Neurologic approach to specific language disability     

Manuel R. Gomez M.D. 《Annals of dyslexia》1970,20(1):17-29

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Mapping air pollution effects on atmospheric degradation of cultural heritage     

Daniel de la Fuente  Jesús Manuel Vega  Fernando Viejo  Iván Díaz  Manuel Morcillo 《Journal of Cultural Heritage》2013,14(2):138-145

The costs for deterioration and soiling of different materials due to air pollution are huge and the damage to culture targets endangers seriously the rich European cultural heritage. Within the sixth Framework Programme of the EU, the overall aim of the CULT-STRAT project has been to assess and predict the effects of different pollutants on materials and objects of cultural heritage in a multipollutant scenario and to identify indicators and thresholds levels of pollutants. In particular, the present paper reports one of the studies carried out in the CULT-STRAT project at city level and focused on the town of Madrid (Spain). Different maps are shown for the past, present and possible future scenarios: inventory of stock of cultural heritage for each selected material, concentration of selected pollutants (SO₂, NO₂, O₃ and PM₁₀), corrosion (cast bronze) and recession (Portland limestone), exceedance of tolerable degradation thresholds for each material and corrosion-cultural heritage overlapped maps. The model and the methodology developed could be useful if apply it to towns, regions or countries in order to quantify the percentage of Cultural Heritage at risk or to quantify the percentage of the area where corrosion/recession exceeds the established tolerable levels.  相似文献   

Quantification of wall surface heterogeneity and its influence on species diversity at medieval castles – implications for the environmentally friendly preservation of cultural heritage     

Manuel Jonas Steinbauer  Andreas Gohlke  Christine Mahler  Andreas Schmiedinger  Carl Beierkuhnlein 《Journal of Cultural Heritage》2013,14(3):219-228

Historic buildings are important for cultural history and provide a variety of habitats for animals and plants. Especially structural heterogeneity of wall surfaces is perceived to support biological diversity. Nevertheless, in traditional approaches goals of biodiversity preservation and monument restoration are perceived to interfere and to be mutually exclusive. As a consequence, priority is often given to constructional restoration accepting the loss of local populations and biodiversity. At walls of medieval castles, including an experimental restoration project where conventional and less intensive restoration techniques were applied, we relate species composition and richness to wall properties. Especially wall surface structure is quantified using a novel approach. The study focuses on lichens, mosses and vascular plants. Boosted regression tree analyses and non-metric multidimensional scaling techniques are applied to detect the influence of abiotic site conditions on biodiversity. We find species richness to be promoted by wall surface heterogeneity. However, species composition is more affected by restoration approaches than species richness. Lichen composition varies considerably while vascular plants and mosses are less affected by wall properties. We suggest strategies that are combining both societal targets, the preservation of historic monuments and of species diversity. Careful restoration is capable of supporting both, the maintenance of cultural heritage and of rare and unique anthropogenic habitats. Wall surface heterogeneity needs to be witnessed for both aspects as it affects both species composition as well as the effectiveness of cleaning methods.  相似文献   

Internal factors determining a firm’s innovative behaviour     

Jesús Galende  Juan Manuel de la Fuente 《Research Policy》2003,32(5):715-736

The present paper investigates the determinant factors in the organisation of a firm’s innovative activities. Set within a theoretical framework combining evolutionary theory and the resource-based view of the firm, the study includes an original proposal to characterise the innovative process and determines the extent to which a firm’s internal resources and factors explain the innovative process. By applying the econometric analyses techniques to a sample of 152 Spanish innovative companies, empirical findings confirm the existence of interesting relations between internal factors and the innovative process.  相似文献   

A model for developing and assessing youth-based environmental engagement programmes     

Manuel Riemer  Gina Hickman 《Environmental Education Research》2014,20(4):552-574

In this paper, we argue that a fundamental cultural shift is needed to effectively address anthropogenic causes of climate change. Evidence suggests that youth are well positioned to create such transformation. While various studies have contributed empirical evidence to numerous youth-based non-formal environmental engagement programmes, what is missing in the environmental education literature is discussion of a systematic approach to the development and evaluation of these programs. In this paper, we draw on the youth civic engagement literature to propose a framework that can be used as a basis to guide further development of evidence-based practices. Five major components are described as follows: (1) the engagement activity; (2) the engagement process; (3) initiating and sustaining factors; (4) mediators and moderators; and (5) outcomes. This approach to youth engagement can inform both researchers trying to study effective ways of creating change and practitioners developing environmental programmes that aspire towards a culture of sustainability.  相似文献   

The importance of having a flexible scope ISO 15189 accreditation and quality specifications based on biological variation – the case of validation of the biochemistry analyzer Dimension Vista     

Pilar Fernandez-Calle  Sandra Pelaz  Paloma Oliver  Maria Jose Alcaide  Ruben Gomez-Rioja  Antonio Buno  Jose Manuel Iturzaeta 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2013,23(1):83-95

Introduction

Technological innovation requires the laboratories to ensure that modifications or incorporations of new techniques do not alter the quality of their results. In an ISO 15189 accredited laboratory, flexible scope accreditation facilitates the inclusion of these changes prior to accreditation body evaluation. A strategy to perform the validation of a biochemistry analyzer in an accredited laboratory having a flexible scope is shown.

Materials and methods:

A validation procedure including the evaluation of imprecision and bias of two Dimension Vista analysers 1500 was conducted. Comparability of patient results between one of them and the lately replaced Dimension RxL Max was evaluated. All studies followed the respective Clinical and Laboratory Standards Institute (CLSI) protocols. 30 chemistry assays were studied. Coefficients of variation, percent bias and total error were calculated for all tests and biological variation was considered as acceptance criteria. Quality control material and patient samples were used as test materials. Interchangeability of the results was established by processing forty patients’ samples in both devices.

Results:

27 of the 30 studied parameters met allowable performance criteria. Sodium, chloride and magnesium did not fulfil acceptance criteria. Evidence of interchangeability of patient results was obtained for all parameters except magnesium, NT-proBNP, cTroponin I and C-reactive protein.

Conclusions:

A laboratory having a well structured and documented validation procedure can opt to get a flexible scope of accreditation. In addition, performing these activities prior to use on patient samples may evidence technical issues which must be corrected to minimize their impact on patient results.  相似文献   

Correlations between serum and salivary hormonal concentrations in response to resistance exercise     

Eduardo Cadore  Francisco Lhullier  Michel Brentano  Eduardo Silva  Melissa Ambrosini  Rafael Spinelli 《Journal of sports sciences》2013,31(10):1067-1072

Abstract

The aim of present study was to examine the relationships between serum and salivary values of free testosterone, dehydroepiandrosterone, and cortisol before and after a session of resistance exercise. Twenty-eight healthy men (mean age 40 years, s = 4) participated in the present study. Serum and salivary samples were collected at rest and after a multiple-sets resistance exercise protocol, of approximately 25 minutes duration. Concentrations of free testosterone, dehydroepiandrosterone, and cortisol were measured using radioimmunoassay kits. No significant correlation was observed between serum free testosterone and salivary testosterone (r = 0.22 to 0.26, P > 0.05). Serum cortisol was significantly correlated with salivary cortisol before (r = 0.52, P = 0.005) and after (r = 0.62, P = 0.001) the exercise protocol. Serum and salivary concentrations of dehydroepiandrosterone were significantly correlated before (r = 0.68, P < 0.001) and after (r = 0.7, P < 0.001) exercise. The results of the present study suggest that even under exercise conditions, the salivary values of cortisol and dehydroepiandrosterone can reflect the behaviour of these hormones in blood. However, further studies are necessary to verify if salivary testosterone reflects the behaviour of serum free testosterone during resistance exercise.  相似文献   

Protection against muscle damage in competitive sports players: the effect of the immunomodulator AM3     

Alfredo Córdova  J Francisco Martin  Eduardo Reyes  Melchor Alvarez-Mon 《Journal of sports sciences》2013,31(9):827-833

Strenuous physical exercise of the limb muscles commonly results in damage, especially when that exercise is intense, prolonged and includes eccentric contractions. Many factors contribute to exercise-induced muscle injury and the mechanism is likely to differ with the type of exercise. Competitive sports players are highly susceptible to this type of injury. AM3 is an orally administered immunomodulator that reduces the synthesis of proinflammatory cytokines and normalizes defective cellular immune fractions. The ability of AM3 to prevent chronic muscle injury following strenuous exercise characterized by eccentric muscle contraction was evaluated in a double-blind and randomized pilot study. Fourteen professional male volleyball players from the First Division of the Spanish Volleyball League volunteered to take part. The participants were randomized to receive either placebo (n?=?7) or AM3 (n?=?7). The physical characteristics (mean±s) of the placebo group were as follows: age 25.7±2.1 years, body mass 87.2±4.1?kg, height 1.89±0.07?m, maximal oxygen uptake 65.3±4.2?ml?·?kg^?1?·?min^?1. Those of the AM3 group were as follows: age 26.1±1.9 years, body mass 85.8±6.1?kg, height 1.91±0.07?m, maximal oxygen uptake 64.6±4.5?ml?·?kg^?1?·?min^?1. All participants were evaluated for biochemical indices of muscle damage, including concentrations of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatine kinase (CK) and its MB fraction (CK-MB), myoglobin, lactate dehydrogenase, urea, creatinine and γ-glutamyltranspeptidase, both before and 30 days after treatment (over the peak of the competitive season). In the placebo group, competitive exercise (i.e. volleyball) was accompanied by significant increases in creatine kinase (494±51 to 560±53?IU?·?l^?1, P?<?0.05) and myoglobin (76.8±2.9 to 83.9±3.1?μg?·?l^?1, P?<?0.05); aspartate aminotransferase (30.8±3.0 to 31.1±2.9?IU?·?l^?1) and lactate dehydrogenase (380±31 to 376±29?IU?·?l^?1) were relatively unchanged after the 30 days maximum effort. AM3 not only inhibited these changes, it led to a decrease from baseline serum concentrations of creatine kinase (503±49 to 316±37?IU?·?l^?1, P?<?0.05) and myoglobin (80.1±3.2 to 44.1±2.6?IU?·?l^?1, P?<?0.05), as well as aspartate aminotransferase (31.1±3.3 to 26.1±2.7?IU?·?l^?1, P?<?0.05) and lactate dehydrogenase (368±34 to 310±3?IU?·?l^?1, P?<?0.05). The concentration of CK-MB was also significantly decreased from baseline with AM3 treatment (11.6±1.2 to 5.0±0.7?IU?·?l^?1, P?<?0.05), but not with placebo (11.4±1.1 to 10.8±1.4?IU?·?l^?1). In conclusion, the use of immunomodulators, such as AM3, by elite sportspersons during competition significantly reduces serum concentrations of proteins associated with muscle damage.  相似文献   

Prediction of adult height in girls: The Beunen-Malina-Freitas method     

Gaston P. Beunen†  Robert M. Malina  Duarte L. Freitas  Martine A. Thomis  José A. Maia  Albrecht L. Claessens 《Journal of sports sciences》2013,31(15):1683-1691

Abstract

The purpose of this study was to validate and cross-validate the Beunen-Malina-Freitas method for non-invasive prediction of adult height in girls. A sample of 420 girls aged 10–15 years from the Madeira Growth Study were measured at yearly intervals and then 8 years later. Anthropometric dimensions (lengths, breadths, circumferences, and skinfolds) were measured; skeletal age was assessed using the Tanner-Whitehouse 3 method and menarcheal status (present or absent) was recorded. Adult height was measured and predicted using stepwise, forward, and maximum R ² regression techniques. Multiple correlations, mean differences, standard errors of prediction, and error boundaries were calculated. A sample of the Leuven Longitudinal Twin Study was used to cross-validate the regressions. Age-specific coefficients of determination (R ²) between predicted and measured adult height varied between 0.57 and 0.96, while standard errors of prediction varied between 1.1 and 3.9 cm. The cross-validation confirmed the validity of the Beunen-Malina-Freitas method in girls aged 12–15 years, but at lower ages the cross-validation was less consistent. We conclude that the Beunen-Malina-Freitas method is valid for the prediction of adult height in girls aged 12–15 years. It is applicable to European populations or populations of European ancestry.  相似文献   

Sport selection in under-17 male roller hockey     

Manuel J. Coelho-E-Silva  Vasco Vaz  Filipe Simões  Humberto M. Carvalho  João Valente-Dos-Santos  António J. Figueiredo 《Journal of sports sciences》2013,31(16):1793-1802

Abstract

Characteristics of 32 international and 41 local under-17 (U-17) (14.5–16.5 years) roller hockey players were considered in the context of discrimination by competitive level using training history, anthropometry, skeletal maturation, and several laboratory and field performance tests. More international (42%) than local (22%) players were advanced in maturity status. International players had slightly less hockey experience (years), but had more practice sessions and match time (minutes) during the season. Local players were shorter and attained better performance in the 25-m dash, while international players performed better in sit-ups, ball throw and 20-m shuttle run. The fatigue index derived from the Wingate anaerobic test was higher among local players, while peak torques of knee extension and flexion were greater in international players. Stepwise discriminant function correctly classified 85% of players by competitive level based on grip strength, ratio of eccentric and concentric knee extension, number of training sessions, playing time and fatigue index. The results suggested an interaction among strength, anaerobic fitness and training plus game time as factors in discriminating international from local level players and by inference in the selection and development of youth roller hockey players.  相似文献