Listen to the Music: Lessons for Publishers from Record Labels’ Digital Debut Decade     

Sam Hollander 《Publishing Research Quarterly》2011,27(1):26-35

Multimedia EBooks present a tremendous growth opportunity for publishers. Yet, industry executives might be cautious after witnessing the astounding collapse of the record business during its digital transition over the last 10 years. This article looks at what went wrong for Big Music, what lessons book publishers can learn from the recording industry’s mistakes and also some visions of the future. And why digitally, for books—at least—it can’t get here fast enough.  相似文献   

Reviews     

Sam Pickering  Leonard Kriegel 《Academic Questions》1996,10(1):87-93

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The analysis and conservation of a Chinese silk birthday hanging of the Qing dynasty     

Angela Cheung  Louise Sam  Lydia Messerschmidt  Evita Yeung 《文物保护研究》2014,59(5):S28-S31

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Handle系统的发展及应用     

郭晓峰  孙洵 《数字图书馆论坛》2013,(8):18-24

Handle系统作为一种通用的名称服务系统,能够为网络中的数字对象提供的永久标识、动态链接和安全管理等基础服务。文章重点介绍Handle系统的发展及应用情况,从数字图书馆、数字内容管理、数字出版、数字博物馆、远程教育到科学数据管理与网格计算、数字权益管理、信息安全管理与隐私保护等领域。近年来随着互联网的发展,以及物联网等新技术的兴起,Handle系统获得了更加广阔的应用前景。文章最后介绍了Handle系统作为联合国ITu推荐的互联网下一代链接技术,在技术上及管理方式上的最新发展情况,并对其应用前景进行展望。  相似文献   

Microstructured multi-well plate for three-dimensional packed cell seeding and hepatocyte cell culture     

Vasiliy N. Goral  Sam H. Au  Ronald A. Faris  Po Ki Yuen 《Biomicrofluidics》2014,8(4)

In this article, we present a microstructured multi-well plate for enabling three-dimensional (3D) high density seeding and culture of cells through the use of a standard laboratory centrifuge to promote and maintain 3D tissue-like cellular morphology and cell-specific functionality in vitro without the addition of animal derived or synthetic matrices or coagulants. Each well has microfeatures on the bottom that are comprised of a series of ditches/open microchannels. The dimensions of the microchannels promote and maintain 3D tissue-like cellular morphology and cell-specific functionality in vitro. After cell seeding with a standard pipette, the microstructured multi-well plates were centrifuged to tightly pack cells inside the ditches in order to enhance cell-cell interactions and induce formation of 3D cellular structures during cell culture. Cell-cell interactions were optimized based on cell packing by considering dimensions of the ditches/open microchannels, orientation of the microstructured multi-well plate during centrifugation, cell seeding density, and the centrifugal force and time. With the optimized cell packing conditions, we demonstrated that after 7 days of cell culture, primary human hepatocytes adhered tightly together to form cord-like structures that resembled 3D tissue-like cellular architecture. Importantly, cell membrane polarity was restored without the addition of animal derived or synthetic matrices or coagulants.  相似文献   

A biomechanical comparison of dominant and non-dominant limbs during a side-step cutting task     

Christine D. Pollard  Marc F. Norcross  Sam T. Johnson  Amanda E. Stone  Eunwook Chang  Mark A. Hoffman 《Sports biomechanics / International Society of Biomechanics in Sports》2020,19(2):271-279

Abstract

Numerous studies have investigated anterior cruciate ligament (ACL) injury risk by examining gender differences in knee and hip biomechanics during a side-step cutting manoeuvre since it is known that ACL injury often occurs during such a task. Recent investigations have also examined lower extremity (LE) biomechanics during side-step cutting in individuals following ACL reconstruction (ACLR). Common research practice is to compare knee and hip biomechanics of the dominant limb between groups but this can add considerable complexity for clinicians and researchers. At this time, it is not known if there is a difference in LE biomechanics between the dominant and non-dominant limb during side-step cutting. Three-dimensional kinematics and kinetics were collected while 31 healthy participants performed five, side-step cutting manoeuvres with the dominant and non-dominant limbs. Knee and hip variables examined are those commonly investigated in ACL injury literature. There were no differences between limbs in all but one variable (knee internal rotation). These results demonstrate that healthy individuals exhibit little side-to-side differences in certain LE biomechanics when performing a side-step cutting manoeuvre. These findings can be utilised by clinicians when conducting dynamic evaluations of their ACLR patients and when developing injury prevention and rehabilitation programmes.  相似文献   

Polyester μ-assay chip for stem cell studies     

Francesco Piraino  ?eila Selimovi?  Marco Adamo  Alessandro Pero  Sam Manoucheri  Sang Bok Kim  Danilo Demarchi  Ali Khademhosseini 《Biomicrofluidics》2012,6(4)

The application of microfluidic technologies to stem cell research is of great interest to biologists and bioengineers. This is chiefly due to the intricate ability to control the cellular environment, the reduction of reagent volume, experimentation time and cost, and the high-throughput screening capabilities of microscale devices. Despite this importance, a simple-to-use microfluidic platform for studying the effects of growth factors on stem cell differentiation has not yet emerged. With this consideration, we have designed and characterized a microfluidic device that is easy to fabricate and operate, yet contains several functional elements. Our device is a simple polyester-based microfluidic chip capable of simultaneously screening multiple independent stem cell culture conditions. Generated by laser ablation and stacking of multiple layers of polyester film, this device integrates a 10 × 10 microwell array for cell culture with a continuous perfusion system and a non-linear concentration gradient generator. We performed numerical calculations to predict the gradient formation and calculate the shear stress acting on the cells inside the device. The device operation was validated by culturing murine embryonic stem cells inside the microwells for 5 days. Furthermore, we showed the ability to maintain the pluripotency of stem cell aggregates in response to concentrations of leukemia inhibitory factor ranging from 0 to ∼1000 U/ml. Given its simplicity, fast manufacturing method, scalability, and the cell-compatible nature of the device, it may be a useful platform for long-term stem cell culture and studies.  相似文献   

Mission Statements, Physical Space, and Strategy in Higher Education     

Sam J. Fugazzotto 《Innovative Higher Education》2009,34(5):285-298

The effectiveness of higher education institutions has bases in institutional structures and cultures. However, structure and culture represent abstract concepts while institutions realize high performance in practice. Given their salience in higher education, mission statements and campus space bring structure and culture into the realm of practice. Moving from abstract to concrete, this paper shows how mission statements embody structure and culture and how physical space, in turn, enacts mission in day-to-day institutional life. By harnessing the mission-space linkage, strategy can access structure and culture for the purpose of increasing effectiveness.  相似文献   

Measuring clearance mechanics based on dynamic leg length     

Sam Khamis  Barry Danino  Shlomo Hayek  Eli Carmeli 《Measurement in physical education and exercise science》2018,22(2):145-153

The aim of this study was to quantify clearance mechanics during gait. Seventeen children diagnosed with hemiplegic cerebral palsy underwent a three-dimensional gait analysis evaluation. Dynamic leg lengths were measured from the hip joint center to the heel, to the ankle joint center and to the forefoot throughout the gait cycle. Significant asymmetry was observed during stance, initial and terminal swing phases, where the hemiplegic limb was found shorter by using a paired t-test at 51 sample points (p < .05). The hemiplegic side was restricted in achieving maximal length during terminal swing. The ratio between the maximal dynamic leg length during the stance phase to minimal dynamic leg length during the swing phase was found higher on the non-involved side and lower on the hemiplegic side (p < .05). Quantifying clearance mechanics based on dynamic leg length can provide an additional insight into the analysis of gait patterns and might assist in detecting time of abnormal kinematic deviations.  相似文献   

Development of a golf-specific load monitoring tool: Content validity and feasibility     

Scott B. Williams  Paul B. Gastin  Anna E. Saw  Sam Robertson 《European Journal of Sport Science》2018,18(4):458-472

Athletes often record details of their training and competitions, supported by information such as environmental conditions, travel, as well as how they felt. However, it is not known how prevalent these practices are in golfers, or how valuable this process is perceived. The purpose of this study was to develop a golf-specific load monitoring tool (GLMT), and establish the content validity and feasibility of this tool amongst high-level golfers. In the first phase of development, 21 experts were surveyed to determine the suitability of items for inclusion in the GLMT. Of the 36 items, 21 received >78% agreement, a requirement to establish content validity and for inclusion in the GLMT. Total duration was the preferred metric for golf-specific activities, whilst rating of perceived exertion (RPE) was preferred for measuring physical training. In the second phase, feasibility of the tool was assessed by surveying 13 high-level male golfers following 28-days of daily GLMT use. All items included in the GLMT were deemed feasible to record, with all players participating in the feasibility study providing high to very high ratings. Golfers responded that they would consider using a load monitoring tool of this nature long term, provided it can be completed in less than five minutes per day.  相似文献