Disambiguation and co-authorship networks of the U.S. patent inventor database (1975–2010)     

Guan-Cheng Li  Ronald Lai  Alexander D’Amour  David M. Doolin  Ye Sun  Vetle I. Torvik  Amy Z. Yu  Lee Fleming 《Research Policy》2014

Research into invention, innovation policy, and technology strategy can greatly benefit from an accurate understanding of inventor careers. The United States Patent and Trademark Office does not provide unique inventor identifiers, however, making large-scale studies challenging. Many scholars of innovation have implemented ad-hoc disambiguation methods based on string similarity thresholds and string comparison matching; such methods have been shown to be vulnerable to a number of problems that can adversely affect research results. The authors address this issue contributing (1) an application of the Author-ity disambiguation approach (0170 and 0175) to the US utility patent database, (2) a new iterative blocking scheme that expands the match space of this algorithm while maintaining scalability, (3) a public posting of the algorithm and code, and (4) a public posting of the results of the algorithm in the form of a database of inventors and their associated patents. The paper provides an overview of the disambiguation method, assesses its accuracy, and calculates network measures based on co-authorship and collaboration variables. It illustrates the potential for large-scale innovation studies across time and space with visualizations of inventor mobility across the United States. The complete input and results data from the original disambiguation are available at (http://dvn.iq.harvard.edu/dvn/dv/patent); revised data described here are at (http://funglab.berkeley.edu/pub/disamb_no_postpolishing.csv); original and revised code is available at (https://github.com/funginstitute/disambiguator); visualizations of inventor mobility are at (http://funglab.berkeley.edu/mobility/).  相似文献   

Pluralism,social action and the causal space of human behavior     

James Tabery  Alex Preda  Helen Longino 《Metascience》2014,23(3):443-459

  相似文献   

How to conduct External Quality Assessment Schemes for the pre-analytical phase?     

Gunn B.B. Kristensen  Kristin Moberg Aakre  Ann Helen Kristoffersen  Sverre Sandberg 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2014,24(1):114-122

In laboratory medicine, several studies have described the most frequent errors in the different phases of the total testing process, and a large proportion of these errors occur in the pre-analytical phase. Schemes for registration of errors and subsequent feedback to the participants have been conducted for decades concerning the analytical phase by External Quality Assessment (EQA) organizations operating in most countries. The aim of the paper is to present an overview of different types of EQA schemes for the pre-analytical phase, and give examples of some existing schemes. So far, very few EQA organizations have focused on the pre-analytical phase, and most EQA organizations do not offer pre-analytical EQA schemes (EQAS). It is more difficult to perform and standardize pre-analytical EQAS and also, accreditation bodies do not ask the laboratories for results from such schemes. However, some ongoing EQA programs for the pre-analytical phase do exist, and some examples are given in this paper. The methods used can be divided into three different types; collecting information about pre-analytical laboratory procedures, circulating real samples to collect information about interferences that might affect the measurement procedure, or register actual laboratory errors and relate these to quality indicators. These three types have different focus and different challenges regarding implementation, and a combination of the three is probably necessary to be able to detect and monitor the wide range of errors occurring in the pre-analytical phase.  相似文献   

Sub-nanomolar detection of thrombin activity on a microfluidic chip     

Nam Cao Hoai Le  Murat Gel  Yonggang Zhu  Jian Wang  Helen Dacres  Alisha Anderson  Stephen C. Trowell 《Biomicrofluidics》2014,8(6)

Bioluminescence resonance energy transfer (BRET) is a form of Förster resonance energy transfer. BRET has been shown to support lower limits of detection than fluorescence resonance energy transfer (FRET) but, unlike FRET, has not been widely implemented on microfluidic devices for bioanalytical sensing. We recently reported a microscope-based microfluidic system for BRET-based biosensing, using a hybrid, high quantum-efficiency, form of BRET chemistry. This paper reports the first optical fiber-based system for BRET detection on a microfluidic chip, capable of quantifying photon emissions from the low quantum-efficiency BRET² system. We investigated the effects of varying core diameter and numerical aperture of optical fibers, as well as varying microfluidic channel design and measurement conditions. We optimized the set-up in order to maximize photon counts and minimize the response time. The optimized conditions supported measurement of thrombin activity, with a limit of detection of 20 pM, which is lower than the microscope-based system and more than 20 times lower than concentrations reported to occur in plasma clots.  相似文献   

Evaluating the Responsiveness of Accelerometry to Detect Change in Physical Activity     

Alexander H. Montoye  Karin A. Pfeiffer  Darijan Suton  Stewart G. Trost 《Measurement in physical education and exercise science》2014,18(4):273-285

The responsiveness to change of the Actical and ActiGraph accelerometers was assessed in children and adolescents. Participants (N = 208) aged 6 to 16 years completed two simulated free-living protocols, one with primarily light-to-moderate physical activity (PA) and one with mostly moderate-to-vigorous PA. Time in sedentary, light, moderate, and vigorous PA was estimated using 8 previously developed cut-points (4 for Actical and 4 for ActiGraph) and 5-sec, 15-sec, and 30-sec epochs. Accelerometer responsiveness for detecting differences in PA between protocols was assessed using standardized response means (SRMs). SRM values ≥.8 represented high responsiveness to change. Both accelerometers showed high responsiveness for all PA intensities (SRMs = 1.2–4.7 for Actical and 1.1–3.3 for ActiGraph). All cut-points and epoch lengths yielded high responsiveness, and choice of cut-points and epoch length had little effect on responsiveness. Thus, both the Actical and ActiGraph can detect change in PA in a simulated free-living setting, irrespective of cut-point selection or epoch length.  相似文献   

Unsteady flow phenomena in human undulatory swimming: a numerical approach     

Steffen Pacholak  Stefan Hochstein  Alexander Rudert  Christoph Brücker 《Sports biomechanics / International Society of Biomechanics in Sports》2014,13(2):176-194

The undulatory underwater sequence is one of the most important phases in competitive swimming. An understanding of the recurrent vortex dynamics around the human body and their generation could therefore be used to improve swimming techniques. In order to produce a dynamic model, we applied human joint kinematics to three-dimensional (3D) body scans of a female swimmer. The flow around this dynamic model was then calculated using computational fluid dynamics with the aid of moving 3D meshes. Evaluation of the numerical results delivered by the various motion cycles identified characteristic vortex structures for each of the cycles, which exhibited increasing intensity and drag influence. At maximum thrust, drag forces appear to be 12 times higher than those of a passive gliding swimmer. As far as we know, this is the first disclosure of vortex rings merging into vortex tubes in the wake after vortex recapturing. All unsteady structures were visualized using a modified Q-criterion also incorporated into our methods. At the very least, our approach is likely to be suited to further studies examining swimmers engaging in undulatory swimming during training or competition.  相似文献   

The Folklore of Wall Street Gamesmanship,Gurus, and the Myth-Making Process     

Arthur G. Neal  Helen L. Youngelson 《Journal of American culture (Malden, Mass. : 2003)》1988,11(1):55-62

  相似文献   

Parental education in Cyprus: Past,present and future     

Helen Phtiaka 《International Studies in Sociology of Education》2013,23(1):95-107

The article examines the history of parental education in Cyprus from its beginnings in the 1960s until the present day, in the wider context of Cypriot history and education. It considers the three main forums of parental education in the country, the Pancyprian School for Parents, the Adult Education Centres of the Ministry of Education and Culture and the University of Cyprus, which roughly coincide with the past, the present and the future of parental education on the island. The article comments on the development of the teaching philosophy and approach in the area of parental education, namely from a passive teacher centred traditional didactic model to a more dynamic participatory partnership.  相似文献   

Writing learning journals: Instructional support to overcome learning-strategy deficits     

Sandra Hübner  Matthias Nückles  Alexander Renkl 《Learning and Instruction》2010,20(1):18-29

Although writing learning journals is a powerful learning tool, instructional support is needed to overcome deficits in the use of self-regulated learning strategies. In a 2 × 2 experimental design with high-school students (N = 70), we analysed the effects of two modes of instruction (namely, informed prompting and learning-journal example) along with prompts. Informed prompting that provided background information on the prompted strategies enhanced learning in the training and transfer session. A learning-journal example that modelled the application of the strategies primarily fostered the strategy used in the training session and learning in the transfer session. Theoretically, the results provide support for the self-regulation view of writing-to-learn.  相似文献   

Israel and the Teaching of Jewish Identity     

Alexander M. Dushkin 《Journal of Jewish Education》2013,79(2-3):21-26

  相似文献