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1.
Objective:Disturbances in lipid and lipoprotein profiles in patients after kidney transplantation (Tx) are still not understood. Methods:Serum levels of lipids,lipoprotein,triglyceride-rich lipoproteins (TRLs),and high-density lipoprotein (HDL) particles were determined,lipid and lipoprotein ratios were calculated,and their relationships in Tx patients with hypertriglyceridemia (HTG) and lower apolipoprotein AI (apoAI) concentration were examined. Serum lipid and lipoprotein levels were measured in 109 Tx p...  相似文献   

2.
Objective： To investigate the association of Graves＇ disease and Graves＇ ophthalmopathy with the C/T transition polymorphism at position -318 of promoter and the A/G transition polymorphism at position 49 of exon 1 within cytotoxic T lymphocyte associated antigen-4 （CTLA-4） gene. Methods： Thirty-three patients with ophthalmopathy of Graves＇ disease, fifty-six Graves＇ patients without ophthalmopathy and sixty normal subjects as control were involved in the present case-control study. The polymorphisms were evaluated by polymerase chain reaction fragment length polymorphism （PCR-RFLP）. Comparisons were made of gene frequencies and allele frequencies between the groups. Results： The gene frequencies of CT and allele frequencies of T were much higher in Graves＇ patients with ophthalmopathy than that in the group without ophthalmopathy （P=-0.020, P=-0.019）. The gene frequencies of GG and allele frequencies of G in patients with Graves＇ disease were significantly increased as compared with control group （P=0.008, P=0.007）. The data suggest that smokers with Graves＇ disease seemed to be more predisposed to ophthalmopathy than non-smokers （P=0.018）. Conclusion： Our results suggest that an allele of T at position -318 of promoter is associated with genetic susceptibility to Graves＇ ophthalmopathy while an allele of G at position 49 of exon 1 is associated with genetic susceptibility to Graves＇ disease instead. Smoking is believed to be a major risk factor for ophthalmopathy.  相似文献   

3.
Sap flow and environmental conditions were monitored at two Eucalyptus (Eucalyptus urophylla S.T. Blake) plantations at Hetou and Jijia, located in Leizhou, Zhanjiang, Guangdong Province. It was found that daily sap flux density (SFD) of Eucalyptus was closely related to daily atmospheric vapor pressure deficit (VPD) (R 2=0.76, P=0.01 at Hetou and R 2=0.7021, P=0.01 at Jijia) at both sites. No significant relationship existed between daily SFD and mean daily air temperature at both sites. Daily SFD varied with wind speed Y=−17585X 3+15147X 2−1250.7X+2278.4 (R 2=0.68; P=0.01) at Hetou and Y=−101.67X 3−1.65X 2−376.4X+1914.8 (R 2=0.40, P=0.05) at Jijia, where Y was daily SFD, X was daily wind speed. Experimental observations yielded the following data: (1) the critical lower and upper daily VPD threshold were 0 and 2 kPa, within which daily SFD varied from 540±70 L/(m2·d) to 4739±115 L/(m2·d) at Hetou site, from 397±26 L/(m2·d) to 3414±191 L/(m2·d) at Jijia site; (2) Diurnal SFDs at Hetou site were much higher under low relative humidity (<30%) and slightly lower under high relative humidity (>80%) compared with those at the Jijia site; (3) The upper and lower threshold of daily and diurnal RAD for the optimal water use of E. urophylla plantations were 18±2.7 and 2±1 MJ/(m2·d), 669 and 0 J/(cm2·h) during the observation period. Project supported by Knowledge Innovation Funds from Chinese Academy of Sciences (Nos. KSCX2-SW-120, KZCX1-SW-01-01A3) and the Key Project of Guangdong Natural Science Foundation (No. 010567), China  相似文献   

4.
Purpose: To verify whether there exists any difference in higher order aberrations after undergoing myopic LASIK (laser in situ keratomileusis) with conventional ablation and customized ablation in different eyes of the same patient. Methods: This was a prospective randomized study of 54 myopic eyes (27 patients) that underwent LASIK using the Nidek EC-5000 ex-cimer laser system (Nidek, Gamagori, Japan). Topography-guided customized aspheric treatment zone (CATz) was used in the first eye of the patient (study group) and the other eye of the same patient was operated on with conventional ablation (control group). Higher order aberrations [root-mean-square (RMS) in the 5-mm zone] of both groups were observed with the Nidek OPD-Scan aberrometer before and 3 months after LASIK. Preoperative mean refractive error was similar between two eyes of the same patient (t=?0.577, P>0.05). Results: Preoperatively, higher order aberrations (RMS in the 5-mm zone) in the CATz ablation and conventional groups were (0.3600±0.0341) μm and (0.2680±0.1421) μm, respectively. This difference was not statistically significant (t=1.292, P>0.05). Three months after LASIK, higher order aberrations (RMS in 5-mm zone) in the CATz ablation and conventional groups were (0.3627±0.1510) μm and (0.3991±0.1582) μm, respectively. No statistically significant difference was noted between pre- and postoperative higher order aberrations in the CATz group (t=?0.047, P>0.05). However, a statistically significant increase in higher order aberrations was observed after conventional ablation (t=?5.261, P<0.05). A statistically sig-nificant difference was noted in the increase of higher order aberrations after LASIK between groups (t=?2.050, P=0.045). Con-clusion: LASIK with conventional ablation and topography-guided CATz ablation resulted in the same BSCVA (best specta-cle-corrected visual acuity) 3 month after LASIK. Higher order aberrations were increased, but the increase of higher order ab-errations after customized ablation treatment was less than that after conventional ablation.  相似文献   

5.
目的:探讨心脑血管疾病患者脂蛋白(a)水平及其他脂类的关系,进一步阐明血浆高脂蛋白(a)水平为心脑血管疾病的独立危险因素,支持脂蛋白(a)的检测具有极为重要的意义.方法:采用ELISA法和酶法分别测定心肌梗塞、心绞痛、脑梗死等心脑血管疾病患者及健康对照者的Lp(a)、LDL-C、HDL-C、TG、TC含量.结果:心脑血管疾病患者血浆Lp(a)水平显著高于健康对照组(P＜0.01).血浆脂蛋白(a)水平变化与LDL-C、HDL-C、TG、TC含量无明显相关性.结论:Lp(a)是独立于其他血脂指标的心脑血管疾病的危险因子.  相似文献   

6.
A rapid sample treatment procedure for the gas chromatography-tandem mass spectrometry (GC-MS) determination of 19-nortestosterone (19-NT) in animal tissues has been developed. In our optimized procedures, enzymatic hydrolysis with β-glucuronidase from Escherichia coli was performed in an acetate buffer (pH 5.2, 0.2 mol/L). Next, the homogenate was mixed with methanol and heated at 60 °C for 15 min, then placed in an ice-bath at −18 °C for 2 h. After liquid-liquid extraction with n-hexane, the analytes were subjected to a normal-phase solid phase extraction (SPE) C18 cartridge for clean-up. The dried organic extracts were derivatized with heptafluorobutyric anhydride (HFBA), and then the products were injected into GC-MS. Using electron impact mass spectrometry (EI-MS) with positive chemical ionization (PCI), four diagnostic ions (m/z 666, 453, 318, and 306) were determined. A standard calibration curve over the concentration range of 1–20 ng/g was reached, with Y=467 084X-68 354 (R 2=0.999 7) for 19-NT, and the detection limit was 0.3 ng. When applied to spiked samples collected from bovine and ovine, the recoveries ranged from 63% to 101% with relative standard deviation (RSD) between 2.7% and 8.9%. The procedure is a highly efficient, sensitive, and more economical method which offers considerable potential to resolve cases of suspected nandrolone doping in husbandry animals.  相似文献   

7.
INTRODUCTION Telomeres are distinctive DNA-protein struc-tures that cap the ends of linear chromosomes.It is very important to keep the chromosomes stabilization.Telomerase activity is closely linked to attainment of cellular immortality,a step in carcinogenesis,while lack of such activity contributes to cellular senes-cence.Telomerase is activated in more than85%ofmalignant tumors(Hiayma et al.,1997).Human te-lomeric repeat binding factor1(TRF1)is a telomere associated with proteins a…  相似文献   

8.
In order to comply with the requirements for a drug listed in China, the study was developed to compare the pharmacokinetics and relative bioavailability of two different enteric formulations of omeprazole (OPZ) in healthy Chinese subjects. A total of 32 volunteers participated in the study. Plasma concentrations were analyzed by nonstereospecific liquid chromatography/tandem mass spectrometric (LC-MS/MS) method. After administration of a single 40-mg dose of the two OPZ formulations, the comparative bioavailability was assessed by calculating individual AUC0−t (the area under the concentration-time curve from time zero to the last measurable concentration), AUC0−∞ (the area under the concentration-time curve extrapolated to infinity), C max (the maximum observed concentration), and T peak (the time to C max) values of OPZ, 5-hydroxyomeprazole (OH-OPZ), and omeprazole sulfone (OPZ-SFN), respectively. The 90% confidence intervals (CIs) of AUC0−t , AUC0−∞, and C max were 85.4%–99.0%/88.8%–98.6%/87.6%–99.4%, 85.5%–99.2%/89.0%–98.6%/88.5%–101.3%, and 72.3%–87.6%/79.6%–91.1%/88.4%–99.1% for OPZ/OH-OPZ/OPZ-SFN, respectively, and T peak values did not differ significantly. In this study, the test formulation of OPZ in fasting healthy Chinese male volunteers met the Chinese bioequivalance standard to the reference formulation based on AUC, C max, and T peak.  相似文献   

9.
本实验在提高血清高密度脂蛋白胆固醇的方法方面作一初步探讨,观察了在平原环境有氧运动和模拟高原环境下大鼠血清高密度脂蛋白胆固醇水平的变化,主要结果如下:1、平原有氧运动能使血清高密度脂蛋白胆固醇显著升高,P<0.05;2、模拟高原环境下不训练能使血清高密度脂蛋白胆固醇升高非常显著P<0.01;3、模拟高原环境下进行有氧运动,血清高密度脂蛋白胆固醇升高极显著P<0.001,三组相比较提示:模拟高原训练在提高血清高密度脂蛋白胆固醇水平上更有意义,高原训练应用于冠心病病人的防治理论上是有意义的。  相似文献   

10.
Chemically processed Nb-doped SrTiO3 films and properties   总被引：1，自引：0，他引：1  
Homogeneous, crack-free SrNbxTi1−x O3 thin films on (110) silicon substrates were successfully fabricated by sol-gel processing. The optimum route and conditions were systematically investigated. Sr(OAc)2 glacial acctic acid solution, after being refluxed and reacted with tartrate, formed Sr(OAc)2(C4H6O6)2; Ti(OBu)4 formed Ti(OAc)4−x (AcAc)x after having the ligand partially exchanged with AcAc, while Nb(OC2H5)5 formed (OAc)2Nb(AcAc) (C4H6O6) by exchanging of ligand in glacial acetic acid with (CH3CO)2O. All the metal species after undergoing partial hydrolysis and polymerization with hydroxyl or oxygen, formed SrNbxTi1−x O13 cluster sol. Methyl cellulose (MCL) caused SrNbxTi1−x O3 sol to have polymeric structure and easily form films. SrNbxTi1−x O3 films with perovskite were subsequently formed after being annealed at 650∼750 °C for 60 min in 25% N2+75% H2 (volume ratio) atmosphere. Resistivity of the SrNb0.1Ti0.9O3 films at room temperature was 64 μω·cm, a particular T 2 temperature dependence of the resistivity, from 25 K up to room temperature, was observed. Project (No. 2002CB613305) supported by the National Basic Research Program (973) of China  相似文献   

11.
Consider the mixed-effect coefficient semiparametric regression modelZ=X'α+Y'β+g(T)+e, whereX, Y andT are random vectors onR p×R q×[0, 1], α is a p-dimensional fixed-effect parameter, β is a q-dimensional random-effect parameter (Eβ=b, Cov(β)=Σ),g(.) is an unknown function on [0, 1], e is a random error with mean zero and variance σ2, and (X, Y, T) and (β,e), β ande are mutually independent. We estimate α,b andg(.) by the nearest neighbor and the least square method. In this paper, we prove that estimations of α,b have asymptotic normality and obtain the best convergence raten −1/3 for the estimation ofg(.). Project supported by the NSFC and the Natural Science Foundation of Zhejiang Province.  相似文献   

12.
1　Ｉｎｔｒｏｄｕｃｔｉｏｎ　Ｔｈｅｆｕｎｄａｍｅｎｔａｌｐｈｙｓｉｃａｌｍｅｔａｌｌｕｒｇｙｏｆｔｈｅｒｍｏｍｅｃｈａｎｉｃａｌｐｒｏｃｅｓｓｉｎｇ(ＴＭＰ)ｈａｓｂｅｃｏｍｅｍｕｃｈｂｅｔｔｅｒｕｎｄｅｒｓｔｏｏｄｏｖｅｒｔｈｅｌａｓｔｔｗｏｄｅｃａｄｅｓ[1～8].ＩｔｉｓｗｅｌｌｃｏｍｍｏｎｌｙｒｅｃｏｇｎｉｚｅｄｔｈａｔｔｈｅｍｉｎｕｔｅａｄｄｉｔｉｏｎｏｆｓｔｒｏｎｇｃａｒｂｏｎｉｔｒｉｄｅｏｒｎｉｔｒｉｄｅｆｏｒｍｉｎｇｅｌｅｍｅｎｔｓｓｕｃｈａｓＮｂ,ＴｉａｎｄＶｔａｋｅｓｖｅｒｙｉｍｐ…  相似文献   

13.
Ｉｎ 1935 ,Ｐ .Ｅｒｄ¨ｏｓａｎｄＧＳｚｅｋｅｒｅｓｏｂｔａｉｎｅｄｔｈｅｃｌａｓｓｉｃａｌｉｎｅｑｕａｌｉｔｙＲ (ｍ ,ｎ)≤Ｒ (ｍ - 1,ｎ) Ｒ(ｍ ,ｎ - 1) .　Ｉｎ 196 8,Ｋ .ＷａｌｋｅｒｐｒｏｖｅｄｔｈａｔＲ(ｎ ,ｎ)≤ 4Ｒ(ｎ- 2 ,ｎ) 2 .　Ｉｎ 1998,ＨｕａｎｇＹ .Ｒ .ａｎｄＺｈａｎｇＫ .Ｍ .[1,2 ] ｐｒｏｖｅｄｔｈａｔＲ(ｍ ,ｎ)≤ 12 (β 3γ 5 ) 　　12 γ(4α 2 β - 3γ 6 ) (β 1) 2　Ｉｎｔｈｉｓｐａｐｅｒ ,ｗｅｏｂｔａｉｎｓｏｍｅｎｅｗｕｐｐｅｒｂｏｕｎｄｓｆｏｒＲ(ｍ ,ｎ ,ｌ)ａｎｄＲ(ｍ …  相似文献   

14.
This study describes the sense-making behaviors of sixth- and seventh-grade students (n = 46 dyads) as they read and discussed expository articles in print and digital formats. Most dyads approached the digital text as if it were static and linear, despite the availability of hyperlinks. Reading through (or covering) the text was the most commonly observed behavior, occurring in 89% of the coded intervals in the print condition and 76% of intervals in the digital condition. Students were observed discussing a variety of cognitive and metacognitive strategies. The most common strategies were process monitoring, summarizing, connecting, and reacting. The dyads used at least one overt sense-making strategy in about 50% of the intervals when reading the print text and about 65% of the intervals with the digital text. Previewing and progress monitoring, which serve important planning and self-regulative functions, were used more frequently in the digital condition. Regression analyses show that several collaborative behaviors were associated with text comprehension, as measured by a researcher-designed multiple choice test, in the print condition but not in the digital condition. These included word recognition monitoring (β = 1.84; SE = 0.90; p = .05), summarizing (β = 2.43; SE = 1.21; p = .05), and connecting (β = −5.20; SE = 2.06; p = .02) at the student level and attending to illustrations (γ = −7.08; SE = 2.17; p = .003) at the dyad level. In both conditions, prior reading achievement and prior knowledge were strong predictors of comprehension.  相似文献   

15.
Background： Recent autopsy study showed a high incidence ofcerebrovascular lesions in Alzheimer＇s disease （AD）. To assess the impact of cerebrovascular pathology in AD, we used diffusion tensor imaging （DTI） to study AD patients with and without cerebrovascular lesions. Materials and Methods： Conventional and DTI scans were obtained from 10 patients with probable AD, 10 AD/V patients （probable AD with cerebrovascular lesions） and ten normal controls. Mean diffusivity （D） and fractional anisotropy （FA） values of some structures involved with AD pathology were measured. Results： D value was higher in AD patients than in controls in hippocampus and the cingulate gyrus. In AD/V patients, increased D value was found in the same structures and also in the thalamus and basal ganglia compared to controls. There was a significant difference of D value between AD and AD/V patients. FA value reduced in the white matter of left inferior temporal gyrus and in the bilateral middle cingulate gyrus in patients with AD/V compared with controls. The MMSE （mini-mental state examination） score significantly correlated with FA value in the right hippocampus （r=0.639, P〈0.019）, in the right anterior cingulate gyrus （r=0.587, P〈0.035） and in left parahippocampal gyrus （r=0.559, P〈0.047）. Conclusion： Cerebrovascular pathology had stronger impact on the D value than the AD pathology alone did. Elevated D value in thalamic and basal ganglia may contribute to cognitive decline in AD/V patients. Reduced FA values in AD/V patients may indicate that cerebrovascular pathology induced more severe white matter damage than the AD pathology alone did.  相似文献   

16.
Let R be a ring, a ,b ∈ R, ( D , α ) and (G , β ) be two generalized derivations of R . It is proved that if aD ( x ) = G ( x )b for all x ∈ R, then one of the following possibilities holds: (i) If either a or b is contained in C , then α = β= 0 and there exist p , q ∈ Qr ( RC) such that D ( x )= px and G ( x )= qx for all x ∈ R;(ii) If both a and b are contained in C , then either a = b= 0 or D and G are C-linearly dependent;(iii) If neither a nor b is contained in C , then there exist p , q ∈ Qr ( RC) and w ∈ Qr ( R) such that α ( x ) = [ q ,x] and β ( x ) = [ x ,p] for all x ∈ R, whence D ( x )= wx-xq and G ( x )= xp + avx with v ∈ C and aw-pb= 0.  相似文献   

17.
１ＩｎｔｒｏｄｕｃｔｉｏｎＤｉｆｅｒｅｎｔｉａｌｅｑｕａｔｉｏｎｓｗｉｔｈｔｕｒｎｉｎｇｐｏｉｎｔｓｅｘｉｓｔｗｉｄｅｌｙｉｎｍａｎｙｐｒｏｂｌｅｍｓｏｆｍａｔｈｅｍａｔｉｃｓｐｈｙｓｉｃｓ,ｓｏｔｈｅｓｅｐｒｏｂｌｅｍｓａｒｅｖｅｒｙｉｍｐｏｒｔａ...  相似文献   

18.
Congruences for finite triple harmonic sums   总被引：1，自引：0，他引：1  
Zhao (2003a) first established a congruence for any odd prime p>3, S(1,1,1;p)≡-2Bp-3 (mod p), which holds when p=3 evidently. In this paper, we consider finite triple harmonic sum S(α,β,γ;p) (mod p) is considered for all positive integers α,β,γ. We refer to w=α β γ as the weight of the sum, and show that if w is even, S(α,β,γ;p)≡0 (mod p) for p≥w 3; if w is odd, S(α,β,γ;p)≡rBp≥w (mod p) for p≥w, here r is an explicit rational number independent of p. A congruence of Catalan number is obtained as a special case.  相似文献   

19.
INTRODUCTION Throughout this paper, we shall work with a filtered complete probability space (?,F,(Ft),P) sat-isfying the usual conditions. Let B=(Bt)t≥0 be a stan-dard Brownian motion with B0=0. Denote by ú the set of all non-negative real numbers. Recall that a diffusion process X starting at x≥0 is called the square of a Bessel process of dimension δ>0 if d X t = δd t 2 | X t |d Bt , X 0= x, (1) Clearly, this equation has a unique non-negative strong solution X, i.e., …  相似文献   

20.
Children (n = 122) and adults (n = 200) with dyslexia completed rapid automatic naming (RAN) letters, rapid automatic switching (RAS) letters and numbers, executive function (inhibition, verbal fluency), and phonological working memory tasks. Typically developing 3rd (n = 117) and 5th (n = 103) graders completed the RAS task. Instead of analyzing RAN/RAS results the usual way (total time), growth mixture modeling assessed trajectories of successive times for naming 10 symbols in each of five rows. For all three samples and both RAN and RAS, two latent classes were identified. The “faster” class performed slowly on the first row and increased time by small increments on subsequent rows. The “slower” latent class performed more slowly on the first row, and children, but not adults, increased time by larger increments on subsequent rows. For children, both the initial row (automaticity index) and slope (sustained controlled processing index) of the trajectory differentiated the classes. For adults, only the initial row separated the classes. The longest time was on row 3 for RAN and row 4 for RAS. For the typically developing 5th graders, close in age to the children with dyslexia, the trajectories were flatter than for children with dyslexia and only the slower class (4%) showed the peak on row 4. For children with dyslexia, inhibition predicted RAN slope within the slower latent class and phonological working memory predicted RAS slope for both latent classes. For adults with dyslexia, inhibition and phonological working memory differentiated both latent classes on RAN intercept and RAS slope. Taken together, RAN, which may assess the phonological loop of working memory, and RAS, which may assess the central executive in working memory, may explain the timing deficit in dyslexia in sustaining coordinated orthographic-phonological processing over time. This research was supported by Grant Ns. P50 33812 and R01 HD25858 from the National Institute of Child Health and Human Development, Virginia W. Berninger, PI.  相似文献   

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