Troponin T and Heart Type Fatty Acid Binding Protein (h-Fabp) as Biomarkers in Patients Presenting with Chest Pain     

Lakshmi Lavanya Reddy  Swarup A. V. Shah  Alpa J. Dherai  Chandrashekhar K. Ponde  Tester F. Ashavaid 《Indian journal of clinical biochemistry : IJCB》2016,31(1):87-92

Acute coronary syndrome (ACS) is a term for a range of clinical signs and symptoms suggestive of myocardial ischemia. It results in functional and structural changes and ultimately releasing protein from injured cardiomyocytes. These cardiac markers play a major role in diagnosis and prognosis of ACS. This study aims to assess the efficacy of heart type fatty acid binding protein (h-FABP) as a marker for ACS along with the routinely used hs-TropT. In our observational study, plasma h-FABP (cut-off 6.32 ng/ml) and routinely done hs-Trop T (cutoff 0.1 and 0.014 ng/ml) were estimated by immunometric laboratory assays in 88 patients with acute chest pain. Based on the clinical and laboratory test findings the patients were grouped into ACS (n = 41) and non-ACS (n = 47). The diagnostic sensitivity, specificity, NPV, PPV and ROC curve at 95 % CI were determined. Sensitivity of hs-TropT (0.1 ng/ml), hs-TropT (0.014 ng/ml) and h-FABP were 53, 86 and 78 % respectively and specificity for the same were 98, 73 and 70 % respectively. Sensitivity, specificity and NPV calculated for a cut-off combination of hs-TropT 0.014 ng/ml and h-FABP was 100, 51 and 100 % respectively. These results were substantiated by ROC analysis. Measurement of plasma h-FABP and hs-TropT together on admission appears to be more precise predictor of ACS rather than either hs-Trop T or h-FABP.  相似文献   

Holographic perspective     

Julian D.C. Jones  Sidney John Rogers 《Endeavour》1984,8(2):52-57

Although the principle of holography was conceived as long ago as 1947, interest was limited until the advent of the laser in 1960 made possible the off-axis holography widely used today. Since then holography has found many applications and become so well known outside the laboratory as to be a recognized art form. Within the last few years considerable progress has also been made in acoustic holography.  相似文献   

Urinary iodine levels in three ecological zones of Bangladesh     

Salamatullah Quazi  M. Mohiduzzaman  Moududur R. Khan  B. Nahar  M. Mostafizur Rahman  M. Nurul Islam  M. Baquer  Chandrakant S. Pandav  Harun K. M. Yusuf 《Indian journal of clinical biochemistry : IJCB》1997,12(2):128-133

Urinary iodine levels in children (5–11 years) and in adult males and females (15–44 years) of three ecological zones (hilly, flood-prone and plains) of Bangladesh were analyzed to determine the status of biochemical iodine deficiency in the country. Data indicated that a large majority of the population all over Bangladesh have biochemical iodine deficiency urinary iodine excretion (UIE) less than the accepted cut-off level of 10 μg/dl. Adults were deficient to comparable degrees, 31.3% severely iodine deficient. The flood-prone zone was less affected: 71.7% children had iodine deficiency and 25% were severely deficient. Adults of this zone were less affected than the children. Iodine deficiency was least severe in the plain zone: 59.8% children were biochemically iodine deficient and of them 23.4% had UIE less than 2.0 μg/dl. In the case of the adults of this zone, 60.8% were biochemically iodine deficient and 20.6% had severe iodine deficiency. The results indicate that Bangladesh as a whole is an iodine deficient region, with the hilly zone being the most severely affected. Children were slightly more affected than the adults, and females were more affected than the males.  相似文献   

The effect of extremely high glucose concentrations on 21 routine chemistry and thyroid Abbott assays: interference study     

Serap ?uhadar  Mehmet K?seo?lu  Yasemin ?inpolat  Güler Bu?dayc?  Murat Usta  Tuna Semerci 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2016,26(1):53-60

Introduction

Extremely high glucose concentrations have been shown to interfere with creatinine assays especially with Jaffe method in peritoneal dialysate. Because diabetes is the fastest growing chronic disease in the world, laboratories study with varying glucose concentrations. We investigated whether different levels of glucose spiked in serum interfere with 21 routine chemistry and thyroid assays at glucose concentrations between 17-51 mmol/L.

Materials and methods

Baseline (group I) serum pool with glucose concentration of 5.55 (5.44-5.61) mmol/L was prepared from patient sera. Spiking with 20% dextrose solution, sample groups were obtained with glucose concentrations: 17.09, 34.52, and 50.95 mmol/L (group II, III, IV, respectively). Total of 21 biochemistry analytes and thyroid tests were studied on Abbott c8000 and i2000sr with commercial reagents. Bias from baseline value was checked statistically and clinically.

Results

Creatinine increased significantly by 8.74%, 31.66%, 55.31% at groups II, III, IV, respectively with P values of < 0.001. At the median glucose concentration of 50.95 mmol/L, calcium, albumin, chloride and FT4 biased significantly clinically (-0.85%, 1.63%, 0.65%, 7.4% with P values 0.138, 0.214, 0.004, < 0.001, respectively). Remaining assays were free of interference.

Conclusion

Among the numerous biochemical parameters studied, only a few parameters are affected by dramatically increased glucose concentration. The creatinine measurements obtained in human sera with the Jaffe alkaline method at high glucose concentrations should be interpreted with caution. Other tests that were affected with extremely high glucose concentrations were calcium, albumin, chloride and FT4, hence results should be taken into consideration in patients with poor diabetic control.Key words: assay interference, glucose interference, preanalytical phase, creatinine, Jaffe kinetic assay, thyroid function tests  相似文献   

“互联网+”环境下大学生网络信息消费影响因素的实证研究   总被引：1，自引：0，他引：1  

程刚  杨春静 《现代情报》2016,36(8):48-54

[目的/意义]为探究互联网+环境下大学生网络信息消费的影响因素,[方法/过程]通过对国内外研究现状以及互联网发展现状的了解,探讨分析了大学生网络信息消费的内涵、大学生网络信息消费的现状以及互联网+对大学生网络信息消费的影响,并采取实证研究的方式,运用SPSS软件对调查问卷所得数据进行信度分析、效度分析、相关性分析和主成分分析,[结果/结论]得出大学生网络信息消费的主要影响因素,并针对大学生网络信息消费当前存在的问题给出优化对策。  相似文献   

Electromagnetism and quantum theory : D.M. Grimes. 151 pages,diagrams, 5 × 8 in. New York,Academic Press, 1969. Price $9.00.     

C.B. Sharpe 《Journal of The Franklin Institute》1971

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Replacing points by compacta in neural network approximation     

Paul C. Kainen 《Journal of The Franklin Institute》2004,341(4):391-399

It is shown that cartesian product and pointwise-sum with a fixed compact set preserve various approximation-theoretic properties. Results for pointwise-sum are proved for F-spaces and so hold for any normed linear space, while the other results hold in general metric spaces. Applications are given to approximation of L_p-functions on the d-dimensional cube, 1?p<∞, by linear combinations of half-space characteristic functions; i.e., by Heaviside perceptron networks.  相似文献   

Liquid–Liquid Extraction and Solid Phase Extraction for Urinary Organic Acids: A Comparative Study from a Resource Constraint Setting     

Chandrawati Kumari  Bijo Varughese  Siddarth Ramji  Seema Kapoor 《Indian journal of clinical biochemistry : IJCB》2016,31(4):414-422

Pre analytical process of extraction for accurate detection of organic acids is a crucial step in diagnosis of organic acidemias by GCMS analysis. This process is accomplished either by solid phase extraction (SPE) or by liquid–liquid extraction (LLE). Both extraction procedures are used in different metabolic laboratories all over the world. In this study we compared these two extraction procedures in respect of precision, accuracy, percent recovery of metabolites, number of metabolites isolated, time and cost in a resource constraint setup. We observed that the mean recovery from SPE was 84.1 % and by LLE it was 77.4 % (p value <0.05). Moreover, the average number of metabolites isolated by SPE and LLE was 161.8 ± 18.6 and 140.1 ± 20.4 respectively. The processing cost of LLE was economical. In a cost constraint setting using LLE may be the practical option if used for organic acid analysis.  相似文献   

Natural History Investigations in South Carolina: from Colonial Times to the Present     

Melinda K. Hayes 《Endeavour》2000,24(4):184

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高校本科生科研的意义、现状与措施   总被引：19，自引：0，他引：19  

季诚钧  黄昌财 《研究与发展管理》2003,15(2):95-98,107

从教学过程、人才培养、科研成果三个角度阐述了本科生科研的意义,并对我国目前高校本科生科研情况作了调查与分析,在此基础上,提出了本列生科研的保障措施。  相似文献