On the influence of the architecture of poly(ethylene glycol)-based thermoresponsive polymers on cell adhesion     

Katja Uhlig  Bj?rn Boysen  Andreas Lankenau  Magnus Jaeger  Erik Wischerhoff  Jean-Fran?ois Lutz  André Laschewsky  Claus Duschl 《Biomicrofluidics》2012,6(2)

Thermoresponsive polymer surface coatings are a promising tool for cell culture applications. They allow for a mild way of cell detachment that preserves the activity of membrane proteins—a prerequisite for reliable cell analysis. To enlarge the application range of these coatings to cells with different adhesion properties, we synthesized various novel poly(ethylene glycol)-based thermoresponsive polymers and describe how (i) their chemical structure and (ii) their surface density affect their efficiency. In order to quantify the influence of both factors, the time for cell spreading and rounding efficiency were observed. As a result, efficiency of cell rounding, which is closely correlated to cell detachment, is less affected by both factors than the time needed for cell spreading. This time can effectively be adjusted by the molecular architecture which includes the length of the polymer backbone and the side chains. Based on this work, recommendations are given for future optimization of functionality of thermoresponsive polymer coatings for cell culture applications.  相似文献   

The ghosts of higher education reform: on the organisational processes surrounding policy borrowing     

Katja Brøgger 《Globalisation, Societies & Education》2014,12(4):520-541

The Bologna Process is one of the most extensive examples of policy borrowing processes. Based on qualitative data, this article argues in favour of studying part of this process as ‘global smallness’, centring on the organisational effects of the implementation of a globalised curriculum. Through Derrida's notion on hauntology, Fenwick and Edward's analysis of multiple reals, and Barad's understanding of entanglement and time, this article explores how the implementation processes evoke simultaneously existing worlds of practices propelled by the agency of the past troubling present higher education reform. Finally, this article addresses how ongoing reforms tend to increase the stretch between ‘what is performed on the outside’ and ‘what is practiced on the inside’.  相似文献   

A conceptual analysis of information need     

Richard L. Derr 《Information processing & management》1983,19(5):273-278

The necessary and sufficient conditions for saying that X has a need for certain information are identified. It is concluded that an information need is a condition in which certain information contributes to the achievement of a genuine or legitimate information purpose. Information need is a relationship which obtains between information and information purposes: it is not a psychological state. Implications for research and practice are drawn from the conceptual analysis.  相似文献   

The concept of information in ordinary discourse     

Richard L. Derr 《Information processing & management》1985,21(6):489-499

The concept of information as it is actually used in ordinary discourse is elucidated, using philosophical methods of conceptual analysis. Five essential properties and four derivative properties of the phenomenon of information are identified. This concept of information is contrasted with several proposed concepts in the literature of information theory, communication theory, and Information Science.  相似文献   

Child Temperament and Total Diurnal Cortisol in Out-of-Home Center-Based Child Care and in At-Home Parental Care     

Katja Tervahartiala  Saara Nolvi  Susanna Kortesluoma  Juho Pelto  Sirpa Hyttinen  Niina Junttila  Annarilla Ahtola  Hasse Karlsson  Linnea Karlsson 《Child development》2021,92(1):408-424

The association between child temperament characteristics and total diurnal saliva cortisol in 84 children (M = 2.3 years, SD = 0.6) attending out-of-home, center-based child care and 79 children (M = 2.0 years, SD = 0.5) attending at-home parental care was examined. Saliva samples were collected during two consecutive days, that is, Sunday and Monday, with four samples taken per day. While children higher in surgency had higher total diurnal cortisol production, we did not find evidence that temperament moderated the associations between child-care context and total diurnal cortisol. Negative affectivity and effortful control were not related to cortisol output. Our findings suggest that temperamental surgency may be associated with higher total cortisol production in early childhood across child-care settings.  相似文献   

Functioning and participation problems of students with ADHD in higher education: which reasonable accommodations are effective?     

Dorien Jansen  Katja Petry  Eva Ceulemans  Saskia van der Oord  Ilse Noens  Dieter Baeyens 《欧洲特需教育杂志》2017,32(1):35-53

Abstract

Students with ADHD struggle in higher education as a result of various functioning and participation problems. However, there are remaining gaps in the literature. First, it remains unclear how often and during which teaching and evaluation methods problems arise. Second, we do not yet know which reasonable accommodations are most effective to deal with the functioning. And third, we do not know which accommodations are most effective to address participation problems of students with ADHD in higher education. This study addresses these three gaps in literature. In total, 86 students with ADHD, 42 student counsellors and 86 students without a disability participated in a survey-based study. The results show that students with ADHD most frequently experience problems with sustaining and focusing attention and it is demonstrated that most problems arise during classical teaching or evaluation methods. Finally, the perception of the effectiveness of reasonable accommodations is strongly dependent on which problems students experience in higher education. These findings suggest that it is important to consider both personal and environmental characteristics when selecting and implementing reasonable accommodations.  相似文献   

Do Parents’ Causal Attributions Predict the Accuracy and Bias in their Children’s Self‐Concept of Maths Ability? A longitudinal study     

Katja Rytkönen  Kaisa Aunola  Jari‐Erik Nurmi 《教育心理学》2007,27(6):771-788

The present study investigated the extent to which parents’ causal attributions predict the accuracy of, and bias in, their children’s self‐concept of maths ability. Participants were 207 children and their 182 mothers and 167 fathers, who were assessed during the children’s first and second primary school years. The results showed that the more parents thought that their children succeeded because of ability, the more accurate the children’s self‐concept of maths ability became. In contrast, the more the parents attributed their children’s success to effort, the less accurate and more optimistic the children’s self‐concept of ability became.  相似文献   

Metacognition, need for cognition and use of explanations during ongoing learning and problem solving   总被引：1，自引：0，他引：1  

Savia Coutinho  Katja Wiemer-Hastings  John J. Skowronski  M. Anne Britt 《Learning and individual differences》2005,15(4):321-337

Two studies assessed whether: (1) high levels of task-relevant metacognition would be related to good task performance; (2) some kinds of feedback (e.g., explanations) would improve task-relevant metacognition (and hence, performance) more than other kinds of feedback; and (3) some kinds of people would be more likely to seek out and use this beneficial feedback than others. Results showed that: (1) students were able to better estimate their task performance with increasing experience at the task; (2) students who provided better estimates of their task success were more successful at the task; (3) students high in need for cognition sought out problem explanations more often than students low in need for cognition; but (4) students who scored high in trait metacognition did not seek out problem explanations more often than students who scored low in trait metacognition; (5) students who were high in need for cognition performed better at the task than those who were low in need for cognition, and (6) the receipt of problem explanations was only weakly related to high levels of task performance, if at all. The implications of these results are discussed.  相似文献   

Joint supervision practices in doctoral education – A student experience     

Katja Lahenius  Heini Ikävalko 《Journal of Further & Higher Education》2014,38(3):427-446

This paper presents a study of students’ experiences of joint supervision practices and supervisors’ professional work in doctoral education in one department of a Finnish university. A qualitative methodology was used to explore students’ experiences of joint supervision practices and an inductive protocol was used to analyse the data gathered through thematic interviews (N=11). The results describe three identified joint supervision practices: the complementary, the substitutive, and the diversified. The results suggest that departments and faculties should develop more official support and guidance for students to identify additional supervisors during their doctoral education.  相似文献   

Between Printed Past and Digital Future   总被引：1，自引：0，他引：1  

Mruck  Katja  Mey  Günter 《Research in Science Education》2002,32(2):257-268

Peer review – processes of quality control and certification – is well established in most sciences. In this contribution we limit ourselves to peer review in scientific journals. The main idea of peer review – to keep science free from individuals' and groups' interests and impact, and to select and publish only what is the best in a special field of research – is briefly summarized. Though peer review has a significant impact in the sciences, it is obviously hard to realize its objects. Highly publicized cases of fraud, large amounts of time necessary for the review process, the continued power of old boys' networks, and so forth – such factors led to many debates, and while some demanded to abolish peer review completely, others looked for possibilities to revise the review process. The Internet appears to provide tools to improve the organisation of peer review and to afford the transparency of the review process and its results. But even if the use of the Internet leads to significant changes in peer review there is no value-free scientific knowledge and evaluation that are separate from (predominant and/or competing) paradigms and their proponents.  相似文献