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ABSTRACTCurrent evidence suggests that chronic inflammation contributes to the development of coronary artery disease (CAD). Interestingly, exercise may constitute a method of reducing inflammation in this patient population. As such, this systematic review and meta-analysis examined the evidence generated by randomised studies that investigated the effect of exercise on inflammatory biomarkers in CAD. Literature was sought from various sources. Outcomes were pooled in a random-effects model to calculate standardised mean differences (SMD) with 95% confidence intervals (CI). Twenty-five studies were reviewed; post-intervention C-reactive protein (SMD: ?0.55 (95% CI: ?0.93, ?0.16), P = 0.005), fibrinogen (SMD: ?0.52 (95% CI: ?0.74, ?0.29, P = <0.00001)), and von Willebrand factor (SMD: ?1.57 (95% CI: ?2.23, ?0.92), P = <0.00001) values were significantly lower in exercise groups compared to controls. In addition, qualitative analyses identified evidence that supports a beneficial effect of exercise on these acute-phase reactants. However, the impact of exercise on anti–inflammatory cytokines, adhesion molecules, and chemokines is equivocal, which may be attributed to a paucity of research. Nevertheless, the findings of this review suggest that exercise induces an anti–inflammatory effect in CAD patients. Although, the quality of evidence needs to be improved by further randomised studies with high methodological qualities and large sample sizes. 相似文献
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Thiolene-based microfluidic devices have been coupled with surface plasmon resonance imaging (SPRI) to provide an integrated platform to study interfacial interactions in both aqueous and organic solutions. In this work, we develop a photolithographic method that interfaces commercially available thiolene resin to gold and glass substrates to generate microfluidic channels with excellent adhesion that leave the underlying sensor surface free from contamination and readily available for surface modification through self-assembly. These devices can sustain high flow rates and have excellent solvent compatibility even with several organic solvents. To demonstrate the versatility of these devices, we have conducted nanomolar detection of streptavidin-biotin interactions using in situ SPRI. 相似文献
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This paper explores historical patterns of change in participation in higher education in Wales, using as an organising framework Halsey's (1992) distinction between higher education as an administrative and as a social system. The nineteenth-century development of Welsh higher education was both part of a distinctive national political project and reflected the specificities of wider Welsh society. Expansion through the early and middle decades of the present century eroded this distinctiveness, as both the governance of Welsh higher education and patterns of student recruitment and participation became increasingly integrated into an 'England and Wales' system. The more recent expansion of higher education institutions in Wales, as well as the participation of Welsh students in higher education overall, has further accentuated this social integration into an 'England and Wales' system. Currently, Wales exhibits a pattern of participation which is unique amongst the home countries, whereby the Welsh higher education institutions serve very substantial numbers of students from England (and to a much lesser extent elsewhere), whilst a large proportion of Welsh students register at institutions in England. This indicates that there is now a significant disjuncture between an increasingly distinct pattern of governance of Welsh higher education and a pattern of participation which is massively integrated in the 'England and Wales' system. 相似文献
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The major findings and conclusions of a survey of manpower in health sciences libraries of the United States in 1969 are summarized. Although there does not appear to be a serious manpower shortage in terms of budgeted positions which are unfilled (demand), the manpower situation can still be considered serious when we introduce into our evaluation of the situation the question of existing levels of training and the urgent requirement (need) to bring manpower levels to a point at which adequate information services can be provided to the whole health sciences community. This is the final paper in a series of papers on a manpower study which also summarizes and analyzes the manpower data obtained by the American Hospital Association survey of 1968 and presents a number of general conclusions and recommendations for manpower planning for health sciences libraries. 相似文献
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