Science Letters：IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis with its expression associated with DNA hypomethylation of exon 1   总被引：1，自引：0，他引：1  

Ruan WJ  Lin J  Xu EP  Xu FY  Ma Y  Deng H  Huang Q  Lv BJ  Hu H  Cui J  Di MJ  Dong JK  Lai MD 《Journal of Zhejiang University. Science. B》2006,7(11):929-932

Insulin-like growth factor binding-protein-7 （IGFBP7） was obtained from our previous colonic adenocarcinoma （CRC） and normal mucosa suppression subtraction hybridization （SSH） cDNA libraries. By RT-PCR and immunohistochemistry, we found that IGFBP7 was overexpressed in CRC tissue compared to normal tissue. However, our in vitro experiments performed in 10 CRC cell lines showed that IGFBP7 expressed only in SW480 and Caco2 cell lines, which implied an underlying reversible regulatory mechanism. Using methylation-specific PCR （MSP） and bisulfite sodium PCR （BSP）, we found that its expression was associated with DNA hypomethylation of exonl. This was further supported by the in vitro study which showed restored IGFBP7 expression after demethylation agent 5-aza-2＇-deoxycytidine treatment. Correlation analysis between IGFBP7 expression and prognosis indicated that overexpression of IGFBP7 in CRC tissue correlated with favourable survival. Investigation of the functional role of IGFBP7 through transfection studies showed that IGFBP7 protein could inhibit growth rate, decrease colony formation activity, and induce apoptosis in RKO and SW620 cells, suggesting it a potential tumor suppressor protein in colorectal carcinogenesis. In conclusion, our study clearly demonstrated that IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis and its expression is associated with DNA hypomethylation of exon 1.  相似文献   

韩国成人爱国主义教育的特色     

阮博 《河北大学成人教育学院学报》2013,(3):97-101,106

韩国的成人爱国主义教育具有鲜明的特色：一是政府在国家政策和教育方针上对爱国主义教育予以凸显和扶持;二是家庭、学校和社会组织共同承担爱国主义教育的任务;三是在儒家伦理的教化下将爱国、爱民族与爱家有机统一起来;四是以韩国的民族历史文化为依托有效挖掘爱国主义教育的元素;五是注重经济爱国主义的灌输。韩国成人爱国主义教育的经验可为我国成人爱国主义提供借鉴。  相似文献   

Reducing subjectivity in special education referrals by educators working with Latino students: using functional behavioral assessment as a pre-referral practice in student support teams     

Gerardo Moreno  Francisco X. Gaytán 《Emotional and Behavioural Difficulties》2013,18(1):88-101

Over the past several decades, the Latino population throughout the USA has demonstrated significant growth and exceeded that of other ethnic minority groups. This influx is particularly evident in the student enrollment of US schools as the number of Latino students has increased by approximately 10 million within the past 10 years. With this dramatic increase, there are a number of critical issues that present significant barriers to a high-quality educational experience for Latino students, specifically overrepresentation of Latinos receiving disciplinary actions and the high number of referrals to special education evaluation for emotional and behavioral disorders. This paper will discuss the impact of the Latino population in US schools, the concern of overrepresentation and biased referrals, and the use of a culturally attuned functional behavioral assessment as a pragmatic solution to better serve this growing population.  相似文献   

上虞覆卮山 赏花采樱桃     

楼丽君  阮国明 《文化交流》2013,(5):78-80

"四月樱桃百果先",眼下正临采摘樱桃时节。春风荡漾的上虞岭南乡覆卮山,俨然成了樱桃花的舞台。车子还在山路上盘旋的时候,窗外的远山上泛出亮色的一簇簇就已经分外夺人眼球。再往上走,连成一片的樱桃花慢慢地映入人们的视野。那时还是早春。山上的村落埋在樱桃花海中,深深的。春风拂过,花海漾漾。偶尔浮出的黑瓦一角,犹如海浪中缓缓移动的舟楫。看着看着,一幕幕的呈现就愈发像一幅幅鲜活的中国画了。眼前的"风景如画",完全是因为有了通人心的樱桃花的灵气。回环的山路,恰好印证了"曲径通幽"。到了东澄村一带,这里就是可以近距离欣赏樱桃花的最佳地方。千百年来,覆卮山民一直以石为邻,依山筑宅。所建的住宅往往是就地取材,  相似文献   

我国地面气温格点化数据集的研制   总被引：1，自引：0，他引：1  

张强  熊安元  阮新 《中国科技资源导刊》2008,40(3)

在大气科学研究领域,特别是气候变化检测和数值模拟研究中,与高精度、高时空分辨率的格点资料相比,离散的站点观测资料具有明显的优势.随着国家气象科学数据共享工作的纵深开展,站点资料已不能完全满足用户的需求,通过空间插值技术进行格点化气象要素数据集的研制和服务日益迫切.本文结合国家气象信息中心最新研制的中国地面气温格点数据集,对数据集研制过程中的几个关键技术问题及数据集验证情况进行了阐述.  相似文献   

Introduction: Information and Communication Technology in Early Childhood Education     

X. Christine Wang  James L. Hoot 《Early education and development》2006,17(3):317-322

  相似文献   

互动式"雨课堂"在成人教育教学中的实践探索     

阮迪女  陈海强 《继续教育研究》2021,(5):44-47

成人教育构建"雨课堂"教学模式既是建设成人教育品质课堂、促进成人品质学习的有效途径,也是全面推进课堂教学信息化、网络化、数字化的重要抓手,更是解决成人教育课堂互动性不强、学习积极性不高、面授到课率偏低等问题的应对策略.基于"雨课堂"的工具性和实际应用的便捷性,强化"雨课堂"模式全面应用于课堂一线,对提高成人教育面授到课率、优化教学过程、提高教学质量、助推品质学习具有积极的效应,同时对变革成人教育沿袭已久的传统形态、促进成人教育人才培养模式深度改革具有全面推广的价值性.  相似文献   

注重引导 促进养成——农村初中生数学学习习惯的培养     

阮炳国 《基础教育研究》2008,(7):31-32

我接手教八年级（上）两个教学班的数学课,发现多数学生没有良好的学习习惯：不会预习,听课不动脑筋,老师“启而不发”,出现老师“自问自答”的尴尬局面。我进行了问卷调查和个别谈心,了解到学生确实没有可行的学习方法和良好的学习习惯,约有75％的学生平时没有预习习惯,约有20％的学生预习也只是把要学习内容看一遍,只有约5％的同学稍懂得预习的方法。我决心扭转这种局面。试着通过从如下几个方面的引导,尝试培养学生学习数学的良好习惯。  相似文献   

预防新闻侵权的八句关键语   总被引：1，自引：0，他引：1  

阮志孝 《湖南大众传媒职业技术学院学报》2005,5(2):43-46

把握八句关键语有利于预防侵权行为的发生。这八句关键语包括：尊重他人权利,加强自我约束;新闻与创作分开,避免虚假新闻;事实与结论分开,避免“传媒审判”;报道与评论分开,把握“公正”原则;客观与主观分开,充分利用“特许”;掌握“平衡”技巧,不作一方“代言”;保护隐私,保障当事人的决定权;对事不对人,保护对象的合法权益。  相似文献   

PhD students’ work conditions and study environment in university- and industry-based PhD programmes     

A. Kolmos  L. B. Kofoed  X. Y. Du 《European Journal of Engineering Education》2008,33(5-6):539-550

During the last 10 years, new models of funding and training PhD students have been established in Denmark in order to integrate industry into the entire PhD education. Several programmes have been conducted where it is possible to co-finance PhD scholarships or to become an employee as an industrial PhD in a company. An important question is what impact these new conditions will have on the PhD students’ training, work conditions and study environment. In this article, the new type of programmes will be presented together with data analysis of PhD students’ work conditions and study environment in various programmes mainly based on a research project from 2006. The results of this study show no significant difference between PhD students in a traditional university PhD programme and PhD students in an industrial programme concerning working environment. However, the study shows significant differences in the intercultural dimension, where foreign PhD students are significantly more satisfied with their study environment compared with Danish PhD students. In general the workload is very high and the environment is stressful for all PhD students.  相似文献