superoxide dismutase activity. 相似文献