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61.
The study aimed to investigate whether heart-type fatty acid binding protein (H-FABP) measurement provides additional diagnostic value to that of conventional cardiac markers in acute myocardial infarction (AMI) within first 6 h after the onset of symptoms. The study included 120 subjects: 60 AMI cases and 60 age and sex matched controls. The cases and controls were further divided into 2 subgroups depending on the time since onset of chest pain as (1) subjects within 3 h and (2) between 3 and 6 h of onset of chest pain. In all the cases and controls, serum H-FABP concentration was measured by Immunoturbidimetric method, serum Troponin I and myoglobin concentrations by Chemiluminescence immunoassay and serum CK-MB concentration by Immuno-inhibition method. The sensitivity, specificity, positive and negative predictive values of H-FABP were significantly greater than CK-MB and myoglobin but were lesser than Troponin I in patients with suspected AMI in both within 3 h and 3–6 h groups. Receiver operating characteristic curves demonstrated greatest diagnostic ability for Troponin I (AUC = 0.99, p < 0.001) followed by H-FABP (AUC = 0.906, p < 0.001) within 3 h and 3–6 h after the onset of chest pain. In conclusion, the diagnostic value of H-FABP is greater than CK-MB and myoglobin but slightly lesser than troponin I for the early diagnosis of AMI within first 6 h of chest pain. H-FABP can be used as an additional diagnostic tool for the early diagnosis of AMI along with troponin I.  相似文献   
62.
A new configuration realizing current/voltage-mode (CM/VM) universal filter using two four terminal floating nullors (FTFN) and four passive components is presented. The current-mode configuration has single input and three outputs and realises simultaneously lowpass (LP), bandpass (BP) and highpass (HP) responses from which allpass (AP) and notch functions can also be implemented. The voltage-mode filter has three inputs and two outputs and can be configured to realise all the five filtering functions. The circuit in current-mode uses grounded capacitors which are ideal for monolithic integration. Besides using a bare minimum number of passive components, the topology enjoys low active and passive sensitivity figures. Experimental and PSPICE simulation results are also included.  相似文献   
63.
Higher Education - There are many factors that motivate students to choose a particular academic major, whether it is due to interest, salary, or family. Government policies and...  相似文献   
64.
65.
This article aims to describe the differences between research-focused and teaching-focused (non-research) universities in terms of usage of web-based library services, as discovered by way of questionnaires and statistical analyses. It was found that the type of university within the country of Malaysia correlates to significant differences in usage of e-journals and Web-based library services in general. Factors such as library budget allocations, research productivity, and extrinsic motivations for using Web-based library services are surmised to have influenced the usage. The results also suggest that library programs at both types of universities are ineffective in creating awareness of the services. This article discusses several aspects of usage in both types of university and makes several suggestions to remedy identified problems.  相似文献   
66.
Myasthenia gravis (MG) is an autoimmune disease that results from antibody mediated damage of Acetylcholine receptor (AChR) at the neuromuscular junction. The autoimmune character of MG and pathogenic role of AChR antibodies have been established by several workers i.e., the demonstration of anti-AChR antibodies in about 90 % of MG patients. It has been demonstrated that patients with MG also have antibodies against a second protein named presynaptic membrane receptor (PsmR), which is identified by utilizing β-Bgtx, a ligand which binds to PsmR. Using β-Bgtx Sepharose 4B affinity matrix, the PsmR was purified from different regions of human cadaver brain by affinity chromatography. Purified receptor was characterized both by biochemical and immunological procedures. PsmR purified from different regions of the brain shows a specific activity of 0.37 ± 0.01, 0.39 ± 0.02 and 0.43 ± 0.005 nM/ μg of protein in Parietal lobe, Occipital lobe and Frontal lobe respectively. The affinity purified PsmR from the brain of 87 and 68 kd (parietal lobe, occipital lobe and frontal lobe) shows immunoreactivity with myasthenic sera. These findings suggest that PsmR from brain is another antigen against which autoantibodies are developed in Myasthenia gravis patients. Upon treatment with various enzymes we concluded that PsmR from brain is a glycoprotein in which the immunoreactivity resides in the carbohydrate as well as the peptide epitopes. In conclusion the PsmR is another antigen against which autoantibodies are formed in different regions of brain. These can be used as a diagnostic tool for detecting antibodies in the sera or cerebrospinal fluid of MG patients.  相似文献   
67.
This study aims to investigate the relationship between past experience and the career mobility of 31 high-flying female academics from eight established Malaysian universities. Based on data gathered from in-depth interviews, it is discerned that the respondents' career mobility at the exploration stage is influenced by early exposure to learning, experience in secondary schools (especially at boarding schools), first-degree experience, and personal qualities. On the other hand, respondents' career mobility during the establishment and maintenance stages is attributed to graduate study experience, career centrality, family support, uniqueness of academic role, health consciousness and adherence to religiosity.  相似文献   
68.
The significance of e-Learning and knowledge management at the workplace cannot be overemphasized. With the rapid change in all types of working environments, especially medical and healthcare environments, there is a constant need to rapidly train and retrain people in new technologies, products, and services found within the environment. There is also a constant and unrelenting need for appropriate management and leveraging of the knowledge base so that it is readily available and accessible to all stakeholders within the workplace environment. In addition, within the medical and healthcare setting, certain other factors reinforce this need for constant refreshing, training, and retraining of its workers. These factors are outlined below:
• Heightened expectations for improved quality of healthcare services from an increasingly aware and empowered public,
• Acute shortage of doctors and other healthcare professionals (requiring “multitasking” efforts from individuals and thus “forced” learning of new skill sets),
• Heterogeneous standards of healthcare as practised by medical practitioners necessitating policies designed to audit and streamline medical and healthcare practices as per enforcement of minimal credit points to be tied up to issuance/renewal of annual practicing certificates (APC),
• Increased complexity of healthcare services, technologies and products, and,
• Accelerated technological changes.
Our TeleHealth Initiative intends to implement this integration into the healthcare setting workplace via the following applications, namely:
• Just-in-time Continuing Medical Education (CME), which refers to significant and relevant information that can value-add to patient management at the appropriate time and appropriate segment of encounter,
• Formal Distant Education (FDE), which refers to electronic courses delivered online resulting in award of certificates conferred by accredited academic institutions or agencies,
• Modular Distance Learning (MDL), which refers to packaged learning modules designed to maintain competencies and to excel at relevant knowledge and skills which are tied in to issuance/renewal of practising licenses of the healthcare professionals, and,
• Personalised CME, which refers to knowledge, information, and skill sets pushed to healthcare professionals tailored to their areas of expertise, interest, and need.
The solutions as outlined above will be delivered via Internet-based content accredited by relevant authorities. This paper describes our mission to integrate e-Learning into health-related settings and into the routine daily life of medical and healthcare professionals.  相似文献   
69.
A quasi-experimental research design was used to investigate the effectiveness of synthetic phonics in the development of early reading skills among struggling young English as a second language (ESL) readers in a rural school. The pretest and posttest, adapted from the Phonological Awareness Literacy Screening (PALS) for Preschool Students and Grades 1 to 3 tests, assessed children’s early reading skills. A semi-structured interview was used to gather information. The findings indicated that the performance of students in the experimental group in decoding was significantly higher in the posttest, where t(39) = 31.441, p < .00005. Likewise, in comprehension, the experimental group achieved significantly higher scores in the posttest, where t(39) = 15.322, p < .00005. There was a significant difference in the achievement between the two groups, where t(78) = 31.010, p < .00005. This indicates that synthetic phonics could be effective in developing early reading skills for struggling readers.  相似文献   
70.
Students' perceptions of the education environment influence their learning. Ever since the major medical curriculum reform, anatomy education has undergone several changes in terms of its curriculum, teaching modalities, learning resources, and assessment methods. By measuring students' perceptions concerning anatomy education environment, valuable information can be obtained to facilitate improvements in teaching and learning. Hence, it is important to use a valid inventory that specifically measures attributes of the anatomy education environment. In this study, a new 11‐factor, 132‐items Anatomy Education Environment Measurement Inventory (AEEMI) was developed using Delphi technique and was validated in a Malaysian public medical school. The inventory was found to have satisfactory content evidence (scale‐level content validity index [total] = 0.646); good response process evidence (scale‐level face validity index [total] = 0.867); and acceptable to high internal consistency, with the Raykov composite reliability estimates of the six factors are in the range of 0.604–0.876. The best fit model of the AEEMI is achieved with six domains and 25 items (X2 = 415.67, P < 0.001, ChiSq/df = 1.63, RMSEA = 0.045, GFI = 0.905, CFI = 0.937, NFI = 0.854, TLI = 0.926). Hence, AEEMI was proven to have good psychometric properties, and thus could be used to measure the anatomy education environment in Malaysia. A concerted collaboration should be initiated toward developing a valid universal tool that, using the methods outlined in this study, measures the anatomy education environment across different institutions and countries. Anat Sci Educ 10: 423–432. © 2017 American Association of Anatomists.  相似文献   
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