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31.
Subir Kumar Das L. Dhanya Sowmya Varadhan Sukhes Mukherjee D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2009,24(3):301-306
Alcohol consumption and health outcomes are complex and multidimensional. Ethanol (1.6g / kg body weight/ day) exposure initially
affects liver function followed by renal function of 16–18 week-old male albino rats of Wistar strain weighing 200–220 g.
Chronic ethanol ingestion increased in thiobarbituric acid reactive substances level and glutathione s-transferase activity;
while decreased reduced gluatathione content and activities of catalase, glutathione peroxidase and glutathione reductase
in a time dependent manner in the hemolysate. Though superoxide dismutase activity increased initially might be due to adaptive
response, but decreased later. Elevation of serum nitrite level and transforming growth factor-b1 activity indicated that long-term ethanol consumption may cause hepatic fibrosis and can elicit pro-angiogenic factors. However,
no alteration in vascular endothelial growth factor-C activity indicated that ethanol consumption is not associated with lymphangiogenesis.
Therefore, we conclude that long-term ethanol-induced toxicity is linked to an oxidative stress, which may aggravate to fibrosis
and elevate pro-angiogenic factors, but not associated with lymphangiogenesis. 相似文献
32.
Subir Kumar Das Sukhes Mukherjee Gaurav Pandey V. Balakrishnan D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2009,24(2):155-158
Non-alcoholic fatty liver disease and its more aggressive form, non-alcoholic steatohepatitis are entities that are becoming
more and more interesting to the medical community in general. A total of 93 Non-alcoholic fatty liver disease patients (64
male and 29 female) within the age range between 28 to 63 years were studied. All of them showed elevated alanine aminotransferase
level (104.07 ± 56.04). Aspartate aminotransferase level (58.13 ± 31.96) was elevated more than its normal level in 82% cases
and AST to ALT ratio was found 0.59 ± 0.26. Predisposing factors were diabetes mellitus (37%), obesity (13%) and hyperlipidemia
(41%). In addition, 32% of the subjects were overweight.18% of the patients had elevated serum bilirubin. Our findings recommend
a lower cutoff value than suggested by the World Health Organization for overweight and obesity among this racial-ethnic group. 相似文献
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The research described in this article aimed to explore and examine the dominant ‘assessment’ and ‘participation’ stories of upper‐primary pupils with long‐standing and marked literacy learning needs, their views on how their level of participation in the assessment and remediation of their additional needs might be increased and also how they perceive themselves as literacy learners. This qualitative small‐scale study adopted a case study approach and utilised creative methodologies in the context of focus groups to investigate sensitively the views and experiences of Key Stage 2 pupils with additional needs in literacy. The findings discussed here are based on the outcomes from the four Northern Irish schools that participated in the original cross‐border (Northern Ireland/Republic of Ireland) study. Findings are discussed in the context of strategies for promoting holistic and empowering pathways for learners with additional needs in literacy. 相似文献
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Forty-five Grade 3 students from a reservation school in Western Canada were divided into two remedial groups and a no-risk control group. One remedial group was given a classroom-administered cognitive enhancement program (COGENT) throughout the school year. The second group received COGENT for the first half of the year followed by a pull-out cognitive-based reading enhancement program (PREP). Children were assessed across phonological awareness, rapid naming, reading, and cognitive ability at the beginning of the year, mid-term, and at the end of the school year. MANOVA results showed a significant interaction for reading measures, with students receiving classroom intervention over the school year making the greatest gains. Results are discussed in terms of group, remediation program, and individual participant improvements. 相似文献
38.
Lu XF He GQ Yu HN Ma Q Shen SR Das UN 《Journal of Zhejiang University. Science. B》2010,11(12):923-930
Polyunsaturated fatty acids (PUFAs) possess anti-cancer action both in vitro and in vivo. In the present study, we detected
cell viability with methyl thiazolyl tetrazolium (MTT) assay and cell membrane permeability with propidium iodide (PI) fluorescence
dyeing, and calculated cell membrane fluidity change as fluorescence anisotropy. Fatty acid content in cells was measured
by gas chromatography/mass spectroscopy (GC/MS), and the relationship between fatty acid composition and cell viability was
studied. We observed that n-6 PUFA linoleic acid (LA) inhibited tumor cell growth at high concentrations (≥300 μmol/L), while low concentrations (100–200
μmol/L) seemed to promote cell proliferation. Analyses of cell membrane permeability, cell membrane fluidity, and cell fatty
acid composition suggested that the anti-cancer action of LA could be related to changes in the ratio of n-6 to n-3 PUFAs. We observed that pre-incubation of cancer cells with 100 μmol/L LA for 24 h enhanced cell sensitivity to the cytotoxic
action of LA, whereas undifferentiated cell line LoVo seemed to have a distinct path in LA-induced death. These results showed
that one of the mechanisms by which supplementation of LA induces cancer cell death could be altering the ratio of n-6/n-3 PUFAs, and this may be related to cell differentiation status. 相似文献
39.
Targeted yield concept and a framework of fertilizer recommendation in irrigated rice domains of subtropical India 总被引:1,自引:0,他引:1
Bera R Seal A Bhattacharyya P Das TH Sarkar D Kangjoo K 《Journal of Zhejiang University. Science. B》2006,7(12):963-968
Soil test crop response (STCR) correlation studies were carried out in Vindhyan alluvial plain during 2001 to 2004 taking IR-36 as test crop to quantify rice production in the context of the variability of soil properties and use of balanced fertilizers based on targeted yield concept. The soils were developed on gently sloping alluvial plain with different physiographic settings and notable variation in drainage condition. Soil properties show moderate variation in texture (loamy to clay), organic carbon content (4.4 to 9.8 g/kg), cation exchange capacity (10,2 to 22.4 cmol (p+)/kg) and pH (5.3 to 6,4), Soil fertility status for N is low to medium (224 to 348 kg/ha), P is medium to high (87 to 320 kg/ha) and K ranges from medium to high (158 to 678 kg/ha). Database regarding nutrient requirement in kg/t of grain produce (NR), the percent contribution from the soil available nutrients [CS (%)] and the percent contribution from the applied fertilizer nutrients [CF (%)] were computed for calibrating and fbrmulating fertilizer recommendations. Validity of the yield target for 7 and 8 t/ha was tested in farmers' fields and yields targets varied at less than 10%. The percent achievement of targets aimed at different level was more than 90%, indicating soil test based fertilizer recommendation approach was economically viable within the agro-ecological zone with relatively uniform cropping practices and socio-economic conditions. 相似文献
40.
Ghizal Fatima Abbas Ali Mahdi Siddharth Kumar Das Baby Anjum Nar Singh Verma Puneet Kumar Ragini Shrivastava 《Indian journal of clinical biochemistry : IJCB》2012,27(4):340-343
The present study was designed to test the hypothesis of a circadian variation in circulating levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in women with fibromyalgia syndrome (FMS). Serum levels of IL-6 and TNF-α were measured at 4 h intervals of the day in 50 women with FMS satisfying American College of Rheumatology criteria for FMS (age 36.68 ± 9.89) as well as 50 healthy control women (age 32.82 ± 10.53). Serum TNF-α levels were substantially increased in patients with FMS but showed no circadian variation. In contrast, no difference in the levels of IL-6 was found. Moreover, there was also no circadian variation in both the groups of patients and controls. We conclude that no circadian pattern exists in the circulating levels of serum IL-6 and TNF-α in patients with FMS, although TNF-α levels are found raised in patients with FMS. 相似文献