Pre-analytical mysteries: A case of severe hypervitaminosis D and mild hypercalcaemia     

Emma Whittle  Elzahn de Waal  Tony Huynh  Oliver Treacy  Adam Morton 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2021,31(1)

We describe a case of severe hypervitaminosis D and mild hypercalcaemia in a 68-year-old woman who presented with fatigue and weight loss. Her 25-hydroxy vitamin D (25OHD) was > 400 nmol/L (50-150) and corrected serum calcium was 2.83 mmol/L (2.1-2.6). Her intact parathyroid hormone (PTH) was 4.9 pmol/L (2.0-9.5). Further investigation revealed an IgM kappa paraprotein, and a bone marrow aspirate confirmed a diagnosis of lymphoplasmacytic lymphoma/Waldenstrom’s macroglobulinemia (LPL/WM). As the vitamin D level was discordant with the patient’s other results and presentation, the presence of an assay interferent was suspected. A 1-in-2 dilution of the sample returned a 25OHD result of 84 nmol/L in keeping with the presence of an interferent. Testing for rheumatoid factor was negative. The sample was treated with an antibody blocking reagent (Scantibodies) and results were not consistent with heterophile antibody interference. The sample was then analysed using liquid chromatography tandem mass spectrometry (LC-MS/MS), which returned a 25OHD result of 82 nmol/L. Testing on an alternative immunoassay platform produced a 25OHD result of 75 nmol/L. Reapeted testing on the original platform following reduction of the monoclonal paraprotein with chemotherapy, returned a result of 64 nmol/L. The patient’s mild hypercalcaemia persisted following resolution of the monoclonal paraprotein, in keeping with a diagnosis of primary hyperparathyroidism. This case highlights the potential for paraproteins to cause assay interference, and the importance of considering interference when results are incongruous with the clinical presentation.  相似文献   

Human Anatomy: Teaching–Learning Experience of a Support Teacher and a Student with Low Vision and Blindness     

Carolina Rodrigues Mendonça  Karla Tais de Oliveira Souza  Jalsi Tacon Arruda  Matias Noll  Nilza Nascimento Guimarães 《Anatomical sciences education》2021,14(5):682-692

In Brazil, a federal law ensures that all students with disabilities are entitled to enrollment in higher education institutions. Higher courses in human anatomy stand out for their complexity in both theoretical and practical contents. Therefore, adaptation is required to accommodate students with special educational needs. This study aimed to describe the experience of a Support Teacher in the development of inclusive pedagogical practices for the discipline of Human Anatomy offered in the physiotherapy course for a student with low vision and blindness. The challenges and learning difficulties faced by a visually impaired student are reported. Qualitative analysis was performed by interviewing a student with low vision and blindness and a Support Teacher. The audio recordings were transcribed, categorized, and analyzed using content analysis. The Support Teacher created schematics and drawings of anatomical structures, reviewed theoretical and practical contents, developed adaptations of the examinations, and applied palpatory anatomy to facilitate the student’s learning process. The findings illustrate that the student faced the greatest difficulty in dealing with the emotional aspects, due to the inability to visualize the anatomical details in human cadavers. Thus, the presence of a Support Teacher was fundamental to ensure that the student could learn the content and overcome this limitation. In conclusion, personalized adaptation, commitment, and collaborative work between the Support Teacher and students with low vision and blindness improve their learning conditions.  相似文献   

Small-scale curriculum changes for improving pre-service teachers’ preparation for Family-School Partnerships     

Erica de Bruïne  Janneke Franssens  Sofie van Eynde  Lijne Vloeberghs  Leen Vandermarliere 《师资教育杂志》2018,44(3):381-396

Abstract

Family-School Partnerships (FSP) are important for students’ academic achievements and social-emotional development. Therefore, pre-service teachers need to learn how to establish this. However, in teacher education programmes this topic is insufficiently addressed partially attributed to already overloaded programmes. This study reports on a small-scale curriculum change, aiming to foster pre-service teachers’ awareness of the importance of FSP, to broaden their concepts and support them in identifying learning goals for the future. An assignment to interview novice-teachers about FSP was followed by a class on this topic. Afterwards, pre-service teachers reported in written reflections that they had become aware of the importance of FSP, emphasising that FSP is more than just communication. However, their focus for further professionalisation remained on improving their communication skills. Though this small-scale curriculum change seems to be a small step forward to a better preparation on FSP, further improvements are necessary to promote a comprehensive view of FSP.  相似文献   

Increasing cheat robustness of crowdsourcing tasks     

Carsten Eickhoff  Arjen P. de Vries 《Information Retrieval》2013,16(2):121-137

Crowdsourcing successfully strives to become a widely used means of collecting large-scale scientific corpora. Many research fields, including Information Retrieval, rely on this novel way of data acquisition. However, it seems to be undermined by a significant share of workers that are primarily interested in producing quick generic answers rather than correct ones in order to optimise their time-efficiency and, in turn, earn more money. Recently, we have seen numerous sophisticated schemes of identifying such workers. Those, however, often require additional resources or introduce artificial limitations to the task. In this work, we take a different approach by investigating means of a priori making crowdsourced tasks more resistant against cheaters.  相似文献   

Gustavo Bueno: Sciences as Categorical Closures     

Íñigo Ongay de Felipe 《Science & Education》2013,22(9):2347-2349

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The COVID-19 epidemic in Brazil: how statistics education may contribute to unravel the reality behind the charts     

da Silva  Alexandre Sousa  Barbosa  Maria Tereza Serrano  de Souza Velasque  Luciane  da Silveira Barroso Alves  Davi  Magalhães  Marcos Nascimento 《Educational Studies in Mathematics》2021,108(1-2):269-289

Educational Studies in Mathematics - The world is now facing the most severe health, social, and economic event of the last hundred years, which has made the need to acquire statistical thinking to...  相似文献   

桥梁结构安全耐久性分析     

徐向晨  刘德喜 《职业圈》2008,(12):106-107

我国经济发展跨入21世纪城市桥梁成为了城市景观的重要组成部分。但是由于某些原因，国内不少桥梁发生倒塌事故。文章对桥梁事故原因进行了分析，并在此基础上，探讨了减少桥梁安全事故的对策，可供桥梁管理部门参考。  相似文献   

Learning benefits of self-controlled knowledge of results in 10-year-old children   总被引：1，自引：0，他引：1  

Chiviacowsky S  Wulf G  de Medeiros FL  Kaefer A  Tani G 《Research quarterly for exercise and sport》2008,79(3):405-410

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Cortisol levels of caregivers in child care centers as related to the quality of their caregiving     

Elles J. de Schipper  J. Marianne Riksen-Walraven  Sabine A.E. Geurts  Carolina de Weerth 《Early childhood research quarterly》2009

The present study examined whether stress in professional caregivers – as reflected in salivary cortisol levels – is related to the quality of their caregiving behavior. The 221 professional female caregivers in 64 child care centers were observed in three different situations and saliva samples were taken three times during the morning. Results showed that higher levels of cortisol, particularly at the beginning of the workday, predicted lower-quality caregiver behavior beyond the contribution of three other predictors, namely a higher self-reported physical workload, more children under age two in the care group, and lower caregiver age. Contrary to the expectation, higher cortisol levels did not mediate the relation between higher self-reported physical workload and more children under age two on the one hand and lower-quality caregiving behavior on the other.  相似文献   

Mi Superheroe/Heroina: Una Composicion Controlada En Ingles     

M. Paz de la Serna 《Cultura y Educación》2013,25(14):125-126

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