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21.
Chao LI Da-ren LIU Long-yun YE Ling-na HUANG Sanjay JAISWAL Xiao-wen LI Hou-hong WANG Li CHEN 《Journal of Zhejiang University. Science. B》2014,15(6):582-589
Objective
Numerous studies examining the relationship between human epidermal growth factor receptor 2 (HER-2) overexpression and survival in patients with colorectal cancer (CRC) have yielded controversial results. We therefore performed a meta-analysis more precisely to estimate its prognostic value.Methods
Published studies investigating the effect of HER-2 overexpression on CRC survival were identified; the hazard ratios (HRs) and their corresponding 95% confidence intervals (95% CIs) were pooled in terms of disease-specific or overall survival.Results
Eleven studies were included in the meta-analysis. The pooled data showed that HER-2 overexpression was negatively related to CRC survival (HR=1.10, 95% CI: 0.77–1.44). Subgroup analyses regarding test method and study quality also demonstrated little association between HER-2 overexpression and CRC survival (HR=0.89, 95% CI: 0.50–1.29; HR=0.90, 95% CI: 0.43–1.37, respectively).Conclusions
Regardless of several limitations, our study suggested that HER-2 overexpression probably had little impact on CRC survival. 相似文献22.
Anuradha Bharosay Vivek Vikram Bharosay Meena Varma Kiran Saxena Ajoy Sodani Ravi Saxena 《Indian journal of clinical biochemistry : IJCB》2012,27(2):186-190
Stroke is the third major cause of death and foremost cause of disability worldwide. Cerebrovascular stroke remains largely a clinical diagnosis. The use of biomarkers in diagnosing stroke and assessing prognosis is an emerging and rapidly evolving field. The study aimed to investigate the predictive value of neurobiochemical marker of brain damage (neuron-specific enolase [NSE]) with respect to degree of disability at the time of admission and neurological worsening in acute ischemic stroke patients. We investigated 150 patients with cerebrovascular stroke who were admitted within 72 h of onset of stroke in the Department of Neurology at SAIMS. Venous blood samples were taken after admission and NSE was analyzed by solid enzyme linked immunosorbent assay using Analyzer and microplate reader from Biored: Code 680. In all patients, the neurological status was evaluated by a standardized neurological examination and the National Institutes of Health Stroke Scale on admission and on day 7. Serum NSE concentration was found to significantly correlate with both degree of disability and neurological worsening in acute ischemic stroke cases in the present study. The maximum serum NSE level within 72 h of admission was significantly higher in patients with greater degree of disability at the time of admission. Serum NSE levels were also found to be significantly elevated in patients with bad neurological outcome. Our study showed that serum NSE has high predictive value for determining severity and early neurobehavioral outcome after acute stroke. 相似文献
23.
To study the explicit organizational knowledge pattern of an education and research institute is a tedious process as it deals with multiple subjects. Also, many qualitative and quantitative indicators such as peer review process, awards and honors received by the constitute members of the institute, national and international grants, and different types of publications can be considered to study the pattern followed in different disciplines over a period of time. Not all of these indicators will be giving the same message, and the choice of which one to select will depend on the type of research being evaluated. In this study to analyze explicit organizational knowledge, publications of Indian Institute of Science (IISc) in different disciplines over a span of 10 years from 1996 to 2005 are considered as given in the multidisciplinary database SCOPUS using correspondence analysis and cluster analysis.According to correspondence analysis, the study indicated that publication productivity of IISc is on the rise during the study period and research in Engineering, Agriculture & Biological science, Chemistry and Life sciences is high. Although a cluster analysis is carried out to find out demarcations between row elements and column elements, no useful interpretation could be drawn.However, this analysis has to be carried out further, by factoring indicators from research input as well as other socio-economic political, and cultural factors affecting the explicit organizational knowledge. Correspondence analysis and cluster analysis highlights what is interesting, and indicates the direction in which further inquiry should be done. 相似文献
24.
Yong Wang Xing Yu Qun-zi Zhao Shu Zheng Wen-jie Qing Chun-di Miao Jaiswal Sanjay 《Journal of Zhejiang University. Science. B》2016,17(7):515-525
We have investigated comprehensively the effects of thyroid function on gallstone formation in a mouse model. Gonadectomized gallstone-susceptible male C57BL/6 mice were randomly distributed into three groups each of which received an intervention to induce hyperthyroidism, hypothyroidism, or euthyroidism. After 5 weeks of feeding a lithogenic diet of 15% (w/w) butter fat, 1% (w/w) cholesterol, and 0.5% (w/w) cholic acid, mice were killed for further experiments. The incidence of cholesterol monohydrate crystal formation was 100% in mice with hyperthyroidism, 83% in hypothyroidism, and 33% in euthyroidism, the differences being statistically significant. Among the hepatic lithogenic genes, Trβ was found to be up-regulated and Rxr down-regulated in the mice with hypothyroidism. In contrast, Lxrα, Rxr, and Cyp7α1 were up-regulated and Fxr down-regulated in the mice with hyperthyroidism. In conclusion, thyroid dysfunction, either hyperthyroidism or hypothyroidism, promotes the formation of cholesterol gallstones in C57BL/6 mice. Gene expression differences suggest that thyroid hormone disturbance leads to gallstone formation in different ways. Hyperthyroidism induces cholesterol gallstone formation by regulating expression of the hepatic nuclear receptor genes such as Lxrα and Rxr, which are significant in cholesterol metabolism pathways. However, hypothyroidism induces cholesterol gallstone formation by promoting cholesterol biosynthesis. 相似文献
25.
Ajay Kumar Khanna Sujit Yadav Z. Ali N. C. Arya Anuradha Khanna 《Indian journal of clinical biochemistry : IJCB》1996,11(1):52-55
Serum Adenosine Deaminase (ADA) activity was studied in 20 control cases and 32 patients with carcinoma breast. In control group the ADA activity ranged from 13–94 IU/L with a mean of 43.75±21.55 IU/L while in patients of carcinoma breast it was 16–95 IU/L with a mean of 47.46±22.54 IU/L, but these values were not statistically different. The ADA activity was also compared with other parameters in patients of carcinoma breast but the difference was not statistically significant in the various parameters like duration of disease, menopausal status, tumor size, hemoglobin level, total leucocyte count, absolute lymphocyte count, total serum proteins, serum albumin, histological grade of tumor and lymphocytic infiltration. The only significant difference in ADA activity was when N1 status of lymph node was compared with N2 status of lymph node. 相似文献
26.
Implementing mobile learning in curriculum-based educational settings faces challenges related to perceived ethical and learning issues. This study investigated the affordances of mobile technologies to support mathematics instruction by teachers. An exploratory study employing questionnaires and semi-structured interviews revealed that, while mathematics instruction can be augmented with mobile learning, the majority of schools in Indonesia have banned student use of mobile phones in classrooms. Teachers are concerned about the improper use of mobile phones that could impact their students' mental well-being and distract them from learning. Most teachers perceive mobile technologies to be disruptive and seem reluctant to use them for teaching delivery. However, teachers are eager to experiment with digital technologies within mathematics instruction. Our findings suggest infusing alternate technologies that fit better with the school's teaching and learning environment. This includes web-based applications that can run on different digital devices ranging from desktop computers, laptops, and tablets, to mobile phones. We propose setting up communities of practice for mathematics teachers to share their instructional repertoire on integrating digital technologies within the classroom. 相似文献
27.
This paper examines the ways in which two Internet-based civil society groups, Hasiru Usiru and Praja, negotiate online and offline spaces of collective action in Bangalore, India’s “IT City.” Based on ethnographic research, the study extends collective action theory through an examination of communicative interactions and experiences of urban civil society actors in a developing country. The paper highlight factors that impede and support collective actions, including attitudes toward the Internet as a tool for democratic engagement, ideological motivations, and perceptions of identity and membership, among others. Such a line of inquiry is significant in highlighting the possibilities of ICTs for collective action, while simultaneously avoiding the tendency to inflate and overestimate their capacity to produce social change. 相似文献
28.
Anuradha Pande 《The Journal of environmental education》2013,44(3):47-53
Abstract This article describes an experimental environmental education course in rural schools in India's central Himalayas. The course was designed to introduce environmental and livelihood issues into mainstream curriculum. The Uttaranchal Environment Education Centre initiated this program in 1987 with the help of national and state departments of education. This practical course focuses on land degradation, which is the region's major environmental problem. Students learn how to manage their village ecosystem to ensure maximum sustainable productivity. Currently, 1,000 teachers in 530 schools offer the course to approximately 68,000 students. 相似文献
29.
In the early 1990s, large numbers of children in India remained out of school. International commitments to achieve education for all (EFA) globally meant that India was an important case for donors. India was pressed to accept aid for primary education, and agreed with some reluctance. Although subsequent donor involvement was substantial and influenced aspects of both policy implementation and management, it is shown that Indian education policy priorities remained self-determined. The Government of India – though falling short of securing universal education for its children – succeeded in using external resources and expertise in ways which suited its own purposes, whilst minimising external impact on policy development. The politics and economics of this process are discussed. 相似文献
30.
Nasreen Noor Najmul Islam Shagufta Moin Abbas Ali Mahdi Sapna Jaiswal Farzana Bano 《Indian journal of clinical biochemistry : IJCB》2008,23(3):227-232
To probe the glutathione peroxidase (GPx) activity coupled to ROS and TNF-α levels in younger versus elderly primigravidas.
Monocytes were isolated from blood of young and elderly primigravidas after 12 hrs, 24 hrs and 14 days postpartum. Age-matched
healthy female donors served as controls. Thereafter, the above monocytes were subjected to evaluation of GPx activity, levels
of pro-inflammatory cytokine TNF-α and reactivity/specificity towards anti-TNF-α antibody. Suppression in GPx activity with
simultaneous enhancement of TNF-α levels in monocytes was observed after 12 hrs and 24 hrs of spontaneous labor pain-induced
maternal delivery through normal vaginal route. Conversely, an enhancement of GPx activity and decrease in TNF-α levels were
observed on day 14 of postpartum, thereby indicating reversal of the impaired neutralizing mechanisms. The antioxidant network
combating ROS was stronger in younger primigravidas. Capability of TNF-α and ROS suppression was somewhat lesser in elderly
primigravidas even 14 days of postpartum via normal vaginal route. The capability of GPx activity enhancement with simultaneous
suppression in ROS and TNF-α, decreases in elderly primigravidas. This may act as one of the important parameters leading
to a variety of complications encountered by elderly primigravidas. 相似文献