The effect of marathon running on carnitine metabolism and on some aspects of muscle mitochondrial activities and antioxidant mechanisms   总被引：2，自引：0，他引：2  

M B Cooper  D A Jones  R H Edwards  G C Corbucci  G Montanari  C Trevisani 《Journal of sports sciences》1986,4(2):79-87

Carnitine is an essential co-factor in the catabolism of fats as an energy source. The primary purpose of this study was to investigate the effect of running a marathon on the metabolism of carnitine by endurance-trained athletes, and to evaluate the effect of carnitine administration on the performance of such exercise. The effects of marathon running on mitochondrial enzymes and cellular anti-oxidants were also examined to assess whether the expression of these activities is altered by exercise. Subjects were 10 experienced male marathon runners aged between 19 and 25 years. Running a marathon caused a fall in the plasma content of unesterified carnitine (37%) and an increase in the level of acetylcarnitine present (288%). Loading of the athletes with L-carnitine for 10 days before running a marathon abolished the exercise-induced fall in plasma-free carnitine (P less than 0.05) whilst amplifying the production of acetylcarnitine (P less than 0.05). Carnitine loading of the athletes studied made no detectable improvement in performance of the marathon (P greater than 0.05). Cytochrome oxidase, succinate cytochrome C reductase and superoxide dismutase activities present in skeletal muscle were unaltered by marathon running. However, such exercise caused a large increase in the tissue content of oxidized glutathione (189%) at the expense of reduced glutathione (-18%).  相似文献   

Include me out: critical readings of social exclusion,social inclusion and lifelong learning     

Richard Edwards  Paul Armstrong  Nod Miller 《International Journal of Lifelong Education》2013,32(5):417-428

Social exclusion and inclusion have emerged as strong policy-leading concepts at both the national and international level in recent years. Policies on lifelong learning are themselves in part premised on the contribution education and training can make to promoting an inclusive society. It is argued that social exclusion offends against human dignity, denies people their fundamental human rights and leads, in conjunction with social and economic instability, to marginalization and deepening inequalities, which threaten the stability of democracy. Social inclusion therefore appears to be an unconditional good. The argument in this paper suggests that this is not the case. Drawing on critical social policy studies and post-structuralist philosophy, we argue that the notion of inclusion relies on exclusions, some of which may be chosen and even desirable. We suggest that those interested in lifelong learning should take a more critical stance towards the social inclusion agenda to which it is being harnessed.  相似文献   

Home on the electronic range: bringing the Journal of Animal Science online     

Gregory S. Lewis  John W. Edwards 《Learned Publishing》1998,11(4):265-270

This article describes why the American Society of Animal Science decided to make the Journal of Animal Science available online, some of the issues that were considered before and during the project, and the responses of those who use the electronic journal. The article also contains discussions of new additions to our electronic offerings and the challenge of granting library access to electronic publications. Based on feedback received from American Society of Animal Science members, our online endeavors have been well received, and members perceive these offerings as an important enhancement of membership services.  相似文献   

Criteria for evaluating alternative MEDLINE search engines     

Jacobs M  Edwards A  Graves RS  Johnson ED 《Medical reference services quarterly》1998,17(3):1-12

With so many options available for searching MEDLINE on the World Wide Web or as a component of an online service, evaluation criteria are suggested as a means of assisting librarians in determining the positive and negative aspects of alternative MEDLINE sites. A set of searches was utilized to systematically compare MEDLINE sites. Sites evaluated included Avicenna, America Online, HealthGate, PubMed, Medscape, and Physicians' Online. Some features used to evaluate these sites were: default fields; operators (default); access to MeSH; subheadings; stop words protected in MeSH; truncation; and stemming. This article will describe the group process used to arrive at the evaluation criteria, as well as some general conclusions which will help librarians in directing their users to a particular MEDLINE site.  相似文献   

Introduction: beyond words     

L. Radford  L. Edwards  F. Arzarello 《Educational Studies in Mathematics》2009,70(2):91-95

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Editorial     

John S Edwards 《知识管理研究与实践》2007,5(2):73-74

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Editorial     

John S Edwards 《知识管理研究与实践》2007,5(1):1-2

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Encyclopedia of Knowledge Management     

John S Edwards 《知识管理研究与实践》2007,5(4):315-316

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Editorial     

John S Edwards 《知识管理研究与实践》2008,6(2):103-104

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Editorial     

Edwards  John S 《知识管理研究与实践》2008,6(1):1-4

Knowledge Management Research & Practice -  相似文献