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41.
42.
Apoptosis plays an important role in cellular homeostasis. In this study we have investigated whether apoptosis is a contributory
factor to alcohol induced liver damage. Long term ethanol (1.6 g/kg body weight/day) exposure augmented liver apoptosis as
reflected by high frequency of positive TUNEL staining nuclei and by an increased activity of caspase-3 and -8. Our study
provides evidence that long-term ethanol consumption triggers apoptotic process in the liver. 相似文献
43.
This article is the second student contribution to the Dissertations into Practice feature. It reports on a study that investigated the everyday health information-seeking practices of a small group of the 'general public' and the implications for information-seeking theory and health information provision. The first student article, about the implementation of radio frequency identification (RFID) in a hospital library, was very different, and the two articles illustrate the broad spectrum of possible subjects for the Dissertations into Practice feature. This study was conducted in summer 2011 by Abir Mukherjee for his MSc dissertation in the Library and Information Sciences programme at City University London. Further information and copies of the full dissertation may be obtained from Abir Mukherjee or David Bawden. AM. 相似文献
44.
In this paper a population based evolutionary optimization methodology called Opposition based Harmony Search Algorithm (OHS) is applied for the optimization of system coefficients of adaptive infinite impulse response (IIR) system identification problem. The original Harmony Search (HS) algorithm is chosen as the parent one and opposition based approach is applied to it with an intention to exhibit accelerated near global convergence profile. During the initialization, for choosing the randomly generated population/solution opposite solutions are also considered and the fitter one is selected as apriori guess for having faster convergence profile. Each solution in Harmony Memory (HM) is generated on the basis of memory consideration rule, a pitch adjustment rule and a re-initialization process which gives the optimum result corresponding to the least error fitness in multidimensional search space. Incorporation of different control parameters in basic HS algorithm results in balancing of exploration and exploitation of search space. The proposed OHS based system identification approach has alleviated from inherent drawbacks of premature convergence and stagnation, unlike Genetic Algorithm (GA), Particle Swarm Optimization (PSO) and Differential Evolution (DE). The simulation results obtained for some well known benchmark examples justify the efficacy of the proposed OHS based system identification approach over GA, PSO and DE in terms of convergence speed, identifying the system plant coefficients and mean square error (MSE) fitness values produced for both same order and reduced order models of adaptive IIR filters. 相似文献
45.
Suzanne Mukherjee Jane Lightfoot Patricia Sloper 《Educational research; a review for teachers and all concerned with progress in education》2013,55(1):59-72
This paper reports on a study which investigated the support needs of pupils in mainstream school with a chronic illness or physical disability. The research was carried out in three local education authorities covering both rural and urban areas. In-depth, qualitative data were collected from 33 pupils in secondary school; 58 parents of primary and secondary school pupils; and 34 primary and secondary school teachers. Overall, the data from young people suggest variability in the support offered to pupils by teachers, even by teachers within the same school, and highlights the importance of teachers' awareness and understanding of special health needs. A number of areas where young people need support from teachers were identified, including: dealing with school absence; taking part in school activities; peer relationships; explaining the condition to other pupils; and having someone to talk to about health-related worries. Data from teachers and parents indicate that school staff need assistance with obtaining health-related information; ensuring health-related information is passed between and within schools; providing emotional support; the provision of medical care; and coordinating support for this group of pupils. The implications of the findings for teachers, schools and educational policy are discussed. 相似文献
46.
G. Mukherjee Damyanti Sharma V. Shanker H. Lai 《Indian journal of clinical biochemistry : IJCB》1994,9(1):17-18
Serum and amniotic fluid mucoprotein concentrations were estimated in normal and toxaemic pregnant women. The levels were
found to be higher in preeclampsia and eclampsia than the normal controls. Comparatively higher concentrations were observed
in amniotic fluid than serum. Data suggest that the estimation of serum and amniotic fluid mucoproteins may be useful in assessing
the severity of toxaemia of pregnancy and fetal well being. 相似文献
47.
Role of plasma amino acids and gaba in alcoholic and non-alcoholic fatty liver disease-a pilot study
S. Mukherjee K. Vaidyanathan D. M. Vasudevan Subir Kumar Das 《Indian journal of clinical biochemistry : IJCB》2010,25(1):37-42
Alcohol appears to affect brain function, primarily by interfering with the action of gamma-aminobutyric acid (GABA) and other
neurotransmitters. As alcohol is mainly metabolized in the liver, therefore we undertook this pilot study to monitor the patterns
of changes in plasma amino-acid concentrations due to alcoholic and nonalcohol fatty liver disease and their relation with
plasma GABA level. Plasma amino-acid concentrations were measured in 25 alcoholic liver disease (ALD) patients, 18 non-alcoholic
fatty liver disease (NAFLD) patients, and 24 age and sex matched control subjects by HPLC. GABA concentration was elevated,
while isoleucine and leucine levels reduced significantly in ALD patients compared to the control subjects. Methionine and
phenylalanine levels elevated and valine content reduced significantly in ALD patients compared to other two groups, and GABA
level was significantly correlated with methionine and phenylalanine. Plasma concentration of lysine was significantly reduced
in both groups of liver disease patients compared to the control group, but was not correlated with GABA level. Glycine and
tyrosine levels reduced significantly in NAFLD patients compared to other two groups and were significantly correlated with
GABA. Interestingly, though amino acids such as alanine, histidine, proline and serine were not affected by liver diseases,
but were significantly correlated with GABA level. This pilot study indicated that alcoholic liver disease presented a more
deranged plasma amino acid pattern than nonalcoholic, and the amino acid imbalances. More studies are necessary to identify
the role of any particular amino acid on brain function and on neurotransmitter(s). 相似文献
48.
Moushumi Lodh Debkanta Pradhan Abhishek Mukherjee 《Indian journal of clinical biochemistry : IJCB》2011,26(4):423-425
We report an unusual presentation of primary biliary cirrhosis. We present the case of a 31-year-old Indian woman who presented
to the hospital with non specific complaints of gastritis, reduced appetite and marked weight loss and no complaints of pruritus.
Serum liver enzymes were elevated. Cytoplasmic pattern of antinuclear antibodies was found on immunofluorescence microscopy
accompanied by positive anti smooth muscle antibody. Endoscopy revealed esophageal varices. Following a liver biopsy, the
diagnosis of primary biliary cirrhosis was made. It is important to consider the diagnosis of hepatic cirrhosis when patient
presents with gastritis, reduced appetite and marked weight loss in both the presence and absence of ascites. 相似文献
49.
This article describes the complex media environment of urban Zambia based on qualitative interviews with 42 active ICT and social media users in Lusaka. After a contextual discussion of media censorship and Internet freedom, the article draws upon interview data to delineate four circumvention practices: (1) platform jumping; (2) anonymity; (3) self-censorship; and (4) negotiation of legal challenges. Rather than approach circumvention as a set of techniques disseminated from the information capitals of the world to those in the “global south,” this study approaches it as a set of cultural practices that emerges within particular sociohistorical conditions and platforms of communication. 相似文献
50.
Molecular techniques are gaining importance in biodiversity conservation in India. They are especially beneficial in the case of rare species with cryptic habits that make them difficult study subjects when using conventional field techniques. Molecular tools can be used to decipher distributions and population connectedness in fragmented habitats and identify populations of immediate conservation concern. We discuss these with case studies on some cat species in India. 相似文献