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1.
Magnetic hyperthermia therapy (MHT) is able to ablate tumors using an alternating magnetic field (AMF) to heat up magnetocaloric agents (e.g. magnetic nanoparticles) administered into the tumors. For clinical applications, there is still a demand to find new magnetocaloric agents with strong AMF-induced heating performance and excellent biocompatibility. As a kind of biocompatible and biodegradable material, magnesium (Mg) and its alloys have been extensively used in the clinic as an implant metal. Herein, we discovered that the eddy thermal effect of the magnesium alloy (MgA) could be employed for MHT to effectively ablate tumors. Under low-field-intensity AMFs, MgA rods could be rapidly heated, resulting in a temperature increase in nearby tissues. Such AMF-induced eddy thermal heating of MgA could not only be used to kill tumor cells in vitro, but also be employed for effective and accurate ablation of tumors in vivo. In addition to killing tumors in mice, we further demonstrated that VX2 tumors of much larger sizes growing in rabbits after implantation of MgA rods could also be eliminated after exposure to an AMF, illustrating the ability of MgA-based MHT to kill large-sized tumors. Moreover, the implanted MgA rods showed excellent biocompatibility and ∼20% of their mass was degraded within three months. Our work thus discovered for the first time that non-magnetic biodegradable MgA, an extensively used implant metal in clinic, could be used for effective magnetic thermal ablation of tumors under a low-field-intensity AMF. Such a strategy could be readily translated into clinical use.  相似文献   

2.
The two-electron reduction of molecular oxygen represents an effective strategy to enable the green, mild and on-demand synthesis of hydrogen peroxide. Its practical viability, however, hinges on the development of advanced electrocatalysts, preferably composed of non-precious elements, to selectively expedite this reaction, particularly in acidic medium. Our study here introduces 2H-MoTe2 for the first time as the efficient non-precious-metal-based electrocatalyst for the electrochemical production of hydrogen peroxide in acids. We show that exfoliated 2H-MoTe2 nanoflakes have high activity (onset overpotential ∼140 mV and large mass activity of 27 A g−1 at 0.4 V versus reversible hydrogen electrode), great selectivity (H2O2 percentage up to 93%) and decent stability in 0.5 M H2SO4. Theoretical simulations evidence that the high activity and selectivity of 2H-MoTe2 arise from the proper binding energies of HOO* and O* at its zigzag edges that jointly favor the two-electron reduction instead of the four-electron reduction of molecular oxygen.  相似文献   

3.
One of the most significant challenges implementing colloidal magnetic nanoparticles in medicine is the efficient heating of microliter quantities by applying a low frequency alternating magnetic field. The ultimate goal is to accomplish nonsurgically the treatment of millimeter size tumors. Here, we demonstrate the synthesis, characterization, and the in vitro as well as in vivo efficiency of a dextran coated maghemite (γ-Fe2O3) ferrofluid with an exceptional response to magnetic heating. The difference to previous synthetic attempts is the high charge of the dextran coating, which according to our study maintains the colloidal stability and good dispersion of the ferrofluid during the magnetic heating stage. Specifically, in vitro 2 μl of the ferrofluid gives an outstanding temperature rise of 33 °C within 10 min, while in vivo treatment, by infusing 150 μl of the ferrofluid in animal model (rat) glioma tumors, causes an impressive cancer tissue dissolution.  相似文献   

4.
Chemotherapy drugs, used for prevention of uncontrolled cell proliferation in certain tissues as well as inducing apoptosis in tumor cells, are important candidates for treatment of cancer. The synthesized 2-amino-4H-chromene-3-carbonitrile derivatives effective on cancerous cells resistant to other drugs such as Paclitaxel were used due to their ability in induction of apoptosis. The growth inhibitory and inducing apoptosis activities were determined. In order to make it target-oriented, the best compound was conjugated with gold nanoparticles (NPs) by aspartic acid with chemical reduction method. Cytotoxicity effect of 2-amino-4H-chromene-3-carbonitrile derivatives against the T47D breast cancer cell line was determined by MTT assay. The synthesis of gold NPs was confirmed by transmission electron microscopy, UV–Vis and dynamic light scattering. To assess the effects of compounds on the process of apoptosis, staining methods with acridine orange–ethidium bromide and Hoechst staining by fluorescence microscopy and DNA fragmentation by the diphenylamine method were used. The synthesized compounds containing two NH2 groups on benzene rings, demonstrated more cytotoxicity effect. The effect of conjugation with gold NPs and the induction of apoptosis were studied with the best compound. The cytotoxicity effects of the synthesized 2-amino-4H-chromene-3-carbonitrile compounds were changed by replacement of NO2 group on thiol ring with different chemical groups on the benzene ring. Analyses of treated cell lines by conjugated and non-conjugated forms of compounds verified their ability in inducing apoptosis while conjugated form demonstrated higher apoptosis.  相似文献   

5.
This paper presents the central finite-dimensional H∞ filter for nonlinear polynomial systems with multiplicative noise, that is suboptimal for a given threshold γ with respect to a modified Bolza-Meyer quadratic criterion including the attenuation control term with the opposite sign. In contrast to the previously obtained results, the paper reduces the original H∞ filtering problem to the corresponding optimal H2 filtering problem, using the technique proposed in [1]. The paper presents the central suboptimal H∞ filter for the general case of nonlinear polynomial systems with multiplicative noise, based on the optimal H2 filter given in [31]. The central suboptimal H∞ filter is also derived in a closed finite-dimensional form for third (and less) degree polynomial system states. Numerical simulations are conducted to verify performance of the designed central suboptimal filter for nonlinear polynomial systems against the central suboptimal H∞ filters available for polynomial systems with state-independent noise and the corresponding linearized system.  相似文献   

6.
This paper investigates an H2/H∞ filter designing for networked systems perturbed by multiple noises. The measurement transmission from the sensor to the remote filter is completed via a communication network in simultaneously presenting of data transmission time-varying delays, data packet dropout and data sequence disorder. Since the filter will receive delayed and disordered information, a zero-order-hold (ZOH) or a logical-ZOH (LZOH) is firstly employed for resorting the chaos data sequence. Afterwards, a hybrid H2/H∞ filtering scheme is designed for accurately estimating the target output. By Itô formula and a novel free-weight method, the almost surely mean square exponentially stable (ASMSES) condition of the error system is conveniently obtained and the corresponding filter design method is finally presented. By the proposed method, not only the ASMSES with a pre-scheduled H2/H∞ performance can be achieved, but also the convergence rate of overall system is pre-regulable. In addition, it has been point out the dynamic filtering performance of LZOH scheme should be better than ZOH ones due to less time-varying delays are introduced and more latest measurement information are employed. Numerical examples are provided to demonstrate the effectiveness of the proposed methods.  相似文献   

7.
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8.
Aerospace milestones in human history, including returning to the moon and manned Martian missions, have been implemented in recent years. Space exploration has become one of the global common goals, and to ensure the survival and development of human beings in the extraterrestrial extreme environment has been becoming the basic ability and technology of manned space exploration. For the purpose of fulfilling the goal of extraterrestrial survival, researchers in Nanjing University and the China Academy of Space Technology proposed extraterrestrial artificial photosynthesis (EAP) technology. By simulating the natural photosynthesis of green plants on the Earth, EAP converts CO2/H2O into fuel and O2 in an in-situ, accelerated and controllable manner by using waste CO2 in the confined space of spacecraft, or abundant CO2 resources in extraterrestrial celestial environments, e.g. Mars. Thus, the material loading of manned spacecraft can be greatly reduced to support affordable and sustainable deep space exploration. In this paper, EAP technology is compared with existing methods of converting CO2/H2O into fuel and O2 in the aerospace field, especially the Sabatier method and Bosch reduction method. The research progress of possible EAP materials for in-situ utilization of extraterrestrial resources are also discussed in depth. Finally, this review lists the challenges that the EAP process may encounter, which need to be focused on for future implementation and application. We expect to deepen the understanding of artificial photosynthetic materials and technologies, and aim to strongly support the development of manned spaceflight.  相似文献   

9.
This work deals with the problem of optimal residual generation for fault detection (FD) in linear discrete time-varying (LDTV) systems subject to uncertain observations. By introducing a generalized fault detection filter (FDF) with four parameter matrices as the residual generator, a novel FDF design scheme is formulated as two bi-objective optimization problems such that the sensitivity of residual to fault is enhanced and the robustness of residual to unknown input is simultaneously strengthened. A generalized operator based optimization approach is proposed to deduce solutions to the corresponding optimization problems in operator forms, where the related H∞/H∞ or H?/H∞ FD performance index is maximized. With the aid of the addressed methods, the connections among the derived solutions are explicitly announced. The parameter matrices of the FDF are analytically derived via solving simple matrix equations recursively. It is revealed that our proposed results establish an operator-based framework of optimal residual generation for some kinds of linear discrete-time systems. Illustrative examples are given to show the applicability and effectiveness of the proposed methods.  相似文献   

10.
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11.
Understanding the mineralogy of the Earth''s interior is a prerequisite for unravelling the evolution and dynamics of our planet. Here, we conducted high pressure-temperature experiments mimicking the conditions of the deep lower mantle (DLM, 1800–2890 km in depth) and observed surprising mineralogical transformations in the presence of water. Ferropericlase, (Mg, Fe)O, which is the most abundant oxide mineral in Earth, reacts with H2O to form a previously unknown (Mg, Fe)O2Hx (x ≤ 1) phase. The (Mg, Fe)O2Hx has a pyrite structure and it coexists with the dominant silicate phases, bridgmanite and post-perovskite. Depending on Mg content and geotherm temperatures, the transformation may occur at 1800 km for (Mg0.6Fe0.4)O or beyond 2300 km for (Mg0.7Fe0.3)O. The (Mg, Fe)O2Hx is an oxygen excess phase that stores an excessive amount of oxygen beyond the charge balance of maximum cation valences (Mg2+, Fe3+ and H+). This important phase has a number of far-reaching implications including extreme redox inhomogeneity, deep-oxygen reservoirs in the DLM and an internal source for modulating oxygen in the atmosphere.  相似文献   

12.
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13.
Grapes are the richest source of antioxidants due to the presence of potent bioactive phytochemicals. In this study, the phytochemical contents, scavenging activities and protective role against H2O2-induced oxidative stress in liver tissue ex vivo of four grape (Vitis vinifera) cultivars extracts, namely Flame seedless (black), Kishmish chorni (black with reddish brown), Red globe (red) and Thompson seedless mutant (green), were evaluated. The total phenolics and flavonoids content in pulp or skin fractions of different grape cultivars were in the range of 47.6–310 mg gallic acid equivalent/g fresh weight (fw), and 46.6–733.3 µg catechin equivalent/g fw respectively. The scavenging activities in skin of different grape varieties against 2,2-diphenyl-1-picrylhydrazyl (44–58 %), hydrogen peroxide (15.3–18.6 %), and hydroxyl radicals (50–85 %), were higher than pulp of the corresponding cultivars. These scavenging activities of grape extracts were found to be significantly (p < 0.01) correlated with the levels of total phenols, flavonoids and ascorbic acid. Liver tissues from goat treated with H2O2 (500 μM) showed significantly decreased GSH content by 42.9 % and activities of catalase by 50 % and glutathione reductase by 66.6 %; while increased thiobarbituric acid reactive substances and nitric oxide level by 2.53- and 0.86-fold, respectively, and activity of glutathione S-transferase by 0.96-fold. Grape skin extracts showed the stronger protective activity against H2O2-induced oxidative stress in liver tissue ex vivo, than its pulp of any cultivar; and the Flame seedless (black) cultivar showed the highest potential. In conclusion, our study suggested that the higher antioxidant potential, phytochemical contents and significant scavenging capacities in pulp and skin of grape extracts showed the protective action of grape extracts against H2O2-induced oxidative stress in liver tissue ex vivo.  相似文献   

14.
This paper investigates the Riemannian trust-region method for H2 model reduction of bilinear systems. The H2 error norm is treated as a cost function on the Stiefel manifold such that the orthogonality constraint for the projection matrix is plainly satisfied. The property related to the Euclidean gradient is studied. Then, the inner product associated with the Riemannian Hessian is derived, which can simplify the expression of the trust-region subproblem. The trust-region method for H2 model reduction is accordingly established and the convergence is further discussed. Finally, two numerical examples are employed to demonstrate the performance of the proposed method.  相似文献   

15.
In this paper, fault detection and isolation (FDI) in linear uncertain dynamic systems is addressed. The main contributions consist of the formulation of the FDI problem as a filter-based multi-objective optimization problem and the study of the tools used for the solution. The design objectives are formulated in terms of H∞, H- and generalized H2 performance specifications as well as regional constraints on filter poles. The problem is solved using linear matrix inequality (LMI) and generalized structured singular value (μg) techniques. Special design features are illustrated through a simulation example and experimental results from a controlled hydraulic process are provided to demonstrate the potential of the proposed procedure.  相似文献   

16.
A linear matrix inequality based mixed H2-dissipative type state observer design approach is presented for smooth discrete time nonlinear systems with finite energy disturbances. This observer is designed to maintain H2 type estimation error performance together with either H∞ or a passivity type disturbance reduction performance in case of randomly varying perturbations in its gain. A linear matrix inequality is used at each time instant to find the time-varying gain of the observer. Simulation studies are included to explore the performance in comparison to the extended Kalman filter and a previously proposed constant gain observer counterpart.  相似文献   

17.
Synthetic lethality was proposed nearly a century ago by geneticists and recently applied to develop precision anti-cancer therapies. To exploit the synthetic lethality concept in the design of chemical anti-cancer agents, we developed a bio-orthogonally catalyzed lethality (BCL) strategy to generate targeting anti-tumor metallodrugs both in vitro and in vivo. Metallodrug Ru-rhein was generated from two non-toxic species Ru-N3 and rhein-alkyne via exclusive endogenous copper-catalyzed azide alkyne cycloaddition (CuAAC) reaction without the need of an external copper catalyst. The non-toxic species Ru-arene complex Ru-N3 and rhein-alkyne were designed to perform this strategy, and the mitochondrial targeting product Ru-rhein was generated in high yield (>83%) and showed high anti-tumor efficacy in vitro. This BCL strategy achieved a remarkable tumor suppression effect on the tumor-bearing mice models. It is interesting that the combination of metal-arene complexes with rhein via CuAAC reaction could transform two non-toxic species into a targeting anti-cancer metallodrug both in vitro and in vivo, while the product Ru-rhein was non-toxic towards normal cells. This is the first example that exclusive endogenous copper was used to generate metal-based anti-cancer drugs for cancer treatment. The anti-cancer mechanism of Ru-rhein was studied and autophagy was induced by increased reactive oxygen species and mitochondrial damage. The generality of this BCL strategy was also studied and it could be extended to other metal complexes such as Os-arene and Ir-arene complexes. Compared with the traditional methods for cancer treatment, this work presented a new approach to generating targeting metallodrugs in vivo via the BCL strategy from non-toxic species in metal-based chemotherapy.  相似文献   

18.
In this paper, we investigate the incremental H∞ performance problem for a class of stochastic switched nonlinear systems by using a state-dependent switching law and the maximum and minimum dwell time approach. By resorting to the state-dependent switching law, some sufficient conditions are provided to cope with the incremental H∞ performance problem, which can be applied even if all subsystems are unstable. Then, based on the maximum and minimum dwell time scheme, the incremental H∞ performance problem to be solvable is derived for two cases: one is all subsystems are incrementally globally asymptotically stable in the mean(IGASiM), another is both IGASiM subsystems and unstable subsystems coexist. When all subsystems are IGASiM, the stochastic switched nonlinear system is IGASiM and possesses a incremental L2-gain under given conditions. When both IGASiM subsystems and unstable subsystems coexist, if the activation time ratio between IGASiM subsystems and unstable ones is not less than a specified constant, the sufficient conditions for the incremental H∞ performance of the stochastic switched nonlinear system are given. Two numerical examples are given to illustrate the validity of methods proposed.  相似文献   

19.
As an emerging and promising treatment method, gas therapy has attracted more and more attention for treatment of inflammation-related diseases, especially cancer. However, therapeutic/therapy-assisted gases (NO, CO, H2S, H2, O2, SO2 and CO2) and most of their prodrugs lack the abilities of active intratumoral accumulation and controlled gas release, resulting in limited cancer therapy efficacy and potential side effects. Therefore, development of nanomedicines to realize tumor-targeted and controlled release of therapeutic/therapy-assisted gases is greatly desired, and also the combination of other therapeutic modes with gas therapy by multifunctional nanocarrier platforms can augment cancer therapy efficacy and also reduce their side effects. The design of nanomedicines with these functions is vitally important, but challenging. In this review, we summarize a series of engineering strategies for construction of advanced gas-releasing nanomedicines from four aspects: (1) stimuli-responsive strategies for controlled gas release; (2) catalytic strategies for controlled gas release; (3) tumor-targeted gas delivery strategies; (4) multi-model combination strategies based on gas therapy. Moreover, we highlight current issues and gaps in knowledge, and envisage current trends and future prospects of advanced nanomedicines for gas therapy of cancer. This review aims to inspire and guide the engineering of advanced gas-releasing nanomedicines.  相似文献   

20.
This paper is concerned with the problem of robust fault-tolerant H∞ dynamic output feedback control for fractional-order linear uncertain systems with the order satisfying 0 < α < 1 in the presence of actuator faults. A new linear matrix inequality (LMI) formulation corresponding to the H∞ norm of fractional-order linear systems is proposed. Based on the new formulation and by introducing a new linearizing change of variables, sufficient conditions for robust fault-tolerant H∞ dynamic output feedback controller designs are derived in term of LMIs. Furthermore, the proposed controller not only enables the system to keep robust stabilization, but also achieves a better H∞ performance compared with the existing methods. Numerical examples are given to illustrate the design procedure and its effectiveness.  相似文献   

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