Effect of water extract of <Emphasis Type="Italic">Trichosanthes dioica</Emphasis> fruits in streptozotocin induced diabetic rats     

Prashant Kumar Rai  Dolly Jaiswal  Devendra K. Rai  Bechan Sharma  Geeta Watal 《Indian journal of clinical biochemistry : IJCB》2008,23(4):387-390

In rats with streptozotocin induced severe diabetes mellitus, aqueous extract of Trichosanthes dioica fruits at a dose of 1000mg/kg body weight daily once for 28 days reduced the levels of fasting blood glucose, postprandial glucose, asparate amino transferase, alanine amino transferase, alkaline phosphatase, creatinine, urine sugar and urine protein where as total protein and body weight was increased. No toxic effect was observed during LD50. Our study suggests that further detailed toxicity studies and mechanism of action of T. dioica would be useful for undertaking human trials.  相似文献