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1.

Background:

Since 2005, International Committee of Medical Journal Editors (ICMJE) member journals have required that clinical trials be registered in publicly available trials registers before they are considered for publication.

Objectives:

The research explores whether it is adequate, when searching to inform systematic reviews, to search for relevant clinical trials using only public trials registers and to identify the optimal search approaches in trials registers.

Methods:

A search was conducted in ClinicalTrials.gov and the International Clinical Trials Registry Platform (ICTRP) for research studies that had been included in eight systematic reviews. Four search approaches (highly sensitive, sensitive, precise, and highly precise) were performed using the basic and advanced interfaces in both resources.

Results:

On average, 84% of studies were not listed in either resource. The largest number of included studies was retrieved in ClinicalTrials.gov and ICTRP when a sensitive search approach was used in the basic interface. The use of the advanced interface maintained or improved sensitivity in 16 of 19 strategies for Clinicaltrials.gov and 8 of 18 for ICTRP. No single search approach was sensitive enough to identify all studies included in the 6 reviews.

Conclusions:

Trials registers cannot yet be relied upon as the sole means to locate trials for systematic reviews. Trials registers lag behind the major bibliographic databases in terms of their search interfaces.

Implications:

For systematic reviews, trials registers and major bibliographic databases should be searched. Trials registers should be searched using sensitive approaches, and both the registers consulted in this study should be searched.Clinical trials registers such as ClinicalTrials.gov and portals to trials registers such as the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) are increasingly used to identify ongoing or completed clinical trials. These resources offer important information on the methods and progress of trials likely to be of interest to a range of users, including researchers, clinicians, and patients. The extent to which these resources can be relied upon as a sole source of trials for inclusion in systematic reviews, including Cochrane systematic reviews (CSRs), is the subject of the research study reported here. This study also investigates the most efficient ways that librarians, information professionals, and other searchers can search these resources. Search efficiency was investigated by evaluating the overlap and unique yield of searches in the two resources and by testing four search approaches. The tested search approaches ranged from the very precise (single specific condition search term combined with a single specific intervention search term) to the very sensitive (at least two interventions terms).  相似文献   

2.

Objective

Google Scholar is often used to search for medical literature. Numbers of results reported by Google Scholar outperform the numbers reported by traditional databases. How reliable are these numbers? Why are often not all available 1,000 references shown?

Methods

For several complex search strategies used in systematic review projects, the number of citations and the total number of versions were calculated. Several search strategies were followed over a two-year period, registering fluctuations in reported search results.

Results

Changes in numbers of reported search results varied enormously between search strategies and dates. Theories for calculations of the reported and shown number of hits were not proved.

Conclusions

The number of hits reported in Google Scholar is an unreliable measure. Therefore, its repeatability is problematic, at least when equal results are needed.  相似文献   

3.
4.

Objective

The research attempted to develop search filters for biomedical literature databases that improve retrieval of studies of clinical relevance for the nursing and rehabilitation professions.

Methods

Diagnostic testing framework compared machine-culled and practitioner-nominated search terms with a hand-tagged clinical literature database.

Results

We were unable to: (1) develop filters for nursing, likely because of the overlapping and expanding scope of practice for nurses in comparison with medical professionals, or (2) develop filters for rehabilitation, because of its broad scope and the profession''s multifaceted understanding of “health and ability.”

Conclusions

We found limitations on search filter development for these health professions: nursing and rehabilitation.  相似文献   

5.
6.

Objective

The purpose of this study was to compare effectiveness of different options for de-duplicating records retrieved from systematic review searches.

Methods

Using the records from a published systematic review, five de-duplication options were compared. The time taken to de-duplicate in each option and the number of false positives (were deleted but should not have been) and false negatives (should have been deleted but were not) were recorded.

Results

The time for each option varied. The number of positive and false duplicates returned from each option also varied greatly.

Conclusion

The authors recommend different de-duplication options based on the skill level of the searcher and the purpose of de-duplication efforts.  相似文献   

7.
8.
9.

Objective

The authors sought to determine whether unexpected gaps existed in Scopus''s author affiliation indexing of publications written by the University of Nebraska Medical Center or Nebraska Medicine (UNMC/NM) authors during 2014.

Methods

First, we compared Scopus affiliation identifier search results to PubMed affiliation keyword search results. Then, we searched Scopus using affiliation keywords (UNMC, etc.) and compared the results to PubMed affiliation keyword and Scopus affiliation identifier searches.

Results

We found that Scopus''s records for approximately 7% of UNMC/NM authors'' publications lacked appropriate UNMC/NM author affiliation identifiers, and many journals'' publishers were supplying incomplete author affiliation information to PubMed.

Conclusions

Institutions relying on Scopus to track their impact should determine whether Scopus''s affiliation identifiers will, in fact, identify all articles published by their authors and investigators.  相似文献   

10.

Objectives

This study assessed the need to develop a public health informatics (PHI) introductory course and determine contents of such a course.

Methods

Community assessments employing focus group interviews and an online survey were utilized to determine course need and content.

Results

Results revealed a need to provide PHI training to graduate public health students and suggested broad course content requirements. Results indicated lack of awareness of libraries and librarians as sources of public health information.

Conclusions

A graduate PHI course was developed and delivered. Additionally, implementation of a subject guide increased the library''s profile.  相似文献   

11.

Objective:

This research measures the effectiveness of the practice of correction and republication of invalidated articles in the biomedical literature by analyzing the rate of citation of the flawed and corrected versions of scholarly articles over time. If the practice of correction and republication is effective, then the incidence of citation of flawed versions should diminish over time and increased incidence of citation of the republication should be observed.

Methods:

This is a bibliometric study using citation analysis and statistical analysis of pairs of flawed and corrected articles in MEDLINE and Web of Science.

Results:

The difference between citation levels of flawed originals and corrected republications does not approach statistical significance until eight to twelve years post-republication. Results showed substantial variability among bibliographic sources in their provision of authoritative bibliographic information.

Conclusions:

Correction and republication is a marginally effective biblioremediative practice. The data suggest that inappropriate citation behavior may be partly attributable to author ignorance.

Highlights

  • The citation of flawed articles occurs at a rate nearly equal to that of corrected versions.
  • The practice of correction and republication is only marginally effective and does not prevent the continued citation of flawed articles post-correction, with the analysis finding only a slight reduction in the citation of flawed articles after publication of the corrected version.
  • Neither MEDLINE nor Web of Science consistently alert users when dealing with corrected and republished literature.

Implications

  • The practice of correction and republication would be more effective if prominent sources of bibliographic information were more consistent in providing users with information about the status of corrected and republished articles and the existence of post-publication modifications to the literature.
  • It is incumbent upon the scientific community to raise the profile of post-publication changes to the literature to prevent the wasteful and potentially tragic consequences of scientists and medical professionals applying flawed information. Failure to do so will surely result in a reduction of public trust in the reliability of the scientific literature and its users.
  相似文献   

12.

Objectives

There is little research on pediatric hospitalists'' use of evidence-based resources. The aim of this study was to determine the electronic resources that pediatric hospitalists prefer.

Methods

Using a web-based survey, the authors determined hospitalists'' preferred electronic resources, as well as their attitudes toward lifelong learning, practice, and experience characteristics.

Results

One hundred sixteen hospitalists completed the survey. The most preferred resource for general information, patient handouts, and treatment was UpToDate. Online search engines were ranked second for general information and patient handouts.

Conclusions

Pediatric hospitalists tend to utilize less rigorous electronic resources such as UpToDate and Google. These results can set a platform for discussing the quality of resources that pediatric hospitalists use.  相似文献   

13.
14.

Question

What to do when a major database ceases publication?

Setting

An urban, academic health sciences library with four campuses serves a university health sciences system, a college of medicine, and five other health sciences colleges.

Methods

Usage statistics of each e-book title in the resource were carefully analyzed. Purchase decisions were made based on the assessment of usage.

Results

Sustainable resources were acquired from other vendors, with perpetual access for library users.

Conclusion

This systematic process of finding alternative resources is an example of librarians'' persistence in acquiring perpetual electronic resources when a major resource is cancelled.  相似文献   

15.

Objectives:

The research determined (1) the information sources that family physicians (FPs) most commonly use to update their general medical knowledge and to make specific clinical decisions, and (2) the information sources FPs found to be most physically accessible, intellectually accessible (easy to understand), reliable (trustworthy), and relevant to their needs.

Methods:

A cross-sectional postal survey of 792 FPs and locum tenens, in full-time or part-time medical practice, currently practicing or on leave of absence in the Canadian province of Saskatchewan was conducted during the period of January to April 2008.

Results:

Of 666 eligible physicians, 331 completed and returned surveys, resulting in a response rate of 49.7% (331/666). Medical textbooks and colleagues in the main patient care setting were the top 2 sources for the purpose of making specific clinical decisions. Medical textbooks were most frequently considered by FPs to be reliable (trustworthy), and colleagues in the main patient care setting were most physically accessible (easy to access).

Conclusions:

When making specific clinical decisions, FPs were most likely to use information from sources that they considered to be reliable and generally physically accessible, suggesting that FPs can best be supported by facilitating easy and convenient access to high-quality information.

Highlights

  • Medical textbooks were the most popular information source for family physicians'' (FPs'') clinical decision-making purposes, and medical journals were the most popular information source for the purpose of updating FPs'' general medical knowledge.
  • FPs considered medical textbooks to be the most reliable (trustworthy) source, colleagues the most physically accessible, and continuing medical education the most relevant and intellectually accessible.
  • The lowest ranked information sources across all four attributes were personal digital assistants, mental health professionals, pharmaceutical sales representatives, and other decision aids.

Implications

  • The most popular information sources for clinical decision-making purposes among FPs were sources characterized as reliable and generally physically accessible.
  • This study suggests the need for further research into interventions that target information access barriers in FPs'' practice settings and the promotion of reliable evidence for FPs'' clinical decision-making purposes.
  相似文献   

16.

Purpose

The study evaluated medical students'' familiarity with information literacy and informatics during the health sciences library orientation.

Methods

A survey was fielded at the start of the 2013 school year.

Results

Seventy-two of 77 students (94%) completed the survey. Over one-half (57%) expected to use library research materials and services. About half (43%) expected to use library physical space. Students preferred accessing biomedical research on laptops and learning via online-asynchronous modes.

Conclusions

The library identified areas for service development and outreach to medical students and academic departments.  相似文献   

17.

Question:

What is the process of developing a clinical information tool to be embedded in the electronic health record of a very large and diverse academic medical center?

Setting:

The development took place at the University of Pittsburgh Health Sciences Library System.

Method:

The clinical information tool developed is a search box with subject tabs to provide quick access to designated full-text information resources. Each subject tab offers a federated search of a different pool of resources. Search results are organized “on the fly” into meaningful categories using clustering technology and are directly accessible from the results page.

Results:

After more than a year of discussion and planning, a clinical information tool was embedded in the academic medical center''s electronic health record.

Conclusion:

The library successfully developed a clinical information tool, called Clinical-e, for use at the point of care. Future development will refine the tool and evaluate its impact and effectiveness.  相似文献   

18.
19.

Objective

The researchers assessed prevalence in the clinical case report literature of multiple reports independently reporting the same (or nearly the same) main finding.

Methods

Results from forty-five PubMed queries were examined for incidence and features of main findings (“nuggets”) shared in at least four case reports.

Results

The authors found that nuggets are surprisingly prevalent and large in the case report literature, the largest found so far was reported in seventeen articles. In most cases, the main findings of case reports were evident from examining titles alone.

Conclusions

Our curated examples should serve as gold standards for developing specific automated methods for finding nuggets. Nuggets potentially enable finding-based (instead of topic-based) information retrieval.  相似文献   

20.

Objective

The purpose of this study was to investigate the relative effectiveness of three web-scale discovery (WSD) tools in answering health sciences search queries.

Methods

Simple keyword searches, based on topics from six health sciences disciplines, were run at multiple real-world implementations of EBSCO Discovery Service (EDS), Ex Libris''s Primo, and ProQuest''s Summon. Each WSD tool was evaluated in its ability to retrieve relevant results and in its coverage of MEDLINE content.

Results

All WSD tools returned between 50%–60% relevant results. Primo returned a higher number of duplicate results than the other 2 WSD products. Summon results were more relevant when search terms were automatically mapped to controlled vocabulary. EDS indexed the largest number of MEDLINE citations, followed closely by Summon. Additionally, keyword searches in all 3 WSD tools retrieved relevant material that was not found with precision (Medical Subject Headings) searches in MEDLINE.

Conclusions

None of the 3 WSD products studied was overwhelmingly more effective in returning relevant results. While difficult to place the figure of 50%–60% relevance in context, it implies a strong likelihood that the average user would be able to find satisfactory sources on the first page of search results using a rudimentary keyword search. The discovery of additional relevant material beyond that retrieved from MEDLINE indicates WSD tools'' value as a supplement to traditional resources for health sciences researchers.  相似文献   

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