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INTRODUCTIONAPSisthesumtotalthatcoversaseriesofclinicalmanifestations,causedbyantiphospho lipidantibodies (APL)associatedwithhabitualabortionorintrauterinefetaldeath ,arterialandvenousthrombus,thrombocytopeniaandhemo lyticanemia.APL ,acomplement fixingant… 相似文献
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Zhang Y Xu CM Zhu YM Dong MY Qian YL Jin F Huang HF 《Journal of Zhejiang University. Science. B》2007,8(7):515-521
Objective： To evaluate the effect ofpreimplantation genetic diagnosis （PGD） conducted for women who had Down syndrome pregnancy previously. Methods： Trisomy 21 was diagnosed by using fluorescence in site hybridization （FISH） before embryo transfer in two women who had Down syndrome pregnancies. Each received one or two PGD cycles respectively. Results： Case 1： one PGD cycle was conducted, two oocytes were fertilized and biopsied. One embryo is of trisomy 21 and the other of monosomy 21. No embryo was transferred. Case 2： two PGD cycles were conducted, in total, sixteen oocytes were fertilized and biopsied. Four embryos were tested to be normal, six of trisomy 21, and one of monosomy 21. Five had no signal. Four normal embryos were transferred but no pregnancy resulted. Conclusion： For couples who had pregnancies with Down syndrome previously, PGD can be considered, and has been shown to be an effective strategy. 相似文献
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SHI Jian-ren ZHAO Xiu-min GE Jian HOKAO Kazunori WANG Zhu 《浙江大学学报(A卷英文版)》2006,7(8):1372-1385
INTRODUCTION Nowadays, as a large number of residential blocks and college campuses are being constructed nationwide in China, improvement in the quality of residential community becomes a rising issue of city policy and urban planning. Layouts of open spaces in residential areas are predicated on their ability to deliver both a mechanism to maintain the viability of citizens’ outdoor lives and a treatment to alleviate the high-density of urban constructions. What kinds of residential o… 相似文献
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目的:探讨老年人急性非结石性胆囊炎(AAC)临床特点与手术治疗.方法:通过设立病例对照,对48例老年人AAC和急性结石性胆囊炎(ACC)的并发症、胆囊病理改变及术后结果进行比较.结果:与老年人ACC相比,AAC患者以心血管疾病为主的并发症明显增多(P＜0.01);胆囊化脓、坏疽与穿孔率明显增高(P值＜0.01,＜0.01,＜0.05);术后并发症发生率明显上升(P＜0.01).结论:老年人AAC并存病多、胆囊病变重、术后并发症发生率高;宜在症状出现48h内手术治疗. 相似文献
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Geng Y Shi GH Jiang Y Xu LX Hu XY Shao YQ 《Journal of Zhejiang University. Science. B》2005,6(1):22-27
Objective: To investigate the role of 99mTc-TRODAT-1 SPECT in diagnosis and assessing severity of idiopathic Parkinson's disease (PD). Methods: Thirty-eight patients with primary, tentative diagnosis of PD and eighteen age-matched normal controls were studied with 99mTc-TRODAT-1 SPECT imaging. The regions of interests (ROIs) were drawn manually on cerebellum (CB), occipital cortex (OC) and three transverse plane slice-views of striatums, the semiquantitative BG (background)/[(OC CB)/2] were then calculated. Results: A lower uptake of 99mTc-TRODAT-Ⅰ in striatums were displayed in thirty-six out of thirty-eight PD patients by visual inspection, compared to controls. In twenty-four PD cases with HYS (Hoehn and Yahr scale) stage I, a greater loss of DAT uptake was found in striatum and its subregions contralateral striatum to the affected limbs than in the same regions of the controls, although the striatal uptake was bilaterally reduced. Using Spearman correlation analysis showed that the reduction of the uptake ratios significantly correlated with the UPDRS in striatum and all its subregions in the PD group (P＜0.05), a similar change was also found in the putamen by using the rating scale of Hoehn and Yahr (P＜0.05).However, analysis of variance (ANOVA) did not show any relationship between the decreasing uptake of 99mTc-TRODAT-1 and increasing severity of PD patients, although the specific uptake of 99mTc-TRODAT-Ⅰ was continuously decreased in the striatum by visual inspection with the progress of PD from HYS stage Ⅰ to Ⅲ. Conclusion: 99mTc-TRODAT- 1 SPECT imaging may serve as a useful method for improving the correct diagnosis of PD. In assessing the role of99mTc-TRODAT- 1 SPECT in disease severity of PD, UPDRS can offer a comprehensive index, although the Hoehn and Yahr assessment may be available in part. 相似文献
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施建平 《江苏经贸职业技术学院学报》2013,(2):33-35,80
"跩"这个词,自从有了"显摆、炫耀"乃至"洒脱、快乐、霸气"的词义后,一直被人们误解和误用:一是误解为方言词——其实它的使用已远远超出了方言的范畴;二是其字形常常被人们误写作"拽"。其实,"显摆,炫耀"的新义是由"跩"的本义"(走路)摇摆"引申而来的。"拽"字不具有"显摆、炫耀"的词义。 相似文献
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目的分析上消化道出血胃B超图象特征,探讨B超对上消化道出血及其病因诊断的意义.方法;选择上消化道出血活动期的位院患者49例,分别于空腹及饮水后依次探查贲门、胃体、胃窦、十二指肠及其邻近器官,记录图像,并结合内镜病理及X线结果进行分析.结果49例中.B超检出相关疾病41例,命中37例;检出率及准确率分别为83.7%和75.5%,X线报告32例,命中29例,检出率及准确率分别为65.3%和59.2%,统计分析结果显示该两种检查方法有显著差异(P＜0.05).结论B型超声可作为上消化道出血病因诊断较可靠的方法. 相似文献
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目的：研究血浆脂蛋白（a）[Lp（a）]水平与肾病综合征（NS）的关系，探讨Lp（a）在肾病综合征合并心脑血管疾病中的作用。方法：用酶联免疫吸附法分别测定了61例肾病综合征患者与55名健康对照者的Lp（a）浓度，并同时测定了BUN、Scr、TG、TC、LDL-C和HDL-C的含量。结果：肾病综合征患者Lp（a）、BUN、Scr、TC、LDL-C水平均明显高于正常对照组。而HDL-C显著低于对照组，NS组Lp（a）浓度与BUN和Scr呈显著正相关，Lp（a）水平变化与LDL-C、HDL-C、TG、TC含量无明显相关性。结论：肾病综合征患者体内存在着Lp（a）等脂代谢紊乱的情况，高血浆Lp（a）水平是肾病综合征合并心脑血管疾病的独立危险因素之一。 相似文献
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目的:对四肢主要血管损伤的诊治进行性回顾性分析。方法:对1994年￣2003年收治四肢血管损伤行自体血管和人造血管移植并得到随访的44例病例进行总结,分析其疗效及影响因素。结果:截肢3例,肢体缺血挛缩6例。神经功能恢复不完全7例。其余移植血管均通畅,远端肢体血循环良好。结论:血管移植治疗血管损伤保肢成功率高;血管移植应有明确指征,尽量采用自体静脉移植,必要时可使用人造血管;早诊断是前提、快救治是关键;须注意积极防治血管感染。 相似文献
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Colak T Akca T Turkmenoglu O Canbaz H Ustunsoy B Kanik A Aydin S 《Journal of Zhejiang University. Science. B》2008,9(4):319-323
Objective: This prospective randomized clinical trial was conducted to evaluate the necessity of drainage after total thyroidectomy or lobectomy for benign thyroidal disorders. Methods: A total of 116 patients who underwent total thyroidectomy or lobectomy for benign thyroidal disorders were randomly allocated to be drained or not. Operative and postoperative outcomes including operating time, postoperative pain assessed by visual analogue scale (VAS), total amount of intramuscular analgesic administration, hospital stay, complications, necessity for re-operation and satisfaction of patients were all assessed. Results: The mean operating time was similar between two groups (the drained and non-drained groups). The mean VAS score was found to be significantly low in the non-drained group patients in postoperative day (POD) 0 and POD 1. The mean amount of intramuscular analgesic requirement was significantly less in the non-drained group. One case of hematoma, two cases of seroma and three cases of transient hypoparathyroidism occurred in the non-drained group, whereas one case of hematoma, two cases of seroma, two cases of wound infections and two cases of transient hypoparathyroidism occurred in the drained group. No patient needed re-operation for any complication. The mean hospital stay was significantly shorter and the satisfaction of patients was superior in the non-drained group. Conclusion: These findings suggest that postoperative complications cannot be prevented by using drains after total thyroidectomy or lobectomy for benign thyroid disorders. Furthermore, the use of drains may increase postoperative pain and the analgesic requirement, and prolong the hospital stay. In the light of these findings, the routine use of drains might not be necessary after thyroid surgery for benign disorders. 相似文献
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This paper studies some special networks structured with serf-organized and driven behavior that coexist in a cluster, moreover, the clusters have dominant intra-cluster and inter-cluster couplings. It is called mixed-system （M-S） here. For this study linear stability analysis was used, and stability conditions for the synchronized state were determined. For the coupling function g（x）, the stability state of the network was discussed in two different cases： the linear case with g（x） = x and the nonlinear case with g（x） = f（x）. Furthermore, the condition for the emergence of chaos in the networks was given. 相似文献
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Archie A. Silver M.D. 《Annals of dyslexia》1963,13(1):91-100
Summary Nine out of ten children with reading disability are found to have a basic syndrome consisting of signs related to lack of
clear-cut cerebral dominance. Two of these nine children have additional signs suggestive of structural brain damage. One
out of ten children with reading disability does not have any of these findings. The methods of detecting these groups are
described and therapeutic implications indicated.
The data described in this paper have been previously reported in: SILVER, A. A. and HAGIN, R., “Specific Reading Disability:
Delineation of the Syndrome and Relationship to Cerebral Dominance,” COMPREHENSIVE PSYCHIATRY, 1, 2 (April, 1960), pp. 126–134.
The author is indebted to Dr. Rosa A. Hagin for permission to use this material.
From BULLETIN OF THE ORTON SOCIETY, Vol. XI, 1961, pp. 5–12. 相似文献
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OBJECTIVE: The aim of this study was to examine the trajectory of cases through four systems: child protection, law enforcement, the dependency courts, and the criminal courts. METHOD: This study focused on a county selected from a 41-county telephone survey conducted for the National Incidence Study of Child Abuse and Neglect (NIS-3). For this analysis prospective samples were drawn from law enforcement (n=225) and the county child protection (CPS) agency (n=225) and followed through in-depth case tracking across all agencies and through both the dependency and criminal court systems. RESULTS: The percentage of CPS cases opened in dependency court was similar to prior studies (29%), but the acceptance and prosecution rates were much higher--92% of the cases referred from CPS, including many cases of physical abuse. Compared to referrals from CPS to law enforcement (93%), few cases were referred from law enforcement to CPS (17%). Anecdotally, case referral patterns appeared to be influenced by communication patterns and mutual positive regard, regardless of the collaborative protocols in place. One of the most instructive findings was the degree of difficulty in tracking cases across organizations and the types of obstacles that impeded success. Disorganization was not an issue, rather internal structures set up to facilitate intra-organizational processing were the same structures that actually impeded cross-organizational case finding. CONCLUSIONS: It is not sufficient to rely on the existence of multi-disciplinary teams or Child Advocacy Centers to ensure collaboration. More attention to daily tasks and activities as well as the nature and quality of communication is warranted. On the technical side, use of common case identifiers on cases that are cross-referred is strongly recommended. Future studies should broaden the scope of inquiry to include the consequences of all case trajectories, rather than solely focusing on the justice system. 相似文献
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INTRODUCTION Tilt-table test (TTT) has been widely accepted asone of the main measures for diagnosing vasovagalsyncope (VVS), with 30%?90% positive rate andabove 90% specificity (Ren et al., 1998). Althoughnon-invasive, TTT may have risks, especially to theelders or in isoproterenol-provocative test. Evensudden deaths were reported in TTT by Grubb andKosinski (1997). This article summarizes the seriousresponses in TTT.OBJECTS AND METHODSObjects Seventy-six elder… 相似文献
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在聚苯胺复合膜的制备过程中以成膜剂聚乙烯醇(PVA),掺杂剂十二烷基苯磺酸(DBSA)及氧化剂过硫酸铵(APS)．在非有机溶剂的两相体系中用乳液聚合法合成了电致变色的聚苯胺PAn/PVA乳液．并以玻片为载体,采用提拉法制备了(PAn)/PVA复合膜．研究了PVA含量、苯胺(An)与DBSA的量比、过硫酸铵(APS)与An的量比及反应温度对膜的电致变色性、导电性的影响．并用循环伏安法对其电化学进行表征．实验结果表明：在w(PVA)=4．3％,n(DBSA)∶n(An)∶n(APs)=1．25∶1∶0．42、反应温度为25℃时,所制得的PAn/PVA复合膜具有良好电致变色性和粘结性能． 相似文献
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AMI患者PCI术对血浆BNP水平变化的初步临床观察 总被引：1，自引：0，他引：1
目的:观察PCI术对AMI患者血浆中BNP的水平变化,初步探讨PCI对AMI患者预后的影响.方法:采用快速荧光免疫测定法对20例AMI患者PCI治疗前后和20例对照组血浆BNP水平进行检测.结果:AMI患者血浆BNP在AMI患者PCI术与对照组比较有显著性差异(P＜0.05),PCI治疗后呈明显下降趋势.结论:AMI患者PCI治疗血浆BNP水平变化说明PCI术能对改善AMI患者的预后有重要意义. 相似文献
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翟鸣春 《河北北方学院学报(医学版)》2005,22(1):63-64
目的:探讨急性脑出血的CT与低场MRI影像特征,并分析二者的优缺点,以便更合理的应用.方法:本文收集了近两年经临床确诊的典型的急性脑出血病例48例,其中行CT检查30例,行MRI检查18例,分析两组检查的影象特征,并进行比较.结果:急性脑出血在低场MRI主要表现为T1等或稍高信号,T2均表现为高信号,病灶周围可伴环行水肿;CT主要表现为脑内边界清楚,密度均匀的高密度灶,部分病例表现为高等混杂密度灶,周围伴不规则低密度环形水肿带,给诊断带来困难.结论:CT,MRI诊断急性脑出血各有优缺点,CT快捷,方便,基本满足诊断需要;MRI定位定性准确,二者结合起来,可提高诊断的正确率,更好的为患者服务. 相似文献
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Yi Yu Shao-min Zhang Huai-jian Zhang Xiao-chun Liu Qiao-sheng Zhang Xiao-xiang Zheng Jian-hua Dai 《Journal of Zhejiang University. Science. B》2010,11(4):298-306
Brain-machine interface (BMI) has been developed due to its possibility to cure severe body paralysis. This technology has been used to realize the direct control of prosthetic devices,such as robot arms,computer cursors,and paralyzed muscles. A variety of neural decoding algorithms have been designed to explore relationships between neural activities and movements of the limbs. In this paper,two novel neural decoding methods based on probabilistic neural network (PNN) in rats were introduced,the PNN decode... 相似文献
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Wang JY Gu YS Wang J Tong Y Wang Y Shao JB Qi M 《Journal of Zhejiang University. Science. B》2008,9(8):610-615
Objective:Leber's hereditary optic neuropathY (LHON)is a maternally inherited degeneration of the optic nerve caused by point mutations of mitochondrial DNA(mtDNA).Many unsolved questions regarding the penetrance and pathophysiological mechanism of LHON demand efficient and reliable mutation testing.This study aims to develop a minor groove binder(MGB) probe assay for rapid detection of mtDNA11778 mutation and heteroplasmy in Chinese LHON patients by real-time polymerase chain reaction(PCR).Methods:Forty-eight patients suspected of having LHON and their maternal relatives underwent a molecular genetic evaluation,with 20 normal individuals as a control group at the same time.A real-time PCR involving two MGB probes was used to detect the mtDNA 11778 mutation and heteroplasmy.A linear standard curve was obtained by pUCmLHONG and pUCmLHONA clones.Results:All 48 LHON patients and their matemal relatives were positive for mtDNA 11778 mutation in our assay,27 heteroplasmic and 21 homoplasmic.Eighteen cases did not show an occurrence of the disease,while 9 developed the disease among the 27 heteroplasmic mutation cases.Eleven did not show an occurrence of the disease,while 10 cases developed the disease among 21 homoplasmic mutation cases.There was a significant difierence in the incidence between the heteroplasmic and the homoplasmic mutation types.The time needed for running a real-time PCR assay was only 80 min.Conclusion:This real-time PCR assay is a rapid,reliable method for mtDNA mutation detection as well as heteroplasmy quantification.Detecting this ratio is very important for predicting phenotypic expression of unaffected carriers. 相似文献