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101.
The effects of training on FNDC5/irisin and its association with fitness and metabolic marker improvements induced by training have been poorly investigated in humans. Thus, the present study assessed the effects of combined training (CT) on FNDC5/irisin levels, metabolic markers and fitness adaptations in obese men. Middle-age obese men (age 49.13?±?5.75, body mass index (BMI) 30.86?±?1.63) were randomly distributed in the CT group (n?=?12) and control group (CG n?=?10). The CT consisted of strength followed by aerobic training, 3 times/week, for 24 weeks. Body composition, physical fitness, plasma FNDC5/irisin, biochemical markers and metabolic scores/index were evaluated. CT maintained FNDC5/irisin levels (µg/mL) (pre: 4.15?±?0.32, post: 4.21?±?0.32; p?=?.96) and improved body composition, metabolic and physical fitness markers. In the CG, decreased FNDC5/irisin (µg/mL) (pre: 4.36?±?0.23, post: 3.57?±?0.94; p?=?.01) and reduced strength (supine exercise/kg) (pre: 71?±?14.7, post: 60.1?±?14.05; p?<?.01) were observed, along with a trend to increase HOMA-IR (pre: 2.63?±?1.11, post: 3.14?±?1.27; p?=?.07) and other indicators of metabolic deterioration. An inverse correlation was found between the change (Δ%) in levels of FNDC5/irisin and Δ% glucose, Δ% total cholesterol, Δ% triglycerides and Δ% waist circumference, in addition to a positive relation with Δ% muscle strength. In conclusion, CT maintained FNDC5/irisin levels and provided metabolic and fitness benefits. The correlation between FNDC5/irisin changes and metabolic parameters, as well as the FNDC5/irisin reduction associated with fitness and metabolic worsening in the CG, suggests a relationship between FNDC5/irisin and a healthy metabolic status in humans.  相似文献   
102.
It is evident that companies and research centres can find a myriad of instruments to fund their R&D (Research & Development) activities. Due to the dynamics of the information management in these circumstances there is a need for intermediary businesses intervention. Consequently, intermediary companies are thus involved in a complex process that needs to be managed and controlled. Within this scenario an Information Technology (IT) platform, named RDi-Advise, was developed by EgeoIT using semantic technologies to support R&D process decisions. This case analysis describes the development and implementation of the platform including the lessons learned during the activity period.  相似文献   
103.
In this paper we evaluate the impact of research grants on the amount of collaboration among scientific researchers in Argentina. We find a positive and significant impact of funding on collaboration which is measured in terms of the number of co-authors for publications in peer-reviewed journals. Our identification strategy is based on comparing collaboration indicators for researchers with financially supported projects with those of a control group of researchers who submitted projects that were accepted in terms of quality, but not supported because of shortage of funds. We obtain consistent results by using different non-experimental techniques including difference-in-differences models combined with propensity score matching algorithms.  相似文献   
104.
Research has shown that many educators do not understand the terminology or displays used in test score reports and that measurement error is a particularly challenging concept. We investigated graphical and verbal methods of representing measurement error associated with individual student scores. We created four alternative score reports, each constituting an experimental condition, and randomly assigned them to research participants. We then compared comprehension and preferences across the four conditions. In our main study, we collected data from 148 teachers. For comparison, we studied 98 introductory psychology students. Although we did not detect statistically significant differences across conditions, we found that participants who reported greater comfort with statistics tended to have higher comprehension scores and tended to prefer more informative displays that included variable-width confidence bands for scores. Our data also yielded a wealth of information regarding existing misconceptions about measurement error and about score-reporting conventions.  相似文献   
105.
The Urban Review - This article concentrates on the educational experiences of urban and suburban Mexican American youth, from recent immigrants to those that have been in the United States for...  相似文献   
106.
Collaborative Filtering techniques have become very popular in the last years as an effective method to provide personalized recommendations. They generally obtain much better accuracy than other techniques such as content-based filtering, because they are based on the opinions of users with tastes or interests similar to the user they are recommending to. However, this is precisely the reason of one of its main limitations: the cold-start problem. That is, how to recommend new items, not yet rated, or how to offer good recommendations to users they have not information about. For example, because they have recently joined the system. In fact, the new user problem is particularly serious, because an unsatisfied user may stop using the system before it could even collect enough information to generate good recommendations. In this article we tackle this problem with a novel approach called “profile expansion”, based on the query expansion techniques used in Information Retrieval. In particular, we propose and evaluate three kinds of techniques: item-global, item-local and user-local. The experiments we have performed show that both item-global and user-local offer outstanding improvements in precision, up to 100%. Moreover, the improvements are statistically significant and consistent among different movie recommendation datasets and several training conditions.  相似文献   
107.
This article gives an account of the use of knowledges from emerging scientific fields in education and youth policy making under the Coalition government (2010–15) in the UK. We identify a common process of ‘translation’ and offer three illustrations of policy-making in the UK that utilise diverse knowledges produced in academic fields (neuroscience, network theory and well-being). This production of ‘new knowledges’ in policy contexts allows for the identification of sites of policy intervention. This process of translation underlies a series of diverse revisions of the rational subject of policy. Collectively, these revisions amount to a change in policy-making and the emergence of a different subject of neoliberal policy. This subject is not an excluded alterity to an included rational subject of neoliberalism, but a ‘plastic subject’ characterised by its multiplicity. The plastic subject does not contradict the rational subject as central to neoliberal policy-making, but diversifies it.  相似文献   
108.
An assumption of culture-based education with respect to American Indian and Alaska Native (AI/AN) children is that discontinuity between home and school cultures is responsible for educational underachievement. Using data from the 2009 round of the National Indian Education Study, a subset of the larger National Assessment of Education Progress (NAEP), the author constructed a measure of cultural discontinuity and examined its relationship to AI/AN students' Grade 4 and 8 reading and mathematics achievement. Contrary to the cultural discontinuity hypothesis, there is no statistically significant negative relationship when the culture of the home is discontinued at school. On the Grade 4 NAEP reading assessment, in particular, cultural discontinuity was positively associated with students' achievement, net of both student- and school-level controls. Findings suggest that the assumptions of culture-based education may be overstated, though longitudinal data are still needed to be able to make causal claims.  相似文献   
109.
Universities must adapt to the challenges of social competitiveness and its new demands but there is still little evidence of how these changes are perceived by the academics. This paper provides insight on this matter and analyses the research culture of five Spanish universities from the perspective of the different academic bodies. A qualitative methodology was employed in the study based on 43 in-depth interviews with institutional leaders (vice-rectors and managers), responsible for research activity, (directors of research centres) and individual researchers (doctoral and postdoctoral researchers). The results point to a clear change in the institutional mission that moves from an institutional model where teaching and research cohabitate together towards another where research activity intensifies. The manifestations of the new research culture is characterised by the quest for efficiency and competitiveness at all levels and bodies. Despite the changes in the university model, participants perceive that the traditional and new models coexist and affect the university structure, the functioning of the centres and departments and the dynamics of the research teams which causes dissatisfaction of the researchers that in this context have to deal with the increasing pressure to publish and obtain external funding to assure ‘survival’. The research culture is also characterised as one that moves towards the scarcity of support measures for training, the confusion perceived between the political discourse and academic practice and the attempt to reposition the university in a social context, through redefining its role and fostering transfer activities.  相似文献   
110.
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