Effect of glycine site/NMDA receptor antagonist MRZ2/576 on the conditioned place preference and locomotor activity induced by morphine in mice   总被引：3，自引：0，他引：3  

Zhu YP  Long ZH  Zheng ML  Binsack R 《Journal of Zhejiang University. Science. B》2006,7(12):998-1005

Objective： To study the effect of glycine site/NMDA （N-methyl-D-aspartate） receptor antagonist MRZ2/576 on the conditioned place preference （CPP） and locomotor activity induced by morphine in mice. Methods： Different doses （1.25, 2.5 and 5 mg/kg, i.p.） of MRZ2/576 were used to evaluate the effect of MRZ2/576 on the acquisition and expression of CPP induced by morphine （5 mg/kg） in mice. In addition, we examined the locomotor activity of mice in conditioning and testing phase of CPP paradigm. Results： MRZ2/576 alone could not establish place preference, but a 5 mg/kg dose of MRZ2/576 could block both acquisition and expression of morphine-induced CPP. In testing phase of CPP, there was no statistical difference for locomotor activity between the groups; injection of MRZ2/576 showed a dose-dependent decrease of locomotor activity on both control and morphine-treated mice, especially 5 mg/kg of MRZ2/576 significantly suppressed the locomotor activity of mice. Conclusion： Based on the present results, we assume that MRZ2/576 can antagonize the rewarding effect of morphine, suggesting that this glycine site/NMDA receptor antagonist could be used to treat addictions due to its light side effect profile.  相似文献   

Familienstruktur und Bildungserfolg     

Ralf Bohrhardt 《Zeitschrift für Erziehungswissenschaft》2000,3(2):189-207

Zusammenfassung Dieser Beitrag befasst sich mit der h?ufig vorgetragenen These, dass sich die Struktur der Herkunftsfamilie und hier insbesondere die Abwesenheit eines Elternteils auf den Bildungserfolg von Kindern auswirke. Diese These wird aus der Perspektive der Lebensverlaufsforschung theoretisch kritisiert und auf der Grundlage deutscher und amerikanischer Umfragedaten empirisch relativiert. Es zeigt sich, dass es nicht die Strukturver?nderungen der Familie als solche sind, die Einfluss auf den Schulerfolg von Kindern nehmen. Statt dessen rücken Selektionseffekte ins Zentrum der Aufmerksamkeit sowie insbesondere die sozialen und politischen Rahmenbedingungen, unter denen sich familiale Ver?nderungen vollziehen.

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Summary This article deals with the frequently made argument that family structure — and here especially the absence of one parent — has an impact on the school success of children. This argument is theoretically criticised from the perspective of life course research and empirically re-analysed on the basis of survey data from Germany and the U.S. It becomes obvious, that the change of family structure as such has no or only very little impact on children’s school success. Instead, selection effects play a major roll as well as the social and political framework, under which changes to the family occure.

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Attention,Working Memory,and Long-Term Memory in Multimedia Learning: An Integrated Perspective Based on Process Models of Working Memory     

Judith Schweppe  Ralf Rummer 《Educational Psychology Review》2014,26(2):285-306

Cognitive models of multimedia learning such as the Cognitive Theory of Multimedia Learning (Mayer 2009) or the Cognitive Load Theory (Sweller 1999) are based on different cognitive models of working memory (e.g., Baddeley 1986) and long-term memory. The current paper describes a working memory model that has recently gained popularity in basic research: the embedded-processes model (Cowan 1999). The embedded-processes model argues that working memory is not a separate cognitive system but is the activated part of long-term memory. A subset of activated long-term memory is assumed to be particularly highlighted and is termed the “focus of attention.” This model thus integrates working memory, long-term memory, and (voluntary and involuntary) attention, and referring to it within multimedia models provides the opportunity to model all these learning-relevant cognitive processes and systems in a unitary way. We make suggestions for incorporating this model into theories of multimedia learning. On this basis, one cannot only reinterpret crucial phenomena in multimedia learning that are attributed to working memory (the split-attention effect, the modality effect, the coherence effect, the signaling effect, the redundancy effect, and the expertise reversal effect) but also derive new predictions.  相似文献   

Silver bullet or red herring? New evidence on the place of aspirations in education     

Ralf St. Clair  Keith Kintrea  Muir Houston 《牛津教育评论》2013,39(6):719-738

This article reports on a longitudinal study of student aspirations at the ages of 13 and 15 in three schools in the United Kingdom, where there has been a great deal of emphasis placed on aspirations in recent policy making. The data, based on individual interviews with 490 students in areas with significant deprivation as well as interviews with parents, teachers and community members, call into question the effectiveness of concentrating educational efforts on raising aspirations. Aspirations, even in these communities struggling with poverty, are very high—the missing element is the knowledge of how to make these aspirations concrete and obtainable. Implications for educators include insights into the highly aspirational nature of marginalised communities, the key role teachers play in helping aspirations come to fruition, and the need to focus on supporting young people to achieve aspirations that already substantially exceed the jobs available in the UK workforce.  相似文献   

Designing collaborative multiplayer serious games   总被引：1，自引：0，他引：1  

Viktor Wendel  Michael Gutjahr  Stefan Göbel  Ralf Steinmetz 《Education and Information Technologies》2013,18(2):287-308

The idea of Computer Supported Collaborative Learning (CSCL) is being investigated for more than twenty years. Since a few years, game-based approaches like video games for learning (Serious Games) offer new fields of application. The combination of game-based learning concepts and collaborative learning may enable new, game-based application areas of CSCL, like collaborative multiplayer Serious Games. Designing such games, however, is very challenging as it requires to take into account traditional single player game design concepts, concepts for multiplayer game design, and concepts for Serious Game design simultaneously. Only very few examples of such games exist today. In this paper we describe an approach for the design of game-based collaborative learning scenarios using multiplayer Serious Games. Our approach aims at combining design concepts from the fields of collaborative learning and (multiplayer) game design. Our approach takes into account the requirements of traditional single player games (fun, narration, immersion, graphics, sound), challenges of multiplayer games (concurrent gaming, interaction) and Serious Game design (seamless inclusion of learning content, adaptation and personalization). Furthermore, requirements of collaborative learning are considered, like group goals, positive interdependence, and individual accountability. Our design concept was used to create a collaborative 3D multiplayer game fostering collaborative behavior as a foundation for game-based collaborative learning in small teams. We performed a user study with eight gaming sessions and a total of 23 participants. Results showed that the game enables a collaborative gameplay and fosters collaborative behavior. This may allow us to use a game-based CSCL approach to combine the advantages of game-based learning with those of collaborative learning in future.  相似文献   

Affective–Reflective Theory of physical inactivity and exercise     

Ralf Brand  Panteleimon Ekkekakis 《Sportwissenschaft》2018,48(1):48-58

This article introduces a new theory, the Affective–Reflective Theory (ART) of physical inactivity and exercise. ART aims to explain and predict behavior in situations in which people either remain in a state of physical inactivity or initiate action (exercise). It is a dual-process model and assumes that exercise-related stimuli trigger automatic associations and a resulting automatic affective valuation of exercise (type-1 process). The automatic affective valuation forms the basis for the reflective evaluation (type-2 process), which can follow if self-control resources are available. The automatic affective valuation is connected with an action impulse, whereas the reflective evaluation can result in action plans. The two processes, in constant interaction, direct the individual towards or away from changing behavior. The ART of physical inactivity and exercise predicts that, when there is an affective–reflective discrepancy and self-control resources are low, behavior is more likely to be governed by the affective type-1 process. This introductory article explains the underlying concepts and main theoretical roots from which the ART of physical inactivity and exercise was developed (field theory, affective responses to exercise, automatic evaluation, evaluation-behavior link, dual-process theorizing). We also summarize the empirical tests that have been conducted to refine the theory in its present form.  相似文献   

Qualitative Methoden der Bildinterpretation     

Ralf?BohnsackEmail author 《Zeitschrift für Erziehungswissenschaft》2003,6(2):239-256

Zusammenfassung Die erheblichen Fortschritte der qualitativen Methoden in den vergangenen zwanzig Jahren sind eng mit dem „linguistic turn“ verbunden. Dessen Konsequenzen ebenso wie die für die empirische Sozialforschung ganz allgemein gültige Pr?misse, dass Protokolls?tze, also Texte, die nicht mehr hintergehbaren Grunddaten der (sozial-)wissenschaftlichen Analyse darstellen, haben zu einer Dominanz textinterpretativer Verfahren und zu einer ‘Textfixierung’ qualitativer Methodologien geführt. Insbesondere — und dies ist gerade für die Erziehungswissenschaft besonders folgenschwer — wurde in der qualitativen Forschung nicht unterschieden zwischen einer (textf?rmigen) Verst?ndigung über das Bild und einer (textunabh?ngigen) Verst?ndigung durch das Bild, d.h. im Medium des Bildes. Den methodischen Zugang zur letzteren Ebene, derjenigen einer vorbegrifflichen oder ‘atheoretischen’ Verst?ndigung im Medium des Bildes, haben in den 1920er-Jahren bereits Erwin Panofsky mit seiner Ikonologie und sein Zeitgenosse Karl Mannheim mit der dokumentarischen Methode er?ffnet. Zwischen diesen Methodologien und denjenigen der Semiotik zeigen sich wesentliche Korrespondenzen. Aus der Einsicht, dass die lkonizit?t in ihrer Eigenlogik der Sprache nicht in ad?quater Weise zug?nglich ist, l?sst sich mit Bezug auf die genannten Autoren sowie u.a. Barthes, Foucault und Imdahl die methodologische Konsequenz ziehen, dass wir unsere Konnotationen, unser sprachvermitteltes ikonographisches Vorwissen, soweit wie m?glich ‘einklammern’, also suspendieren müssen, wenn wir der Eigenart des Bildes gerecht werden wollen. Dabei führt der methodische Weg zur Rekonstruktion der Eigensinnigkeit des Bildes über dessen Formalstruktur — insbesondere über die planimetrische Struktur.

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Summary Qualitative methods of interpreting pictures The considerable progress in qualitative methods during the last twenty years is essentially connected with the „linguistic turn“. Its consequences as well as the presumption that textual records are the basic data of all scientific research are responsible for the predominance of methods of text-interpretation and for the particular ‘fixation’ on texts in qualitative methodologies. Especially, there is a lack of differentiation between a communication about pictures and a communication through pictures, i.e. a text-independent understanding via the medium of pictures. The methodical access to a pre-conceptual or ‘atheoretic’ understanding was opened up by Erwin Panofsky in the 1920s with his iconology and by his contemporary Karl Mannheim with his documentary method. Important correspondences between these methodologies and those in the field of semiotics can be demonstrated. From the insight that the iconic character in its obstinacy is not accessible to language in an adequate way, we can — with reference to the mentioned authors as well as to Barthes, Foucault and Imdahl — draw the conclusion that to approach the peculiarities of a picture means to suspend our connotations of language-mediated iconographic (pre-)knowledge as far as possible, to put them „in brackets“. Methodologically, the iconic character can only be reconstructed by describing the formal, especially the planimetric, structure of a picture.

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Diagnosing Decay Mechanisms at the Porta Nocera Necropolis,Pompeii: The First Step Towards Effective Preventive Conservation     

Martin Michette  Stefan Bichlmair  Ralf Kilian 《文物保护研究》2018,63(5):195-202

ABSTRACT

Aspects of preventive conservation are central to the long-term preservation of archaeological sites such as Pompeii. Mitigating moisture ingress and its manifold effects on decay mechanisms such as salt degradation are of critical importance when planning durable conservation strategies. A suite of non-destructive techniques was used to diagnose decay mechanisms at an ancient tomb monument at the Porta Nocera Necropolis. Rising damp and salt contamination are shown to be actively contributing to on-going deterioration of the plaster surfaces. An existing shelter is shown to be inadequate in its protection. These initial results are used to inform a more in-depth, long-term survey as well as the design of a holistic preventive strategy.  相似文献   

Erwartungshaltungen von Sekundärschullehrern in Nairobi     

Neuner  Ralf 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》2001,47(6):597-610

This article analyses the factors influencing the attitude of secondary school teachers in Nairobi. The findings are based on data collected in a three months field study. 30 interviews supplemented by questionnaires and observation show that due to the principle of equal pay for equal work the younger male teachers suffer from relative deprivation in status and are therefore the least motivated and the most likely to change the profession. An explanation can be found in their socio-economic situation and in the incompatibility of male expectations with career opportunities. In this context, direct working conditions don't seem to have a significant influence on teachers' attitude.  相似文献   

Entwurf und Implementierung eines SQL-normkonformen Datenbankkatalogs für ein relationales Datenbankmanagementsystem     

Steffen Skatulla  Ralf Schaarschmidt  Peter Pistor und Klaus Küspert 《Informatik - Forschung und Entwicklung》2000,15(3):161-170

Zusammenfassung.   Bei relationalen Datenbanksystemen haben sich de-jure-Normen für SQL stetig weiterentwickelt; mit diesen Normen wird es einfacher, portable Datenbankanwendungen zu entwickeln. Die SQL-Norm ruht auf zwei S?ulen, zum einen auf der Datenbanksprache SQL, zum anderen auf einer Vorgabe eines Datenbankkatalogs, welcher die gespeicherten Daten beschreiben soll. Im vorliegenden Beitrag wird derjenige Teilbereich des Datenbankkatalogs der aktuellen SQL99-Norm dargestellt, der bereits in der SQL92-Norm (ISO/IEC 9075:1992 bzw. DIN 66315) definiert ist und die klassischen (nicht objektrelationalen) Elemente einer relationalen Datenbank beschreibt. In dieser Darstellung nimmt der zweischichtige Spezifikationsansatz (Informationsschema, Definitionsschema) einigen Raum ein; mit seiner Hilfe weist SQL einen eleganten Weg, auf dem existierende Datenbanksysteme normkonforme Datenbankkataloge bereitstellen k?nnen. Anhand des Datenbankmanagementsystems DB2 wird anschlie?end untersucht, wie ein normkonformer Datenbankkatalog (das sogenannte Informationsschema) „oberhalb” des verfügbaren DB2-Katalogs realisiert werden kann, d. h. wie die vom Informationsschema geforderten Sichten auf DB2-Katalogtabellen abgebildet werden k?nnen. Auf generelle Schwierigkeiten und M?glichkeiten einer solchen Abbildung (ein- oder zweistufig) wird ebenso eingegangen wie auf Probleme, die sich speziell bei DB2 ergeben. In einer prototypischen Realisierung konnte das Informationsschema bis auf wenige Einschr?nkungen komplett umgesetzt werden. Damit wurde die Machbarkeit normkonformer Kataloge nachgewiesen. In heute verfügbaren DBMS-Produkten sind Datenbankkataloge in dieser konsequent normkonformen Gestalt leider immer noch nicht anzutreffen. Eingegangen am 5. M?rz 1999 / Angenommen am 1. Mai 2000  相似文献