Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Data Visualization as Participatory Research: A Model for Digital Collections to Inspire User-Driven Research     

A. Miller 《Journal of Web Librarianship》2019,13(2):127-155

The emerging creative practices of digital collections are increasing in prominence thanks to the access to, and appeal of, data visualizations. Interactive data visualizations, such as a map, timeline, chart, graph, or artist’s rendering of data, enable users to pursue their own research interests within a collection and participate in new areas of research. Use of these data visualizations enhances the scope of the collection and enables a modern and diverse thematic collection to emerge. This article considers the question: Does the addition of data visualizations affect how users participate with a research collection? Impacts on collection development, application of user-centered design, and analysis of users’ exploratory strategies are discussed. Examples of data visualizations used in digital humanities projects and digital collections are presented as case studies.  相似文献   

全球化视角下的日本足球     

WolframManzenreiter 《体育学刊》2003,10(4):8-11

通过对日本足球体制与职业足球实践等方面的分析，探讨了体育运动全球化的理论框架．认为流行时尚和国内政治塑造了日本足球，推动了日本足球的全球化。还探讨了体育文化与政治决策如地区发展规划、城市政策、卫生政策、国家建设等因素之间的相互影响。  相似文献   

电视新闻策划的实践思考     

夏冰 《浙江传媒学院学报》2003,10(3):18-20

新闻策划是对新闻报道活动的策划,电视新闻策划是现代社会受众和电视自身发展的需要。电视新闻的策划重在发挥电 视传播的优势,强调整体的协作。  相似文献   

中国传统文化与学校体育可持续发展   总被引：2，自引：0，他引：2  

吴刚 《湖北体育科技》2003,22(2):156-157,160

中国传统文化是学校体育可持续发展的外环境因素，它主要由儒家、道家和禅宗文化构成，具有中庸和平、泛道德性、人文精神、非独立性、静止停滞、乡土情结等特质，通过研究它的理性因素对学校体育可持续发展的正面影响和非理性因素带来的负面影响，来探讨在学校体育思想、内容和方法上应采取的发展对策。  相似文献   

《普通高等学校图书馆规程(修订)》学习体会     

那春光  董颖  刁云霞 《大学图书情报学刊》2003,21(2):19-21

论述了学习《普通高等学校图书馆规程(修订)》的体会，分析了(普通高等学校图书馆规程(修订)》对新形势下高校图书馆数字化献资源建设和服务、特色建设和资源共享、“学科馆员”的培养、网络建设和献信息传递的强调和重视。  相似文献   

GM(1,h)系统状态模型在田径训练中的应用   总被引：4，自引：0，他引：4  

刘嘉津  孙桂云 《上海体育学院学报》2003,27(1):78-81,F003

将多因素整体状态GM（1，h)模型及其特列GM（1，1）模型结合起来，用于高水平田径训练的建模问题研究，使建立的系统模型既能反映系统内部多因素的整体关系，又能满足超前预测和规划的需要，旨为田径训练提供了一种有效的科学方法。  相似文献   

中、美、日体育学科硕士研究生课程设置的比较研究   总被引：12，自引：0，他引：12  

谭政典  周兰君 《西安体育学院学报》2003,20(4):18-20

用文献法、比较法调查和Internet查询等方法,对中、美、日等国体育学科硕士研究生课程设置进行比较分析,旨在为改进我国研究生课程设置提供参考。结果显示:通过对三国体育学科研究生课程从基础理论、专业、相关学科、学科前沿知识及科研能力培养等方面进行分析,美国、日本注重实践能力的培养,我国注重理论知识的培养。结论:根据我国研究生教育的实际情况,提出改进课程设置的建议。  相似文献   

电大生《经济数学基础》课程学习困难的成因分析   总被引：1，自引：0，他引：1  

潘红卫 《广西广播电视大学学报》2003,14(4)

本文对电大生《经济数学基础》课程学习困难的成因进行了分析,并对教师在该课程教学中要注意的问题提出了几点建议。  相似文献   

日本百科辞书发展脉络初探     

张勃励 《津图学刊》2001,(4):70-72

本文概述了日本百科辞书从引进使用中国类书开始，经编纂日本自己的类书和百科辞书，到翻译西方现代百科全书和编纂日本百科事典的发展历程。  相似文献