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31.
Huma Nasrat Surajeet K. Patra Binita Goswami Anju Jain Chitra Raghunandan 《Indian journal of clinical biochemistry : IJCB》2016,31(1):104-107
Polycystic ovary syndrome (PCOS) is a common endocrinological disorder among women of the reproductive age group with long term sequelae which include diabetes mellitus, hypertension and CAD. The present study was conducted to evaluate the association of leptin—an adipokine playing an important role in carbohydrate metabolism and markers of insulin resistance among women with PCOS. Sixty diagnosed cases of PCOS as per Rotterdam criteria were enrolled in this study after informed written consent. Insulin resistance was estimated using the homeostatic model assessment-insulin resistance (HOMA-IR). HOMA-IR was calculated as the product of the fasting plasma insulin value (mU/ml) and the fasting plasma glucose value (mg/dl), divided by 405 and HOMA β was calculated as 360 × [insulin]/([glucose] − 63) % (glucose in mg/dl). Estimation of serum leptin levels was done by ELISA using leptin ELISA kit from (DRG). A positive correlation of serum leptin levels was observed with markers of insulin resistance. Multiple regression analysis with HOMA-IR as dependent variable demonstrated a statistically significant contribution of fasting insulin levels. This study highlights the role of leptin in alterations in carbohydrate metabolism in patients with PCOS. 相似文献
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Moushumi Lodh Binita Goswami Rajni Dawar Mahajan Dipankar Sen Nirmal Jajodia Abhishek Roy 《Indian journal of clinical biochemistry : IJCB》2015,30(2):174-179
Low back pain is very disabling and dispiriting because of the physical impediment it causes and its psychological effects. Innumerable factors have been implicated in its etiology. In spite of improvements in diagnostic modalities, a considerable number of such cases fall in the ambiguous zone of unknown etiology or ‘idiopathic.’Early diagnosis of low back pain will allow effective prevention and treatment to be offered. This study was conducted to assess the contribution of vitamin D levels and other biochemical factors to chronic low back pain in such cases. All patients attending the orthopedics OPD for low back pain in whom a precise anatomical cause could not be localized, were prospectively enrolled in this study. We measured serum levels of glucose, calcium, phosphorus, uric acid, rheumatoid factor, C reactive protein, alkaline phosphatase, total protein, albumin and 25 (OH) D concentrations in 200 cases and 200 control samples. The patients showed significantly lower vitamin D levels compared to controls with p value < 0.0001. The maximum number of low back pain patients were in the age group of 31–50 years (42 %).The average BMI was 23.27 ± 5.17 kg/sq m, 73 % of total patient population were females and 27 % were known case of type 2 diabetes mellitus. Calcium, alkaline phosphatase, was positively correlated with vitamin D and glucose showed a negative correlation with vitamin D in the patient population. The problem of low back pain provides a challenge to health care providers. The problem in developing countries is compounded by ignorance to report for early treatment and occupational compulsions in rural areas and sedentary lifestyle in urban youth. The authors strongly recommend early frequent screening for vitamin D along with glucose, protein, albumin, calcium, phosphorus, CRP as part of general health checkup for non-specific body pain, especially low back pain. 相似文献
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Usha Goswami 《Educational Psychology in Practice》2005,21(4):273-282
Arguments about how to teach initial reading are once more in the news. Proponents of “synthetic phonics” argue that there is only one effective way to teach a child to read. In this anniversary issue, it is worth taking a step back from the polarisation of the “synthetic” versus “analytic” phonics debate, to consider the evidence base for reading acquisition across languages. Most children will eventually become competent, indeed skilled, readers of their languages, but in some languages this happens much faster than in others. There appear to be two key factors. One is the phonological complexity of the spoken language, and the other is the spelling consistency of the written language. A thorough understanding of cross‐language similarities and differences in the key developmental processes for literacy acquisition is required if teaching strategies are to be optimised in different languages. 相似文献
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Sue Lacey Bryant David Stewart Louise Goswami Maria J. Grant 《Health information and libraries journal》2016,33(3):167-171
Significant progress has been made in implementing Knowledge for Healthcare. This editorial reports the central contribution of effective partnerships and the involvement of librarians and knowledge specialists in this work. There are compelling business priorities. Key elements of work‐streams on demonstrating impact, workforce development and streamlining are indicated, along with areas of growing importance – knowledge management, embedded roles and health information for the public and patients. Knowledge, and the skills to help people to use it, are business critical. 相似文献
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Mahajan RS Veerpathran A Dakshinamoorthy G Sharma RD Goswami K Reddy MV 《Indian journal of clinical biochemistry : IJCB》2010,25(4):362-366
WHO-Tropical Disease Research scheme highlighted the need for development of new anti-filarial drugs. Certain antibiotics
have recently been found effective against Wolbachia, co-existing symbiotically with filarial parasites. Inflammatory response
entails oxidative mechanism to educe direct anti-microbial effect. In the present study microfilariae were maintained in vitro
in medium supplemented with varying concentrations of tetracycline, doxycycline (20–100 μg/ml) or ciprofloxacin (50–250 μg/ml)
separately to find out any involvement of oxidative mechanism in the anti-filarial effect of these antibiotics. Loss of motility
of the microfilariae was measured after 48 h and correlated with the levels of MDA, nitric oxide and protein-carbonylation.
Significant loss of microfilarial motility was recorded with increasing concentration of tetracycline and doxycycline but
with ciprofloxacin the effect was not marked. Agents with high antifilarial activity revealed significant association with
oxidative parameters in a dose dependent manner. The result suggests that oxidative effect might be exploited to design novel
antifilarial drug candidate. 相似文献
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Elisabeth S. Pasquini Kathleen H. Corriveau Usha Goswami 《Scientific Studies of Reading》2013,17(3):259-286
Studies of basic (nonspeech) auditory processing in adults thought to have developmental dyslexia have yielded a variety of data. Yet there has been little consensus regarding the explanatory value of auditory processing in accounting for reading difficulties. Recently, however, a number of studies of basic auditory processing in children with developmental dyslexia have suggested that a reduced ability to discriminate the rate of change in amplitude envelope onsets (rise time) may be linked to phonological processing difficulties and thereby to reading difficulties. Here, we select a range of different rise-time tasks used with children, and give them to adults with developmental dyslexia, along with 2 other auditory tasks (intensity discrimination and temporal order judgment). Deficits in both rise-time perception and temporal order judgment were found to predict literacy attainment in adults with developmental dyslexia, but the data were suggestive of different causal pathways. 相似文献
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Sue Lacey Bryant David Stewart Louise Goswami Maria J. Grant 《Health information and libraries journal》2015,32(3):163-167
Many people are still not receiving the right care. It is imperative for health care librarians to come together around a common vision to achieve Knowledge for Healthcare so that the right knowledge and evidence is used at the right time in the right place. The authors describe five workstreams within a modernisation programme: Service Transformation, Workforce Planning and Development, Quality and Impact, Resource Discovery and Optimising Investment. Communications, engagement and partnership working are central to success. The development framework sets out principles on which to base decisions, and design criteria for transforming services. 相似文献