共查询到19条相似文献，搜索用时 140 毫秒
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目的:对比分析肝脏增强CT检查与肝脏MRI检查在诊断肝癌方面准确率。方法:本次研究对象为肝胆外科就诊的90例患者,均经肝胆彩色B超初筛确诊为肝脏中小型占位病变,分别经肝脏增强CT检查与肝脏MRI检查,并经病理确诊,以病理诊断为金标准评价检查方法的准确率。结果:肝脏MRI扫描准确率明显高于肝脏增强CT检查,有统计学意义(P0.05)。结论:肝脏MRI检查方法诊断肝癌的准确率高于肝脏增强CT检查方法,可作为临床诊断肝癌的首选方法。 相似文献
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如何有效延长肝脏保存的时间以及减少肝移植过程中肝脏的缺血再灌注损伤一直是肝脏外科面临的一个重要课题.近年来,随着基础研究的深入,对肝脏的保存方法及保存液的改进,以及缺血再灌注损伤的机制以及预防有了进一步的认识.本文就肝脏保存方法,保存液选择,缺血再灌注损伤的分子机制及中药对肝缺血再灌注损伤的预处理等相关方面的进展作一综述. 相似文献
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《大众科技》2015,(11)
目的:研究匙羹藤总皂苷对大鼠肝脏超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、和脂质过氧化物(LPO)作用的影响。方法:通过硫代巴比妥酸(TBA)分光光度法测定大鼠肝脏脂质过氧化(LPO)的二级分解产物丙二醛(MDA)的含量,以考察匙羹藤总皂苷对实验大鼠肝脏LPO的作用影响,采用黄嘌呤氧化酶法测定SOD活力,钼酸铵显色法测定CAT的活力,考察匙羹藤总皂苷对实验大鼠肝脏SOD和CAT的作用大小。结果:与对照组比较匙羹藤总皂苷在1.0mg/ml~6.0mg/ml浓度范围可抑制大鼠肝脏LPO作用;在1.0mg/ml~6.5mg/ml浓度范围内可提高大鼠肝脏SOD和CAT的活性。结论:匙羹藤总皂苷可以提高大鼠肝脏SOD和CAT的活性,降低MDA的产生。 相似文献
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来自英国纽卡斯尔大学的尼科·福拉兹博士和科林·麦克古金教授,在美国科学家的协助之下,在人工器官培育领域取得一项重大突破.他们在实验室内,成功培育出世界上第一块人造人体肝脏组织.虽然那不过是一块不到2.5厘米见方的人造"迷你肝脏"组织,其大小约为一枚1便士的硬币,但他们相信,随着时间的推移,这块"迷你肝脏"将会越长越大,直至长成一块完整肝脏,最终用于器官移植. 相似文献
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肝病专家认为,现代人的生活环境和生活方式都非常不利于肝脏的健康,熬夜是家常便饭,加班、开夜车看书、通宵卡拉OK等等,都影响情绪的稳定与平静,直接危害着肝脏的健康。临床医学证明,除去遗传、传染因素,大多数的肝脏疾病都是"熬"出来的。过大的工作量、学习量,常常使人精神疲劳、肉体乏顿,再加上长期缺少睡眠,或者睡眠过少,长此以往,肝脏就慢慢出现病症。 相似文献
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Gamma Glutamyl Transferase (γ-GT) is a microsomal enzyme. Its activity in serum is assayed in alcoholics with liver abscess
and alcoholics without liver abscess after screening by ultrasonography. The enzyme activity in serum is increased by 334%
in the patients with liver abscess compared to normal control subjects (p<0.0001), and 172% when compared to patients with
chronic alcoholism without liver abscess (p<0.0001). The enzyme activity was increased by 59.3% in the serum of patients without
liver abscess compared to the normal control subjects (p<0.001). Measurement of γ-GT in serum appears to be a sensitive index
in the diagnosis of alcoholics with liver abscess. 相似文献
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综述近年来肝衰竭的中医病因病机、证候研究进展,探讨了慢性肝衰竭的治疗方法,为该病的临床诊治提供了新思路和新方法。 相似文献
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Ethanol-induced liver injury may be linked, at least partly, to an oxidative stress resulting from increased free radical
production and/or decreased antioxidant defence. Distinguishing alcoholic and non-alcoholic liver disease has important implications.
This study looked at the possible changes between alcoholic and non-alcoholic liver diseases by examining the presence of
oxidative damage, as monitored by several parameters relating to oxidative stress. Lipid peroxides concentration, superoxide
dismutase activity and glutathione S-transferase activity increased, where as glutathione content, glutathione peroxidase
activity and glutathione reductase activity decreased among the tested subjects in comparison to normal healthy group. Determination
of these parameters may be valuable in the evaluation of liver disease. However, oxidative stress related enzymes and non-enzymes
can not be utilized as a marker for alcoholic liver diseases, as these parameters responded in the same way after liver is
damaged irrespective of their cause. Their level may help in determining the degree of liver damage. Degree of oxidative injury
was similar in patients with non-alcoholic liver disease and in moderate drinkers; while significantly higher in heavy drinkers.
The differences between the groups might be based on the type of liver pathological condition rather than its etiology (i.e.
alcohol and non alcohol related causes). 相似文献
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Paraoxonase is an anti-oxidant enzyme, which circulates in the plasma, tightly bound to HDL. This enzyme is known to be synthesized
in the liver. This study was carried out in order to ascertain the diagnostic utility of this enzyme in acute liver disease.
Serum basal as well as salt (NaCl) stimulated paraoxonase was estimated in 50 patients with an established diagnosis of acute
liver disease and also in 50 healthy blood donors. Paraoxonase levels were significantly lower in patients as compared with
controls (P < 0.05). The ‘receiver operating characteristic’ plot showed that this enzyme has a high degree of sensitivity and specificity
for the diagnosis acute liver disease. Serum PON is likely to emerge as an additional test of liver function, as it encompasses
three different attributes of hepatic function namely, synthetic capacity, detoxication and secretory functions. 相似文献
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Paul L. Wolf 《Indian journal of clinical biochemistry : IJCB》1999,14(1):59-90
It is important that clinicians and laboratorians, including clinical chemists and pathologists, recognize and understand
the clinical significance of abnormal liver function tests. The liver regulates many important metabolic functions. Hepatic
injury is associated with distortion of these metabolic functions. Hepatic disease can be evaluated and diagnosed by determining
serum concentrations of a number of serum analytes. Many serum analytes exist to assist in the biochemical diagnosis of liver
disease. The focus of this paper is on the analytes which are associated with hepatic necrosis, cholestasis, defects in excretion
and end stage hepatic disease which results in decreased synthetic function. The abnormalities of these serum analytes will
be correlated with the important types of liver disease. 相似文献
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Najma Zaheer Baquer Dhananjay Gupta Jayadev Raju 《Indian journal of clinical biochemistry : IJCB》1998,13(2):63-80
Diabetes has been classified as a disease of glucose overproduction by tissues, mainly liver and glucose underutilization
by insulin requiring tissues like liver, adipose and muscle due to lack of insulin. There is, however, glucose over utilization
in tissues not dependent on insulin for glucose transport like kidney, nerve and brain. There are serious complications due
to this excess glucose in these tissues and their reversal is important for a good metabolic control and normalisation of
other parameters. Insulin, trace metals and some plant extracts have been used to see the reversal effects of the complications
of diabetes in liver and kidney in experimental diabetes. Almost complete reversal of the metabolic changes has been achieved
in the activities of key enzymes of metabolic pathways in liver and kidney and an effective glucose control has been achieved
suggesting a combination of therapies in the treatment of metabolic disturbance of the diabetic state. 相似文献
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Naoki Mantani Hiroshi Oka Takashi Watanabe Kyohei Miyakawa Yoko Kimura 《Indian journal of clinical biochemistry : IJCB》2021,36(3):375
HLA association with drug-induced liver injury has recently been pointed out about multiple medicines. The aim of this study was to evaluate relationship between HLA gene and liver injury related to Baikal skullcap-containing Kampo medicines (BSCK). We previously examined HLA genes in 3 cases of BSCK-induced liver injury. Recently we could encounter 2 cases diagnosed as “definitely-related case” of BSCK-induced liver injury. HLA genes of the 2 cases were analyzed by Sequencing Based Typing method with Next Generation Sequencer at HLA Laboratory in Kyoto. HLA-DPA1*02:02:02 and DPB1*05:01:01 were observed in the 2 cases: concordance was not observed in HLA-A, B, C, DRB1, DRB4, DQA1, or DQB1. The previous 3 cases of BSCK-induced liver injury had the same allele type to the 2 cases only in HLA-DPA1. Putting all these together, HLA-DPA1*02:02:02 was observed in common among 5 cases of BSCK-induced liver injury. HLA-DPA1*02:02:02 is possibly associated with BSCK-induced liver injury. 相似文献
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肝细胞大量凋亡坏死进而引起肝脏功能严重损伤是肝衰竭的根本病因。近年来,我国对中医药防治肝衰竭进行了大量的研究,基本认可了"毒邪为肝衰竭的致病之因,贯穿疾病的始终,痰瘀为本,毒、痰、瘀互为因果";运用活血、解毒、化瘀的方法治疗肝衰竭成为广大医家的共识。大黄、赤芍均为传统的活血化瘀类中药。两药为相须配伍之药,是治疗热毒、瘀血的要药,与肝衰竭的中医病因病机及症候较为吻合。文章总结了近年来大黄、赤芍及其复方在治疗肝衰竭中作用机制的研究成果,重点从调节机体免疫、改善内毒素血症、抗凝、促进肝细胞再生的角度来阐述。 相似文献