BMD and Serum Intact Osteocalcin in Postmenopausal Osteoporosis Women     

Jagtap VR  Ganu JV  Nagane NS 《Indian journal of clinical biochemistry : IJCB》2011,26(1):70-73

India seems to have the highest prevalence of osteoporosis. With growing awareness of osteoporosis and its impact on life span especially in India, special attention is being paid to early detection, management and treatment of postmenopausal osteoporosis in women. Measurement of BMD and osteocalcin are of value in estimating bone turnover rates. The aim of this study is (1) to measure the specific, sensitive bone formation marker such as osteocalcin and BMD in postmenopausal osteoporosis women and postmenopausal non-osteoporosis women; (2) the follow up study to evaluate the impact of specific antiresorptive therapy (alendronate + calcium + vitamin D) regimen in postmenopausal osteoporosis by assaying osteocalcin and BMD. Sixty clinically diagnosed postmenopausal osteoporosis patients and 60 normal subjects (postmenopausal non-osteoporosis women) were recruited as control. Mean bone mineral density T score and Z score was significantly decreased (P < 0.001) in postmenopausal osteoporosis patients as compared to controls. Highly significant increase in the mean score of BMD—T score and Z score from baseline to post therapy of 3 months was observed in postmenopausal osteoporosis women. Serum osteocalcin levels were significantly increased (P < 0.001) as compared to control group. Serum osteocalcin levels were decreased significantly (P < 0.001) from baseline to post therapy of 3 months in postmenopausal osteoporosis women. BMD is the best quantifiable predictor of osteoporotic fracture and osteocalcin is specific, sensitive, promising, currently used marker for better prognosis of osteoporosis and for monitoring responses to antiresorptive therapy.  相似文献   

A Review on Salivary Genomics and Proteomics Biomarkers in Oral Cancer     

Franky D. Shah  Rasheedunnisa Begum  Bhairavi N. Vajaria  Kinjal R. Patel  Jayendra B. Patel  Shilin N. Shukla  Prabhudas S. Patel 《Indian journal of clinical biochemistry : IJCB》2011,26(4):326-334

Oral cancer has emerged as an alarming public health problem with increasing incidence and mortality rates all over the world. Therefore, the implementation of newer screening and early detection approaches are of utmost importance which could reduce the morbidity and mortality associated with this disease. Sensitive and specific biomarkers for oral cancer are likely to be most effective for screening, diagnosis, staging and follow-up for this dreaded malignancy. Unlike other deep cancers, oral cancer is located in oral cavity. Hence, the direct contact between saliva and oral cancer lesion makes the measurement of tumor markers in saliva an attractive alternative to serum and tissue testing. The DNA, RNA and protein molecules derived from the living cancer cells can be conveniently obtained from saliva. Thus, salivary biomarkers, a non-invasive alternative to serum and tissue-based biomarkers may be an effective modality for early diagnosis, prognostication and monitoring post therapy status. In the current post-genomic era, various technologies provide opportunities for high-throughput approaches to genomics and proteomics; which have been used to evaluate altered expressions of gene and protein targets in saliva of oral cancer patients. The emerging field of salivary biomarkers has great potentials to prove its clinical significance to combat oral cancer. Hence, we have reviewed importance of several salivary genomics and proteomics biomarkers for oral cancer.  相似文献   

The European university landscape: A micro characterization based on evidence from the Aquameth project   总被引：2，自引：0，他引：2  

Cinzia Daraio  Andrea BonaccorsiAldo Geuna  Benedetto LeporiLaurent Bach  Peter BogetoftMargarida F. Cardoso  Elena Castro-MartinezGustavo Crespi  Ignacio Fernandez de LucioHarold Fried  Adela Garcia-AracilAnnamaria Inzelt  Ben JongbloedGerhard Kempkes  Patrick LlerenaMireille Matt  Maria OlivaresCarsten Pohl  Tarmo RatyMaria J. Rosa  Cláudia S. SarricoLéopold Simar  Stig SlipersaeterPedro N. Teixeira  Philippe Vanden Eeckaut 《Research Policy》2011,40(1):148-164

This paper provides a new and systematic characterization of 488 universities, from 11 European countries: Finland, France, Germany, Hungary, Italy, Netherlands, Norway, Portugal, Spain, Switzerland and UK. Using micro indicators built on the integrated Aquameth database, we characterize the European university landscape according to the following dimensions: history/foundation of university, dynamics of growth, specialization pattern, subject mix, funding composition, offer profile and productivity.  相似文献   

Reliability modelling and analysis of a two unit continuous casting plant     

A.G. Mathew  S.M. Rizwan 《Journal of The Franklin Institute》2011,348(7):1488-1505

The aim of this paper is to present a reliability modeling and analysis of a two-unit system of a continuous casting (CC) plant. Real maintenance data of a steel production plant have been used for the purpose. Three types of failures were noted: repairable, replaceable and reconditioning/reinstallation. The two-unit system is operating in parallel, on full-reduced installed capacity. Upon the unit failure, an inspection is carried out to decide the type of maintenance task to be performed. Optimized reliability indices of the plant such as mean time to system failure, availability, expected busy periods of the repairman for various maintenance tasks, expected number of visits by the repairman, expected number of repairs, replacements and reconditioning/reinstallation are obtained. Semi-Markov processes and regenerative point techniques are used for the analysis. Profit incurred to the CC plant is also evaluated and related graphs are plotted to demonstrate the results.  相似文献   

Exact analysis for the identification of non-minimum phase processes     

P.K. Padhy  S. Majhi 《Journal of The Franklin Institute》2011,348(10):2734-2743

Analytical expressions are derived from a single symmetrical relay feedback test for the identification of open loop stable and unstable non-minimum phase processes. The second derivative of the limit cycle output helps in finding the time delay of the process. The derived expressions can be used to identify the process models with up to five unknowns. The effectiveness of the proposed identification method is verified through different simulation results.  相似文献   

New results on BIBO stability analysis for a class of neutral delay systems     

B. Wang  J. Wang  S.M. Zhong 《Journal of The Franklin Institute》2011,348(2):426-437

This paper studies bounded input bounded output (BIBO) stability for a class of neutral systems with time-varying delays. Based on Lyapunov method and linear matrix inequalities, some new BIBO stability criteria are established. The numerical simulation is made to demonstrate the effectiveness of the theoretical results obtained in this paper.  相似文献   

A simple design method for the cosine-modulated filter banks using weighted constrained least square technique   总被引：1，自引：0，他引：1  

A. Kumar  G.K. Singh  R.S. Anand 《Journal of The Franklin Institute》2011,348(4):606-621

This paper presents a simple and efficient design method for cosine-modulated filter banks with prescribed stopband attenuation, passband ripple, and channel overlap. The method casts the design problem as a linear minimization of filter coefficients such that their value at ω=π/2M is 0.707, which results in a simpler, more direct design procedure. The weighted constrained least squares technique is exploited for designing the prototype filter for cosine modulation (CM) filter banks. Several design examples are included to show the increased efficiency and flexibility of the proposed method over the exiting methods. An application of the proposed method is considered in the area of sub-band coding of the ECG and speech signals.  相似文献   

Is it a question of trust or why are we afraid to go to Nineveh?     

Michael S. Moss 《Archival Science》2011,11(3-4):409-425

Trust is an overused concept in our contemporary world. This paper explores the complex relationship of trust, efficiency, accountability, transparency and responsibility and their relationship to recordkeeping in our globalizing culture. It focuses on the profound changes that have taken place in the meaning and practice of audit within neo-liberal societies and how the ??rituals of verification?? and the ??managerialism?? may pervert the resulting record. It challenges the unthinking use of much of the rhetoric surrounding these concepts by archivists to justify their existence. It reflects on why the archival voice often remains silent or at best goes unheard in much of the discussion about these questions that have profound consequences for democratic societies. It is easy to lay the blame at the door of a perceived breakdown of trust rather than to consider whether the root of the problem lies with archivists and records managers themselves. This paper draws on my experience in directing the Information Management and Preservation MSC programme at the University of Glasgow and wide and serendipitous reading, which has sometimes been brought to my notice by students.  相似文献   

Editorial     

John S Edwards 《知识管理研究与实践》2011,9(1):1-3

  相似文献   

Editorial     

John S Edwards 《知识管理研究与实践》2011,9(4):277-278

  相似文献