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1.
Valerie Yule 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1996,42(1-3):187-203
In the past, it has not been possible to teach oneself to read at home, because learners could not read the books to teach them. Videos and interactive compact discs have changed that situation and challenge current assumptions of the pedagogy of literacy. This article describes an experimental adult literacy project using video technology. The language used is English, but the basic concepts apply to any alphabetic or syllabic writing system. A half-hour cartoon video can help adults and adolescents with learning difficulties. Computer-animated cartoon graphics are attractive to look at, and simplify complex material in a clear, lively way. This video technique is also proving useful for distance learners, children, and learners of English as a second language. Methods and principles are to be extended using interactive compact discs.
Zusammenfassung In der Vergangenheit war es nicht möglich, sich selbst in Heimarbeit lesen beizubringen, da die Lernenden die Lehrbücher nicht lesen konnten. Videos und interaktive Compact discs haben diese Situation geändert und gegenwärtige Meinungen zur Pädagogik der Alphabetisierung herausgefordert. Dieser Artikel beschreibt ein experimentelles Erwachsenenalphabetisierungsprogramm, das Videotechnologie anwendet. Arbeitssprache ist Englisch, aber das Grundkonzept gilt für jedes alphabetische oder syllabische Schreibsystem. Ein halbstündiges Zeichentrickvideo soll Erwachsenen und Jugendlichen mit Lernschwierigkeiten helfen. Computeranimierte Zeichentrickgraphiken sind attraktive Lernmittel, die komplexes Material klar und lebendig vereinfachen. Diese Videotechnik dient auch Fernlerndenden, Kindern und Lernenden mit Englisch als Zweitsprache. Methoden und Prinzipien müssen durch den Gebrauch von interaktiven Compakt Discs erweitert werden.
Resumen Durante el pasado, no ha sido posible el autoaprendizaje de la lectura en el hogar, ya que los lectores no estaban en condiciones de leer los libros de enseñanza. Ahora, los videos y los discos compactos interactivos cambiaron esta situación, creando un desafío para los conceptos corrientes de la pedagogía de alfabetización. Este artículo describe un proyecto experimental de alfabetización de adultos mediante el uso de tecnología de video. El lenguaje utilizado es el inglés, pero los conceptos básicos son aplicables para cualquier sistema de escritura alfabética o silábica. Un video de dibujos animados de media hora de duración puede ayudar a los adultos y adolescentes con dificultades de aprendizaje. Las gráficas animadas por computadora son atractivas para el espectador y simplifican materias complejas de un modo claro y ameno. Esta técnica de video también está mostrando su utilidad para el estudio a distancia, para la instrucción de niños y para el aprendizaje del inglés como segunda lengua. Los métodos y los principios también se pueden ampliar mediante la utilización de discos compactos interactivos.
Résumé Jusqu'à présent, il n'était pas possible d'apprendre à lire seul chez soi, puisque les apprenants ne pouvaient pas lire les manuels d'enseignement. La vidéographie et le disque compact interactif ont modifié cette situation et remettent en cause les principes courants de la pédagogie de l'alphabétisation. L'article décrit un projet expérimental d'alphabétisation des adultes qui exploite la technologie vidéo. La langue utilisée est l'anglais, mais les concepts de base peuvent être appliqués à tout système d'écriture alphabétique ou syllabique. Un dessin animé sur vidéo d'une demi-heure se propose d'aider les adultes et adolescents éprouvant des difficultés. Les graphiques animés par électronique sont agréables à regarder et illustrent de façon claire et vivante les matières complexes. Cette technique vidéo se révèle également utile pour les apprenants à distance, les enfants et pour l'enseignement de l'anglais en seconde langue. Les méthodes et principes d'utilisation de disques compact interactifs restent à développer.
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2.
Wojciech Szczęsny Magdalena Kuligowska-Prusińska Stanisław Dąbrowiecki Jakub Szmytkowski Adrian Reśliński Maciej Słupski 《Journal of Zhejiang University. Science. B》2018,19(1):65-70
Purpose
Metalloproteinases are a key component of the pathogenesis of abdominal hernias. Obesity is considered a risk factor in herniogenesis and hernia recurrence. The aim of this study was to evaluate the serum concentrations of metalloproteinase-2 (MMP-2), MMP-9, MMP-13, and adiponectin in morbidly obese and nonoverweight controls.Materials and methods
The participants were recruited from among patients undergoing bariatric and non-bariatric surgery and divided into two groups: I (body mass index (BMI)≥35 kg/m2, n=40) and II (BMI<25 kg/m2, n=30). Serum concentrations of MMP-2, MMP-9, MMP-13, and adiponectin were measured using enzyme-linked immunosorbent assay (ELISA).Results
A statistically significant difference between groups was observed for MMP-2 concentration. The median MMP-9 concentration was higher in the obese group, but the difference was not statistically significant. Median MMP-13 concentrations did not differ between groups. Serum adiponectin concentration was insignificantly higher in the non-obese group.Conclusions
The elevated serum MMP-2 and MMP-9 concentrations in obese individuals may be related to the higher incidence of incisional hernias in this population.3.
Guang-yong Ye Ke-yi Wang Qiao-di Gui Min Wang 《Journal of Zhejiang University. Science. B》2018,19(8):654-661
Objective
The purpose of this study was to determine the role of Ureaplasma urealyticum-derived lipidassociated membrane proteins (LAMPs) in the host innate immune system, specifically their effect on Toll-like receptors (TLRs).Methods
LAMPs were derived from U. urealyticum strains, and human amniotic epithelial cells (HAECs) were isolated from healthy full-term placentas. Cytokine concentrations were determined by enzyme-linked immunosorbent assay (ELISA) and TLR2 mRNA by real-time PCR. Expression of TLR2 was confirmed by Western blotting and immunohistochemistry.Results
LAMPs induced HAECs to produce inflammatory cytokines interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α. Cytokine production was reduced after blocking TLR2 using TLR2 inhibitor (anti-hTLR2-IgA).Conclusions
LAMPs isolated from U. urealyticum induced TLR2-dependent up-regulation of inflammatory genes and cytokines in HAECs.4.
Chao LI Da-ren LIU Long-yun YE Ling-na HUANG Sanjay JAISWAL Xiao-wen LI Hou-hong WANG Li CHEN 《Journal of Zhejiang University. Science. B》2014,15(6):582-589
Objective
Numerous studies examining the relationship between human epidermal growth factor receptor 2 (HER-2) overexpression and survival in patients with colorectal cancer (CRC) have yielded controversial results. We therefore performed a meta-analysis more precisely to estimate its prognostic value.Methods
Published studies investigating the effect of HER-2 overexpression on CRC survival were identified; the hazard ratios (HRs) and their corresponding 95% confidence intervals (95% CIs) were pooled in terms of disease-specific or overall survival.Results
Eleven studies were included in the meta-analysis. The pooled data showed that HER-2 overexpression was negatively related to CRC survival (HR=1.10, 95% CI: 0.77–1.44). Subgroup analyses regarding test method and study quality also demonstrated little association between HER-2 overexpression and CRC survival (HR=0.89, 95% CI: 0.50–1.29; HR=0.90, 95% CI: 0.43–1.37, respectively).Conclusions
Regardless of several limitations, our study suggested that HER-2 overexpression probably had little impact on CRC survival. 相似文献5.
Objective
To investigate the protective effects of parecoxib from oxidative stress induced by hydrogen peroxide (H2O2) in rat astrocytes in vitro.Methods
All experiments included 4 groups: (1) negative control (NC) group, without any treatment; (2) H2O2 treatment group, 100 µmol/L H2O2 treatment for 24 h; (3) and (4) parecoxib pretreatment groups, 80 and 160 µmol/L parecoxib treatment for 24 h, respectively, and then treated with 100 µmol/L H2O2. Several indices were investigated, and the expressions of Bax, Bcl-2, and brain-derived neurotrophic factor (BDNF) were quantified.Results
Compared to the NC group, exposure to H2O2 resulted in significant morphological changes, which could be reversed by pretreatment of parecoxib. In addition, H2O2 treatment led to loss of viability (P=0.026) and increased intracellular reactive oxygen species (ROS) levels (P<0.001), and induced apoptosis (P<0.01) in the primary astrocytes relative to the NC group. However, in the parecoxib pretreatment groups, all the above changes reversed significantly (P<0.05) as compared to the H2O2 treatment group, and were nearly unchanged when compared to the NC group. Mechanical investigation showed that dysregulated Bax, Bcl-2, and BDNF could be implicated in these changes.Conclusions
Our results indicated that parecoxib provided a protective effect from oxidative stress induced by exposure to H2O2.6.
7.
Face to Face
Going solo: Adventures in organic synthesis 相似文献8.
Chan KL 《Child abuse & neglect》2011,35(7):532-542
Objective
This study assessed the co-occurrence of child maltreatment and intimate partner violence (IPV) and examined the association between them.Method
The cross-sectional study recruited a population-based sample of 1,094 children aged 12-17 years in Hong Kong. Structured questionnaires were used to collect data from the children. The prevalence of occurrence of child abuse and neglect by parents and exposure to IPV in both the past year and lifetime was examined, and their correlates were assessed using univariate and multivariate logistic regression.Results
The results show that 26% and 14.6% of child participants had been exposed to IPV physical assault, and 44.4% and 22.6% had been subjected to a parent's corporal punishment or to physical maltreatment from a parent in their lifetime and the year preceding the study, respectively. Among those families characterized by IPV, 54.4% and 46.5% were involved in child physical maltreatment over the child's lifetime and in the preceding year, respectively.Conclusions
Multivariate logistic regression analyses revealed that children exposed to IPV were at higher risk of being victims of neglect, corporal punishment, and physical maltreatment or severe physical maltreatment by their parents than children who were not exposed to IPV, even when child and parent demographic factors were controlled for.Practical implications
The higher risk of child physical maltreatment associated with IPV highlights the need for an integrated assessment to screen for the presence of multiple forms of family violence within the family, and for intervention to assess effective responses to both IPV and child maltreatment by child protective service workers and domestic violence agencies. 相似文献9.
《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》2003,166(2):403-406
Instructions for Authors
Instructions to Authors and Guest Editors 相似文献10.
Milton W. Petruk 《Children‘s Literature in Education》2006,37(4):355-357
Acknowledgments
Acknowledgments to Reviewers 相似文献11.
Volume Contents
Contents Vol. 2 相似文献12.
Sara Lippincott 《Resonance》2011,16(9):881-885
Face to Face
Excerpt of the interview with Mathew Sands Mathew Sands talks to Finn Aaserud 相似文献13.
14.
《International Journal for Educational and Vocational Guidance》2009,9(3):221-225
Announcements
Announcements 相似文献15.
16.
《International Journal for Educational and Vocational Guidance》2010,10(3):207-210
ANNOUNCEMENTS
Announcements 相似文献17.
《Resonance》2012,17(1):101-101
Information and Announcements
Science Academies Refresher Course in Statistical Physics 29 April to 12 May 2012 相似文献18.
A preliminary evaluation of VEGF-A,VEGFR1 and VEGFR2 in patients with well-controlled type 2 diabetes mellitus 总被引：4，自引：0，他引：4
Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Maciej W. SOCHA Zofia RUPRECHT Lidia HA?AS Barbara GóRALCZYK Krzysztof GóRALCZYK Gra?yna GADOMSKA Danuta RO?? 《Journal of Zhejiang University. Science. B》2014,15(6):575-581
Objective
Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the concentration of vascular endothelial growth factor A (VEGF-A) and its receptors in patients with well-controlled diabetes.Methods
The study was conducted on 31 patients with well-controlled type 2 diabetes without micro-or macroangiopathy. Thirty healthy volunteers were enrolled in a control group. Serum concentrations of VEGF-A, VEGF receptors 1 and 2 (VEGFR1 and VEGFR2), fasting glucose, and lipid profiles were measured, and the plasma concentration of glycated hemoglobin (HbA1c) was determined.Results
No significant differences were observed between the concentration of VEGF-A, VEGFR1 or VEGFR2 in the subject group and that in the control group. Positive correlations were noted between the levels of VEGF-A, VEGFR2, and triglyceride, and there was a negative correlation between the levels of VEGFR2 and high-density lipoprotein (HDL)-cholesterol in the study group.Conclusions
The concentrations of VEGF-A and its receptors 1 and 2 in patients with well-controlled diabetes are comparable to those of healthy individuals, which may indicate that appropriate control of glucose levels delays the occurrence of vascular complications. A negative correlation between VEGFR2 and HDL-cholesterol levels, and positive correlations between VEGF-A, VEGFR2, and triglyceride levels, suggest that lipid abnormalities occurring in diabetes may be involved in the modulation of angiogenesis. 相似文献19.
20.
Naama Sabar 《Educational technology research and development : ETR & D》2000,48(4):100-102