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1.
Goverdhan Lal S. P. S. Yadav S. K. Aggarwal Sadhna Bansal Kiran Chugh Harbans Lal 《Indian journal of clinical biochemistry : IJCB》1996,11(1):46-48
Plasma vitamin E and malondialdehyde (MDA) concentrations were estimated in a group of 25 patients (17 males and 8 females) with head and neck cancer and the results were compared with a group of normal healthy controls. Plasma vitamin E levels were found to be significantly reduced while MDA levels were increased in patients than the controls. The fall in vitamin E was nearly same in all the patients studied irrespective of the site, TNM stage, histopathology and character of lesion. The levels did not vary immediately after radiotherapy but were significantly increased 3 months after the radiotherapy. These preliminary data suggest that the cancer patients have suboptimal vitamin E status which may be a contributory factor for increased lipid peroxidation in such cases. 相似文献
2.
Soma Gupta K. K. Singh V. J. Vyas V. N. Chaturvedi M. V. R. Reddy B. C. Harinath 《Indian journal of clinical biochemistry : IJCB》2000,15(1):52-55
Oxidative stress was studied by estimating plasma levels of malondialdehyde (MDA), beta carotene, vitamin E and erythrocytic
superoxide dismutase(E-SOD) activity in 50 cases of carcinoma of upper digestive tract which included carcinoma of oral cavity,
pharynx and oesophagus. While plasma MDA level was found to be increased (3.5±1.0 nmole/ml), a significant decrease in beta
carotene (81.2±14.5mg%), vitamin E (8.5±1.1 mg/L) level and E-SOD activity (657.0±80.6 U/G Hb) were observed in carcinoma
of upper digestive tract. Patients were treated with radiotherapy which itself was toxic enough and produced its deleterious
effects by generation of reactive oxygen species (ROS). As antioxdiants can detoxify ROS, beneficial effect if any, of antioxidant
administration during radiotherapy was studied in two groups of patients, group A (n=5, supplemented with antioxidants) and
group B (n=5, without antioxidant supplementation). Plasma MDA level was found to be elevated in both the groups but the increase
in group B was significant, compared to pretreatment level. Further, body weight was found to be significantly decreased in
group B patients, which was maintained in group A patients. Moreover, group A patients showed significant elevation in beta
carotene concentration, thus showing beneficial effect of administration of antioxidants during radiotherapy without disturbing
the desirable therapeutic effect of radiotherapy. 相似文献
3.
Kadam DP Suryakar AN Ankush RD Kadam CY Deshpande KH 《Indian journal of clinical biochemistry : IJCB》2010,25(4):388-392
Psoriasis is a chronic inflammatory, proliferative skin disease characterized by pathological skin lesions due to various
exogenous and endogenous factors. It is associated with a number of biochemical and immunological disturbances. Recently,
it has been suggested that increased reactive oxygen species (ROS) production and compromised function of antioxidant system
may be involved in the pathogenesis of this disease. In the present study, 90 psoriasis patients were selected. Disease severity
was assessed by psoriasis area severity index score and grouped as mild, moderate and severe (each group consists of 30 subjects)
and compared with 30 healthy controls. Serum levels of malondialdehyde, nitric oxide end products and the activities of antioxidant
enzymes such as erythrocyte-superoxide dismutase, catalase and total antioxidant status were investigated in these groups/subjects.
As compared to controls, we found severitywise significantly increased serum malondialdehyde, nitric oxide end products with
decrease in erythrocyte-superoxide dismutase activity, catalase activity and total antioxidant status in patients with psoriasis
suggesting worsening of the disease. It seems to be linked with the enhancement of Reactive Oxygen Species production and
decreased antioxidant potential in psoriasis. 相似文献
4.
R. B. Bhogade A. N. Suryakar N. G. Joshi R. Y. Patil 《Indian journal of clinical biochemistry : IJCB》2008,23(3):233-237
Hemodialysis represents a chronic stress status for its recipients. Many hypotheses state that this may be associated with
oxidative stress. Thus, there may be deficiency of antioxidants like erythrocytic superoxide dismutase, catalase, vitamin
E or increased generation of free radicals like superoxide anions. A study was carried out to investigate oxidant and antioxidant
status in chronic renal failure patients undergoing hemodialysis and effect of vitamin E supplementation on these two status.
Blood samples were collected from patients before and after hemodialysis and from controls. The samples were analyzed for
quantitation of MDA as index of lipid peroxide, nitric oxide, vitamin E, vitamin C and enzymatic antioxidants namely erythrocyte
SOD and catalase. As compared to controls, the levels of serum MDA were significantly increased and activities of erythrocyte
SOD and catalase, levels of serum nitric oxide, serum vitamin E and plasma vitamin C were significantly decreased both before
and after hemodialysis. The efficiency of vitamin E therapy in hemodialysis patients was assessed by re-evaluating oxidant
and antioxidant status of same patients after supplementation of vitamin E. Vitamin E supplementation caused decrease in serum
MDA and increase in levels of serum nitric oxide, vitamin E, vitamin C and activities of erythrocytic SOD and catalase. Our
results suggest the presence of oxidative stress and the possible preventive role of vitamin E therapy in hemodialysis patients. 相似文献
5.
Forty cases of head and neck cancer were studied for plasma superoxide dismutase, malondialdehyde and thiol levels and results
were compared with a group of forty normal healthy volunteers. Mean plasma superoxide dismutase activity was not found to
be altered while malondialdehyde concentration was significantly higher when compared with the control group. On the other
hand, mean thiol level was significantly lowered. The data suggests increased level of oxidative stress in patients with head
and neck cancer. 相似文献
6.
Y. P. Singh O. P. Sachdeva S. K. Aggarwal K. Chugh Harbans Lal 《Indian journal of clinical biochemistry : IJCB》2008,23(3):290-292
Blood glutathione was estimated in fifty patients of head and neck cancer in the age group of 18–76 years and the results
were compared with a group of normal healthy controls. Mean blood glutathione level was found to be significantly lowered
in patients than the controls. Irrespective of the site, TNM classification, histopathology, and character of lesion, fall
in blood glutathione was nearly same in all the patients. The mean level was significantly increased after radiotherapy when
compared with the levels before radiotherapy. The decreased levels of GSH in-patients with head and neck cancer, observed
in the present study, may be due to its increased utilization by the cells. The results suggest that patients with head and
neck cancer have increased oxidative stress. 相似文献
7.
M. Cariappa K. Poornima M. Nandini K. Asha H. P. Kedilaya 《Indian journal of clinical biochemistry : IJCB》2005,20(1):103-108
Habitual consumption of moderate amounts of fish is associated with reduced mortality from coronary heart disease. However
the beneficial effects of fish enriched diet seem contradictory, due to the susceptibility of the PUFAs in them to oxidation.
It is also acclaimed that vegetarians in general, have a lower serum total cholesterol and LDL-cholesterol and a better antioxidant
status. This contradiction was the basis for the study, where the validity of the above finding was tested in a general population
consuming a vegetarian or predominantly fish diet as a regular dietary habit. The oxidant status and the lipid profile of
23 vegetarians and 22 fish eaters was studied by estimating the plasma lipid peroxides measured as malondialdehyde (MDA) and
the lipid parameters viz. Total Cholesterol (TC), HDL-Cholesterol (HDL-C) and triglycerides (TG). Statistical analysis was
carried out to compare the MDA values and the lipemic status between the two groups. MDA was also correlated with the various
lipid indices among the study groups. None of the compared and correlated values was statistically significant, although certain
altered trends were seen. From this study, it may be concluded that oxidant status and lipid profile does not vary significantly
in the two groups, suggesting that neither a vegetarian diet nor a fish diet has a definite benefit over the other. 相似文献
8.
K. Kaur G. Bedi M. Kaur Anil Vij Inderpreet Kaur 《Indian journal of clinical biochemistry : IJCB》2008,23(1):33-37
Coronary Artery Disease is the major cause of mortality and morbidity worldwide. Traditional risk factors account for only
half of the morbidity and mortality from coronary artery disease. There is substantial evidence that oxidative stress plays
the major role in the atherosclerotic process. The present study was undertaken to evaluate the level of lipid peroxidation
(by measuring malondialdehyde) and antioxidant enzymes (ceruloplasmin, glutathione, superoxide dismutase) in coronary artery
disease. Serum malondialdehyde levels and serum ceruloplasmin levels were significantly raised in all the subgroups of study
group as compared to control group (p<0.001). Whole blood glutathione levels and hemolysate superoxide dismutase activity
was significantly decreased in all the subgroups of study group as compared to control group (p<0.001). Above results suggests
that the patients of coronary artery disease show increased oxidative stress and decreased levels of antioxidant enzymes.
So it is recommended that the management protocol for coronary artery disease patients should include antioxidant supplementation
along with simultaneous lowering of lipid peroxidation. 相似文献
9.
O. P. Sachdeva Vikas Girdhar S. P. Gulati Harbans Lal 《Indian journal of clinical biochemistry : IJCB》1993,8(1):51-53
Ceruloplasmin levels were estimated in sera of, 40 patients with head and neck cancers. The levels were found to be significantly
higher in patients as compared to the controls. The rise was nearly same in all the patients studied irrespective of the site,
character or histopathology of lesion but was directly proportional to the stage of cancer. A reduction in serum ceruloplasmin
was observed after radiotherapy. 相似文献
10.
Carcinoembryonic antigen (CEA) levels were estimated in sera of 25 patients with head and neck cancer. The levels were found
to be significantly higher in patients as compared to the controls. However, the rise was nearly to the same extent in all
the patients studied, irrespective of the site or character of lesion but was directly proportional to the stage of cancer
and to the presence of lymphnode metastasis. After radiotherapy serum CEA levels were significantly reduced. 相似文献
11.
Vaishali N. Thorat Adinath N. Suryakar Pradeep Naik Bipin M. Tiwale 《Indian journal of clinical biochemistry : IJCB》2009,24(1):102-104
Liver transplantation is an accepted therapy for chronic liver disease patients. These patients generally have low levels
of fat soluble vitamins, which have important antioxidant roles. Therefore, this study was undertaken to investigate whether
such patients had evidence of antioxidant depletion and increased lipid peroxidation before transplant and whether the subsequent
ischemia and reperfusion encountered during liver transplantation have any effect on antioxidant levels and lipid peroxidation.
We assessed plasma total antioxidant capacity and serum lipid peroxide in 12 patients undergoing liver transplantation and
equal numbers of healthy subjects. We found that before reperfusion, antioxidant levels were significantly decreased along
with significantly elevated lipid peroxidation levels as compared with healthy controls (P<0.001). On reperfusion of the liver
graft, further declined values of total antioxidant accompanied with highly elevated lipid peroxidation were seen than those
of pre-reperfusion samples (P<0.001). This data shows that patients undergoing liver transplant have lowered antioxidant defenses
and evidence of free radical damage, which compound the additional insult of reperfusion injury. Therefore antioxidant therapy
in these patients before transplantation may ameliorate the effects of reperfusion. 相似文献
12.
Avneet Kaur Pooja Negi Veena Sarna Rajendra Prasad Bir S. Chavan Anita Malhotra Gurjit Kaur 《Indian journal of clinical biochemistry : IJCB》2017,32(2):179-185
The present study was undertaken to study the impact of surgical menopause on oxidant and antioxidant status in relation to estrogen levels after 3 months of surgery. Total 130 women who had undergone total hysterectomy (TH) with or without bilateral salpingo-oophorectomy (BSO) were included in this study. The oxidant status was assessed by measuring plasma levels of malondialdehyde and antioxidant status was assessed by measuring superoxide dismutase, catalase, glutathione, glutathione peroxidase, estrogen, and Vitamin A, E and C levels. The malondialdehyde level was significantly increased (p < 0.05) in all women who underwent TH with or without BSO. Significant increased levels of superoxide dismutase were observed in women who underwent TH with BSO. The blood glutathione levels were significantly decreased in women after TH only but significantly increased in women who had undergone TH with BSO. The levels of estrogen, vitamin E and vitamin C were significantly decreased in women who underwent TH with BSO. The catalase, GPx and vitamin A did not differ significantly in all groups. The result suggests that surgical menopause is associated with oxidative stress which reiterates the fact that ovaries retain some function even after menopause. 相似文献
13.
Sarita N. Chavan Umesh More Shruti Mulgund Vishal Saxena Alka N. Sontakke 《Indian journal of clinical biochemistry : IJCB》2007,22(2):101-105
Osteoporosis encompasses a wide spectrum of conditions associated with imbalance of osteoclastic and osteoblastic activities.
The increased activity of osteoclasts leads to increased free radical formation and hence lipid peroxidation. Present study
probes into the role of antioxidants as a palliative treatment for osteoporosis. It involved 50 healthy controls and 75 clinically
diagnosed osteoporosis patients. Both the groups underwent baseline assessment of biochemical markers viz. osteoblastic markers:
serum Alkaline phosphatase. Free or ionic calcium and Inorganic phosphorus, osteoclastic markers: serum Tartarate resistant
acid phosphatase and Malondialdehyde and the antioxidant status: serum Superoxide dismutase and Erythrocyte reduced glutathione.
The osteoporotic group was then divided into groups A (Vitamin E-Evinal 400 mg), B (Vitamin C-Celin 500 mg), C (Vitamin E+C-Evinal+Celin)
for antioxidant supplementation for a period of 90 days. The results reveal that there is significant fall in concentration
of serum MDA (p<0.001), TrACP (p<0.01). Improvement in antioxidant status is reflected by significant rise in concentration
of serum SOD (p<0.001) and erythrocyte GSH (p<0.001) after 90 days of antioxidant supplementation in osteoporosis. The findings
indicate that on the whole bone status improved with prolonged antioxidant vitamin supplementation, which can be used as a
palliative treatment for osteoporosis. The efficacy is not affected whether the vitamins are administered singly or conjointly. 相似文献
14.
Fasting blood sample of 50 normal subjects (control) and 100 patients of breast cancer were investigated for serum total cholesterol,
high density lipoprotein cholesterol, low density lipoprotein cholesterol, very low density lipoprotein, high density lipoprotein
cholesterol:low density lipoprotein cholesterol ratio and total cholesterol:high density lipoprotein cholesterol ratio during
breast cancer of women. Five cancer stages, types, age groups, parity and menopausal status were undertaken for the study.
It was observed that there was a significant rise in serum total cholesterol and low density lipoprotein cholesterol whereas
high density lipoprotein cholesterol and very low density lipoprotein cholesterol were not significant. The ratio of high
density lipoprotein cholesterol:low density lipoprotein cholesterol and total cholesterol:high density lipoprotein cholesterol
values increased significantly in breast cancer patients. 相似文献
15.
Rukmini M. S. Benedicta D'Souza Vivian D'Souza 《Indian journal of clinical biochemistry : IJCB》2004,19(2):114-118
Free radical mediated pathological processes may have a role in schizophrenia. Free radicals (oxy radicals, such as superoxide,
hydroxyl ions and nitric oxide) cause cell injury, when they are generated in excess or when the antioxidant defense is impaired.
Both these processes seem to be affected in schizophrenia. In this study we investigated erythrocyte superoxide dismutase
(SOD) and catalase (CAT) activities as antioxidant enzymes, malondialdehyde (MDA) as a sign of lipid peroxidation in schizophrenic
patients. Activities of superoxide dismutase, catalase and malondialdehyde were greater in patients compared with the control
group which may reflect increased oxidative stress in the brain tissue of schizophrenics. In the patient group erythrocyte
SOD and CAT activities were weakly negative correlated with MDA concentration. These data reveal that antioxidant defense
mechanisms might be impaired in schizophrenic patients. These findings also provide a theoretical basis for the development
of novel therapeutic strategies, such as antioxidant supplementation. 相似文献
16.
Serum glycoproteins were evaluated in oral squamous cell carcinoma patients treated with radiotherapy and also the effect
of vitamin E was studied. Cell surface glycoconjugates are important parameters in the detection of malignancy. Thus, the
objective of the present study is to evaluate the efficacy of vitamin E on glycoproteins in oral cavity cancer patients treated
with radiotherapy. The study includes 26 age and sex matched normal healthy individuals and 26 patients with squamous cell
carcinoma of oral cavity. These patients were divided into two groups, one for radiotherapy alone (at a dosage of 6000 cGy
in five fractions per week for a period of six weeks) and the other for radiotherapy plus vitamin E supplementation (at a
dosage of 400 IU / day of vitamin E) for the entire period of radiotherapy. Levels of hexose, hexosamine, fucose and sialic
acid were increased in oral squamous cell carcinoma patients and a significant decrease was observed in radiation treated
patients when compared to control. The levels of glycoconjugates were significantly decreased in radiation treated patients
supplemented with vitamin E. This measurement may be useful in assessing disease progression and identifying patients resistant
to therapy and a possible role of vitamin E on reduction in glycoconjugate levels of radiation treated oral squamous cell
carcinoma patients. 相似文献
17.
Amit Kumar Mani Tiwari Abbas Ali Mahdi Sanjay Mishra 《Indian journal of clinical biochemistry : IJCB》2018,33(1):31-37
Iron deficiency anemia is one of the causes that lead to significant mortality and morbidity among pregnant women and fetus. The present study was undertaken to explore oral iron supplementation can modify the metal contents in pregnant anemic women. Iron and folic acid supplementations was given to 500 anemic women (mild = 200, moderate = 200, and severe = 100) and 100 age matched non-anemic controls daily for 100 days. Blood index values and plasma trace minerals were estimated as per standard protocols. Haemoglobin and ferritin levels were found significantly increased (p < 0.001) in anemic and control subjects after treatment. Moreover, the serum transferring receptor levels and total iron binding capacity were found significantly decreased in all treated groups. Iron (Fe), zinc (Zn) and copper (Cu) levels were found increased (p < 0.01) after oral iron supplementation groups. Moreover, selenium (Se) manganese (Mn) and were found to be decreased in all treated groups. Data provides the conclusion that iron and folic acid supplementation recovered the essential trace minerals, except manganese, which may lead to various complications including peroxidation of vital body molecules resulting in increased risk for pregnant women as well as fetus. 相似文献
18.
Abdul Samad Aziz Madhav Govind Kalekar Adinath Narayan Suryakar Tabita Benjamin Milsee Jaya Prakashan Bijle Mohammed Nadeem Ahmed Mehmood Sayyad 《Indian journal of clinical biochemistry : IJCB》2013,28(4):374-380
The present study aims to assess and compare the biochemical oxidative stress markers in male smokers and non-smokers with chronic periodontitis. One hundred thirty-four male chronic periodontitis patients and 64 apparently healthy male volunteers were recruited for the study. The periodontal status was evaluated by measuring gingival index, plaque index, papillary bleeding index and clinical attachment loss using UNC-15 probe. The biochemical markers estimated were total antioxidant capacity, RBC-superoxide dismutase, glutathione peroxidase, vitamin C, malondialdehyde and C-reactive protein. The obtained results indicate higher oxidative stress in chronic periodontitis. Smokers with chronic periodontitis show significantly higher periodontal clinical parameters and relatively higher systemic oxidative stress. Vitamin C estimation may be an important biochemical parameter in conjunction with clinical parameters for diagnosis of chronic periodontitis in smokers. 相似文献
19.
Sharmila Upadhya Subramanya Upadhya S. Krishna Mohan K. Vanajakshamma Mamatha Kunder Seema Mathias 《Indian journal of clinical biochemistry : IJCB》2004,19(2):80-83
Erythrocyte antioxidant glutathione and malondialdehyde levels in erythrocytes and plasma glutathione S-transferase levels
were estimated in patients with colorectal cancer and compared to controls. Further, the patients underwent four weeks of
radiotherapy with adjuvant chemotherapy. The same parameters were estimated after four weeks of radiotherapy and compared
with pretreatment levels. It was observed that there was a decrease in erythrocyte glutathione and malondialdehyde levels
in patients with colorectal cancer compared to controls, but not in case of GST. However, after chemoradiotherapy, there were
no statistically significant differences in all the parameters studied. 相似文献
20.
Can serum Glutathione-S-transferase levels in carcinoma cervix be a predictor of radiation response?
Krishnananda Prabhu P. Gopalakrishna Bhat D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2005,20(1):95-97
We conducted a pilot study wherein serum Glutathione-S-transferase levels were measured before and after radiotherapy in carcinoma
cervix patients and correlated with response to treatment during a two-year follow-up period. Out of 17 patients who received
radiotherapy, 9 showed a significant decrease (p<0.005) while 8 showed significant increase (p<0.004) in post radiotherapy
glutathione-S-transferase values as compared to pre treatment values respectively. These patients were followed up for two
years and we observed that 71% who had significant increase in post radiotherapy values had relapse of cancer within 2 years
where as 66% of those who had significant decrease in post radiotherapy values had no evidence of relapse. This shows that
alterations in serum Glutathione-S-transferase levels may help us to predict radiation response 相似文献