共查询到12条相似文献，搜索用时 140 毫秒
1.
目的 探讨风心病二尖瓣狭窄并发左房血栓患者行经皮二尖瓣球囊成形术(PBMV)安全性、效果及处置对策.方法 16例左房血栓患者术前经2～12周口服阿司匹林、华法令,皮下注射低分子量肝素钠,左房血栓消失或机化后行PBMV术,术中精细操作.结果 MVA0.88±0.33至2.10±0.47cm2,MVG17.3±4.8至4.63±1.74mmHg,术中无一例发生栓塞,未出现重度二尖瓣返流.结论 左房血栓仅为PBMV相对禁忌症,对左心耳、左房顶部血栓经充分抗凝后行PBMV术,操作恰当可与无血栓者取得相似效果. 相似文献
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九年前，食品与药品管理局批准组织纤溶酶原激活因子（tPA）作为第一种、也是至今为止唯一获准用于治疗缺血性中风的药物。缺血性中风是由于脑血栓导致神经细胞缺氧而引起的疾病。但是，只有3％的缺血性中风患者接受了这种溶栓药物的治疗，主要原因是他们能够在发病后3小时内到达急诊室。超过3小时，tPA降低死亡率和残疾率的疗效就会降低，而引起危险性出血的相对风险则会增加。近来，科学家们已经发现了延长tPA的治疗时间的办法——至少对于部分患者来说是这样的，同时也发现了在发病3小时后使用起来既有效又安全的替代药物。 相似文献
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老年高血压病左室肥厚与神经体液因素及室性早搏的相关性 总被引：1，自引：0，他引：1
为探讨老年高血压病左室肥厚（LVH）与部分神经体液因素之间的关系及与室性早搏，心肌缺血的相关性，老年高血压病伴左室肥厚60例为A组，单纯老年高;血压病60例为B组，对比观察心率变异，肾素（Ren)，血管紧张素（AT－II），醛固酮（Ald)，胰岛素峰值（Ins),24h动态心电图和血压等指标，结果显示：1）A组病人交感神经张力明显增高，迷走神经活性下降不明显，室性早搏的发生与交感神经张力增高有关；室性早搏与心肌缺血具有相关性；2）A组病人与Ald及Ins水平有关，与Ren和AT－II无明显相关；3）A组病人与室性早搏和心肌缺血明显相关，结论表明，老年高血压病在室肥厚患者交感神经张力增高，Ald及Ins水平升高，与室性早搏，心肌缺血具有正相关。 相似文献
4.
观察功劳木溶液联合麻油、白糖外敷治疗Ⅱ～Ⅲ期褥疮的临床疗效。132例Ⅱ～Ⅲ期褥疮患者随机分为治疗组（67例）与对照组（65例）;2组均采用相同的综合护理治疗,在此基础上,治疗组以无菌的功劳木溶液联合麻油、白糖浸透的纱布外敷创面,对照组以无菌的凡士林纱布外敷创面,均每日换药一次,观察4周后评价疗效。治疗组治愈40例,显效15例,有效8例,无效4例,总有效率94.03%;对照组治愈20例,显效6例,有效18例,无效21例,总有效率67.69%。2组疗效比较,治疗组明显优于对照组,差异有极显著性意义（经Ridit检验,u=4.27,P〈0.01）。功劳木溶液联合麻油、白糖外敷治疗褥疮具有较好的临床疗效,值得推广应用。 相似文献
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主动脉内气囊反搏的抗凝问题 总被引：2，自引：0，他引：2
目的 研究主动脉内气囊反搏(IABP)是否需要常规抗凝.方法 连续选择IABP病人153例,随机分组进入抗凝组(A组)71例,非抗凝组(B组)82例.抗凝组静脉给予肝素针维持aPTT于50～70s.非抗凝组无肝素针静脉维持.检测二组即刻,24h,48h以及IABP拔除后24h血小板计数,D 二聚体,纤溶酶原活化剂抑制物 1(PAI 1)和纤维蛋白降解产物(FDP)水平.观察IABP引起的肢体缺血或肢体出血等并发症、以及IABP表面的血栓情况.结果 抗凝组和非抗凝组的血小板计数和PAI 1水平于24h和48h均较本身的基础值显著下降(P<0.05).抗凝组和非抗凝组的D 二聚体和FDP水平于24h和48h均较本身的基础值显著升高(P<0.05).但二组间各个时段血小板计数,D 二聚体,PAI 1和FDP水平的比较均无显著性差异.抗凝组3例,非抗凝组2例发生一般肢体缺血.抗凝组2例大出血,8例一般出血;非抗凝组2例一般出血(P<0.05).IABP表面血栓二组均无发生.结论 IABP不需常规抗凝,抗凝不能预防IABP引起的肢体缺血.选择适当的导管经路和早期发现是预防并发症的关键. 相似文献
7.
建立了人体细胞间液多相模型,研究了人体细胞间液中Pr(Ⅲ)对Zn(Ⅱ)物种的作用.结果表明,Pr(Ⅲ)能够影响Zn(Ⅱ)的物种分布.Zn(Ⅱ)主要分布于[Zn(HSA)],[Zn(IgG)]和[Zn(Cys)2H]中.Pr(Ⅲ)不能与Zn(Ⅱ)竞争HSA和IgG配体;但是,Pr(Ⅲ)能够与Zn(Ⅱ)竞争磷酸盐和碳酸盐配体,这会引起Zn(Ⅱ)物种的重新分布. 相似文献
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Reema George Harikrishnan Sivadasanpillai Narayani Jayakumari Anugya Bhatt Jissa V. Thulaseedharan Jaganmohan A. Tharakan 《Indian journal of clinical biochemistry : IJCB》2016,31(3):302-309
Thrombotic risk factors may contribute to premature coronary artery disease (CAD), in addition to the conventional risk factors. There is paucity of data on studies evaluating the role of thrombotic factors in premature CAD in Indian patients. Thus a case–control study was performed to evaluate the role of thrombotic and atherogenic factors in young patients with angiographically proven CAD who are on treatment with statins and anti-platelet drugs. 152 patients (≤55 years) with angiographically proven CAD and 102 asymptomatic controls were recruited. Clinical and biochemical data were obtained in both groups. Blood levels of thrombotic factors-fibrinogen, antithrombin-III, tissue-plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), von-Willebrand factor (v-WF), lipoprotein(a) [Lp(a)] and homocysteine were analyzed. Patients had high levels of conventional CAD risk factors (diabetes mellitus, smoking, hypertension, dyslipidemia and positive family history) compared to controls. Logistic regression analysis revealed that low antithrombin-III (odds ratio/OR 11.2; 95 % confidence interval/CI 2.29–54.01), high fibrinogen (OR 6.04; 95 % CI 1.09–33.21) and high Lp(a) (OR 4.54; 95 % CI 0.92–22.56), as important, independent risk factors in patients. PAI-1(OR 0.15; 95 % CI 0.03–0.69) levels were significantly lower in patients. But other thrombotic risk factors studied (t-PA, v-WF and homocysteine) were comparable among patients and controls. The treatment using statins and anti-platelet drugs might be contributing to the control of some of the thrombotic risk factors. The strategies aiming at lowering the levels of thrombotic risk factors along with conventional risk factors may be useful in primary and secondary prevention of CAD. 相似文献
9.
Xi Zhang Goce Dimeski Chamindie Punyadeera 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2014,24(2):258-265
Introduction:
We have previously shown that the concentrations of D-dimer are significantly elevated in saliva compared with plasma. Saliva offers several advantages compared with blood analysis. We hypothesised that human saliva contains plasminogen activator inhibitor-1 (PAI-1) and that the concentrations are not affected by the time of saliva collection. The aim was to adopt and validate an immunoassay to quantify PAI-1 concentrations in saliva and to determine whether saliva collection time has an influence in the measurement.Materials and methods:
Two saliva samples (morning and afternoon) from the same day were collected from healthy subjects (N = 40) who have had no underlying heart conditions. A customized AlphaLISA® immunoassay (PerkinElmer®, MA, USA) was adopted and used to quantify PAI-1 concentrations. We validated the analytical performance of the customized immunoassay by calculating recovery of known amount of analyte spiked in saliva.Results:
The recovery (95.03%), intra- (8.59%) and inter-assay (7.52%) variations were within the acceptable ranges. The median salivary PAI-1 concentrations were 394 pg/mL (interquartile ranges (IQR) 243.4–833.1 pg/mL) in the morning and 376 (129.1–615.4) pg/mL in the afternoon and the plasma concentration was 59,000 (24,000–110,000) pg/mL. Salivary PAI-1 did not correlate with plasma (P = 0.812).Conclusions:
The adopted immunoassay produced acceptable assay sensitivity and specificity. The data demonstrated that saliva contains PAI-1 and that its concentration is not affected by the time of saliva collection. There is no correlation between salivary and plasma PAI-1 concentrations. Further studies are required to demonstrate the utility of salivary PAI-1 in CVD risk factor studies. 相似文献10.
70例自发性气胸临床分析 总被引：1，自引：0，他引：1
对７０例自发性气胸进行了临床分析,自发性气胸多发于男性青少年,右侧多见,其中又 原发性气胸发生率为高（７１％）,继发性气胸原发病主要为慢性阻塞性肺部疾病和肺结核,部分（５１％）有明显诱因,复发率达２６％,卧床休息、胸腔抽气术、胸腔闭式引流术仍是目前应用最普遍的疗法,其总有效率达８５％,治疗中严重并发症为重复和张性肺水肿,少数病例需手术治疗。 相似文献
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卢宝荣 《中国科学院研究生院学报》1994,32(6):504-513
为了进一步研究Elymus sibiricus L.、E．nutans Griseb．和E．burchan-buddae(Neuski)Tzelev
[＝Roegneria nutans(Keng)Keng]的外部形态差异及其系统学关系，本文对这三种植物的6个穗部形
态性状进行了观测和比较，并对这三个Elymus种进行了种间杂交及杂种F1的减数分裂染色体配对行
为的分析研究。结果表明：这三个Elymus种的穗长及颖长等性状均变异很大，而内稃的长、宽则变异
不大并具有明显的种间差异。E. nutans×E．barchan-buddae及E.nutans×E．sibiricus的杂种F1均完
全不育，减数分裂不规则。E．nutans×E．burchan-buddae杂种F1的减数分裂构型为：7.70I+13.40
Ⅱ+0.06Ⅲ+O.08 Ⅳ，而E．sibiricus×E．nutans杂种F1的构型为11.98 Ⅰ+9.61Ⅱ+O.64Ⅲ+0.39
Ⅳ+0.01V。由本实验的形态学和细胞学的研究结果得出以下结论：1．利用内稃形态性状结合穗部
其它性状的差异能对这三个物种进行较准确的鉴定；2．E．nutans与E.burchan-buddae的亲缘关系较
近，而E．nutans与E．sibiricus的亲缘关系则较远；3. E，burchan-buddae×E．nutans的杂种Fl中存在着染色体配对控制因子。 相似文献
12.
用AP-PCR技术测定了中国慈姑属植物基因组DNA的多态性,以其为分子性状用UPGMA方
法聚类,结果表明:中国慈姑属植物可分为3大类,包括7种3变种或变型(未包括浮叶慈姑)。本文的结果与基于形态和核型分析的结果一致。 相似文献