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1.
Abstract

In this study, we examined indirect markers of muscle damage and muscle soreness following a 50-km cross-country ski race completed in 2 h and 57 min to 5 h and 9 min by 11 moderately trained male university students. Maximal strength of the knee extensors, several blood markers of muscle damage and inflammation, and muscle soreness (visual analog scale: 0 = “no pain”, 50 mm = “unbearably painful”) were measured one day before, immediately after, and 24, 48, 72, and 144 h after the race. Changes in the measures over time were analysed using one-way repeated-measures analysis of variance and a Fisher's post-hoc test. Maximal strength of the knee extensors decreased significantly (P<0.05) immediately after the race (mean ?27%, s=6), but returned to pre-exercise values within 24 h of the race. All blood markers increased significantly (P<0.05) following the race, peaking either immediately (lactate dehydrogenase: 253.7 IU · l?1, s=13.3; myoglobin: 476.4 ng · ml?1, s=85.5) or 24 h after the race (creatine kinase: 848.0 IU · l?1, s=151.9; glumatic oxaloacetic transaminase: 44.3 IU · l?1, s=4.2; aldolase: 10.0 IU · l?1, s=1.3; C-reactive protein: 0.36 IU · l?1, s=0.08). Muscle soreness developed in the leg, arm, shoulder, back, and abdomen muscles immediately after the race (10–30 mm), but decreased after 24 h (<15 mm), and disappeared 48 h after the race. These results suggest that muscle damage induced by a 50-km cross-country ski race is mild and recovery from the race does not take long.  相似文献   

2.
Runners often experience delayed onset muscle soreness (DOMS), especially of the knee extensors, following prolonged running. Sagittal knee joint biomechanics are altered in the presence of knee extensor DOMS but it is unclear how muscle soreness affects lower limb biomechanics in other planes of motion. The purpose of this study was to assess the effects of knee extensor DOMS on three-dimensional (3D) lower limb biomechanics during running. Thirty-three healthy men (25.8?±?6.8 years; 84.1?±?9.2?kg; 1.77?±?0.07?m) completed an isolated eccentric knee extensor damaging protocol to elicit DOMS. Biomechanics of over-ground running at a set speed of 3.35?m?s?1±5% were measured before eccentric exercise (baseline) and, 24?h and 48?h following exercise in the presence of knee extensor DOMS. Knee flexion ROM was reduced at 48?h (P?=?0.01; d?=?0.26), and peak knee extensor moment was reduced at 24?h (P?=?0.001; d?=?0.49) and 48?h (P?<?0.001; d?=?0.68) compared to baseline. Frontal and transverse plane biomechanics were unaffected by the presence of DOMS (P?>?0.05). Peak positive ankle and knee joint powers and, peak negative knee joint power were all reduced from baseline to 24?h and 48?h (P?<?0.05). These findings suggest that knee extensor DOMS greatly influences sagittal knee joint angular kinetics and, reduces sagittal power production at the ankle joint. However, knee extensor DOMS does not affect frontal and transverse plane lower limb joint biomechanics during running.  相似文献   

3.
Abstract

The aim of this study was to assess the effects of cold-water immersion (cryotherapy) on indices of muscle damage following a bout of prolonged intermittent exercise. Twenty males (mean age 22.3 years, s = 3.3; height 1.80 m, s = 0.05; body mass 83.7 kg, s = 11.9) completed a 90-min intermittent shuttle run previously shown to result in marked muscle damage and soreness. After exercise, participants were randomly assigned to either 10 min cold-water immersion (mean 10°C, s = 0.5) or a non-immersion control group. Ratings of perceived soreness, changes in muscular function and efflux of intracellular proteins were monitored before exercise, during treatment, and at regular intervals up to 7 days post-exercise. Exercise resulted in severe muscle soreness, temporary muscular dysfunction, and elevated serum markers of muscle damage, all peaking within 48 h after exercise. Cryotherapy administered immediately after exercise reduced muscle soreness at 1, 24, and 48 h (P < 0.05). Decrements in isometric maximal voluntary contraction of the knee flexors were reduced after cryotherapy treatment at 24 (mean 12%, s x  = 4) and 48 h (mean 3%, s x  = 3) compared with the control group (mean 21%, s x  = 5 and mean 14%, s x  = 5 respectively; P < 0.05). Exercise-induced increases in serum myoglobin concentration and creatine kinase activity peaked at 1 and 24 h, respectively (P < 0.05). Cryotherapy had no effect on the creatine kinase response, but reduced myoglobin 1 h after exercise (P < 0.05). The results suggest that cold-water immersion immediately after prolonged intermittent shuttle running reduces some indices of exercise-induced muscle damage.  相似文献   

4.
Abstract

In this study, we investigated the effect of ingesting carbohydrate alone or carbohydrate with protein on functional and metabolic markers of recovery from a rugby union-specific shuttle running protocol. On three occasions, at least one week apart in a counterbalanced order, nine experienced male rugby union forwards ingested placebo, carbohydrate (1.2 g · kg body mass?1 · h?1) or carbohydrate with protein (0.4 g · kg body mass?1 · h?1) before, during, and after a rugby union-specific protocol. Markers of muscle damage (creatine kinase: before, 258 ± 171 U · L?1 vs. 24 h after, 574 ± 285 U · L?1; myoglobin: pre, 50 ± 18 vs. immediately after, 210 ± 84 nmol · L?1; P < 0.05) and muscle soreness (1, 2, and 3 [maximum soreness = 8] for before, immediately after, and 24 h after exercise, respectively) increased. Leg strength and repeated 6-s cycle sprint mean power were slightly reduced after exercise (93% and 95% of pre-exercise values, respectively; P < 0.05), but were almost fully recovered after 24 h (97% and 99% of pre-exercise values, respectively). There were no differences between trials for any measure. These results indicate that in experienced rugby players, the small degree of muscle damage and reduction in function induced by the exercise protocol were not attenuated by the ingestion of carbohydrate and protein.  相似文献   

5.
Delayed-onset muscle soreness refers to the skeletal muscle pain that is experienced following eccentric exercise. The aim of the present study was to examine the physiological effects of physical activity with or without ibuprofen on delayed onset muscle soreness. Forty-four non-athletic male volunteers (age 24.3?±?2.4 years) were randomly assigned to one of four groups: physical activity (n = 11), ibuprofen (n = 11), physical activity and ibuprofen (combination, n = 11), or control (n = 11). The physical activity programme comprised 5?min of walking and jogging, 10?min of static stretching of the hands and shoulder girdle, and 5?min of concentric movements with sub-maximal contractions. The total amount of ibuprofen consumed by a single individual was 2800?mg; this was taken from 1?h before the eccentric actions up to 48?h after it. Delayed onset muscle soreness was induced by performing 70 eccentric contractions of the biceps muscle of the non-dominant side on a modified arm curl machine. Perceived muscle soreness, maximal eccentric contraction, creatine kinase enzyme activity and elbow range of motion were assessed 1?h before and 1, 24 and 48?h after the eccentric actions. The results indicated that, after the eccentric actions, soreness increased (P?<?0.001) across time in all groups, with the highest values being recorded at 24?h. At 24 and 48?h, greater soreness (P <?0.001) was observed in the control group than in the physical activity and combination groups. After the eccentric actions, creatine kinase increased and was elevated (P?<?0.001) compared with baseline in all groups, with values returning to baseline in the physical activity and combination groups by 48?h. However, creatine kinase in the control and ibuprofen groups was still significantly higher than at baseline after 48?h. Creatine kinase was higher (P?<?0.001) in the control group than in physical activity and combination groups at 24 and 48?h. There was also a reduction (P?<?0.001) in elbow range of motion across time. This reduction in elbow range of motion was greater (P?<?0.001) in the control and ibuprofen groups than in the physical activity and combination groups at 1, 24 and 48?h. The reduction in maximum eccentric contraction was greater (P?<?0.001) in the control and ibuprofen groups than in the physical activity group at 24 and 48?h and the combination group at 48?h. In conclusion, the results add to our understanding of the effects of physical activity and the combination of physical activity and ibuprofen in reducing the severity of muscle soreness induced by eccentric exercise. Physical activity conducted before eccentric exercise alleviates muscle soreness. Our results indicate that physical activity with or without ibuprofen helps to prevent delayed-onset muscle soreness.  相似文献   

6.
Abstract

This study was undertaken to examine the acute effect of interferential current on mechanical pain threshold and isometric peak torque after delayed onset muscle soreness induction in human hamstrings. Forty-one physically active healthy male volunteers aged 18?33 years were randomly assigned to one of two experimental groups: interferential current group (n = 21) or placebo group (n = 20). Both groups performed a bout of 100 isokinetic eccentric maximal voluntary contractions (10 sets of 10 repetitions) at an angular velocity of 1.05 rad · s?1 (60° · s?1) to induce muscle soreness. On the next day, volunteers received either an interferential current or a placebo application. Treatment was applied for 30 minutes (4 kHz frequency; 125 μs pulse duration; 80?150 Hz bursts). Mechanical pain threshold and isometric peak torque were measured at four different time intervals: prior to induction of muscle soreness, immediately following muscle soreness induction, on the next day after muscle soreness induction, and immediately after the interferential current and placebo application. Both groups showed a reduction in isometric torque (P < 0.001) and pain threshold (P < 0.001) after the eccentric exercise. After treatment, only the interferential current group showed a significant increase in pain threshold (P = 0.002) with no changes in isometric torque. The results indicate that interferential current was effective in increasing hamstrings mechanical pain threshold after eccentric exercise, with no effect on isometric peak torque after treatment.  相似文献   

7.
Abstract

This study investigated the influence of dehydration during soccer-type intermittent exercise on isokinetic and isometric muscle function. Eight soccer players performed two 90-min high-intensity intermittent shuttle-running trials without (NF) or with (FL) fluid ingestion (5 ml · kg?1 before and 2 ml · kg?1 every 15 min). Isokinetic and isometric strength and muscular power of knee flexors and knee extensors were measured pre-exercise, at half-time and post-exercise using isokinetic dynamometry. Sprint performance was monitored throughout the simulated-soccer exercise. Isokinetic knee strength was reduced at faster (3.13 rad · s?1; P = 0.009) but not slower (1.05 rad · s?1; P = 0.063) contraction speeds with exercise; however, there was no difference between FL and NF. Peak isometric strength of the knee extensors (P = 0.002) but not the knee flexors (P = 0.065) was significantly reduced with exercise with no difference between FL and NF. Average muscular power was reduced over time at both 1.05 rad · s?1 (P = 0.01) and 3.14 rad · s?1 (P = 0.033) but was not different between FL and NF. Mean 15-m sprint time increased with duration of exercise (P = 0.005) but was not different between FL and NF. In summary, fluid ingestion during 90 min of soccer-type exercise was unable to offset the reduction in isokinetic and isometric strength and muscular power of the knee extensors and flexors.  相似文献   

8.
Abstract

In this study, we investigated changes in creatine kinase, perceptual and neuromuscular fatigue of professional rugby league players after match-play. Twenty-three male rugby league players (10 backs, 13 forwards) had their creatine kinase, perceptual ratings of fatigue, attitude to training, muscle soreness, and flight time in a countermovement jump measured before and 1 and 2 days after (day 1 and day 2 respectively) league matches. Total playing time, offensive and defensive contacts were also recorded for each player. Creatine kinase was higher both 1 and 2 days after than before matches (P < 0.05) in forwards and backs. Similarly, perceived fatigue and muscle soreness were higher than pre-match on both days 1 and 2 (P < 0.05), but did not differ between groups (P > 0.05). Jump performance was lower on day 1 but not day 2 for both groups (P < 0.05). While total playing time was longer in backs (P < 0.05), relative frequencies for all contacts were greater in forwards (P < 0.05). Contacts for forwards were correlated with all markers of fatigue (P < 0.05), but only flight time was correlated with offensive contacts in backs (P < 0.05). Despite the mechanisms of fatigue being different between forwards and backs, our results highlight the multidimensional nature of fatigue after a rugby league match and that these markers do not differ between positions.  相似文献   

9.
Abstract

This study investigated the effects of knee localised muscle damage on running kinematics at varying speeds. Nineteen young women (23.2 ± 2.8 years; 164 ± 8 cm; 53.6 ± 5.4 kg), performed a maximal eccentric muscle damage protocol (5 × 15) of the knee extensors and flexors of both legs at 60 rad · s-1. Lower body kinematics was assessed during level running on a treadmill at three speeds pre- and 48 h after. Evaluated muscle damage indices included isometric torque, muscle soreness and serum creatine kinase activity. The results revealed that all indices changed significantly after exercise, indicating muscle injury. Step length decreased and stride frequency significantly increased 48 h post-exercise only at the fastest running speed (3 m · s-1). Support time and knee flexion at toe-off increased only at the preferred transition speed and 2.5 m · s-1. Knee flexion at foot contact, pelvic tilt and obliquity significantly increased, whereas hip extension during stance-phase, knee flexion during swing-phase, as well as knee and ankle joints range of motion significantly decreased 48 h post-exercise at all speeds. In conclusion, the effects of eccentric exercise of both knee extensors and flexors on particular tempo-spatial parameters and knee kinematics of running are speed-dependent. However, several pelvic and lower joint kinematics present similar behaviour at the three running speeds examined. These findings provide new insights into how running kinematics at different speeds are adapted to compensate for the impaired function of the knee musculature following muscle damage.  相似文献   

10.
Abstract

Aim: To investigate the effect of different water immersion (WI) treatments on recovery from intermittent shuttle running exercise in comparison to an ecologically relevant control.

Methods: Forty males performed 90 minutes intermittent shuttle running, following which they were assigned to either: (1) 12-min standing WI at 12°C; (2) 12-min standing WI at 35°C; (3) 2-min seated WI at 12°C; (4) an ecologically relevant control consisting of 12 minutes walking at 5 km h?1. Muscle soreness, maximal voluntary contraction (MVC) of the knee flexors and extensors, hop distance, creatine kinase activity and myoglobin concentration were measured before exercise and in the 168 hours following the intervention. Between-group differences, time effects and interaction effects were investigated by mixed-model ANOVA.

Results: The shuttle running exercise induced an increase in muscle soreness (1, 24, 48 and 72 hours post-intervention) creatine kinase activity and myoglobin concentration (post-exercise and 1, 24 and 48 hours post-intervention), and reduced MVC of the knee extensors (11% reduction at 24 hours, remaining reduced at 48 and 72 hours), flexors (24% reduction at 24 hours, remaining reduced at 24, 48, 72 and 168 hours), and hop distance (24 and 48 hours). However, no between-group differences or interaction effects were evident for any of these parameters.

Conclusion: The WI protocols investigated were not better than light exercise in facilitating recovery from shuttle running exercise. Future studies examining the efficacy of WI as a recovery intervention should include a representative control condition to increase their relevance to sporting populations.  相似文献   

11.
The purpose of this paper is to provide a comprehensive review of the science of rugby league football at all levels of competition (i.e. junior, amateur, semi-professional, professional), with special reference to all discipline-specific scientific research performed in rugby league (i.e. physiological, psychological, injury epidemiology, strength and conditioning, performance analysis). Rugby league football is played at junior and senior levels in several countries worldwide. A rugby league team consists of 13 players (6 forwards and 7 backs). The game is played over two 30?–?40 min halves (depending on the standard of competition) separated by a 10?min rest interval. Several studies have documented the physiological capacities and injury rates of rugby league players. More recently, studies have investigated the physiological demands of competition. Interestingly, the physiological capacities of players, the incidence of injury and the physiological demands of competition all increase as the playing standard is increased. Mean blood lactate concentrations of 5.2, 7.2 and 9.1?mmol?·?l?1 have been reported during competition for amateur, semi-professional and professional rugby league players respectively. Mean heart rates of 152 beats?·?min?1 (78% of maximal heart rate), 166 beats?·?min?1 (84% of maximal heart rate) and 172 beats?·?min?1 (93% of maximal heart rate) have been recorded for amateur, semi-professional and junior elite rugby league players respectively. Skill-based conditioning games have been used to develop the skill and fitness of rugby league players, with mean heart rate and blood lactate responses during these activities almost identical to those obtained during competition. In addition, recent studies have shown that most training injuries are sustained in traditional conditioning activities that involve no skill component (i.e. running without the ball), whereas the incidence of injuries while participating in skill-based conditioning games is low. Collaborative research among the various sport science disciplines is required to identify strategies to reduce the incidence of injury and enhance the performance of rugby league players. An understanding of the movement patterns and physiological demands of different positions at all standards of competition would allow the development of strength and conditioning programmes to meet the precise requirements of these positions. Finally, studies investigating the impact of improvements in physiological capacities (including the effect of different strength and conditioning programmes) on rugby league playing performance are warranted.  相似文献   

12.
Abstract

Elite badminton requires muscular endurance combined with appropriate maximal and explosive muscle strength. The musculature of the lower extremities is especially important in this context since rapid and forceful movements with the weight of the body are performed repeatedly throughout a match. In the present study, we examined various leg-strength parameters of 35 male elite badminton players who had been performing resistance exercises as part of their physical training for several years. The badminton players were compared with an age-matched reference group, the members of whom were physically active on a recreational basis, and to the same reference group after they had performed resistance training for 14 weeks. Maximal muscle strength of the knee extensor (quadriceps) and flexor muscles (hamstrings) was determined using isokinetic dynamometry. To measure explosive muscle strength, the contractile rate of force development was determined during maximal isometric muscle contractions. In general, the badminton players showed greater maximal muscle strength and contractile rate of force development than the reference group: mean quadriceps peak torque during slow concentric contraction: 3.69 Nm · kg?1, s=0.08 vs. 3.26 Nm · kg?1, s=0.8 (P<0.001); mean hamstring peak torque during slow concentric contraction: 1.86 Nm · kg?1, s=0.04 vs. 1.63 Nm · kg?1, s=0.04 (P<0.001); mean quadriceps rate of force development at 100 ms: 24.4 Nm · s?1·kg?1, s=0.5 vs. 22.1 Nm·s?1 · kg?1, s=0.6 (P<0.05); mean hamstring rate of force development at 100 ms: 11.4 Nm · s?1·kg?1, s=0.3 vs. 8.9 Nm · s?1 · kg?1, s=0.4 (P<0.05). However, after 14 weeks of resistance training the reference group achieved similar isometric and slow concentric muscle strength as the badminton players, although the badminton players still had a higher isometric rate of force development and muscle strength during fast (240° · s?1) quadriceps contractions. Large volumes of concurrent endurance training could have attenuated the long-term development of maximal muscle strength in the badminton players. The badminton players had a higher contractile rate of force development than the reference group before and after resistance training. Greater explosive muscle strength in the badminton players might be a physiological adaptation to their badminton training.  相似文献   

13.
Fatigue represents a reduction in the capability of muscle to generate force. The aim of the present study was to establish the effects of exercise that simulates the work rate of competitive soccer players on the strength of the knee extensors and knee flexors. Thirteen amateur soccer players (age 23.3±3.9 years, height 1.78±0.05?m, body mass 74.8±3.6?kg; mean±s) were tested during the 2000–2001 soccer season. Muscle strength of the quadriceps and hamstrings was measured on an isokinetic dynamometer. A 90?min soccer-specific intermittent exercise protocol, incorporating a 15?min half-time intermission, was developed to provide fatiguing exercise corresponding in work rate to a game of soccer. The exercise protocol, performed on a programmable motorized treadmill, consisted of the different intensities observed during soccer match-play (e.g. walking, jogging, running, sprinting). Muscle strength was assessed before exercise, at half-time and immediately after exercise. A repeated-measures analysis of variance showed significant reductions (P?<0.001) in peak torque for both the quadriceps and hamstrings at all angular velocities (concentric: 1.05, 2.09, 5.23 rad?·?s?1; eccentric: 2.09 rad?·?s?1). The peak torque of the knee extensors (KE) and knee flexors (KF) was greater before exercise [KE: 232±37, 182±34, 129±27, 219±41?N?·?m at 1.05, 2.09 and 5.23 rad?·?s?1 (concentric) and 2.09 rad?·?s?1 (eccentric), respectively; KF: 126±20, 112±19, 101±16, 137±23?N?·?m] than at half-time (KE: 209±45, 177±35, 125±36, 214±43?N?·?m; KF: 114±31, 102±20, 92±15, 125±25?N?·?m) and greater at half-time than after exercise (KE: 196±43, 167±35, 118±24, 204±43?N?·?m; KF: 104±25, 95±21, 87±13, 114±27?N?·?m). For the hamstrings?:?quadriceps ratio, significant changes were found (P?<0.05) for both legs, the ratio being greater before than after exercise. For fast?:?slow speed and left?:?right ratios, no significant changes were found. We conclude that there is a progressive reduction in muscle strength that applies across a range of functional characteristics during exercise that mimics the work rate in soccer.  相似文献   

14.
Altogether, 100 uninjured professional rugby league players were evaluated over a 2-year period. Their height, body mass, sum of skinfolds, girths and bone diameters were recorded. A Cybex 340 isokinetic dynamometer was used to determine peak torque, work, power, endurance ratios and peak torque ratios of the hip abductors and adductors (5 repetitions at 0.52 and 2.08 rad?·?s??1; 20 repetitions at 3.66 rad?·?s??1) and knee flexors and extensors (4 repetitions at 1.04 and 3.14 rad?·?s??1; 30 repetitions at 5.22 rad?·?s??1). Hip abduction and adduction were also assessed with the hip in external rotation. Discriminant function analysis was conducted on all predictor variables to develop a multivariate predictive model capable of classifying players with a high degree of accuracy into groups with and without a groin injury. The model consisted of eight variables and correctly classified 91.7% of the non-injured players and 90.5% of the injured players. The correct classification for the model as a whole was 91.4%. The aetiological factors identified as being related to injury of the groin musculotendinous unit included abduction and adduction-with-rotation peak torque, angle of adduction and abduction-with-rotation peak torque, strength ratio of hip muscle groups, bilateral difference in extension peak torque, femur diameter and body mass.  相似文献   

15.
Abstract

In this study, we wished to determine whether the observed reduction in quadriceps muscle oxygen availability, reported during repetitive bouts of isometric exercise in simulated sailing efforts (i.e. hiking), is because of restricted muscle blood flow. Six national-squad Laser sailors initially performed three successive 3-min hiking bouts followed by three successive 3-min cycling tests sustained at constant intensities reproducing the cardiac output recorded during each of the three hiking bouts. The blood flow index (BFI) was determined from assessment of the vastus lateralis using near-infrared spectroscopy in association with the light-absorbing tracer indocyanine green dye, while cardiac output was determined from impedance cardiography. At equivalent cardiac outputs (ranging from 10.3±0.5 to 14.8±0.86 L · min?1), the increase from baseline in vastus lateralis BFI across the three hiking bouts (from 1.1±0.2 to 3.1±0.6 nM · s?1) was lower (P = 0.036) than that seen during the three cycling bouts (from 1.1±0.2 to 7.2±1.4 nM · s?1) (Cohen's d: 3.80 nM · s?1), whereas the increase from baseline in deoxygenated haemoglobin (by ～17.0±2.9 μM) (an index of tissue oxygen extraction) was greater (P = 0.006) during hiking than cycling (by ～5.3±2.7 μM) (Cohen's d: 4.17 μM). The results suggest that reduced vastus lateralis muscle oxygen availability during hiking arises from restricted muscle blood flow in the isometrically acting quadriceps muscles.  相似文献   

16.
Two experiments (n = 10) were conducted to determine the effects of roller massager (RM) on ankle plantar flexor muscle recovery after exercise-induced muscle damage (EIMD). Experiment 1 examined both functional [i.e., ankle plantar flexion maximal isometric contraction and submaximal (30%) sustained force; ankle dorsiflexion maximal range of motion and resistance to stretch; and medial gastrocnemius pain pressure threshold] and morphological [cross-sectional area, thickness, fascicle length, and fascicle angle] variables, before and immediately, 1, 24, 48, and 72 h after an EIMD stimulus. Experiment 2 examined medial gastrocnemius deoxyhaemoglobin concentration kinetics before and 48 h after EIMD. Participants performed both experiments twice: with (RM) and without (no-roller massager; NRM) the application of a RM (6 × 45 s; 20-s rest between sets). RM intervention did not alter the functional impairment after EIMD, as well as the medial gastrocnemius morphology and oxygenation kinetics (P > 0.05). Although, an acute increase of ipsilateral (RM = + 19%, NRM = ?5%, P = 0.032) and a strong tendency for contralateral (P = 0.095) medial gastrocnemius pain pressure threshold were observed. The present results suggest that a RM has no effect on plantar flexors performance, morphology, and oxygenation recovery after EIMD, except for muscle pain pressure threshold (i.e., a soreness).  相似文献   

17.
Strenuous physical exercise of the limb muscles commonly results in damage, especially when that exercise is intense, prolonged and includes eccentric contractions. Many factors contribute to exercise-induced muscle injury and the mechanism is likely to differ with the type of exercise. Competitive sports players are highly susceptible to this type of injury. AM3 is an orally administered immunomodulator that reduces the synthesis of proinflammatory cytokines and normalizes defective cellular immune fractions. The ability of AM3 to prevent chronic muscle injury following strenuous exercise characterized by eccentric muscle contraction was evaluated in a double-blind and randomized pilot study. Fourteen professional male volleyball players from the First Division of the Spanish Volleyball League volunteered to take part. The participants were randomized to receive either placebo (n?=?7) or AM3 (n?=?7). The physical characteristics (mean±s) of the placebo group were as follows: age 25.7±2.1 years, body mass 87.2±4.1?kg, height 1.89±0.07?m, maximal oxygen uptake 65.3±4.2?ml?·?kg?1?·?min?1. Those of the AM3 group were as follows: age 26.1±1.9 years, body mass 85.8±6.1?kg, height 1.91±0.07?m, maximal oxygen uptake 64.6±4.5?ml?·?kg?1?·?min?1. All participants were evaluated for biochemical indices of muscle damage, including concentrations of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatine kinase (CK) and its MB fraction (CK-MB), myoglobin, lactate dehydrogenase, urea, creatinine and γ-glutamyltranspeptidase, both before and 30 days after treatment (over the peak of the competitive season). In the placebo group, competitive exercise (i.e. volleyball) was accompanied by significant increases in creatine kinase (494±51 to 560±53?IU?·?l?1, P?<?0.05) and myoglobin (76.8±2.9 to 83.9±3.1?μg?·?l?1, P?<?0.05); aspartate aminotransferase (30.8±3.0 to 31.1±2.9?IU?·?l?1) and lactate dehydrogenase (380±31 to 376±29?IU?·?l?1) were relatively unchanged after the 30 days maximum effort. AM3 not only inhibited these changes, it led to a decrease from baseline serum concentrations of creatine kinase (503±49 to 316±37?IU?·?l?1, P?<?0.05) and myoglobin (80.1±3.2 to 44.1±2.6?IU?·?l?1, P?<?0.05), as well as aspartate aminotransferase (31.1±3.3 to 26.1±2.7?IU?·?l?1, P?<?0.05) and lactate dehydrogenase (368±34 to 310±3?IU?·?l?1, P?<?0.05). The concentration of CK-MB was also significantly decreased from baseline with AM3 treatment (11.6±1.2 to 5.0±0.7?IU?·?l?1, P?<?0.05), but not with placebo (11.4±1.1 to 10.8±1.4?IU?·?l?1). In conclusion, the use of immunomodulators, such as AM3, by elite sportspersons during competition significantly reduces serum concentrations of proteins associated with muscle damage.  相似文献   

18.
Abstract

The aim of this study was to determine if inducing metabolic alkalosis would alter neuromuscular control after 50 min of standardized submaximal cycling. Eight trained male cyclists (mean age 32 years, s = 7; [Vdot]O2max 62 ml · kg?1 · min?1, s = 8) ingested capsules containing either CaCO3 (placebo) or NaHCO3 (0.3 g · kg?1 body mass) in eight doses over 2 h on two separate occasions, commencing 3 h before exercise. Participants performed three maximal isometric voluntary contractions (MVC) of the knee extensors while determining the central activation ratio by superimposing electrical stimulation both pre-ingestion and post-exercise, followed by a 50-s sustained maximal contraction in which force, EMG amplitude, and muscle fibre conduction velocity were assessed. Plasma pH, blood base excess, and plasma HCO3 were higher (P < 0.01) during the NaHCO3 trial. After cycling, muscle fibre conduction velocity was higher (P < 0.05) during the 50-s sustained maximal contraction with NaHCO3 than with placebo (5.1 m · s?1, s = 0.4 vs. 4.2 m · s?1, s = 0.4) while the EMG amplitude remained the same. Force decline rate was less (P < 0.05) during alkalosis-sustained maximal contraction and no differences were shown in central activation ratio. These data indicate that induced metabolic alkalosis can increase muscle fibre conduction velocity following prolonged submaximal cycling.  相似文献   

19.
Downhill backwards walking causes repeated, cyclical loading of the muscle–tendon unit. The effect this type of repeated loading has on the mechanical behaviour of the Achilles tendon is presently unknown. This study aimed to investigate the biomechanical response of the Achilles tendon aponeurosis complex following a downhill backwards walking protocol. Twenty active males (age: 22.3 ± 3.0 years; mass: 74.7 ± 5.6 kg; height: 1.8 ± 0.7 m) performed 60 min of downhill (8.5°), backwards walking on a treadmill at ?0.67 m · s?1. Data were collected before, immediately post, and 24-, 48- and 168-h post-downhill backwards walking. Achilles tendon aponeurosis elongation, strain and stiffness were measured using ultrasonography. Muscle force decreased immediately post-downhill backward walking (P = 0.019). There were increases in Achilles tendon aponeurosis stiffness at 24-h post-downhill backward walking (307 ± 179.6 N · mm?1, P = 0.004), and decreases in Achilles tendon aponeurosis strain during maximum voluntary contraction at 24 (3.8 ± 1.7%, P = 0.008) and 48 h (3.9 ± 1.8%, P = 0.002) post. Repeated cyclical loading of downhill backwards walking affects the behaviour of the muscle–tendon unit, most likely by altering muscle compliance, and these changes result in tendon stiffness increases.  相似文献   

20.
Abstract

Tart Montmorency cherry concentrate (MC) has been reported to attenuate the symptoms of exercise-induced muscle damage (EIMD) and to accelerate exercise recovery, which has been attributed to its high anti-inflammatory and antioxidant properties. Although these data are promising, there are no data regarding exclusively female populations. Therefore, the aim of this investigation was to examine the efficacy of MC on recovery following EIMD in females. In a randomised, double-blind, placebo-controlled study, twenty physically active females (mean?±?SD age 19?±?1?y; stature 167?±?6?cm; body mass 61.4?±?5.7?kg) consumed MC or a placebo (PL) for eight days (30?mL twice per day). Following four days of supplementation, participants completed a repeated-sprint protocol and measures of muscle soreness (DOMS), pain pressure threshold (PPT), limb girth, flexibility, muscle function, and systemic indices of muscle damage and inflammation were collected pre, immediately post (0?h) and 24, 48 and 72?h post-exercise. Time effects were observed for all dependent variables (p?<?0.05) except limb girth and high sensitivity C-reactive protein. Recovery of countermovement jump height was improved in the MC group compared to PL (p?=?0.016). There was also a trend for lower DOMS (p?=?0.070) and for higher PPT at the rectus femoris (p?=?0.071) in the MC group. The data demonstrate that MC supplementation may be a practical nutritional intervention to help attenuate the symptoms of muscle damage and improve recovery on subsequent days in females.  相似文献   

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