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Cancer is a genetic disorder.Although heredi-tary cancers account for only a small fraction of all tumors,most cancers are caused by a variable mix of heredity and environment that leads to accumulations of genetic alterations and then uncontrolled cell pro-liferations(Kops et al.,2005).In addition,genetic alteration is one of the a few most important bio-logical factors that determine the diagnosis and prognosis of different cancers and dictate the treat-ment strategies for cancer patients.Fu…  相似文献   
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Higher education is facing a conundrum relevant to the field of educational development: expectations regarding entrance criteria and graduation attributes are changing simultaneously. Biggs' model of constructive alignment can be used to analyze the challenges presented by these shifts in expectation and help educational developers understand their pedagogical implications. In the present article, an expanded model is proposed in which entrance requirements are added to Biggs' original conceptualization. In so doing, the length of the “learning journey” – from entrance to outcomes – can be charted. When entrance requirements and graduate attributes change simultaneously, higher education must accommodate learning journeys of varying lengths and nature. Moving targets such as these can engender a sense of frustration, if not helplessness, for academic staff responsible for curricular and pedagogical enhancement. However, rather than responding with a sense of helplessness, the educational developer should see these shifts as a real opportunity to support the implementation of a broader range of student-centred teaching/learning activities. Recommendations related to educational development consultations are offered.  相似文献   
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Abstract

Rural landholders are undergoing extended economic hardship, manifested in a range of social and ecological problems that limit the capacity of local areas to recover to economic levels necessary to sustain settlement. The uncertain influence of climate on production represents just one of the range of risk factors that landholders must face. Survival depends on the capacity of landholders to respond strategically to the stress which these risk factors generate. Our research indicates landholders’ capacity to modify land‐management practices, are dictated by their underlying personality traits and by presence or absence of other psychiatric morbidity. Where stresses exist, the capacity of people to respond actively to a planned problem solution diminishes. The psychological profiles of people tend to fall into three groups ‐ those who can generally cope; those who can usually cope but undergo dysfunctional episodes under acute stresses, and those who generally cannot cope.

In the grazing lands of central western Queensland, our findings suggest a predominant personality profile consistent with an ability to cope with isolation and the other particular challenges that characterise this way of life. There are two important implications in these results. The first relates to land stewardship and has significant lessons for government intervention in terms of rural policy and approaches to extension. In particular, there are lessons pertinent to the success of Landcare and associated community based initiatives. The second relates to the broad area of rural health as highlighted by the alarming rates of suicide found in rural Australia. In previous decades, those with personality styles less well‐suited to this industry, found employment in nearby rural towns. This option has declined as government policy has favoured the withdrawal of services and resources, hastening depopulation of rural areas. The resultant weakening of the social fabric of rural society is a cause of tension and stress with serious health implications. Previous approaches to rural sociology have not emphasised individual personality traits in seeking to understand the complexity of the human‐environment relationships which determine land use. Nor has personality been invoked is assessing the potential of landholders to adopt ecologically sustainable practices. Further research is planned to consolidate our findings through comparative investigations in other branches of rural industry. JAgr Educ Ext (2001, 7, 3, pp 167–178)  相似文献   
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Two Lagrange multiplier (LM) methods may be used in specification searches for adding parameters to models: one based on univariate LM tests and respecification of the model (LM‐respecified method) and the other based on a partitioning of multivariate LM tests (LM‐incremental method). These methods may result in extraneous parameters being included in models due to either sampling error or the model being misspecified. A 2‐stage specification search may be used to reduce errors due to misspecification. In the 1st stage, parameters are added to models based on LM tests to maximize fit. Second, parameters added in the 1st stage are deleted if they are no longer necessary to maintain model fit. Illustrations are presented to demonstrate that errors due to misspecification occur with the LM‐respecified method and are even more likely with the LM‐incremental approach. These illustrations also show how the deletion stage can help eliminate some of these errors.  相似文献   
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As we enter the new century, there are multiple debates about what teachers need to know, who should provide education for teachers, how teachers should be certified and licensed, and what role (if any) university-based teacher preparation should play in school improvement. The author argues that the future of teacher education in the United States depends to a great extent on the ways three fundamental questions are framed: the knowledge question, the learning question, and the outcomes question. To a great extent, the ways these questions are framed and their larger agendas for the purposes and consequences of schooling will determine the future of the field.  相似文献   
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One-hundred and fifty-six children were randomly evaluated at an inner-city juvenile/family court. These children were removed from their parent's custody subsequent to a finding of severe child maltreatment. From our original sample of 156 children, 62 met strict criteria for Post Traumatic Stress Disorder (PTSD). Fifty-two of these 62 were successfully recruited and participated in the 2 year re-examination. Each PTSD diagnosis was conferred by the Diagnostic Interview for Children and Adolescents (DICA). From our sample of 52 PTSD children re-examined after 2 years, 17 (32.7%) retained the full PTSD diagnosis, while 67.3% did not meet criteria.  相似文献   
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The exterior design of existing preschool environments is evaluated in the context of contemporary writings by architects focusing on creating designs that nurture children’s emotions. Sense of place research is discussed in relation to young children’s experiences. Findings reveal that the majority of sites included in the study incorporated many physical design elements that create a sense of place for children in preschool environments, including small-scale structures, windows, landscaping, natural wall materials, and thresholds. Recommendations for administrators and directors planning and designing a new or remodeled preschool environment include incorporating features that reflect home-like environments with windows, thresholds, and landscaping.  相似文献   
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