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101.
Simple and sensitive Liquid Chromatography-Tandem Mass Spectrometry (LCMS/MS)
method was developed and validated, then was implicated on hypertensive human
subjects to study drug interaction of atorvastatin (ATVS) and Olmesartan (OLM) on
status of Angiotensin-II (ANG-II). The ANG-II in plasma was extracted with 5 mL
methanol containing 5 % formic acid through C18 (cartridges)
liquid–liquid extraction, dried and reconstituted with 1 mL of 16 % acetonitrile in
0.1 % formic acid in water. The chromatographic separation of ANG-II with a Agilent
technology 6410 Triple quadrupole was carried multiple reaction monitoring scan mode
with a Agilent 1290 Infinity LC system for UHPLC. The sample were separated on a
(Thermo Scientific) Hy-Purity advance (50 × 4.6 mm, 5 μm) using Mobile Phase A: 16 %
acetonitrile in 0.1 % formic acid in water and Mobile Phase B: 0.1 % formic acid in
methanol at a flow rate of 0.3 mL/min, performed at ambient temperature. The mobile
phase gradient of 16 % acetonitrile in water was linearly increased to 38 %
acetonitrile over 10 min and subsequently the mobile-phase was increased to 100 %
acetonitrile over 15 min. The developed method was validated for specificity,
accuracy, precision, stability, linearity, sensitivity and recovery. The method was
linear between peak area ratio of standard and internal standard over the range of
50–800 ng/mL. The method was successfully applied for the drug interaction study
revealed levels of ANG-II were significantly higher in ATVS + OLM treatment
condition as compared to individual treatment of OLM. This reflects the reason of
low effectiveness of ATVS + OLM in combination instead of synergistic
activity.
Electronic supplementary material
The online version of this article (doi:10.1007/s12291-014-0457-x) contains supplementary material, which is available to authorized users. 相似文献102.
Mascha Verma Rashmi Khadapkar Priyadarshi Soumyaranjan Sahu Bibhu Ranjan Das 《Indian journal of clinical biochemistry : IJCB》2006,21(2):90-94
An increase in the communication within the healthcare services, both nationally and internationally, has strengthened the
need for harmonization of measurements and reference intervals in laboratory medicine. In the present report, the calculated
reference interval for serum creatinine (sCr) levels of healthy normal individuals (n=1121) in different sex and age groups
are compared with the established interval. The calculated reference interval for sCr level was 0.4–1.3 mg/dL and 0.6 to 1.3
mg/dL in the age groups of 21–40 and 41–60 years respectively. The difference between the mean sCr values in total males and
total females (age range 21–60 years) was statistically significant (p<0.0001); When male and female subjects were analyzed
age-group wise, the data showed a significant difference in mean sCr values (p<0.0001) in three age groups (21–30, 31–40 and
41–50 years) however, in older age group (51–60 years), the difference was non-significant (p=0.07). The reference ranges
were 0.7–1.3 and 0.4–1.0 mg/dL for males and females respectively where the lower limit was 0.1–0.2 units less than that of
standard limits. An increase in the mean value of sCr was observed particularly in females with an increase in age. Hence
it is of interest to validate an age specific reference ranges for sCr in our population. 相似文献
103.
The concepts of photoperiodic induction, hormonal regulation and florigens used to form the basis of our knowledge of flowering.
Consequent upon the advancement of technology, our present day understanding suggests that a number of events like switching
on of a cascade of genes, and the subsequent activation of MADS box genes, result in the activation of the the genes responsible
for flowering in angiosperms. 相似文献
104.
Historically low average pass rate has been a perennial challenge for the universities and provincialised colleges in the North-Eastern states of India (Assam, Meghalaya, Mizoram, Nagaland, Tripura, Manipur and Arunachal Pradesh). Pass rate refers to the proportion of students promoted from one semester to the next and also the proportion of students who pass the final examination to be a graduate. The paper attempts to trace the key parameters for quality improvement for higher education in the region and subsequently augment the pass rate. An inductive content analysis was conducted based on focus group interviews at various levels at Assam University, Silchar and its affiliated provincialised colleges. The four broad categories thus identified (academic, administrative, socio-economic and placement issues) were subjected to Pareto 80-20 principle to identify the issues that are to be given priority for evolving the system. The study would help the administrators to measure the quality of higher education system in a hostile environment characterised by adverse topography, political disturbances, skewed distribution of income, widespread poverty and lack of literacy. 相似文献
105.
An economical and less time consuming microtitration method is presented. The method has been applied to two types of titration,
viz., neutralization and complexometric. The results obtained by the new method are comparable to those obtained by conventional
method using burette and pipette. It is proposed that this method can be implemented in high school and undergraduate classes
as the quantities of chemicals consumed are far less and the experiment can be completed within the given laboratory period. 相似文献
106.
Subir Kumar Das Sowmya Varadhan L. Dhanya Sukhes Mukherjee S. Mohana V. Balakrishnan D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2009,24(1):60-64
Chronic pancreatitis, an irreversible inflammatory disease of the pancreas, is associated with the replacement of the destroyed
parenchyma by extended development of fibrosis. Despite marked progress in diagnostic tools, no consensus has been reached
in diagnosis of chronic pancreatitis. In this study we examined the hematological and biochemical parameters among 40 chronic
pancreatitis patients within 18 to 67 yrs. ESR level and ALP activity was elevated in 40% cases. Serum amylase activity increased
in 32 patients and it showed significant correlation with ALP (r=0.458, p=0.003), CA-19.9 (r=0.556, p<0.001), and calcium
level (r=−0.472, p=0.002). Type IV collagen level in chronic pancreatitis also elevated (164.4 ± 55.5 ng/ml) and showed negative
significant correlation with calcium level (r= −0.505, p=0.001). However, no significant correlation was observed between
amylase activity and type IV collagen (r=0.289, p= 0.07). 相似文献
107.
Pallab Basu Sabyasachi Som Nabendu Choudhuri Harendranath Das 《Indian journal of clinical biochemistry : IJCB》2008,23(4):361-364
A randomized case control hospital based study was conducted over 12 months time on 31 asphyxiated and 31 normal newborn to
see whether urinary uric acid can be used as a marker of perinatal asphyxia and can be correlated with the clinical diagnosis
by Apgar score. Uric acid and creatinine were estimated in spot urine within 24 hours after birth in both cases and controls.
A ratio between concentrations of uric acid to creatinine was estimated and compared between cases and controls. It was found
that the ratios were significantly higher in cases than controls (3.1± 1.3 vs 0.96± 0.54; P < 0.001) and among asphyxia patients,
a significant negative linear correlation was found between the uric acid to creatinine ratio and the Apgar score (r = −0.857,
P < 0.001). So urinary uric acid to creatinine ratio can be used as an additional non-invasive dispace, easy and at the same
time early biochemical marker of birth asphyxia which biochemically supports the clinical diagnosis and severity grading of
asphyxia by Apgar score. 相似文献
108.
109.
Jyoti Das 《Resonance》2010,15(6):573-580
Loci of points in the Euclidean plane are determined from prescribed relations of the points with given points, and/or, lines.
The dependence of these relations on parameters lead to the diffrential equations representing the family of loci under concern.
Incidentally most of the diffrential equations thus obtained are nonlinear ordinary diffrential equations. 相似文献
110.
Purba Das 《Journal of Intercultural Communication Research》2014,43(3):264-282
This paper investigates how the official discourse of race and caste are constructed in response to the Dalits’ claims that casteism is racism and caste should be included in the World Conference against Racism, Racial Discrimination, and Xenophobia (WCAR held in Durban in 2001). The research question driving this project probes into discursive strategies and logics, which deny any association of caste with race in the Indian context and the significance of race denial. The paper also questions whether the denial of association of race and caste is indicative of racial Indianization. I argue that in India, race lives through the category of caste as a form of racial Indianization. 相似文献