共查询到20条相似文献，搜索用时 25 毫秒
1.
The super-high strength of single-layer graphene has attracted great interest. In practice, defects resulting from thermodynamics or introduced by fabrication, naturally or artificially, play a pivotal role in the mechanical behaviors of graphene. More importantly, high strength is just one aspect of the magnificent mechanical properties of graphene: its atomic-thin geometry not only leads to ultra-low bending rigidity, but also brings in many other unique properties of graphene in terms of mechanics in contrast to other carbon allotropes, including fullerenes and carbon nanotubes. The out-of-plane deformation is of a ‘soft’ nature, which gives rise to rich morphology and is crucial for morphology control. In this review article, we aim to summarize current theoretical advances in describing the mechanics of defects in graphene and the theory to capture the out-of-plane deformation. The structure–mechanical property relationship in graphene, in terms of its elasticity, strength, bending and wrinkling, with or without the influence of imperfections, is presented. 相似文献
2.
A non-positional (or suspension) cell microarray was developed using shape-coded SU-8 photoresist microboards for potential application in multiplex and high-throughput cell-based assays. A conventional photolithography process on glass slides produced various shapes of SU-8 micropatterns that had a lateral dimension of 200 μm and a thickness of 40 μm. The resultant micropatterns were detached from the slides by sonication and named "microboards" due to the fact that had a much larger lateral dimension than thickness. The surfaces of the SU-8 microboards were modified with collagen to promote cell adhesion, and it was confirmed that collagen-coated SU-8 microboards supported cell adhesion and proliferation. Seeding of cells into poly(ethylene glycol)(PEG) hydrogel-coated well plates containing collagen-modified microboards resulted in selective cell adhesion onto the microboards due to the non-adhesiveness of PEG hydrogel toward cells, thereby creating non-positional arrays of microboards carrying cells. Finally, two different cell types (fibroblasts and HeLa cells) were separately cultured on different shapes of microboards and subsequently mixed together to create a non-positional cell microarray consisting of multiple cell types where each cell could be easily identified by the shape of the microboard to which they had adhered. Because numerous unique shapes of microboards can be fabricated using this method by simply changing the photomask designs, high throughput and multiplex cell-based assays would be easily achieved with this system in the future. 相似文献
3.
In this study, we propose and evaluate a novel low-auto-fluorescence photoresist (SJI photoresist) for bio-application, e.g., in gene analysis and cell assay. The spin-coated SJI photoresist has a wide thickness range of ten to several hundred micrometers, and photoresist microstructures with an aspect ratio of over 7 and micropatterns of less than 2 μm are successfully fabricated. The emission spectrum intensity of the SJI photoresist is found to be over 80% less than that of the widely used SU-8 photoresist. To evaluate the validity of using the proposed photoresist in bio-application for fluorescence observation, we demonstrate a chromosome extension device composed of the SJI photoresist. The normalized contrast ratio of the SJI photoresist exhibits a 50% improvement over that of the SU-8 photoresist; thus, the SJI photoresist is a versatile tool for bio-application. 相似文献
4.
Polymer-based microneedles have drawn much attention in the transdermal drug delivery resulting from their flexibility and biocompatibility. Traditional fabrication approach deploys various kinds of molds to create sharp tips at the end of needles for the penetration purpose. This approach is usually time-consuming and expensive. In this study, we developed an innovative fabrication process to make biocompatible SU-8 microtubes integrated with biodissolvable maltose tips as novel microneedles for the transdermal drug delivery applications. These microneedles can easily penetrate the skin''s outer barrier represented by the stratum corneum (SC) layer. The drug delivery device of mironeedles array with 1000 μm spacing between adjacent microneedles is proven to be able to penetrate porcine cadaver skins successfully. The maximum loading force on the individual microneedle can be as large as 7.36 ± 0.48N. After 9 min of the penetration, all the maltose tips are dissolved in the tissue. Drugs can be further delivered via these open biocompatible SU-8 microtubes in a continuous flow manner. The permeation patterns caused by the solution containing Rhodamine 110 at different depths from skin surface were characterized via a confocal microscope. It shows successful implementation of the microneedle function for fabricated devices. 相似文献
5.
Kai Luo Zhi-Hong Guan Chang-Xin Cai Ding-Xue Zhang Qiang Lai Jiang-Wen Xiao 《Journal of The Franklin Institute》2019,356(8):4690-4715
This paper studies coordination of a team of nonholonomic mobile robots with smart actuators for defending against invasive threat to a planar convex area. The threat refers to a kind of harmful substance such as chemical pollutant appearing outside and moving towards the area. The invasion of threat can be modeled by a 2D unsteady reaction-diffusion process. To reflect the adverse effect of threat on the area, a so-called risk intensity field is introduced. The value of risk intensity is equal to the concentration of threat measured by a static mesh sensor network. Based on this risk intensity field, a coordination control scenario using Voronoi tessellation is formulated. In order to minimize the actuator performance loss and reduce the total average risk intensity simultaneously, a generalized centroidal Voronoi tessellation (CVT) algorithm including optimal motion control and risk mitigation control is designed. The proposed algorithm is gradient-based and guides mobile robots to track their optimal trajectories asymptotically. Meanwhile, two conditions of choosing control gains are derived to keep the total average risk intensity below a safety level. Several simulation examples with different cases of threat invasion are provided and the advantage of proposed algorithm over traditional control method is presented. 相似文献
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In this paper we present a new fabrication method that combines for the first time popular SU-8 technology and PerMX dry-photoresist lamination for the manufacturing of high aspect ratio three-dimensional multi-level microfluidic networks. The potential of this approach, which further benefits from wafer-level manufacturing and accurate alignment of fluidic levels, is demonstrated by a highly integrated three-level microfluidic chip. The hereby achieved network complexity, including 24 fluidic vias and 16 crossing points of three individual microchannels on less than 13 mm(2) chip area, is unique for SU-8 based fluidic networks. We further report on excellent process compatibility between SU-8 and PerMX dry-photoresist which results in high interlayer adhesion strength. The tight pressure sealing of a fluidic channel (0.5 MPa for 1 h) is demonstrated for 150 μm narrow SU-8/PerMX bonding interfaces. 相似文献
8.
提出了一种利用同步双端口存储器IP和标准单元来实现嵌入式可编程存储器中的字宽配置的方案以降低设计的复杂性,提高设计效率. 通过寄存输出控制信号来优化嵌入式可编程存储器混合宽度配置的实现结构以增强读出数据的稳定性. 对比试验表明,优化后的结构还有利于提高复杂实现电路的性能. 该优化结构的嵌入式可编程存储器已在SMIC 0.18μm 1P6M CMOS工艺线上流片. 测试结果表明,其读出数据具有良好的稳定性,在读出时间方面与相近工艺、相同存储容量的采用全定制方法设计的商用嵌入式可编程存储器相当. 相似文献
9.
Salman Ijaz Lin Yan Mirza Tariq Hamayun Cun Shi 《Journal of The Franklin Institute》2019,356(3):1302-1332
In this paper, an active fault tolerant control (AFTC) scheme is proposed for more electric aircraft (MEA) equipped with dissimilar redundant actuation system (DRAS). The effect of various fault/failure of hydraulic actuator (HA) on the system performance is analyzed in this work. In nominal condition, the state feedback control law is designed for primary control surfaces. In the presence of fault/failure of certain HA, control allocation (CA) scheme together with integral sliding mode controller (ISMC) is retrofitted with existing control law and engaged the secondary (redundant) actuators into the loop. A modified recursive least square (RLS) algorithm is proposed to identify the parametric faults in HA and to measure the effectiveness level of the actuator. In an event of failure of all HA’s in the system, electro hydraulic actuators (EHA) are taken in loop to bring the system back to its nominal operation. In order to stabilize the closed-loop dynamics of HA and EHA, fractional order controllers are designed separately for each actuator. Simulations on the lateral directional model of aircraft demonstrated the effectiveness of the proposed scheme as compared to the existing methods in the literature. 相似文献
10.
A simple method of irreversibly sealing SU-8 microfluidic channels using PDMS is reported in this paper. The method is based on inducing a chemical reaction between PDMS and SU-8 by first generating amino groups on PDMS surface using N2 plasma treatment, then allowing the amino groups to react with the residual epoxy groups on SU-8 surface at an elevated temperature. The N2 plasma treatment of PDMS can be conducted using an ordinary plasma chamber and high purity N2, while the residual epoxy groups on SU-8 surface can be preserved by post-exposure baking SU-8 at a temperature no higher than 95 °C. The resultant chemical bonding between PDMS and SU-8 using the method create an interface that can withstand a stress that is greater than the bulk strength of PDMS. The bond is permanent and is long-term resistant to water. The method was applied in fabricating SU-8 microfluidi-photonic integrated devices, and the obtained devices were tested to show desirable performance. 相似文献
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In this paper, an adaptive output feedback fault tolerant control (FTC) based on actuator switching is proposed for a class of single-input single-output (SISO) nonlinear systems with uncertain parameters and possible actuator failures, for which a set of healthy actuators are available as backups. While high-gain K-filters are utilized to estimate the unmeasured states, an adaptive control law is designed to compensate for the parameter uncertainties and certain actuator failures, an actuator switching strategy based on a set of appropriately designed monitoring functions (MFs) is proposed to tackle those serious actuator failures, make tracking error satisfy prescribed transient and steady-state performance and guarantee closed-loop signal boundedness. 相似文献
12.
《Journal of The Franklin Institute》2022,359(9):4260-4287
In this paper, we formulate and study a reliability-performance balancing problem (RPBP) for long-term operational and unattended control systems with degrading actuators. It preliminarily explores a new type of autonomous maintenance method to extend the useful lifetime of the control system. The actuator, as the crucial component of a control system, executes calculated control actions and thereby is often exposed to the high-load working environment. As the actuator degrades, the control action will gradually alter with increasing magnitude to maintain the desired control performance, but this will accelerate the actuator degradation and thus reduce the useful lifetime (use reliability) of the control system. Therefore, conditionally balancing the control performance and use reliability is meaningful, for which a novel dynamic regulation strategy under the model predictive control (MPC) framework is proposed. Specifically, we model the actuator degradation using a diffusion Wiener process coupled with the control action or system state, and the corresponding actuator reliability is derived. By fusing the degradation model and system dynamics, a degradation-incorporated state space (DISS) model is formulated, in which the basic idea is to consider the actuator degradation as an extended state variable and to control it accordingly. Based on the DISS model, a mixed-index nonlinear MPC integrated with a weight tuning strategy is proposed to achieve a satisfactory balance between control performance and use reliability in the presence of actuator degradation. Further, the reference curve and the upper bound of actuator degradation are given for constructing the objective function and the constraint in the MPC optimization problem. An illustrative example is presented to demonstrate the availability of the proposed method. 相似文献
13.
文章构建了我国生态—经济—科技系统耦合协调发展评价指标体系,采用熵值法进行客观赋权,然后引入耦合协调发展的函数模型,测算了2014年我国省域生态—经济—科技系统的耦合度和协调度,最后借助空间计量模型对耦合协调度的影响因素进行回归分析。研究结果表明：(1)我国省域生态—经济—科技系统耦合度多处在拮抗时期,发展特点表现为生态环境逐渐被破坏,承载力变小;(2)我国省域生态—经济—科技系统耦合协调度基础处于勉强协调状态;(3)经济结构、经济效益以及科技成果转化水平是影响耦合协调度的突出因素。 相似文献
14.
This paper is concerned with the exponential stabilization problem for a class of diffusion processes described by a linear parabolic partial differential equation (PDE) using mobile collocated actuators and sensors. Each collocated actuator/sensor pair is capable of moving within the respective spatial domain divided in advance and a mode indicator function is employed to indicate the different modes for all actuator/sensor pairs according to whether each actuator/sensor pair is static or mobile. By utilizing Lyapunov direct method, an integrated design of switching controllers and mobile actuator/sensor guidance laws for the diffusion process is developed such that the resulting closed-loop system is exponentially stable. Finally, numerical simulations are presented to illustrate the effectiveness of the proposed design method. 相似文献
15.
Kevin Luongo Angela Holton Ajeet Kaushik Paige Spence Beng Ng Robert Deschenes Shankar Sundaram Shekhar Bhansali 《Biomicrofluidics》2013,7(3)
In this paper, we report the design, fabrication, and testing of a lab-on-a-chip based microfluidic device for application of trapping and measuring the dielectric properties of microtumors over time using electrical impedance spectroscopy (EIS). Microelectromechanical system (MEMS) techniques were used to embed opposing electrodes onto the top and bottom surfaces of a microfluidic channel fabricated using Pyrex substrate, chrome gold, SU-8, and polydimethylsiloxane. Differing concentrations of cell culture medium, differing sized polystyrene beads, and MCF-7 microtumor spheroids were used to validate the designs ability to detect background conductivity changes and dielectric particle diameter changes between electrodes. The observed changes in cell medium concentrations demonstrated a linear relation to extracted solution resistance (Rs), while polystyrene beads and multicell spheroids induced changes in magnitude consistent with diameter increase. This design permits optical correlation between electrical measurements and EIS spectra. 相似文献
16.
Chi Zhang Junyang Tan Yikun Pan Xingke Cai Xiaolong Zou Hui-Ming Cheng Bilu Liu 《国家科学评论(英文版)》2020,7(2):324
The scalable and high-efficiency production of 2D materials is a prerequisite to their commercial use. Currently, only graphene and graphene oxide can be produced on a ton scale, and the inability to produce other 2D materials on such a large scale hinders their technological applications. Here we report a grinding exfoliation method that uses micro-particles as force intermediates to resolve applied compressive forces into a multitude of small shear forces, inducing the highly efficient exfoliation of layer materials. The method, referred to as intermediate-assisted grinding exfoliation (iMAGE), can be used for the large-scale production of many 2D materials. As an example, we have exfoliated bulk h-BN into 2D h-BN with large flake sizes, high quality and structural integrity, with a high exfoliation yield of 67%, a high production rate of 0.3 g h−1 and a low energy consumption of 3.01 × 106 J g−1. The production rate and energy consumption are one to two orders of magnitude better than previous results. Besides h-BN, this iMAGE technology has been used to exfoliate various layer materials such as graphite, black phosphorus, transition metal dichalcogenides, and metal oxides, proving its universality. Molybdenite concentrate, a natural low-cost and abundant mineral, was used as a demo for the large-scale exfoliation production of 2D MoS2 flakes. Our work indicates the huge potential of the iMAGE method to produce large amounts of various 2D materials, which paves the way for their commercial application. 相似文献
17.
在创新人才、创新主体和创新环境要素构成体系的基础上,引入耦合协调模型,利用2004年和2014年截面数据,对23个中国科技创新城市进行创新要素耦合评价。结果显示,样本城市整体耦合协调水平不高,多处于高度和中度耦合协调阶段,极度耦合协调阶段和低度耦合协调阶段的城市极少;样本城市的区域特征明显,京津冀地区、长三角地区、珠三角地区的城市位居前列,中西部地区和东北地区城市表现乏力;以上海、北京和深圳为代表的部分城市具备创建全球科技创新中心的基础优势,可在政策方面有所侧重,有效推进全球科技创新中心建设进程。 相似文献
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Yujia Wang Tong Wang Xuebo Yang Jiae Yang Feihu Jin 《Journal of The Franklin Institute》2021,358(9):4705-4720
This paper investigates a novel strategy which can address the fault-tolerant control (FTC) problem for nonlinear strict-feedback systems containing actuator saturation, unknown external disturbances, and faults related to actuators and components. In such method, the unknown dynamics including faults and disturbances are approximated by resorting to Neural-Networks (NNs) technique. Meanwhile, a back-stepping technique is employed to build a fault-tolerant controller. It should be stressed that the main advantage of this strategy is that the NN weights are updated online based on gradient descent (GD) algorithm by minimizing the cost function with respect to NNs approximation error rather than regarding weights as adaptive parameters, which are designed according to Lyapunov theory. In addition, the convergence proof of NN weights and the stability proof of the proposed FTC method are given. Finally, simulation is performed to demonstrate the effectiveness of the proposed strategy in dealing with unknown external disturbances, actuator saturation and the faults related to the components and actuators, simultaneously. 相似文献