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1.
Early in development, many word‐learning phenomena generalize to symbolic gestures. The current study explored whether children avoid lexical overlap in the gestural modality, as they do in the verbal modality, within the context of ambiguous reference. Eighteen‐month‐olds’ interpretations of words and symbolic gestures in a symbol‐disambiguation task (Experiment 1) and a symbol‐learning task (Experiment 2) were investigated. In Experiment 1 (N = 32), children avoided verbal lexical overlap, mapping novel words to unnamed objects; children failed to display this pattern with symbolic gestures. In Experiment 2 (N = 32), 18‐month‐olds mapped both novel words and novel symbolic gestures onto their referents. Implications of these findings for the specialized nature of word learning and the development of lexical overlap avoidance are discussed.  相似文献   

2.
In order to test the hypothesis that genetic influences are moreimportant as a cause of reading disability in girls than in boys,composite reading performance data from identical and fraternal twinpairs were analyzed using both concordance and multiple regressionmethods. The sample included 206 identical (99 male, 107 female), 159same-sex fraternal (90 male, 69 female), and 117 opposite-sex fraternaltwin pairs, in which at least one member of each pair had readingdifficulties. Although the difference between the concordance rates forreading disabilities in female identical and same-sex fraternal twinpairs was somewhat greater (65% for identical twins vs.32% for fraternal twins) than the difference in concordance ratesfor boys (68% vs. 39%), loglinear analysis of thesecategorical data revealed that the interaction between sex, zygosity,and concordance was not significant (p > 0.70). Moreover,the heritability of reading disability(h 2 g) estimated from regression analysisof the reading performance data in males was nearly identical to that infemales (h 2 g = 0.58 and 0.59,respectively; p > 0.90). Thus, results of this studyprovide little or no evidence for the hypothesis of greater geneticinfluence on reading difficulties in girls than in boys.  相似文献   

3.
中国大规模空分研究进展   总被引：1，自引：0，他引：1  
中国钢铁、化工等行业对工业气体需求的快速增长,极大地促进了大规模空分技术的发展。目前,中国生产的单套空分设备最大氧产量达到了120000Nm^3／h,单位能耗为0．38kWh／m^3。本文介绍了中国大规模空分技术发展水平,回顾了中国大规模空分工业的发展历史。以成熟的60000Nm^3／h空分系统为例,详细介绍了分子筛吸附器、空压机、板翅换热器、透平膨胀机和精馏塔等主要设备的技术参数。然后介绍了中国正在发展中的80000～120000Nm^3／h空分工艺和装备。最后讨论了中国大规模空分技术存在的主要问题及未来发展方向。  相似文献   

4.
目的探讨食管癌骨转移患者的核素骨显像特征及临床应用。方法收集我院2007年1月至2011年12月接受全身骨显像的158例食管癌患者病历资料。对全身骨显像结果进行统计和分析,归纳食管癌患者骨转移显像特点。结果 158例食管癌患者骨转移发生率为17.72%（28/158）,其中以脊柱及肋骨转移最为多见,发生率分别为89.29%（25/28）,64.29%（18/28）。依据病理类型,鳞癌、腺癌、小细胞癌的骨转移发生率分别为13.83%（13/94）,21.95%（9/41）和26.09%（6/23）。结论放射性核素骨显像对食管癌患者具有重要的临床意义,应作为治疗前后骨转移诊断和随访的常规检查手段。  相似文献   

5.
Youth that are victims of commercial sexual exploitation of children (CSEC) have a host of clinical problems and often run away from home, residential care, and treatment, which complicates and limits treatment effectiveness. No research to date has attempted to predict running away in CSEC victims. The present study aimed to 1) characterize a clinically referred sample of girls who were victims of CSEC and compare them to other high-risk girls (i.e., girls who also have a history of trauma and running away, but deny CSEC); and 2) examine the utility of using the Youth Level of Service/Case Management Inventory (YLS/CMI) to predict future running away. Data were collected from de-identified charts of 80 girls (mean age = 15.38, SD = 1.3, 37.9% White, 52.5% CSEC victims) who were referred for psychological assessment by the Department of Child Services. Girls in the CSEC group were more likely to have experienced sexual abuse (χ2 = 6.85, p = .009), an STI (χ2 = 6.45, p = .01), a post-traumatic stress disorder diagnosis (χ2 = 11.84, p = .001), and a substance use disorder diagnosis (χ2 = 11.32, p = .001) than high-risk girls. Moderated regression results indicated that YLS/CMI scores significantly predicted future running away among the CSEC group (β = 0.23, SE = .06, p = .02), but not the high-risk group (β = −.008, SE = .11, p =.90). The YLS/CMI shows initial promise for predicting future running away in girls who are CSEC victims. Predicting running away can help identify those at risk for and prevent running away and improve treatment outcomes. We hope current findings stimulate future work in this area.  相似文献   

6.
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7.
目的探讨D-二聚体检测在DIC、溶栓治疗、恶性肿瘤及乙型肝炎等疾病中应用的临床价值.方法收集40例正常对照组和71例病例组,均采用D-二聚体试剂盒进行检测,检测原理为胶乳凝集试验.结果各检测组D-二聚体水平显著高于对照组(P＜0.01).结论D-二聚体检测对DIC、溶栓治疗、恶性肿瘤及乙型肝炎疾病的诊断、治疗及疗效观察提供一定的依据.  相似文献   

8.
Orthotopic liver transplantation (OLT) is the only proven effective treatment for both end-stage and metabolic liver diseases. Hepatocyte transplantation is a promising alternative for OLT, but the lack of available donor livers has hampered its clinical application. Hepatocyte-like cells (HLCs) differentiated from many multi-potential stem cells can help repair damaged liver tissue. Yet almost suitable cells currently identified for human use are difficult to harvest and involve invasive procedures. Recently, a novel mesenchymal stem cell derived from human menstrual blood (MenSC) has been discovered and obtained easily and repeatedly. In this study, we examined whether the MenSCs are able to differentiate into functional HLCs in vitro. After three weeks of incubation in hepatogenic differentiation medium containing hepatocyte growth factor (HGF), fibroblast growth factor-4 (FGF-4), and oncostain M (OSM), cuboidal HLCs were observed, and cells also expressed hepatocyte-specific marker genes including albumin (ALB), α-fetoprotein (AFP), cytokeratin 18/19 (CK18/19), and cytochrome P450 1A1/3A4 (CYP1A1/3A4). Differentiated cells further demonstrated in vitro mature hepatocyte functions such as urea synthesis, glycogen storage, and indocyanine green (ICG) uptake. After intrasplenic transplantation into mice with 2/3 partial hepatectomy, the MenSC-derived HLCs were detected in recipient livers and expressed human ALB protein. We also showed that MenSC-derived HLC transplantation could restore the serum ALB level and significantly suppressed transaminase activity of liver injury animals. In conclusion, MenSCs may serve as an ideal, easily accessible source of material for tissue engineering and cell therapy of liver tissues.  相似文献   

9.
There has been considerable growth in the uptake of digital clinical education (DCE) over the last few years. This growth has coincided with similar growth in social media platforms available to both educators and learners. In this article, we describe a novel, innovative video-based medical education project using YouTube for teaching, training, and learning. We created a series of short ‘System based’ clinical scenario videos and uploaded it to YouTube. Using the analytics function provided by Google and YouTube, end-user data including viewer engagement, uptake, and comments were then analyzed. To date, the channel has garnered more than 5.5 million views over five years between July 2012-July 2017.

With the increase in the use of video-based learning and the popularity of social media platforms, the uptake of DCE is set to increase. YouTube offers a novel approach to streaming medical education for training purposes. A quality assessed, structured and sustainable educational online platform is likely to meet the future requirements of a new generation of learners.  相似文献   


10.
Research on information spillover effects between financial markets remains active in the economic community. A Granger-type model has recently been used to investigate the spillover between London Metal Exchange(LME) and Shanghai Futures Exchange(SHFE) ,however,possible correlation between the future price and return on different time scales have been ignored. In this paper,wavelet multiresolution decomposition is used to investigate the spillover effects of copper future returns between the two markets. The daily return time series are decomposed on 2n(n=1,…,6) frequency bands through wavelet mul-tiresolution analysis. The correlation between the two markets is studied with decomposed data. It is shown that high frequency detail components represent much more energy than low-frequency smooth components. The relation between copper future daily returns in LME and that in SHFE are different on different time scales. The fluctuations of the copper future daily returns in LME have large effect on that in SHFE in 32-day scale,but small effect in high frequency scales. It also has evidence that strong effects exist between LME and SHFE for monthly responses of the copper futures but not for daily responses.  相似文献   

11.
This study presents a new method of 4-pipelined high-performance split multiply-accumulator （MAC） architecture, which is capable of supporting multiple precisions developed for media processors. To speed up the design further, a novel partial product compression circuit based on interleaved adders and a modified hybrid partial product reduction tree （PPRT） scheme are proposed. The MAC can perform 1-way 32-bit, 4-way 16-bit signed/unsigned multiply or multiply-accumulate operations and 2-way parallel multiply add （PMADD） operations at a high frequency of 1.25 GHz under worst-case conditions and 1.67 GHz under typical-case conditions, respectively. Compared with the MAC in 32-bit microprocessor without interlocked piped stages （MIPS）, the proposed design shows a great advantage in speed. Moreover, an improvement of up to 32% in throughput is achieved. The MAC design has been fabricated with Taiwan Semiconductor Manufacturing Company （TSMC） 90-nm CMOS standard cell technology and has passed a functional test.  相似文献   

12.
Objective: In addition to pH regulation, Na+/H+ exchange (NHE) has been shown to facilitate cell growth and proliferation. However, the effects of long-term inhibition of Na+/H+ exchange on cardiac structural and functional remodeling post myocardial infarction (MI) are still controversial. The present study was therefore carried out to further investigate the effects of long-term treatment with cariporide, a specific inhibitor of NHE-1, on cardiac remodeling after MI in rats; Methods: Male Wistar rats that underwent coronary ligation were randomly selected for cariporide treatment starting 6 h after induction of MI or no treatment. Treatment was continued up to 6 weeks post MI, after which, the arterial, venous and left ventricular catheters were chronically implanted. Twenty-four h later, after hemodynamic signals were recorded in conscious rats, they were sacrificed and hearts were taken out for morphological examinations; Results: Cariporide treatment decreased the heart weight and heart weight to body weight ratio (bothP<0.05), decreased left ventricular end-diastolic pressure (P<0.001), improved myocardial contractility (dP/dt max) (P<0.05) and tended to increase the survival of treated rats compared to that of untreated infarct rats; Conclusion: The results of the present study indicate that the long-term inhibition of NHE with cariporide can attenuate cardiac structural remodeling and improve left ventricular dysfunction in infarcted rats, and suggest that Na+/H+ exchange inhibition could be an effective therapeutic strategy for myocardial infarction-induced heart failure.  相似文献   

13.
While debate about the use of—and alternatives to—human cadaveric dissection in medical training is robust, little attention has been paid to questions about timing. This study explores the perspectives of medical students and recent graduates with regard to two key questions: when in the degree program do students prefer dissection opportunities and what are the students getting out of participating in dissection? Self-report survey data from students in preclinical years (n = 105), clinical years (n = 57), and graduates (n = 13) were analyzed. Most (89%) preferred dissection during the preclinical years, with no effect by training year (χ2 = 1.98, p = 0.16), previous anatomy (χ2 = 3.64, p = 0.31), or dissection (χ2 = 3.84, p = 0.26) experience. Three key findings emerged. First, the majority of students prefer to dissect in the preclinical years because they view dissection as important for developing foundation knowledge and delivering an opportunity for consolidation prior to transitioning to primarily clinical studies. In addition, students recognize that it is a time-consuming activity requiring specialized facilities. Second, three main understandings of the purpose of dissection were reported: depth of learning, learning experience, and real-world equivalence. Third, these student perspectives of the purpose of dissection are associated with timing preferences for dissection opportunities. The results identify the preclinical phase as the optimal time to strategically integrate dissection into medical training in order to maximize the benefits of this unique learning opportunity for students and minimize its impact upon curricular time.  相似文献   

14.
As my playful title suggests, I am referring to the process where the statement, ‘send reinforcements; we’re going to advance,’ is said to have become, ‘send three- and four-pence; we’re going to a dance’.1 This quotation springs to mind when asked to think about how research gets picked up and recommendations from research are implemented in schools. This paper draws on the professional experiences of the author who has held a variety of roles in schools and the system and has also worked with a university as a system representative on a ‘collaborative’ research project. This paper focuses on the ‘Transient Students Project’2 that has recently been described in Changing Schools (DEST and DoD 2002). This example is described as having many of the features of ‘forward-reaching research’, as described in ‘Backtracking practice’ (Figgis et al 2000), in Chapter 3 of The Impact of Educational Research (DETYA 2000). At the heart of this paper is the question ‘who is research for?’  相似文献   

15.
C.H. Patterson (Pat) has long been a prominent contributor to counseling and counselor education. His published works have been many and varied, including such books as Theories of Counseling and Psychotherapy and Foundations for a Theory of Instruction and Educational Psychology. Though these efforts have proven of considerable value, Pat's presentation and interpretation of client-centered therapy has been of particular significance. In this article Pat is interviewed regarding his current views on the client-centered approach.  相似文献   

16.

The coronavirus disease 2019 (COVID-19) pandemic is a major public health event caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 has spread widely all over the world. A high proportion of patients become severely or critically ill, and suffer high mortality due to respiratory failure and multiple organ dysfunction. Therefore, providing timely and effective treatment for critically ill patients is essential to reduce overall mortality. Convalescent plasma therapy and pharmacological treatments, such as aerosol inhalation of interferon-α (IFN-α), corticosteroids, and tocilizumab, have all been applied in clinical practice; however, their effects remain controversial. Recent studies have shown that extracorporeal therapies might have a potential role in treating critically ill COVID-19 patients. In this review, we examine the application of continuous renal replacement therapy (CRRT), therapeutic plasma exchange (TPE), hemoadsorption (HA), extracorporeal membrane oxygenation (ECMO), and extracorporeal carbon dioxide removal (ECCO2R) in critically ill COVID-19 patients to provide support for the further diagnosis and treatment of COVID-19.

  相似文献   

17.
The effects of dietary supplementation with Clostridium butyricum on growth performance and humoral immune response in Miichthys miiuy were evaluated. One hundred and fifty Miichthys miiuy weighing approximately 200-260 g were divided into five groups and reared in 15 tanks with closed circuiting culture system. The animals were fed 5 diets： basal diet only （control） or supplemented of the basal diet with C. butyricum at doses of 10^3 （CB1）, 10^5 （CB2）, 10^7 （CB3） or 10^9 （CB4） CFU/g. Compared with the control, the serum phenoloxidase activity was significantly increased by the supplementation （P〈0.05）, acid phosphatases activity was increased significantly （P〈0.05） at the doses of 10^9 CFU/g. Serum lysozyme activity peaked at dose of 10^7 CFU/g and in the skin mucus at dose of 10^9 CFU/g. Immunoglobulin M level in the serum and skin mucus was increased except at dose of 10^3 CFU/g （P〈0.05）. The growth at the dose of 10^9 CFU/g was higher than that of the control （P〈0.05）. It is concluded that supplementation of C. butyricum can mediate the humoral immune responses and improve the growth performance in Miichthys miiuy.  相似文献   

18.
In their paper,How has school productivity changed in Australia? social economists Andrew Leigh and Chris Ryan (2008)1 attempt to show that Australian (government) schools and their teachers’ productivity has declined by some 73 per cent between 1964 and 2003 compared to an overall increase of 64 per cent across the Australian economy. In response I contend that Leigh and Ryan use an inappropriate statistical device to "decompose" student demographics to arrive at conclusions that contradict the original positive assessment of student standards by independent authorities (Rothman, 2007). Their work, which for many years seemed to be the foundation stone for Howard government education policy has by their own admission (A. Leigh &; C. Ryan, personal communication, February 14, 2008), never been put to the test of peer review prior to publication. This paper critically analyses and contests their research by placing their claims within a social policy context that has subtly changed from one where teachers can make a difference to teachers are the difference.  相似文献   

19.
BackgroundThe Child Sexual Behavior Inventory (CSBI) is one of the few instruments available to assess sexual behavior in children. Because of cross-cultural differences in the definition of normal and atypical sexual behaviors, the CSBI is not generalizable to other countries.ObjectiveThe current study examined psychometric properties of the Dutch version of the CSBI.Participants and settingThe study represents 3206 children from a normative sample, and 932 children from clinical samples.MethodsParents ratings on the CSBI, and questionnaires for psychosocial problems were obtained to assess psychometric properties.ResultsResults showed that Dutch parents interpret more CSBI items as developmentally appropriate than USA parents. Reliability coefficients indicated internal consistency (α = .39–.82), test-retest (r = .86, p < .000) and interrater reliability (Cohen's d =0.47, p >.05). Positive correlations between the CSBI total scale and the subscales demonstrated content validity (r = .32–.96, p < .01). Differences between normative and clinical samples on the CSBI total (ηp2 = .01–.65, p < .000), DRSB (ηp2 = .00–.03, p = .00–.38) and SASI scales (ηp2 =.00–.18, p < .01) indicated construct validity. Within the clinical samples, highest associations were found between the CSBI score and convergent measures (r = .64, p < .000). Lowest associations were found between the CSBI scores and divergent measures r = .14–.54, p = n.s.−<.000.ConclusionsCross-cultural differences in the perception of developmental appropriate sexual behavior underscore the importance of country-specific normative data. Good psychometric properties of the Dutch version of the CSBI were supported by this study.  相似文献   

20.
Introduction

In years past, Jewish supplementary education has been the basis of religious growth for thousands of youngsters. Congregational and communal schools throughout the country have touched the lives of many Jewish youth.  相似文献   

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