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991.
Reinforced concrete (RC) columns lacking adequately detailed transverse reinforcement do not possess the necessary ductility to dissipate seismic energy during a major earthquake without severe strength degradation. In this paper, a new retrofit method, which utilized fiber-reinforced plastics (FRP) confinement mechanism and anchorage of embedded bars, was developed aiming to retrofit non-ductile large RC rectangular columns to prevent the damage of the plastic hinges. Carbon FRP (CFRP) sheets and glass FRP (GFRP) bars were used in this test, and five scaled RC columns were tested to examine the function of this new method for improving the ductility of columns. Responses of columns were examined before and after being retrofitted. Test results indicate that this new composite method can be very effective to improve the anti-seismic behavior of non-ductile RC columns compared with normal CFRP sheets retrofitted column.  相似文献   
992.
Hamiltonian system for the problem on clamped Mindlin plate bending was established by introducing the dual variables for the generalized displacements in this letter. By separation of variables, the transverse eigen-problem was derived based on the sympletic geometry method. With the solved sympletic eigen-values, the generalized sympletic eigen-solution was derived through eigenfunction expansion. An example of plate with all edges clamped was given. The sympletic solution system was worked out directly from the Hamiltonian system. It breaks the limitation of traditional analytic methods which need to select basis functions in advance. The results indicate that the sympletic solution method could find its more extensive applications.  相似文献   
993.
Oral Cancer is one of the five leading sites of cancer in Indian population. The circulating immune complexes were investigated in 100 serum samples of 60 oral cancer patients having different grades of the disease and 40 patients with precancerous lesions obtained from Nair Hospital Dental collage, Mumbai. The results obtained were compared with those of group of 40 healthy blood donors. Elevated levels of Circulating Immune Complexes were observed in oral cancer patients and patients with oral precancerous lesions. 92% positive samples were observed in well differentiated squamous cell carcinoma whereas 100% positive samples were observed in both moderately and poorly differentiated squamous cell carcinoma. Oral leukoplakia and oral submucous fibrosis showed 15% and 90% positivity respectively. Increased level of Circulating Immune complexes in high grade tumor suggest that Circulating Immune complexes is likely to contribute in evaluating the degree of malignancy, but follow up study is needed to draw any conclusion regarding it's prognostic role  相似文献   
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Developing technology that accounts for values has been achieved in many areas, including security, gaming, finance, engineering, and many more. The main methodological approach has been that of value sensitive design. But most of the work to date has been on the first of its three stages. The focus of this article is on advances related to its second stage, empirical investigation, and in particular the impact of contextual understanding in that stage. Although lessons can be learnt from other domains, the specific context of dementia means that there are nuances to understanding values, including justice and autonomy, that differ from other areas. The integration of value considerations in the development of assistive technology in dementia is explored in two broad categories: the traditional and ongoing need for fixed decision support, and adaptable decision support technologies. For fixed decision support the A&D Benchmark is particularly useful in design. But for adaptable technologies, that benchmark requires further development, including consideration of the values of additional stakeholders, such as the general public.  相似文献   
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A rational approach for developing effective filaricides awaits greater knowledge on the biochemical pathways operating in filarial parasites. For example, metabolic pathways or key enzymes that are so pivotal to the parasite that their interruption or inhibition causes spontaneous death, could be exploited to develop effective chemotherapeutic agents. Similarly, developing a safe and nontoxic filaricidal will require precise understanding of whether or not the potential molecular target in the parasite is unique or at least different enough from the host system. Recently, we identified a novel transglutaminase enzyme (EC2.3.2.13; TGase) in filarial parasites that plays an important role during their normal growth and development. Based on these principles, TGase may serve as a new target for the development of effective chemotherapeutic agent and vaccine for controlling and preventing the infections caused by these parasites.  相似文献   
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