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61.
Ranjana Singh Sumita Sharma Raj K. Singh Germaine Cornelissen 《Indian journal of clinical biochemistry : IJCB》2016,31(2):215-223
The circadian rhythm of human circulating lipid components was studied under nearnormal tropical conditions in 162 healthy volunteers (103 males and 59 females; 7 to 75 years of age). They followed a diurnal activity from about 06:00 to about 22:00 and nocturnal rest. These volunteers were divided into four groups: Group A (7–20 years), Group B (21–40 years), Group C (41–60 years) and Group D (61–75 years), comprising 42, 60, 35 and 25 participants, respectively. A marked circadian rhythm was demonstrated for each studied variable in each group by population-mean cosinor analysis (almost invariably p < 0.001). Furthermore, circadian rhythm characteristics were compared among the 4 groups by parameter tests and regressed as a function of age, separately for males and females. A second-order polynomial characterized the MESOR of HDL cholesterol, phospholipids and total lipids, as well as the 24-h amplitude of total cholesterol and phospholipids. The 24-h amplitude of total lipids decreased linearly with age. The 24-h acrophase of the oldest age group (Group D) was advanced in the case of total cholesterol, HDL cholesterol, and total lipids, whereas that of phospholipids was delayed. Mapping the circadian rhythm (an important component of the broader time structure or chronome, which includes a. o., trends with age and extra-circadian components) of lipid components is needed to explore their role in the aging process in health. 相似文献
62.
The government has made great strides in redressing past imbalances in education through the National Norms and Standards for School Funding (NNSSF) policy that focuses on equity in school funding. This NNSSF model compels the state to fund public schools according to a poverty quintile system, where poor schools are allocated much more funding for resources than affluent schools. Using qualitative research, school management teams, school governing bodies and principals of six public schools located within the Gauteng West District were interviewed to determine their views of how the NNSSF policy had been implemented. One of the findings revealed that equity in public schools has not been fully achieved since funding provided by the state is insufficient to address the backlog in educational resources. It is recommended that the state abandons the policy of funding schools according to quintile rankings but instead, fund schools based on resource needs. 相似文献
63.
P. J. Sanjeeva Raj 《Resonance》2008,13(7):648-654
Keystone species are crucial in restoration ecology. Among all the keystone species known so far, live oysters are by far,
the most efficient ‘keystone niches’, attracting hundreds of species to them. A new classification of keystone species is
presented, including oysters as the best keystone niches.
P J Sanjeeva Raj taught, researched and published on ecology, for the past 55 years. For his work on the Pulicat Lake, he
was awarded the Karmavirar Kamrajar Environmental Award for 2002–2003, by the Department of Environment of the Tamil Nadu
Government. 相似文献
64.
Rizwan Ahmad Anil K. Tripathi Payal Tripathi Ranjana Singh Sushma Singh Raj K. Singh 《Indian journal of clinical biochemistry : IJCB》2008,23(4):328-333
Chronic myeloid leukemia is a myeloproliferative disorder with a unique rearrangement, the Philadelphia chromosome. Oxidative
stress, a pervasive condition of an increased number of reactive oxygen species, is now recognized to be prominent feature
of various diseases and their progression. Thus antioxidants, which control the oxidative stress state, represent a major
line of defense regulating overall true state of health. The relationship between antioxidants status and levels of well-known
markers of oxidative stress that are measured as lipid peroxides and oxidized proteins reflect better health indices and postures.
The aim of this study was to evaluate the role of oxidative stress in pathophysiology of Chronic myeloid leukemia by measuring
the circulating plasma lipid peroxide levels in terms of malonyldialdehyde, total lipid hydroperoxide and oxidized proteins
as protein carbonyl whereas antioxidant status were estimated in terms of reduced glutathione and total thiol in plasma of
Chronic myeloid leukemia patients. The present study included 47 Chronic myeloid leukemia patients and 20 age-and sex-matched
healthy subjects. Out of 47 Chronic myeloid leukemia patients, 31 were in chronic phase (CML-CP) and 16 in accelerated phase
(CML-AP). The median age of Chronic myeloid leukemia patients was 33 years and that of controls was 32 years. Oxidative stress
and antioxidant status in plasma were evaluated by spectrophotometric procedures. There was a significant increase (p<0.05)
in plasma malonyldialdehyde, total lipid hydroperoxide and protein carbonyl levels in Chronic myeloid leukemia patients as
compared to healthy subjects. Our results also showed that plasma malonyldialdehyde and protein carbonyl levels were markedly
elevated (p<0.05) in both chronic phase (CML-CP) and accelerated phase (CML-AP) as compared to healthy volunteers. Antioxidant
status was found to be significantly decreased (p<0.05) in Chronic myeloid leukemia patients and its phases as compared to
healthy participants. It could be concluded that oxidative stress may be associated with the pathophysiology of Chronic myeloid
leukemia. 相似文献
65.
Manisha Mavai Yogendra Raj Singh R. C. Gupta Sandeep K. Mathur Bharti Bhandari 《Indian journal of clinical biochemistry : IJCB》2018,33(2):222-228
Autonomic activity may be deranged in thyroid dysfunctions and may lead to cardiovascular morbidity and mortality. Myopathy is a common manifestation in thyroid disorders and may be associated with raised serum creatine kinase (CK). We hypothesized that cardiovascular abnormality in thyroid dysfunction may manifest as raised CK-MB. This study was designed to investigate the correlation of CK and its isoform CK-MB with thyroid profile and linear parameters of heart rate variability (HRV). The study was conducted on 35 hypothyroid and hyperthyroid patients each, and 25 age-matched healthy controls. Autonomic activity was assessed by simple short term 5-min HRV. Biochemical evaluation of serum thyroid profile, CK-NAC and CK-MB were estimated in all the subjects. Our results demonstrated low HRV in hypo- as well as hyperthyroid patients. We observed significantly higher serum CK levels in hypothyroid patients when compared to hyperthyroids and controls. However, no significant differences were observed in CK-MB levels in the three groups. Significant positive correlation of CK with TSH and negative correlation with some HRV parameters (LF power, HF power, total power, SDNN, RMSSD) was observed in hypothyroid patients. Whereas correlation of CK-MB with thyroid profile as well as HRV parameters was non-significant in all the groups. Based on the CK and CK-MB findings and their correlation, we conclude that the cardiovascular changes seen in thyroid dysfunctions may primarily be due to autonomic imbalance without apparent cardiac muscle involvement. Whereas, raised CK levels indicate predominantly skeletal muscle involvement in hypothyroid patients. 相似文献
66.
Rajeev Singh Kushwaha R. C. Gupta J. P. Sharma Sumita Sharma Raj Kumar Singh Germaine Cornelissen 《Indian journal of clinical biochemistry : IJCB》2017,32(2):220-224
Circadian periodicity of plasma lipid peroxides and serum ascorbic acid and uric acid levels were studied in one hundred renal stone formers (55 women and 45 men; age 20–60 years) and 50 clinically healthy volunteers (21 women and 29 men; age 21–45 years) with diurnal activity from 06:00 to 22:00 and nocturnal rest. A marked circadian variation was demonstrated by population-mean-cosinor for all studied variables in stone formers and healthy subjects. By comparison to the healthy controls, parameter tests indicate that the stone formers had a higher MESOR (±SE) of MDA (2.90 ± 0.03 vs. 2.28 ± 0.06; F = 94.929, p < 0.001), a lower MESOR of serum ascorbic acid (0.722 ± 0.010 vs. 0.839 ± 0.10; F = 32.083, p < 0.001), and a similar MESOR of serum uric acid. Furthermore, the patients also differed from the healthy subjects in terms of their circadian amplitude and acrophase (tested jointly) of all three variables (p < 0.001). The demonstration herein of a circadian rhythm in MDA, serum ascorbic and uric acid suggests that these variables could also serve as markers to optimize the timing of treatment and to assess the patient’s response to treatment for further management. 相似文献
67.
Interchange - With frequent curriculum changes in South Africa since 1994, educational standards and learner performance has been progressing at a slow pace. The role of the principal’s... 相似文献
68.
Creativity is usually defined in terms of the production end of ideas or products, yet a neglected aspect of creativity, though no less vital, is the process by which creative products are critically evaluated, selected, altered or dismissed by the creator. Any attempt to promote creative thinking skills in schools needs to also address this aspect of critical thinking in creativity—failure to do so results not in usefully creative children, but merely indulgent ones. 相似文献