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ObjectivesTo determine the impact of child sexual abuse (CSA) on adult sexual behaviors and outcomes over three age periods.MethodsA longitudinal study of a birth cohort born in Dunedin, New Zealand in 1972/1973 was used. Information on CSA was sought at age 26, and on sexual behaviors and outcomes at ages 21, 26, and 32. Comparisons were over the whole period from age 18 to 32, then for the three age periods from age 18 to 21, 21 to 26, and 26 to 32, adjusting for measures of family environment.ResultsOverall, 465 women and 471 men (91.9% of the surviving cohort) answered questions about CSA. Contact CSA was reported by 30.3% of women and 9.1% of men. For abused women, significantly increased rates were observed for number of sexual partners, unhappy pregnancies, abortion, and sexually transmitted infections from age 18 to 21; with rates approaching those of nonabused over time. Conversely, for abused men rates were not significantly elevated in the youngest age period, but were for number of partners from age 26 to 32 and acquisition of herpes simplex virus type 2 from age 21 to 32.ConclusionsGender and age are critical when considering the effect of CSA. While the profound early impact of CSA demonstrated for women appears to lessen with age, abused men appear to carry increased risks into adulthood.Practice implicationsCSA is common and should be considered when young women present with unwanted conceptions or seek multiple terminations, and when men continue to have high risk sexual behavior into adulthood. Furthermore, if CSA is disclosed, sexual risks in adulthood need to be considered.  相似文献   
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This article uses urban middle school student's interviews to describe the instructional differences they faced each day and the effects of these differences on what they learned. Data from a cohort of nearly 200 students over two years revealed common definitions of how they wanted their teachers to act and the kinds of classroom activities they wanted to be engaged in. But more important, their observations revealed stark differences in their actual experiences. Too few students experienced the quality instruction they desired. Students praised teachers who were willing to help, were strict but nice, and were able to explain. They also wanted instructional settings where they were challenged by meaningful projects and experiments, worked more interdependently with their peers, and combined work with fun. We conclude from these student observations that reform efforts will be more successful in settings that nurture, maintain, and reinforce classrooms like those so aptly described by students and promote the spread of these classrooms by taking advantage of the talents of exemplary staff within buildings (i.e., scaling within).  相似文献   
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This paper argues that the United Kingdom Ministry of Defence's (MoD) sponsorship of industrial semiconductor research and development (R&D) has, by its very nature, influenced the type of R&D performed, and the directions it has taken, to the extent of limiting its potential for subsequent commercial utilization. While much of the fault appears to lie with the semiconductor industry's response to MoD funding of its R&D, especially its over-reliance on such external support, the paper also suggests that the structure, modus operandi, and funding mechanisms of the MoD department concerned have significantly affected the industry's R&D activities. With these criticisms in mind, while at the same time noting the advantageous features of this department's activities, such as its relative autonomy, brief suggestions for ensuring more coherent and continuous state support for semiconductor R&D, including, for example, the use of innovation-oriented procurement policies, are offered.  相似文献   
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A new model for studying localised axonal stretch injury is presented, using a microfluidic device to selectively culture axons on a thin, flexible poly (dimethylsiloxane) membrane which can be deflected upward to stretch the axons. A very mild (0.5% strain) or mild stretch injury (5% strain) was applied to primary cortical neurons after 7 days growth in vitro. The extent of distal degeneration was quantified using the degenerative index (DI, the ratio of fragmented axon area to total axon area) of axons fixed at 24 h and 72 h post injury (PI), and immunolabelled for the axon specific, microtubule associated protein-tau. At 24 h PI following very mild injuries (0.5%), the majority of the axons remained intact and healthy with no significant difference in DI when compared to the control, but at 72 h PI, the DI increased significantly (DI = 0.11 ± 0.03). Remarkably, dendritic beading in the somal compartment was observed at 24 h PI, indicative of dying back degeneration. When the injury level was increased (5% stretch, mild injury), microtubule fragmentation along the injured axons was observed, with a significant increase in DI at 24 h PI (DI = 0.17 ± 0.02) and 72 h PI (DI = 0.18 ± 0.01), relative to uninjured axons. The responses observed for both mild and very mild injuries are similar to those observed in the in vivo models of traumatic brain injury, suggesting that this model can be used to study neuronal trauma and will provide new insights into the cellular and molecular alterations characterizing the neuronal response to discrete axonal injury.  相似文献   
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Higher Education - Higher education in the United Arab Emirates (UAE) is a relatively modern phenomenon, but it is a sector which has experienced immense growth since the first national university...  相似文献   
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