Lipids changes in liver cancer   总被引：9，自引：1，他引：8  

Jiang JT  Xu N  Zhang XY  Wu CP 《Journal of Zhejiang University. Science. B》2007,8(6):398-409

Liver is one of the most important organs in energy metabolism. Most plasma apolipoproteins and endogenous lipids and lipoproteins are synthesized in the liver. It depends on the integrity of liver cellular function, which ensures homeostasis of lipid and lipoprotein metabolism. When liver cancer occurs, these processes are impaired and the plasma lipid and lipoprotein patterns may be changed. Liver cancer is the fifth common malignant tumor worldwide, and is closely related to the infections of hepatitis B virus （HBV） and hepatitis C virus （HCV）. HBV and HCV infections are quite common in China and other Southeast Asian countries. In addition, liver cancer is often followed by a procession of chronic hepatitis or cirrhosis, so that hepatic function is damaged obviously on these bases, which may significantly influence lipid and lipoprotein metabolism in vivo. In this review we summarize the clinical significance of lipid and lipoprotein metabolism under liver cancer.  相似文献   

A summer program designed to educate college students for careers in bioinformatics     

Krilowicz B  Johnston W  Sharp SB  Warter-Perez N  Momand J 《CBE life sciences education》2007,6(1):74-83

A summer program was created for undergraduates and graduate students that teaches bioinformatics concepts, offers skills in professional development, and provides research opportunities in academic and industrial institutions. We estimate that 34 of 38 graduates (89%) are in a career trajectory that will use bioinformatics. Evidence from open-ended research mentor and student survey responses, student exit interview responses, and research mentor exit interview/survey responses identified skills and knowledge from the fields of computer science, biology, and mathematics that are critical for students considering bioinformatics research. Programming knowledge and general computer skills were essential to success on bioinformatics research projects. General mathematics skills obtained through current undergraduate natural sciences programs were adequate for the research projects, although knowledge of probability and statistics should be strengthened. Biology knowledge obtained through the didactic phase of the program and prior undergraduate education was adequate, but advanced or specific knowledge could help students progress on research projects. The curriculum and assessment instruments developed for this program are available for adoption by other bioinformatics programs at http://www.calstatela.edu/SoCalBSI.  相似文献   

Supplemental instruction in introductory biology I: enhancing the performance and retention of underrepresented minority students     

Rath KA  Peterfreund AR  Xenos SP  Bayliss F  Carnal N 《CBE life sciences education》2007,6(3):203-216

Supplemental instruction classes have been shown in many studies to enhance performance in the supported courses and even to improve graduation rates. Generally, there has been little evidence of a differential impact on students from different ethnic/racial backgrounds. At San Francisco State University, however, supplemental instruction in the Introductory Biology I class is associated with even more dramatic gains among students from underrepresented minority populations than the gains found among their peers. These gains do not seem to be the product of better students availing themselves of supplemental instruction or other outside factors. The Introductory Biology I class consists of a team-taught lecture component, taught in a large lecture classroom, and a laboratory component where students participate in smaller lab sections. Students are expected to master an understanding of basic concepts, content, and vocabulary in biology as well as gain laboratory investigation skills and experience applying scientific methodology. In this context, supplemental instruction classes are cooperative learning environments where students participate in learning activities that complement the course material, focusing on student misconceptions and difficulties, construction of a scaffolded knowledge base, applications involving problem solving, and articulation of constructs with peers.  相似文献   

Teachers' education, classroom quality, and young children's academic skills: results from seven studies of preschool programs   总被引：10，自引：0，他引：10  

Early DM  Maxwell KL  Burchinal M  Alva S  Bender RH  Bryant D  Cai K  Clifford RM  Ebanks C  Griffin JA  Henry GT  Howes C  Iriondo-Perez J  Jeon HJ  Mashburn AJ  Peisner-Feinberg E  Pianta RC  Vandergrift N  Zill N 《Child development》2007,78(2):558-580

In an effort to provide high-quality preschool education, policymakers are increasingly requiring public preschool teachers to have at least a Bachelor's degree, preferably in early childhood education. Seven major studies of early care and education were used to predict classroom quality and children's academic outcomes from the educational attainment and major of teachers of 4-year-olds. The findings indicate largely null or contradictory associations, indicating that policies focused solely on increasing teachers' education will not suffice for improving classroom quality or maximizing children's academic gains. Instead, raising the effectiveness of early childhood education likely will require a broad range of professional development activities and supports targeted toward teachers' interactions with children.  相似文献   

Cumulative stress and substantiated maltreatment: the importance of caregiver vulnerability and adult partner violence   总被引：1，自引：0，他引：1  

Wekerle C  Wall AM  Leung E  Trocmé N 《Child abuse & neglect》2007,31(4):427-443

OBJECTIVE: Our goal is to assess the effect of caregiver vulnerabilities, singly and in combination, on the substantiation of child abuse (physical, sexual) and neglect, while controlling for relevant background variables. We test the moderator role of adult partner violence in qualifying the relationship between caregiver vulnerabilities and maltreatment substantiation. METHOD: Secondary analyses of the 1998 Canadian Incidence Study of Reported Child Maltreatment (CIS) are used to predict child protective service investigation substantiation versus non-substantiation from a range of caregiver vulnerability factors. Involvement in partner violence was examined as a moderator in the relation between caregiver vulnerabilities and maltreatment substantiation. The CIS is an epidemiological survey of first-reported cases to child protective services, using a random sample of child welfare agencies across Canada. Child welfare workers completed a research form on the child, primary caregiver, family, perpetrator, severity and type of maltreatment, as well as services and court outcomes. All maltreatment classifications were assigned according to the Canadian legal definition of child abuse and neglect. Hierarchical logistic regression analyses were used, with stepped entry of: (1) demographic factors, socioeconomic disadvantage, and caregiver's own history of maltreatment; (2) caregiver vulnerability factors; (3) involvement in partner violence; (4) the interaction between caregiver vulnerability and partner violence. RESULTS: Caregiver substance abuse was found to be the single most potent kind of caregiver vulnerability in predicting maltreatment substantiation. When the total number of vulnerabilities was used as the predictor, prediction across all types of maltreatment increased, especially for substantiated neglect. Analyses also showed that the presence of partner violence in the home exacerbated the effect of caregiver vulnerability on substantiation. CONCLUSIONS: The total number of caregiver vulnerabilities was the best predictor of the substantiation of child abuse and neglect. This relationship was moderated by the existence of partner violence: high caregiver vulnerability and high partner violence increased the likelihood of substantiation versus non-substantiation. These results suggest that caregiver issues should be considered in tandem with partner relationships. Among child welfare cases, caregiver vulnerability and partner violence are critical targets for child maltreatment prevention and early child protective services intervention.  相似文献   

Re-referral to child protective services: the influence of child, family, and case characteristics on risk status   总被引：2，自引：0，他引：2  

Connell CM  Bergeron N  Katz KH  Saunders L  Tebes JK 《Child abuse & neglect》2007,31(5):573-588

INTRODUCTION: This study examines child, family, and case characteristics that impact rates of re-referral to Child Protective Services (CPS) using data on all closed CPS investigations for the state of Rhode Island between 2001 and 2004. METHOD: A longitudinal dataset of all referrals to CPS was created using state submissions to the National Child Abuse and Neglect Data System (NCANDS). After excluding children whose initial CPS investigation resulted in removal from the home, a Cox proportional hazards model was tested to examine factors impacting the likelihood of re-referral. RESULTS: Consistent with other research in this area, the initial 6-month period following case disposition is the period of greatest risk of re-referral. Approximately 13% of cases experienced a recurrent allegation during the first 6-month period; an additional 14% experienced a re-referral over the following 12-month period; 7% during the next 12-month period. Family poverty was the strongest predictor of re-referral, though a number of child and case characteristics were significantly related to recurrence. Cases that were substantiated at index were significantly less likely to result in a new allegation, though substantiated cases of physical abuse or those receiving post-investigation services were at higher risk. CONCLUSIONS: Children from families facing multiple stressors (e.g., low SES, parental substance abuse child disability) are at highest risk of re-referral to CPS and may benefit from the development of preventive services targeted immediately following case closings within CPS.  相似文献   

学生物理兴趣的培养     

林里元 《师道》2011,(1)

初中生的认知水平和心理特征决定他们的学习活动最容易从兴趣出发.学习兴趣是吸引学生注意力,提高其观察能力和思维能力的关键.因此,在初中物理教学中,教师应充分利用学生的心理特征和物理科的知识特点,有效地培养学生的学习兴趣,使他们在兴趣中学习,并养成自主探究的好习惯.  相似文献   

“乡政村治”格局下乡镇政府职能转变的困境及出路探析     

暴元 《新乡师范高等专科学校学报》2011,25(2)

改革开放以来,农村基层政权和社会管理体制逐渐形成了"乡政村治"格局,即在乡镇建立基层政权,对本乡镇事务行使国家行政管理职能,在村级建立村民自治组织——村民委员会,对本村事务行使自治权。农村治理结构改革是一项系统工程。现阶段我国乡村治理结构的制度设计应以"为农民提供公共服务"为原则,转变乡镇政府职能,建立公共服务型政府。  相似文献   

所有权对儿童学习效果的影响     

吴慧芬  刘华山  陈幺元  姜永志 《教育研究与实验》2019,(3):78-84

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钟嵘《诗品》之陶渊明品第再研究     

元文广 《许昌学院学报》2011,30(4):28-31

1925年陈延杰撰成《诗品注》一书,为钟嵘《诗品》的研究拉开了序幕,迄今为止对于《诗品》的研究已有九十余年的历史。在这九十余年的研究历程中,《诗品》对于陶渊明的品第问题一直以来都是学术界讨论的热点话题。钟嵘在《诗品》中以"古今隐逸诗人之宗"将陶渊明置于中品,唐以后,特别是宋、明、清以来的一大批学者为陶渊明叫屈并纷纷著文以批判钟嵘品第之失。在文学研究当中对于陶渊明所持有不同的批评态度,是批评家个人的主见,还是受其背后某种共同的思想观念、审美趣味的左右?是一个值得深入研究的课题。  相似文献