Role of Plasma MMP 9 levels in the Pathogenesis of Chronic Pancreatitis     

Venkateshwari A  Sri Manjari K  Krishnaveni D  Nallari P  Vidyasagar A  Jyothy A 《Indian journal of clinical biochemistry : IJCB》2011,26(2):136-139

Pancreatic fibrosis is a key pathological feature in the etiology of chronic pancreatitis that leads to obliteration of exocrine and endocrine pancreatic tissues and its replacement by fibrous tissue resulting in clinical manifestations. Matrix metalloproteinase 9 is a member of the MMP family that is also known as gelatinase B, degrades type IV collagen of extracellular matrix and basal membrane. The present study is aimed at evaluating the clinical significance of plasma concentration of MMP-9 in chronic pancreatitis. The samples were obtained from 112 chronic pancreatitis patients and an equal number of age and sex matched healthy controls. MMP-9 levels were quantitatively measured by ELISA assay. Statistical analysis was applied to test the significance of results. The present study revealed a significant increase of plasma MMP 9 levels in chronic pancreatitis patients compared to control subjects. Elevated levels were also observed in all the patient groups compared to control subjects with regard to sex, age, addictions etc. MMP-9 degrades the type IV collagens in normal basement membrane, which in turn activates the pancreatic stellate cells which promote the development of pancreatitic fibrosis. Thus, elevated plasma levels of MMP-9 may act as a susceptibility factor for the development of chronic pancreatitis.  相似文献   

Organic Acidurias: An Updated Review     

Kannan Vaidyanathan  M. P. Narayanan  D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2011,26(4):319-325

Organic acidurias are an important class of inherited metabolic disorders arising due to defect in intermediary metabolic pathways of carbohydrate, amino acids and fatty acid oxidation. This review summarizes the current knowledge about the important organic acidurias in the Indian population. Specifically, diagnosis and principles of treatment of organic acidurias are covered. The salient features of common organic acidurias as well as their prevalence in various parts of the world are reviewed in some detail.  相似文献   

Profile of Plasma Amino Acid Levels in Rats Exposed to Acute Hypoxic Hypoxia     

Haruhiro Muratsubaki  Akiko Yamaki 《Indian journal of clinical biochemistry : IJCB》2011,26(4):416-419

The effect of acute hypoxic hypoxia on the profile of plasma amino acids in rats was studied and compared to that resulting from acute liver injury induced by giving carbon tetrachloride. In hypoxic rats exposed to 45% air in N₂ for 5 h, the concentrations of branched chain amino acids, including valine, leucine and isoleucine, and aromatic amino acids such as phenylalanine and tyrosine were significantly increased as compared to those in normoxic rats. The ratio of branched-chain to aromatic amino acids (Fischer’s ratio) was significantly decreased. The levels of arginine and citrulline, which are related to the urea cycle, were also depressed. Furthermore, plasma proline level was reduced in hypoxic rats. The activities of plasma marker enzymes for tissue damage remained unchanged during hypoxia, indicating that tissue injury was not induced by exposure to hypoxic conditions. We suggest that the characteristic profile of plasma amino acids and the Fischer ratio are valuable tools for understanding the pathology of acute hypoxia in the absence of systemic tissue damage.  相似文献   

Putting the mangle to the test     

Stephen?HealyEmail author 《Metascience》2011,20(3):525-528

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Fraud from the frontlines: the importance of being nice     

Heather Douglas 《Metascience》2011,20(3):553-556

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Remembering Kolmogorov     

Paul?M.?B.?VitányiEmail author 《Metascience》2011,20(3):509-511

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Owen revisited     

Henry A. McGhie 《Metascience》2011,20(2):335-337

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Circulating Biomarkers and their Possible Role in Pathogenesis of Chronic Hepatitis B and C Viral Infections     

Khan S  Bhargava A  Pathak N  Maudar KK  Varshney S  Mishra PK 《Indian journal of clinical biochemistry : IJCB》2011,26(2):161-168

The present study evaluated the plausible role of circulating biomarkers in immune pathogenesis of chronic hepatitis considered a priority in clinical hepatology. Total viral load of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) patients was quantified and correlation studies were performed with circulating levels of Th1/Th2 cytokines; C reactive protein and circulating nucleosomes; glutathione reductase (GR) and superoxide dismutase. To our knowledge, the study is first among its kind that validates strong positive correlation of viral load with IL-4, IL-6, GR in HBV and IL-6, IL-10, GR in HCV infections. Although, multi-centric studies including large cohorts are required for translating our findings to clinical practice, however, role of these biomarkers with potential diagnostic or prognostic significance might be helpful in clinical assessment of high-risk individuals, thereby, designing interventional strategies, towards development of personalized medicare. The results of our study also offer valuable insights of immune signaling mediators engaged in development of hepatocellular carcinoma.  相似文献   

Adiponectin Gene Polymorphism and its Association with Type 2 Diabetes Mellitus     

Biswas D  Vettriselvi V  Choudhury J  Jothimalar R 《Indian journal of clinical biochemistry : IJCB》2011,26(2):172-177

Mutations in different regions of adiponectin gene have been reported to be associated with obesity, atherosclerosis and type 2 diabetes mellitus. The present study was aimed to investigate the association among SNP 45 T > G of adiponectin gene and type 2 diabetes in South Indian population. 75 clinically diagnosed case of type 2 diabetes were studied and compared with 75 apparently healthy controls. The genotype frequency of SNP45 T > G in exon 2 of adiponectin gene was determined by PCR based restriction enzyme analysis using the restriction enzyme SmaI. (recognition site: CCC↓GGG). Three kind of genotypes: wild type TT (470 bp), heterozygous type TG (470 bp, 336 bp, 134 bp) and homozygote mutant type GG (336 bp, 134 bp) were studied. A positive association has been found between SNP45 T > G and type 2 diabetes in the study population (P = 0.010, OR = 3.797, 95% CI = 1.312–10.983). Therefore, SNP45T > G in adiponectin gene may be one of the risk factors for type 2 diabetes.  相似文献   

“Omics” and Biomedical Informatics: The Future of Pathology and Pathology Informatics. But,are we Ready for the Future?     

Wong MC  Udayan R  Yee KC 《Indian journal of clinical biochemistry : IJCB》2011,26(3):217-221

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